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Simulation of 1991-2005 Meiyu seasons in the Yangtze-Huaihe region using BCC_RegCM 1.0

Chinese Science Bulletin 2010年第11期55卷 1077-1083页

作者： HU YaMin1,2,3& DING YiHui4 1 Institute of Tropical and Marine Meteorology, china Meteorological Administration, guangzhou 510080, china 2.guangdong climate center, guangzhou 510080, china 3 Chinese Academy of Meteorological Sciences, Beijing 100081, china 4 National climate center, china Meteorological Administration, Beijing 100081, china Institute of Tropical and Marine Meteorology China Meteorological Administration Guangzhou 510080 China guangdong climate center Guangzhou 510080 China Chinese Academy of Meteorological Sciences Beijing 100081 China National climate center China Meteorological Administration Beijing 100081 China

By using BCC_RegCM 1.0 (RegCM for short) from Beijing climate center (BCC), china Meteorological Administration (CMA), the Meiyu season characters over the Yangtze-Huaihe region during 1991-2005 are simulated. The major conclusions of this study may be summarized as the following: (1) RegCM can reproduce the interannual variation and the spatial distribution of the summertime precipitation and temperature in the Yangtze-Huaihe region. (2) By use of a generalized Meiyu criterion and in accordance with model-calculated precipitation and temperature, the Meiyu onset and ending date have been determined. Compared with the observation, RegCM can simulate the interannual variation of the Yangtze-Huaihe Meiyu with preferable capability for most of the normal Meiyu years (such as 1995, 1997, 2000, 2001, 2002 and 2004), especially for the rich Meiyu years of 1996, 1998 and 1999. (3) In terms of the average simulation for the recent 15 years, the timings of onset and ending of Meiyu occur on June 1 and July 13, respectively, which are earlier than the climatological observation. For duration, Meiyu persists for 32 d, 3 d shorter than the observation. The index of Meiyu intensity is 2.45, while the climatological one is 3.00. Therefore, RegCM is capable of simulating the climatological Meiyu duration and intensity, while the capability of simulating the onset and ending date of Meiyu still needs to be improved.

关键词：梅雨季节模拟计算长江气候观测发病时间强度指数中国气象局空间分布

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Field measurement and analysis of turbulence coherence for Typhoon Nuri at Macao Friendship Bridge

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Science china(Technological Sciences) 2010年第10期53卷 2647-2657页

作者： SONG LiLi1, PANG JiaBin2, JIANG ChengLin3, HUANG HaoHui3 & QIN Peng3 1 guangzhou Institute of Tropical and Marine Meteorology, CMA, guangzhou 510080, china 2 Tongji University, Shanghai 200092, china 3 guangdong climate Centre, guangzhou 510080, china 1. guangzhou Institute of Tropical and Marine Meteorology CMA Guangzhou 510080 China2. Tongji University Shanghai 200092 China3. Guangdong Climate Centre Guangzhou 510080 China

For the purpose of investigating the turbulent and spatial coherent characteristics of strong wind during typhoon landing period,two 3-dimensional ultrasonic anemometer stations were set up 30 m horizontally apart on the Macao Friendship Bridge to caputure the turbulent wind velocities of Typhoon Nuri. Based on the reliable and representative field measured data,the mean wind speed and direction,turbulence intensity,turbulence integral scale,turbulence power spectra,spatial correlation coefficient and coherence function were statistically evaluated. The field measurement analysis have presented the following results: 1) Two anemometer stations provided consistent results. The mean wind speed variation in time domain presented typical M-shape curves. The strong wind (10-minute mean wind speed higher than 8th grade in Beaufort wind scale) direction changed in a big range up to 122-degrees-angle,indicating the field measurements scoped over the typhoon landing period. 2) The ratio of the longitudinal,lateral and vertical turbulence intensities of the strong wind in the typhoon eye wall region was 1:0.96:0.36. Compared with the code defined ratio 1:0.88:0.5,the lateral component was larger and the vertical component was smaller. 3) The value of integral scale increased when the eye wall of Typhoon Nuri passed over the field measurement site. Before the center of Typhoon Nuri arrived,the integral scale of the strong typhoon wind was about twice compared with that for the non-typhoon wind. 4) The spatial correlation of the turbulent wind,coherence function curve and the decay factor had significant differences at different times during the typhoon process. In the eye wall of the typhoon,the horizontal spatial correlation was relatively strong and horizontally spatial correlation spectrum decayed slower with frequency increase. The minimum regressed coefficient C in coherence function model was 4.67,which is lower than the code defined low limit. The maximum decay factor w

关键词： typhoon field measurement and analysis turbulence characteristics coherence spectral function

