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In Memoriam: Professor Ray WU

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Science china(Life sciences) 2010年第4期53卷 531-532页

作者： HUANG Bing-Ren National Laboratory of medical Molecular Biology, Department of Biochemistry and Molecular Biology, peking union medical college & chinese academy of medical sciences, beijing 100005, china 1. National Laboratory of medical Molecular Biology Department of Biochemistry and Molecular Biology Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100005 China

During the chinese New Year holidays in 2008, Professor Zhang Nai-Heng, former chair of the Department of Biochemistry, beijing medical college, informed me of the sad news that Professor Ray Wu had passed away in Ith... 详细信息

关键词： In Memoriam very Professor Ray WU DNA

Study on the Total Synthesis of Hainanolide (V)-Oxidation of the Tricyclic Alkenes with Singlet Oxygen

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chinese Chemical Letters 1999年第8期10卷 657-658页

作者： Xiao Ming YU Lu Yan ZHANG Shi Zhi CHEN Liang HUANG (Institute of Materia Medica, chinese academy of medical sciences and peking union medical college, beijing 100050) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

Six tricyclic compounds containing C-3, C-4 double bonds were oxidized with singlet oxygen. Different regio-selectivity was found with regard to steric hinderence.

关键词： hainanolide singlet oxygen

Synthesis and in vitro Antimycobacterial Activity of Moxifloxacin Methylene and Ethylene Isatin Derivatives

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Chemical Research in chinese Universities 2012年第1期28卷 61-66页

作者： FENG Lian-shun, LIU Ming-liang, WANG Shuo, CHAI Yun, LI Su-jie and GUO Hui-yuan Institute of medicinal Biotechnology, chinese academy of medical sciences and peking union medical college, beijing 100050, P. R. china chinese Acad Med Sci Inst Med Biotechnol Beijing 100050 Peoples R China

A series of novel moxifloxacin methylene and ethylene isatin derivatives with remarkable improvement in lipophilicity, compared to the parent moxifloxacin, was designed, synthesized and characterized by 1H NMR, MS and HRMS. These derivatives were initially evaluated for their in vitro antimycobacterial activity against M. smegmatis CMCC 93202. Compounds 3a―3f, 5a, 5f and 5j were chosen for the further evaluation of their in vitro activity against Mycobacterium tuberculosis（MTB） H37Rv ATCC 27294 and MDR-MTB 09710. All the target com pounds[minimum inhibitory concentration（MIC）： 0.39―〉16 μg/mL] were far more active than rifampin（MIC： 2.0―〉256 μg/mL）, but less active than moxifloxacin（MIC： 0.1―1.0 μg/mL） against the three tested strains. The most active compounds 3a and 3c were found to be 2―64 fold more potent than isoniazid and rifampin against M. smegmatis CMCC 93202, 2 fold more potent than rifampin against MTB H37Rv ATCC 27294, and 16―〉64 fold more potent than ethambutol, isoniazid and rifampin against MDR-MTB 09710.

关键词： Moxifloxacin derivative Antimycobacterial activity Isatin

MURICATALIN, A NEW POLYKETIDE FROM ANNONA MURICATA (ANNONACEAE)

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chinese Chemical Letters 1995年第1期6卷 45-48页

作者： Hua Qing GUI jing Guang YU and Zhi Li YU￣aInstitute of medicinal plant development, chinese academy of medical sciences and peking union medical college. beijing 100O94 chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China beijing union Med Coll Beijing 100094 Peoples R China

Muricatalin (1), a new polyketide (acetogenin) has been isolated from Annona muricata L. Its structure and relative stereochemistry were elucidated on the basis of the spectral analyses of 1 and its derivatives, the a...

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Study on the Mechanism of the Rearrangement Reaction of 3-n-Butylphthalide by Deuterium-Labelling

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chinese Chemical Letters 1997年第6期8卷 479-482页

作者： Bai Ling XU Zong Ru GUO Xiao Tian LIANG Guang Zhong YANG (Institute of Materia Medica, chinese academy of medical sciences, peking union medical college, beijing 100050) chinese ACAD MED SCI PEKING UNION MED COLLINST MAT MEDBEIJING 100050PEOPLES R CHINA

By the Grignard reaction of 1,1-di-deutero-1-bromobutane with phthalaldehydic acid 1',1'-di-deutero-3-n-butyl phthalide was obtained, which underwent a rearrangement reaction using AlCl3 as catalyst in CS2 to give 1-methyl-5-carboxy-3,4-di-deutero-tetrahydronaphthalene. The mechanism was proposed to be a series of consecutive 1,2- hydride transfers rather than a direct 1,4-hydride transfer.

关键词： ppm CHD Study on the Mechanism of the Rearrangement Reaction of 3-n-Butylphthalide by Deuterium-Labelling

Distinct Pattern of Human Vδ1 γδ T Cells Recognizing MICA

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Cellular & Molecular Immunology 2005年第4期2卷 253-258页

作者： Jianqiang Li~1 Lianxian Cui~1 Wei He~(1,2) ~1Department of Immunology,Institute of Basic medical sciences,chinese academy of medical sciences and School of Basic Medicine,peking union medical college,5 Dong Dan San Tiao,beijing 100005,china Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College Beijing 100005 China.

