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钩虫病低度流行区人群目标化疗和集体化疗效果观察

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寄生虫病与感染性疾病 2004年第1期2卷 5-7页

作者：邵靖鸥杨维平陈业军匡瑞祥陈世兰沈一平江苏省扬州市疾病预防控制中心血吸虫病防治所江苏扬州225002 扬州大学医学院江苏扬州225001 高邮市血吸虫病防治站江苏高邮225600 南京医科大学病原生物学系江苏南京210029

目的　探讨钩虫病低度流行区的防治措施。方法　采用 Kato- Katz法对高邮市 3个村 (目标化疗村、集体化疗村和空白对照村 )居民抽样粪检。目标化疗和集体化疗均采用甲苯咪唑 6 0 0 mg,1.5d,3次分服 ,空白对照以 N a HCO3 片剂作安慰剂... 详细信息

目的　探讨钩虫病低度流行区的防治措施。方法　采用 Kato- Katz法对高邮市 3个村 (目标化疗村、集体化疗村和空白对照村 )居民抽样粪检。目标化疗和集体化疗均采用甲苯咪唑 6 0 0 mg,1.5d,3次分服 ,空白对照以 N a HCO3 片剂作安慰剂。服药后 2个月及 16个月以同法复查 ,考核近、远期疗效。结果　目标化疗村钩虫感染率从 6 .90 %下降至 1.4 1%和 1.92 % ;集体化疗村钩虫感染率从 10 .10 %下降至 2 .2 2 %和 0 .6 5% ;空白对照村 3次结果分别为 5.14 %、3.54 %、1.94 %。结论　在钩虫低度流行区。

关键词：钩虫病低度流行区目标化疗集体化疗预防治疗

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多西他赛每周方案联合顺铂二线治疗治疗非小细胞肺癌

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临床和实验医学杂志 2007年第12期6卷 33-33,37页

作者：卢凯华仇金荣黄普文刘平束永前南京医科大学第一附属医院肿瘤中心江苏南京210029

目的研究多西他赛每周方案联合顺铂二线治疗非小细胞肺癌（NSCLC）的疗效和毒性反应。方法48例晚期非小细胞肺癌患者，既往曾接受1个含铂方案治疗，采用多西他赛30mg／m^2，静脉滴注60min，第1、8、15d给药，顺铂40mg静脉滴注60rain，第... 详细信息

目的研究多西他赛每周方案联合顺铂二线治疗非小细胞肺癌（NSCLC）的疗效和毒性反应。方法48例晚期非小细胞肺癌患者，既往曾接受1个含铂方案治疗，采用多西他赛30mg／m^2，静脉滴注60min，第1、8、15d给药，顺铂40mg静脉滴注60rain，第1～3d，每28d为1周期。患者的行为状态评分（PS）均为ECOG≤2。结果48例患者均可评价，总共化疗周期数为189周期。1例完全缓解（CR）占2，1％，14例部分缓解（PR）占29．2％，有效率（ORR）为31．3％，中位生存时间为37周，1年生存率为33％，粒细胞减少与乏力为主要的毒性反应，其他的毒性反应为脱发和体液潴留。结论多西他赛30mg／m^2每周给药联合顺铂二线治疗NSCLC有确切的疗效且耐受性好。

关键词：晚期非小细胞肺癌多西他赛联合化疗每周方案

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低浓度混苯暴露对早早孕丢失的影响的初步研究

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中国职业医学 2000年第4期27卷 2-4页

作者：王守林宋玲陈海燕张绮王顶贤杜冰 XPXu 王心如南京医科大学公共卫生学院江苏南京210029 仪化集团公司医院预防保健中心扬子石化公司职业病防治所南京医科大学哈佛大学公共卫生学院生态遗传与临床流行病学合作研究中心

目的　探讨低浓度混苯暴露对早早孕丢失 (EFL)的影响。方法　选择某石化企业有混苯接触的女工 42人为暴露组、无混苯接触的女工 49人为内对照组、某化纤企业无混苯暴露的女工 118人为外对照组 ,自不采取避孕措施的第一个月经周期起留取... 详细信息