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Impact of EnKF assimilating Himawari-8 all-sky infrared radiance on the forecasting of a warm-sector rainstorm event

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Science china Earth Sciences 2024年第10期67卷 3110-3127页

作者： Shanshan LOU Lei ZHU Xuexing QIU guangzhou CHEN Song YUAN Shengnan ZHOU Anhui Meteorological Observatory Hefei 230031China Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Joint International Research Laboratory of Climate and Environment Change(ILCEC)Nanjing University of Information Science&TechnologyNanjing 210044China Huaihe River Basin Meteorological center Hefei 230031China Shouxian National Climatology Observatory Huaihe River Basin Typical Farm Eco-Meteorological Experiment Field of CMAShouxian National Comprehensive Meteorological Observation Special Experimental OutfieldShouxian 232200China Anhui Province Key Laboratory of Atmospheric Science and Satellite Remote Sensing Hefei 230031China

Warm-sector rainstorms are highly localized events, with weather systems and triggering mechanisms are not obvious,leading to limited forecasting capabilities in numerical models. Based on the ensemble Kalman filter(PSU-En KF) assimilation system and the regional mesoscale model WRF, this study conducted a simulation experiment assimilating all-sky infrared(IR)radiance for a warm-sector rainstorm in East china and investigated the positive impact of assimilating the Himawari-8 moisture channel all-sky IR radiance on the forecast of the rainstorm. Results indicate that hourly cycling assimilation of all-sky IR radiance can significantly improve the forecast accuracy of this warm-sector rainstorm. There is a notable increase in the Threat Score(TS), with the simulated location and intensity of the 3-hour precipitation aligning more closely with observations. These improvements result from the assimilation of cloud-affected radiance, which introduces more mesoscale convective information into the model's initial fields. The adjustments include enhancements to the moisture field, such as increased humidity and moisture transport, and modifications to the wind field, including the intrusion of mid-level cold air and the strengthening of lowlevel convergent shear. These factors are critical in improving the forecast of this warm-sector rainstorm event.

关键词： Ensemble Kalman filter WRF model Himawari-8 All-sky radiance Warm-sector rainstorm

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Analysis on the Microstructure and Performance Evolvement of Alloyed Tool Steel Hot Rolling Strip Produced by CSP Technology

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Journal of Iron and Steel Research International 2011年第S1期18卷 621-624页

作者： CHEN Jing-hu 1,2,JIE Xiao-hua 1 (1.Faculty of Materials and Energy,guangdong University of Technology,guangzhou510006,guangdong,china 2.Technology center of guangzhou Steel Group Co Ltd.,guangzhou510380,guangdong,china) guangdong Univ Technol Fac Mat & Energy Guangzhou 510006 Guangdong Peoples R China guangzhou Steel Grp Co Ltd Ctr Technol Guangzhou 510380 Guangdong Peoples R China

This thesis determinates the microstructure and inclusions of the alloyed tool steel by CSP processing with the help of *** results show that the slab microstructures are the fine branched crystalline grains and the branch width has little disparity from the surface to the central *** the product,the grain microstructures are fine pearlites and few ferrites with the pearlite space 0.4μm to 0.2μm.

关键词： compact strip production alloyed tool steel microstructure grain

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Adjuvant interferon therapy for malignant melanoma:the debate

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Chinese Journal of Cancer 2010年第11期29卷 907-913页

作者： Qiang Zhou1,2, Xiao-Shi Zhang1,2 1 State Key Laboratory of Oncology in South china, guangzhou, guangdong 510060, P. R. china 2 Biotherapy center, Sun Yat-sen University Cancer center, guangzhou, guangdong 510060, P. R. china Biotherapy center Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Based on the results of the Kirkwood high-dose interferon alpha-2b (HDI) adjuvant therapy trial of the Eastern Cooperative Oncology Group 1684, the US Food and Drug Administration (FDA) approved HDI as the postoperative adjuvant therapy for high-risk melanoma. Unfortunately, controversies continue regarding the use of interferon (IFN) as adjuvant therapy for melanoma owing to the inconsistent results of subsequent trials. Numerous trials of adjuvant interferon therapy demonstrated a benefit in terms of relapse-free survival (RFS), but without confirmed significant effect on overall survival (OS). The optimal timing, dose, and type of interferon are not yet defined. Therefore, adjuvant interferon treatment is preferentially applied in the randomized clinical trials in specialized centers. Decisions about the appropriateness of adjuvant interferon alfa-2b treatment for patients should be made on an individual basis, after discussion with the patient, including an explanation of the potential benefits and side effects of interferon therapy. Moreover, we also need to use available regimens reasonably, seek feasible and predictable prognostic factors to serve patients with individualized therapy.

