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Structures and properties of novel 5,15-di[4-(5-acetylsulfanylpentyloxy)phenyl] porphyrin derivatives:Density functional theory calculations

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Science china Chemistry 2010年第10期53卷 2183-2192页

作者： ZHU YiFei1,2, QI DongDong1, ZHANG LiJuan1, WAN Liang1, ZHANG YueXing1 & JIANG JianZhuang1 1department of Chemistry, university of Science and Technology Beijing, Beijing 100083, china 2department of Chemistry, hebei north university, zhangjiakou 075000, china 1. department of Chemistry University of Science and Technology Beijing Beijing 100083 China2. Department of Chemistry Hebei North University Zhangjiakou 075000 China

Density functional theory (DFT) calculations have been carried out in order to compare the molecular structures, atomic charges, molecular orbitals, electronic absorption spectra, and infrared (IR) spectra of the metal-free 5,15 -di[4-(5-acetylsul-fanylpentyloxy)phenyl]porphyrin H2[DPP(OC5H10SCOCH3)2] (1) (DPP = 5,15-diphenylporphyrin) and its zinc complex Zn[DPP(OC5H10SCOCH3)2] (2), which exhibit novel structures with two 5-acetylsulfanylpentyloxy side chains at the para-positions of opposite meso-attached phenyl groups. The calculated molecular structure and electronic absorption and IR spectra of 1 and 2 are consistent with the experimental results. The influences of meso-substitution, polar solvents, and central metal substitution on the structure and properties of porphyrin derivatives have been investigated by comparing the corresponding data for 1 and 2 with the help of data for the unsubstituted porphyrin derivatives, namely the metal-free porphyrin H2Por (3) and the porphyrinato-zinc compound (4). The identities of the main transitions in the electronic absorption spectra of 1 and 2 are assigned and the vibrational modes in their IR spectra are identified with the assistance of animated pictures produced based on normal coordinates. The theoretical work presented here will be helpful in increasing our understanding of the structure and spectroscopic properties, as well as substituent and solvent effects, for these novel porphyrin compounds.

关键词： porphyrin substituent effect electronic absorption spectra IR spectra density functional theory (DFT)

谷氨酸N-甲基-D-天冬氨酸受体拮抗剂的抗抑郁作用研究进展

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中国新药与临床杂志 2011年第12期30卷 891-894页

作者：杨辉许丽娟河北北方学院药学系河北张家口075000 张家口第四医院药剂科河北张家口075000

谷氨酸是脑内主要的兴奋性神经递质,谷氨酸能神经元是构成中枢神经网络的主神经元,其数量超过脑内神经元总数的1/2。虽然中枢单胺类神经系统功能紊乱导致抑郁发生的假说已为大多数人所接受,但有证据表明谷氨酸类神经递质同样在抑郁发生... 详细信息

谷氨酸是脑内主要的兴奋性神经递质,谷氨酸能神经元是构成中枢神经网络的主神经元,其数量超过脑内神经元总数的1/2。虽然中枢单胺类神经系统功能紊乱导致抑郁发生的假说已为大多数人所接受,但有证据表明谷氨酸类神经递质同样在抑郁发生中扮演着重要的角色。谷氨酸与抑郁症发生的相关确切机制还不清楚,但是研究发现谷氨酸能神经异常主要是通过谷氨酸N-甲基-D-天冬氨酸(NMDA)受体介导的。临床前研究及临床研究表明氯胺酮和利鲁唑等谷氨酸NMDA受体拮抗剂具有抗抑郁作用,提示治疗抑郁的新靶点,并需要更多样本量的随机对照试验进行验证。

关键词：谷氨酸受体,N-甲基-D-天冬氨酸抑郁

A Safety Group Key Management Scheme in Mobile Ad Hoc Network

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A Safety Group Key Management Scheme in Mobile Ad Hoc Networ...

