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物理实验 2004年第4期24卷 31-32,34页

作者：张启林河北北方学院物理系河北张家口075000

介绍了一种测试晶体管基区电阻rbb的方法 ,得出了晶体管电流放大系数 β值不同rbb值不同的结论。

关键词：晶体管基区电阻输入电阻电压放大倍数电阻测量空载电流放大系数电子线路实验实验设计

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中线旁双侧丘脑梗死综合征10例临床分析

陕西医学杂志 2005年第1期34卷 72-73,94页

作者：薛茜常凤鸣河北北方学院第一附属医院神经内科张家口075000

目的 :探讨中线旁双侧丘脑梗死综合征的临床表现、影像学改变、诊断及预后。方法 :对 1 0例中线旁双侧丘脑梗死综合征患者的临床表现、病因、CT/MRI以及预后进行综合分析。结果 :中线旁双侧丘脑梗死综合征主要临床特征为多数急性起病 ,... 详细信息

目的 :探讨中线旁双侧丘脑梗死综合征的临床表现、影像学改变、诊断及预后。方法 :对 1 0例中线旁双侧丘脑梗死综合征患者的临床表现、病因、CT/MRI以及预后进行综合分析。结果 :中线旁双侧丘脑梗死综合征主要临床特征为多数急性起病 ,有不同程度意识障碍 ,Korsakoff遗忘综合征 ,垂直性眼球运动障碍 ,预后差。结论 :中线旁双侧丘脑梗死综合征是一种罕见的昏迷综合征 ,诊断主要依据 CT或 MRI,DSA检查对于病因诊断有重要价值。

关键词：中线旁双侧丘脑梗死综合征临床表现血液供应脑保护疗法 DSA检查

长骨及骨盆骨折后脂肪栓子的干预时机和产生的因素

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复旦学报（医学版） 2004年第4期31卷 425-428页

作者：张海鹏张力苏峰李玉清朱颖波刘建平赵宝山朱永河北省涿鹿县医院创伤外科张家口075600 河北北方大学药理生化研究所张家口075000 河北北方大学附属第一医院骨科张家口075000 河北省涿鹿县医院检验科张家口075600 河北省涿鹿县卫生防疫站检验科张家口075600

目的　探索长骨及骨盆骨折后脂肪栓子的干预时机和脂栓形成的因素。方法　分析了 172例长骨及骨盆骨折 ,包括其中临床和亚临床脂肪栓塞 [(sub - )CFE]的病例资料 ;比较长骨及骨盆骨折中尿酮体阳性 (PK)和阴性 (NK)者的发病情况 ;比较长... 详细信息

目的　探索长骨及骨盆骨折后脂肪栓子的干预时机和脂栓形成的因素。方法　分析了 172例长骨及骨盆骨折 ,包括其中临床和亚临床脂肪栓塞 [(sub - )CFE]的病例资料 ;比较长骨及骨盆骨折中尿酮体阳性 (PK)和阴性 (NK)者的发病情况 ;比较长骨及骨盆骨折 (LP组 )与创伤严重程度 (ISS)相当的颅面骨骨折 (CF组 )的血TG。结果　PK组 (sub - )CFE发生率高于NK组 ,差异有非常显著意义 (P <0 .0 1) ,其中 4例有进行性的血沉或血小板异常。LP组中的PK组TG水平高于NK组 ,差异有显著意义 (P <0 .0 5 ) ;LP组的TG及其阳性率高于同等ISS的CF组 ,差异分别有非常显著和极显著意义 (P <0 .0 1和P <0 .0 0 1)。结论　长骨及骨盆骨折后TG高至并发酮尿时 ,脂肪栓塞综合征的发病风险显著增高 ,可作干预TG增高和预防FES的临床时机。ISS不是脂栓形成中的主要因素。

关键词：长骨骨盆骨折脂肪栓子干预时机三酰甘油酮尿

大黄酚对脑缺血再灌注小鼠学习记忆障碍及耐缺氧的影响

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陕西医学杂志 2008年第4期37卷 402-404页

作者：王树薛贵平张丹参张力安芳王静河北北方学院药理学教研室张家口075000

目的:探讨大黄酚对脑缺血再灌注小鼠学习记忆障碍的保护作用及其耐缺氧的影响。方法:60只健康小鼠随机分为假手术组、模型对照组、大黄酚高、中、低剂量组,采用暂时性阻断两侧颈总动脉的方法制备小鼠脑缺血再灌注损伤的模型,进行避暗法... 详细信息