关键词：恶性黑色素瘤干扰素α 辅助治疗治疗试验人类发展指数美国食品临床试验合理利用

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Temporal and Tight Hepatitis C Virus Gene Activation in Cultured Human Hepatoma Cells Mediated by a Cell-Permeable Cre Recombinase

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Acta Biochimica et Biophysica Sinica 2004年第10期36卷 687-694页

作者： Dong XIAO*, Kang XU1, Ying YUE, Zhong-Min GUO, Bing HUANG, Xin-Yan DENG, Huan TANG2, and Xi-Gu CHEN* center of Experimental Animals, Zhongshan University, guangzhou 510080, china 1The first affiliated hospital of Sun Yat-sen University, Zhongshan University, guangzhou 510080, china 2The Third Military Medical University, Chongqing 400010, china center of Experimental Animals Zhongshan University The first affiliated hospital of Sun Yat-sen University Zhongshan University The Third Military Medical University

Conditional gene expression has greatly facilitated the examination of the functions of particular gene products. Using the Cre/lox P switching expression system, we plan to develop efficient conditional transgeneactivation of hepatitis C virus core protein (HCV-C) cDNA (nucleotide 342–914) in the transgenic mice to overcome “immune tolerance” formed during the embryonic period and “immune escape” against hepatitis virus antigen in our project. To use this system in vivo, the dormant transgenic construct, i.e., pApoE-SCS-EGFP-HCV-C, was generated using techniques of standard molecular biology. The liver- specific human apoE promoter was here used to target expression of genes of interest (EGFP and HCV-C) to murine liver. Prior to generating the transgenic mice, the availability of Cre/lox P system and construct functionality were successfully verified by a cell-free recombination system and via checking the expression of EGFP and HCV-C in the human hepatoma cells at the mRNA and protein levels. These results suggest that the Cre/lox P system could tightly control expression of EGFP and HCV-C in vitro, which laid a solid foundation to conditionally activate expression of target gene(s) in transgenic mice by Cre-mediated site-specific recombination.

关键词： hepatitis C virus Cre/lox P switching expression system cell-free and intracellular recombination systems cell-permeable Cre recombinase EGFP human hepatoma cells

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Antiangiogenic therapy:a novel approach to overcome tumor hypoxia

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Chinese Journal of Cancer 2010年第8期29卷 715-720页

作者： Fang Peng1,2, Ming Chen1,2 1 State Key Laboratory of Oncology in South china, guangzhou, guangdong 510060, P. R. china 2 Department of Radiation Oncology, Sun Yat-sen University Cancer center, guangzhou, guangdong 510060, P. R. china Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Hypoxia is a common phenomenon in solid tumors. Resistance of hypoxic tumor cells to radiation is a significant reason of failure in the local control of tumors. The growth and metastasis of solid tumors rely on blood vessels. Antiangiogenic agents mainly target tumor blood vessels, and radiation therapy mainly targets tumor cells. Combination of antiangiogenic treatment and radiation exhibits synergistic effect, which improves the response of tumors to radiation therapy. The mechanisms of interaction between antiangiogenic agents and ionizing radiation are complex and involve interactions between tumor cells and tumor microenvironment, including tumor oxygenation, stroma, and vasculature. The original mechanism of antiangiogenesis is to induce ischemia and hypoxia in tumors, thereby, "starve" the tumors. However, recently, emerging data suggest that antiangiogenic agents could reduce the proportion of hypoxic cells through normalizing tumor vasculature, decreasing oxygen consumption, and other mechanisms. The use of antiangiogenic agents provides a new approach to overcome the hypoxia problem, and ultimately improves the efficacy of radiation therapy. In this review, we discuss tumor hypoxia, tumor angiogenesis and its regulation, mechanisms of antiangiogenic therapy combined with radiation therapy, and how antiangiogenic therapy overcomes tumor hypoxia.

关键词：抗血管生成肿瘤细胞抗缺氧疗法放射治疗电离辐射肿瘤血管生成相互作用

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Tetracycline-controlled transcriptional regulation systems: countermeasures to eliminate basal transgene leaks in Tet-based systems

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Progress in Natural Science:Materials International 2007年第1期17卷 11-19页

作者： XIAO Dong, SUN Yan, GU Weiwang and CHEN Xigu ( center of Experimental Animals and Institute of Comparative Medicine, Southern Medical University, guangzhou 510515, china center of Experimental Animals, Sun Yat-sen University, guangzhou 510080, china) [a]center of Experimental Animals and Institute of Comparative Medicine Southern Medical University Guangzhou China [b]center of Experimental Animals Sun Yat-sen University Guangzhou China