目的　探讨低浓度混苯暴露对早早孕丢失 (EFL)的影响。方法　选择某石化企业有混苯接触的女工 42人为暴露组、无混苯接触的女工 49人为内对照组、某化纤企业无混苯暴露的女工 118人为外对照组 ,自不采取避孕措施的第一个月经周期起留取每日晨尿 ,分别收集到 96、14 6和 435个周期共 15 0 84份尿样 ,用免疫放射法 (IRMA)测定尿液中人绒毛膜促性腺激素 (β hCG)的含量 ,并对早早孕丢失进行评价。结果　三组女工EFL的发生率较接近 ,约为 30 %～40 % ,但暴露组和内对照组EFL的女工发生率及其周期发生率均高于外对照组 ,且暴露组和内对照组EFL阳性女工的周期发生率显著高于外对照组 (P <0 0 5 )。

关键词：混苯暴露人绒毛膜促性腺激素早早孕丢失

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Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cellapoptosis, and inhibits the proliferation of human gastric cancer cells in vitro

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南京医科大学学报(自然科学版) 2008年第7期 932-932页

作者： Zhu,F. Chen,G.S. Su,H. Luo,C. Zhao,Q.S. Zhang,Y. Shao,Y. Sun,J. Zhou,S.M. Ding,G.X. Cheng,Y.L.Nanjing Med Univ,Affiliated Hosp 1,Dept Geriatr,Nanjing 210029,Jiangsu,Peoples R China.Shanghai Jiao Tong Univ,Dept Gastroenterol,Shanghai Peoples Hosp 1,Shanghai 200080,Peoples R China.Govt Off Hosp Jiangsu Prov Peoples Govt,Dept Med,Nanjing 210024,Jiangsu,Peoples R China.Chinese Acad Sci,State Key Lab Phytochem & Plant Resources W China,Kunming Inst Bot,Kunming 650204,Peoples R China.Univ Turku,Inst Biomed,FIN-20520 Turku,Finland.Univ Hong Kong,Dept Chem,Hong Kong,Hong Kong,Peoples R China.

Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric ***,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric ***,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 *** results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland *** rights reserved.

关键词： cholecystokinin-2 receptor cyclooxygenase-2 MKN-45 cell proliferation apoptosis hepatocyte growth-factor helicobacter-pylori epithelial-cells semiempirical methods human stomach up-regulation expression carcinoma proteins bcl-2

Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis

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南京医科大学学报(自然科学版) 2008年第10期 1368-1368页

作者： Jin, G. F. Wang, H. F. Hu, Z. B. Liu, H. L. Sun, W. W. Ma, H. X. Chen, D. Miao, R. F. Tian, T. Jin, L. Wei, Q. Y. Huang, W. Lu, D. R. Shen, H. B. Nanjing Med Univ, Canc Res Ctr, Dept Epidemiol & Biostat, Nanjing 210029, Peoples R China. Chinese Natl Human Genome Ctr, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai 201203, Peoples R China. Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China. Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA.

Exonuctease 1(EXO1) is an important nucleases involved in mismatch repair system that contributes to maintain genomic stability, to modulate DNA recombination, and to mediate cell cycle arrest. Potentially functional polymorphisms in EXO1 may alter cancer risks by influencing the repair activity of EX01. Therefore, we hypothesized that single nucteotide polymorphisms(SNPs) in EX01 were associated with risk of lung cancer. To test this hypothesis, we genotyped five common SNPs (rs1776177A/G, rs1047840G/A(Gtu589Lys), rs1776148G/A(Gly670Glu), rs9350C/T(Leu757Pro) and rs851797T/C) that tag eight SNPs located at exon regions of EX01 by using the Ilumina high-throughput genotyping platform in 500 incident lung cancer cases and 517 cancerfree controls in a Chinese population. Significant differences of allele and genotype distributions were observed in Gtu589Lys (rs1047840) of EX01 between the cases and controls (P = 0.028 and 0.025 for allele and genotype distributions, respectively). Lo- gistic regression analyses revealed that individuals carrying the variant 589Lys allele(589Glu/Lys or 589Lys/Lys) had a significantly increased risk of lung cancer[adjusted odds ratio(OR) = 1.41, 95% confidential interval(Cl) = 1.09-1.84] compared with those who carried the wild-type homozygote (589Glu/Glu). Furthermore, we found that haplotype AAGTT was more frequent in cases than in controls(P < 0.001 for both two-sided chi(2)-test and 1000 times permutation tests). These results suggest that the EXO1 Glu589Lys polymorphism and its surrounding regions might be genetic susceptibility markers for lung cancer in this study population. (c)2007 Elsevier Ireland Ltd. All rights reserved.

关键词： EXO1 MMR Polymorphisms lung cancer susceptibility molecular epidemiology nonpolyposis colorectal-cancer dna mismatch repair single nucleotide polymorphisms human exonuclease-i mutation avoidance gene recombination inactivation variants tobacco