γδT cells represent one unique recognition pattern,the limited recognition,which distinguishes from the specificrecognition for αβT cells and pattern recognition for macrophages.Vδ1 γδT cell is the major subset of human γδT cells,which predominates in mucosal tissue including the intestinal ***,a few antigens thathuman Vδ1TCR can recognize have been *** them,MHC class I chain-related molecules A (MICA)have been studied most *** Vδ1TCR,MICA is also the ligand of NKG2D,a C-type lectin-likeactivating *** human,only Vδ1 cells can simultaneously express both types of receptors of MICAwhile NK cells,αβT cells and other subsets of γδT cells likewise express *** the precisemechanisms are still enigmatic,this distinct pattern of Vδ1 cells recognizing MICA predicts unique biologicalsignificance of Vδ1 cells in immune *** years,some progresses have been made in this *** thisreview we summarize the related reports and put forward some novel views based on our group’s ***& Molecular Immunology.2005;2(4):253-258.

关键词： Vδ1TCR MICA NKG2D γδ T cell

STUDIES ON THE STRURE OF LIGUSTIPHENOL FROM LIGUSTICUM SINENCE OLIV

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chinese Chemical Letters 1996年第8期7卷 721-722页

作者： De Quan YU Feng Zhi XIE Ruo Yun CHEN and Yan He HUANG(Institute of Materia Medica, chinese academy of medical sciences and peking union medical college, beijing, 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050

Ligustiphenol (1), a new sesquiterpenoid with bisabolane skeleton, has beenisolated from the alcohol extract of roots of Ligusticum silence Oliv, and its strcutureincluding absolute configuration established on the ba...

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Synthesis of (+) 8-O-Cinnamyl-p-chlorogoniotriol and its Analogues

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chinese Chemical Letters 1999年第6期10卷 449-452页

作者： Hong CHEN Long En ZHOU Yan Jun ZHANG De Quan YU(Institute of Meteria Medica chinese academy of medical sciences &peking union medical college. beijing 100050) chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

(+) 8-O-Cinnamyl-p-chlorogoniotriol (p-chlorohowiinol A) and its analogues have been synthesized in nine steps from alpha-D-glucoheptonic-gamma-lactone. Pharmacological tests showed that most of the compounds possesse... 详细信息

关键词： stereoselective synthesis (+) 8-O-cinnamyl-p-chlorogoniotriol (p-chlorohowiinol A) antitumor activity analogues

High-and Low-Frequency Probe Tone Tympanometry in chinese Infants

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Journal of Otology 2007年第1期2卷 42-51页

作者： SHANG Ying-ying1, NI Dao-feng1, LIU Shi-lin2 1 Department of Otorhinolaryngology, peking union medical college Hospital, chinese academy of medical sciences and peking union medical college, beijing, china 2 Department of Otorhinolaryngology, beijing Children’s Hospital, Capital medical University, beijing, china Department of Otorhinolaryngology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Otorhinolaryngology Beijing Children’s Hospital Capital Medical University Beijing

Objective To assess the utility of low- and high-frequency tympanometry in the diagnosis of middle ear dysfunction in chinese infants. Methods Tympanograms were obtained with 226 Hz, 678 Hz and 1000 Hz probe tones from infants aged 5-25 weeks with normal auditory brainstem responses(ABRs)(15 infants, 30 ears) and with prolonged wave I latencies(17 infants, 20 ears), suggesting middle ear dysfunction, using a GSI Tympstar middle ear analyzer Version II. Results The single-peaked tympanogram was the most characteristic type in both groups and seen in 25 ears (83.3%) in the normal ABR group and in 18 ears (90%) in the delayed wave I group, respectively. The peak pressure, peak compensated static acoustic admittance and gradient of 226 Hz tympanometry were of no significant differences between the two groups. The 678 Hz tympanograms of admittance, susceptance and conductance demonstrated non-peak, single-, double- and tri-peaked patterns in both groups. The agreement between ABRs and 678 Hz tympanograms of admittance,susceptance and conductance were 70.0%, 58.0% and 64.0%(kappa=0.324, 0.234 and 0.118) respectively. For 1000 Hz probe tone, admittance, susceptance and conductance tympanograms showed single peaked patterns in 28(93.3%), 25 (83.3%) and 26(86.7%) of the 30 normal ears. Admittance, susceptance and conductance tympanograms using the 1000 Hz probe tone were flat in 15 (75%), 17(85%) and 13 (65%) of the ears in infants with prolonged wave I latencies. For 1000 Hz admittance, susceptance and conductance Tympanograms, the agreement between tympanometry and ABR results were 90.0%, 92.0% and 86.0% with kappa at 0.783, 0.831 and 0.690, respectively. Conclusion 1000 Hz probe tone tympanometry is a promising middle ear function test for infants of 1-6 months age, while 226 Hz and 678 Hz probe tones are less efficient in detecting middle ear dysfunction in infants.

关键词： ABR High-and Low-Frequency Probe Tone Tympanometry in chinese Infants