To analyze the function of any given transgene(s) accurately in transgenic mice, and to produce credible transgenic animal models of various human diseases (precisely and realistically mimicking disease states), it is critical to be able to control gene expression in the animals conditionally. The ability to switch gene expression "on" or "off" in the restricted cells or tissue(s) at specific time(s) allows unprecedented flexibility for exploring gene function(s) in both the health and the disease. Pioneering work on inducible transgene expression has led to the development of a wide variety of controlled gene expression systems that meet this criterion. Among them, the tetracycline-inducible systems (e.g. Tet-off and Tet-on) have been widely, frequently and successfully employed in vitro and in vivo. These systems, however, are not always tight but leaky; sometimes the leakage is significant. In some circumstances, the resulting leak is acceptable, but in others, it is more problematic. Though these systems face this disadvantage, i. e. basal transgene leakage in vitro and in vivo, several approaches, including using improved versions (e.g. rtTA2S-M2 and rtTA2S-S2) of rtTA, tetracycline-controlled transcriptional silencer (tTS), an "ideal" minimal promoter in responsive components or combinations thereof, have been developed to avoid this limitation effectively. In this review we discuss the countermeasures available to eliminate basal transgene leakage from Tet-based systems.

关键词： tetracycline inducible system transgenic mice leaky expression transcriptional silencer.

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Entropy correction of BTZ black holes in a tunneling framework

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Science china(Physics,Mechanics & Astronomy) 2010年第8期53卷 1427-1433页

作者： ZHANG JingYi center for Astrophysics, guangzhou University, guangzhou 510006, china 1. center for Astrophysics Guangzhou University Guangzhou 510006 China

In this paper, using the Parikh-Wilczek tunneling framework, we first calculate the emission rates of non-rotating BTZ black holes and rotating BTZ black holes to second order accuracy. Then, by assuming that the emission process satisfies an underlying unitary theory, we obtain the corrected entropy of the BTZ black holes. A log term emerges naturally in the expression of the corrected entropy. A discussion about the inverse area term is also presented.

关键词： Hawking radiation black hole tunneling black hole entropy correction quantum theory

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One patient with metastastic colorectal cancer successfully treated by combination of targeted agents after failure of chemotherpay

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Chinese Journal of Cancer 2010年第12期29卷 1023-1028页

作者： Liang-Ping Xia1,2, Pei-Hong Wu1,3, Jian-Chuan Xia1,4, Bei Zhang1,2, Zhong-Zhen Guan1,5, De-Sen Wan1,6, Gui-Fang Guo1,2, Yi-Xin Zeng1,7 1 State Key Laboratory of Oncology in South china, guangzhou, guangdong 510060, P. R. china 2 VIP Region, Sun Yat-sen Universty Cancer center, guangzhou, guangdong 510060, P. R. china 3 Department of Medical Imaging and Interventional Radiology, Sun Yat-sen Universty Cancer center, guangzhou, guangdong 510060, P. R. china 4 Biotherapy Cancer, Sun Yat-sen Universty Cancer center, guangzhou, guangdong 510060, P. R. china 5 Department of Medical Oncology, Sun Yat-sen Universty Cancer center, guangzhou, guangdong 510060, P. R. china 6 Department of Colorectal Cancer,Sun Yat-sen Universty Cancer center, guangzhou, guangdong 510060, P. R. china 7 Sun Yat-sen Universty Cancer center, guangzhou, guangdong 510060, P. R. china VIP Region Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Medical Imaging and Interventional Radiology Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 Biotherapy Cancer Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Medical Oncology Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Colorectal Cancer Sun Yat-sen Universty Cancer Center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060 Sun Yat-sen Universty Cancer center StateKey Laboratory of Oncology in South China Guangdong Guangzhou 510060

Either cetuximab or bevacizumab can improve the survival of patients with metastastic colorectal cancer (mCRC) if administered combided with cytotoxic agents. However, the effect of two or more target agents in combination is uncertain in these patients. Here, we reported a patient with mCRC successfully treated by a combination of target agents after the failure of chemotherapy. The patient received palliative resection of primary tumor followed by 9 cycles of postoperative XELOX regimen, cytokine-induced killer cell (CIK)-based biotherapy, traditional Chinese medicine, particle implantation in the lung metastatic lesions. The tumor progressed 20 months after the standard treatments. Then, the regimen cetuximab, bevacizumab and cefitinib was applied. During the treatment with targeted agents, grade IV acne-like rash and relatively severe parionychia of the toes occurred. Both of them recovered smoothly. The PET-CT reexamination at 40 days after the target treatment showed that the metabolism of mediastinal lymph nodes basically recovered to a normal level. The combination of multiple targeted agents obtained a progression-free survival(PFS) of 11 months and the patient with a good quality of life during this period.

关键词：药物治疗结直肠癌转移性患者大肠细胞毒性靶向药物不确定性

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