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THE　ISOLATION　AND　CHEMICAL　STRUCTURE　OF　ISOANNONARETICINS，A　PAIR　OF　2－EPIMERS　FROM　ANNONA　RETICULATA（ANNONACEAE）

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chinese Chemical Letters 1996年第1期7卷 19-22页

作者： Jing’Guang YU and Dong LIU(Institute of medicinal plant development, chinese academy of medical sciences andpeking union medical college, beijing 100094) Inst. of medicinal plant development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094

A new acetogenin 2,4ets-cis-isoannonareticin (2-1) (2,4-cis-bullatacinone) and a known bullatacinone (2,4--trans-isoannonareticin) (2-2) were a pair of isomersepimeric at C-2 which were isolated as two pure natural compounds from Annonareticulata L. by using preparative TLC. Their structures and the relativestereochemistry were elucidated on the basis of the spectral analysis.

关键词： DENSICOMA ANNONACEAE ACETOGENINS POLYKETIDES BULLATA

A new Kaurane Derivative from Aralia Fargesii

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chinese Chemical Letters 1999年第8期10卷 673-674页

作者： Yu Mei ZHANG Jun Shan YANG Xu Dong XU (Institute of medicinal plant development, chinese academy of medical Science peking union medical college, beijing 100094) peking union Med Coll Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China

A new ent-kaurane diterpene was isolated from the rhizome of Aralia fargesii. On the basis of chemical and spectral evidences, its structure was established as 16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid.

关键词： Aralia fargesii ent-kaurane 16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid

Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae)

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chinese Chemical Letters 2000年第1期11卷 37-38页

作者： Jian Hua JU Jun Shan YANG Jin LI Pei Gen XIAO (Institute of medicinal plant development. chinese academy of medical sciences and peking union medical college, beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

A new phenanthraquinone, cypripediquinone A, was isolated from the rhizome of Cypripedium macranthum ( Orchidaceae ) and its structure was established as 2,4,7-trimethoxy-9, 10- phenanthraquinone mainly by spectroscop... 详细信息

关键词： Cypripedium macranthum cypripediquinone A

New Flavonoid Glycoside from Thalictrum przewalskii

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chinese Chemical Letters 1999年第4期10卷 295-296页

作者： Shi Chun YU Qing Li WU Li Wei WANG Pei Gen XIAO(Institute of medicinal plant development, chinese academy of medical sciences and peking union medical college, beijing 100094.) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was determ... 详细信息

关键词： Thalictrum Thalictrum przewalskii flavonoid glycoside 5, 7-dihydroxy-4 '-methoxyflavonoid 7-O-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside

Erythrinarbine,a Novel nor-A ring Erythrina Alkaloid from Erythrina arborescens

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chinese Chemical Letters 1999年第2期10卷 139-142页

作者： Dong Lei YU Jian GUO Li Zhen XU Shi Lin YANG(Institute of medicinal plant development, chinese academy of medical sciencesand peking union medical college, beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

Erythrinarbine 2, a novel alkaloid was isolated from the stem of Erythrina arborescens Roxb. Its structure and stereochemistry were elucidated on the basis of the spectral analysis (C-13 - H-1 COSY, H-1-H-1 COSY, NOES... 详细信息

关键词： Erythrina arborescens erythrinarbine nor-A ring erythrina alkaloid

Muricatenol, a Linear Acetogenin from Annona muricata (Annonaceae)

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chinese Chemical Letters 2000年第3期11卷 239-242页

作者： De Yu LI Jing Guang YU Xiu Zhen LUO Lan SUN Shi Lin YANG (Institute of medicinal plant development. chinese academy of medical sciences and peking union medical college. beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

Muricatenol 1, a new acetogenin, has been isolated from the seeds of Annona muricata L.. Compound 1 is a C-37 acetogenin without any THF rings. with four hydroxyls and one double bond in the long aliphatic chain. The hydroxyls of 1 are located at C-4, C-10, C-18 and C-19. respectively. The vicinal diet at C-18/C-19 is threo-configuration, and the double bond at C-14/C-15 is cis-configuration.