目的:探讨大黄酚对脑缺血再灌注小鼠学习记忆障碍的保护作用及其耐缺氧的影响。方法:60只健康小鼠随机分为假手术组、模型对照组、大黄酚高、中、低剂量组,采用暂时性阻断两侧颈总动脉的方法制备小鼠脑缺血再灌注损伤的模型,进行避暗法实验,测试其被动回避能力;另取60只健康小鼠,分组、造模方法同上,进行常压耐缺氧实验,测试其生存时间。结果:大黄酚可明显延长脑缺血再灌注小鼠进入暗室的潜伏期,减少错误次数;明显延长常压耐缺氧的生存时间。结论:大黄酚对脑缺血再灌注小鼠学习记忆功能有保护作用和抗缺氧的作用。

关键词：脑缺血/并发症再灌注损伤缺氧动物实验小鼠

A Novel Taxane with An Unprecedented Skeleton from Taxus cuspidata Needles

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A Novel Taxane with An Unprecedented Skeleton from Taxus cus...

Sesquiterpenoids Possessing an Unprecedented Skeleton from Roots of Echinops spinosus

第九届全国中药和天然药物学术研讨会

作者： Shiping Chen~1 Sa Lv~1 Zuoping Li~2 Changhong Huo~2 Yongmin Zhao~3 Qingwen Shi~(2*) Yucheng Gu~4 1.Depatment of Environmental Biochemistry Graduate School of Medicine,Chiba university,1-8-1,Inohana,Chuo-ku,Chiba 260-8670,Japan 2.department of Natural Product Chemistry,School of Pharmaceutical Sciences,hebei Medical university,361 Zhongshan East Road,050017,Shijiazhuang,hebei Province,P.R.china 3.School of Basic Medical Science,hebei north university,zhangjiakou 075000,china 4.Jealott''s Hill International Research Centre,Syngenta,Berkshire,RG42 6EY,UK

＜正＞A novel metabolite with an unprecedented skeleton was isolated from the needles of Taxus *** structure was characterized as 2,7,9,10-tetraacetoxy-5,12-dihydroxy-11,12-secotaxa-4（20）-en-11, 13-dione（1）on the ... 详细信息

关键词： Taxus cuspidata Taxaceae needles isolation

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Sesquiterpenoids Possessing an Unprecedented Skeleton from R...

Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus

第九届全国中药和天然药物学术研讨会

作者： Sa Lv~1 Shiping Chen~1 Changhong Huo~2 Yongmin Zhao~3 Qingwen Shi~(2*) Yucheng Gu~4 1.Depatment of Environmental Biochemistry Graduate School of Medicine,Chiba university,1-8-1,Inohana,Chuo-ku,Chiba 260-8670,Japan 2.department of Natural Product Chemistry,School of Pharmaceutical Sciences,hebei Medical university,361 Zhongshan East Road,050017,Shijiazhuang,hebei Province,P.R.china 3.School of Basic Medical Science,hebei north university,zhangjiakou 075000,china 4.Jealott''s Hill International Research Centre,Syngenta,Berkshire,RG42 6EY,UK

＜正＞Echinopine A（1）,a novel sesquiterpenoid with an unprecendented rearrangemental skeleton named echinopane was isolated from the roots of Echinops *** structure of 1 were elucidated by extensive spectroscopic *** relative stereochemistry of 1 was assigned by combination of NOESY correlations and a simulation *** methyl ester,echinopine B（2）,was also isolated from same source.A possible biosynthetic pathway for echinopine A（1）was discussed.

关键词： Echinops spinosus sesquiterpenoid Echinopine A.

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Biomedical and Environmental Sciences 1998年第1期11卷 61-69页

作者： HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of pharmacology and Toxicology, university ofMississippi Medical Center, 2500 north State Street,Jackson, MS 39216, USA) department of pharmacology and Toxicology University of Mississippi Medical Center Jackson 39216 USA.

Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children.

关键词： Activity Pb Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus

Two New Taxanes from Taxus cuspidata Needles and *** Rooted Cuttings

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Two New Taxanes from Taxus cuspidata Needles and *** Rooted ...

Constraints on the late Mesozoic regional angular unconformity in West Liaoning-north hebei by LA-ICP-MS dating

第九届全国中药和天然药物学术研讨会

＜正＞A novel metabolite with an unprecedented hemiketal ring between C-13 and C-9 and a taxane with an amino-side chain on C-5 were isolated from the needles of Taxus cuspidata and rooted cuttings of Taxus canadensis,*** structure,s were characterized as 2,10-diacetoxy-5-cinnamoyloxy-11.1-dihydroxy-9,13-epoxide-taxa-4（20）-ene（1）and 7,9 ,10.1-tetraacetoxy-5-[3’-（N-formyl-N-methylamino）-3’-phenylpropanoyl]oxytaxa-4（20）,12-diene（2）on the basis of 1D-, 2D-NMR data *** spectra of 2 in CDCh solution revealed that 2 was composed of two epimers（2 and 3）in a ratio of 2:1 approximately.