关键词： Annona muricata Annonaceae acetogenins muricatenol

Reference ranges and age-related changes of peripheral blood lymphocyte subsets in chinese healthy adults

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Science china(Life sciences) 2009年第7期52卷 643-650页

作者： JIAO Yang1,QIU ZhiFeng1,XIE Jing1,LI DongJing2 & LI TaiSheng1 1 Department of Infectious Disease,peking union medical college Hospital,peking union medical college & chinese academy of medical sciences,beijing,china 2 Department of Special Care Unit,peking union medical college Hospital,peking union medical college & chinese academy of medical sciences,beijing,china Department of Infectious Disease Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China Department of Special Care Unit Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China

This study was performed to build region-specific reference ranges of peripheral blood lymphocyte subsets for chinese healthy adults from the young to the elderly and analyze the trends of changes in lymphocyte subsets for evaluating the impact of age on the values.151 healthy adults aged 19-86 were recruited based on the SENIEUR *** sets of reference ranges were finally built applicable for the healthy young(19-44 years),middle-aged(45-64 years) and elder adults(≥65).Comparisons in parameters among the three cohorts showed that a statistically significant increase in CD16CD56+ NK cell was observed between the middle-aged and elder cohorts,whereas for the majority of the parameters,a significant decline was observed between the young and the middle-aged *** results showed that inverse correlations were observed between the age and CD19+ B,CD3+ T,CD3+CD4+ T,CD4+CD45RA+CD62L+ nave T cell and CD4+CD28+/CD4+,while the positive one was identified between the age and the NK *** significant changes of the most of immune parameters provided evidence for ***,T cell activation markers of CD8+CD38+ and CD8+HLA-DR+ showed reverse trends of association with age,which provides a clue for further researches on the mechanisms underlying the paradoxical clinical presentation of the elder patients.

关键词： lymphocyte subsets age reference range immunosenescence

Mechanism for chronic pain generation

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chinese Science Bulletin 2000年第9期45卷 775-783页

作者： XIE YikuanInstitute of Basic medical sciences, peking union medical college, chinese academy of medical sciences, beijing 100005. Institute of Basic medical sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing China

Neuropathic pain and the other abnormalities of sensation induced by axon injury or by peripheral nerve inflammation should result from functional compensations of the injured neurons during their regeneration. Ectopic distribution of proteins related to Na+, K+ and Ca2+ channels as well as of receptors on both membranes of injured axon and its cell body becomes a main pacemaker from which spontaneous ectopic afferent of primary sensatory neurons and crosstalk between neurons occur. Abnormal ectopic afferent activities lead to disorders of the sensation, such as hyperalgesia, allodynia, spontaneous pain and paraesthesia. Administration of some ion channel agents and/or α2-adrenergic blockers has shown efficiency in preventing neuropathic pain development and in relieving neuropathic pain.

关键词： chronic pain nerve injury ectopic firing ion channels sympathetic activity.

Studies on the Chemical Constituents of Lysimachia capillipes Hemsl

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chinese Chemical Letters 1998年第12期9卷 0-0页

作者： Chen XIE Li Zhen XU Bao Hua ZHAO and Shi Lin YANG(Institute of medicinal plant development, chinese academy of medical sciences and pekingunion medical college, beijing 100094) chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China peking union Med Coll Beijing 100094 Peoples R China

Eight compounds were isolated from the ethanolic extracts of Lysimachia capillipes Hemsl. They were identified as capilliplactone 1, capillipnin 2,beta-daucosterol 3, succinic acid 4, quercetin 5, 3',4',5,5',7-pentahydroxyflavone 6, quercetin-3-O-beta-D-glucopyranoside 7 and kaempferol 8 on the basis of chemical and spectral methods. Among them, 1 and 2 were new, their structures were established as all-cis-5-deoxy-pentonic acid-gamma-lactone and 1,2,4,5 -tetrahydroxy-3-n-pentylbenzen-2,4-di-O-beta-D-glucopyranoside through their spectral data ((HNMR)-H-1, (CNMR)-C-13, DEFT, H-1-H-1 COSY, H-1-C-13 COSY, HMBC etc).

关键词： Lysimachia lysimachia capillipes, capillplactone capillipnin