关键词： Taxus cuspidata Taxus canadensis Taxaceae needles rooted cutting taxane isolation

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Progress in Natural Science:Materials International 2008年第11期18卷 1395-1402页

作者： Hong Zhang~(a,b,*) Wenmin Guo~a Xiaoming Liu~b a College of Mechanical and Energy Engineering,Jiangsu Polytechnic university,Changzhou 213016,china b Key Laboratory of Continental Dynamics,department of Geology,northwest university,Xi’an 710069,china College of Mechanical and Energy Engineering Jiangsu Polytechnic University Changzhou 213016 China Key Laboratory of Continental Dynamics Department of Geology Northwest University Xi’an 710069 China

The angular unconformity between the Tuchengzi Formation and the zhangjiakou Formation in the Chengde area is commonly regarded as the direct evidence of boundary between Jurassic and Cretaceous systems,and as the evidence of tectonic transformation interfaces in Mesozoic Era in the West Liaoning-north ***,the lower boundary age of the zhangjiakou Formation in the Chengde was to be thought about 135 Myr in the *** on the detailed study and systematic sampling in Yixian-Beipiao,Lingy- uan,Chengde and Luanping areas in the field,the authors obtained the following isotopic ages by means of LA-ICP-MS dating:In the Lingyuan area,the zhangjiakou Formation and the Yixian Formation are in angular unconformable contact;the age range of the zhangjiakou Formation volcanic rock is from 133 to 130 Myr(seven samples),and that of the Yixian Formation volcanic rock is from 126 to 121 Myr(eleven samples).In the Luotuoshan of Chengde,the Tuchengzi Formation and the zhangjiakou Formation are in angu- lar unconformable contact;the age at the lower zhangjiakou Formation is about 124 Myr(one sample),which reflects that the age range of the lower zhangjiakou Formation is from 129 to 124 Myr combined with the previous *** the Luanping basin,there is the larg- est sediment gap in upper Mesozoic,whose lower boundary age is confined in 131 to 130 *** the Yixian-Beipiao area,the second Member of the Yixian Formation,making up more than 3/4 thickness of the Yixian Formation,was formed in 126 to 119 Myr,and the age of the Yixian Formation at the bottom is about 132 ***,the upper boundary age of the Tuchengzi Formation is about 136 Myr in the West Liaoning-north hebei *** on the above isotopic data combined with the geological characteristics in the field in the West Liaoning-north hebei region,it reflects that there was a widespread tectonic event in the period of 136 to 126 Myr (mainly in 130-126 Myr)in the West Liaoning-north hebei,and it formed the

关键词： Dating LA-ICP-MS Angular unconformity Interface of tectonic transformation West Liaoning-north hebei

BCL-2与P53在腭发育及腭裂形成中的作用

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毒理学杂志 2009年第4期23卷 267-270页

作者：王浩宇安峰吴靖芳张耕任君旭河北北方学院组织胚胎教研室河北张家口075000 河北北方学院口腔医学系河北张家口075000

目的探讨BCL-2和P53在地塞米松诱导胎鼠腭裂形成中的表达及意义。方法以腹腔注射醋酸地塞米松诱导胎鼠腭裂畸形,应用免疫组织化学法和图像分析研究BCL-2和P53在不同时期实验组与对照组中腭突间充质(EPM)细胞的表达情况。结果1.对照组中B... 详细信息

目的探讨BCL-2和P53在地塞米松诱导胎鼠腭裂形成中的表达及意义。方法以腹腔注射醋酸地塞米松诱导胎鼠腭裂畸形,应用免疫组织化学法和图像分析研究BCL-2和P53在不同时期实验组与对照组中腭突间充质(EPM)细胞的表达情况。结果1.对照组中BCL-2表达随着腭部发育而逐渐降低;P53表达在妊娠(gestationday,GD)13.5～15.5d中随时间变化降低,而在GD16.5增高;2.实验组中BCL-2表达GD13.5～15.5降低,GD16.5中增高;P53表达GD14.5中最高,GD15.5中最低;3.与对照组比较,实验组GD14.5～15.5中BCL-2表达明显降低(P2表达明显高于对照组(P<0.01),而P53表达明显低于对照组(P<0.05)。结论地塞米松诱导的腭裂与EPM细胞凋亡水平升高有关。

关键词： BCL-2 P53 腭裂 EPM细胞免疫组织化学法(IHC)