The 8th International Conference on Reliability,Maintainability and Safety(ICRMS 2009)

作者： Yongfei Ye department of computer hebei north university zhangjiakou hebei Province 075000 china Xiqing Zhao Xifeng Guo department of computer hebei north university zhangjiakou hebei Province 075000 china

＜正＞Ad hoc networks have dissimilar characters from wire networks.A safe group key management protocol was given in the paper,which combines the advantage of two tradition *** scheme imposes key tree to manage group key. By some mechanism,a user becomes the manager,which will update the group key and distributes it to other users safely. Group key is protected from attacks and many security problems have been settled,so we can enhanced the reliability and usability of the networks.

关键词： Ad Hoc networks group key key tree trust value

MAPKs and Mst1/Caspase-3 pathways contribute to H2B phosphorylation during UVB-induced apoptosis

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Science china(Life Sciences) 2010年第6期53卷 663-668页

作者： LU ChengRong1SHI Ying1LUO Yuan1,DUAN LianNing1,HOU Yong2,HU HongBo3,WANG Zhe1 & XIANG PeiDe1 1Aviation Medicine Research Laborabory,General Hospital of Air Force,Beijing 100142,china 2.department of pharmacology,hebei north university,zhangjiakou 075000,china 3 Nutrition and Food Safety Center,College of Food Science and Nutritional Engineering,china Agricultural university,Beijing 100083,china 1. Aviation Medicine Research Laborabory General Hospital of Air Force Beijing 100142 China2. Department of Pharmacology Hebei North University Zhangjiakou 075000 China3. Nutrition and Food Safety Center College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 China

Apoptosis is a highly coordinated or programmed cell suicide mechanism in *** modification is associated with nuclear events in apoptotic *** H2B phosphorylation at serine 14 (Ser14) catalyzed by Mst1 kinase has been linked to chromatin condensation during *** report that activation of MAPKs (ERK1/2,JNK1/2 and p38) together with Mst1 and caspase-3 is required for phosphorylation of H2B (Ser14) during ultraviolet B light (UVB)-induced *** can trigger activation of MAPKs and induce H2B phosphorylation at Ser14 but not acetylation in a time-dependent *** of ERK1/2,JNK1/2 or p38 activity blocked H2B phosphorylation (Ser14).Furthermore,caspase-3 was activated by UVB to regulate Mst1 activity,which phosphorylates H2B at Ser14,leading to chromatin *** inhibition of caspase-3 activity reduced Mst1 activation and partially inhibited H2B phosphorylation (Ser14),but ERK1/2,JNK1/2 and p38 activities were not *** together,these data revealed that H2B phosphorylation is regulated by both MAPKs and caspase-3/Mst1 pathways during UVB-induced apoptosis.

关键词： apoptosis H2B MAPK Mst1

Pharmacokinetics of theophylline in patients with COPD and its interference factors

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Pharmacokinetics of theophylline in patients with COPD and i...

中国药理学会临床药理学专业委员会会议暨第十次全国临床药理学学术会议

作者： LIU Xiao-ming department of Pharmacy,the First Affiliate Hospital of hebei north university,zhangjiakou 075000,hebei,china

AIM:To study the pharmacokinetics of theophylline in patients with chronic obstructive pulmonary diseases (COPD)and its interference factors. METHODS:Serum theophylline concentrations in 9 pa- tients with COPD after oral administration of theophylline (200 mg,tid)for 5 consecutive days or combining with nifedipine(10 mg,tid)for 5 consecutive days were deter- mined by high performance liquid chromatography(HPLC) with ultraviolet spectrophotometry. RESULTS:The pharmacokinetics of theophylline in COPD patients was one-compartment model after oral ad- ministration of theophylline(200 mg,tid)for 5 consecu- tive *** significant difference in individual variation on phannacokinetics of theophylline was observed in this *** volume of distribution(V)was(0.50± 0.21)L/kg,the elimination half-life(t)was(5.4± 1.3)h and clearance(CL)was(0.07±0.03) L·h·kgin the patients with *** was no significant difference in V,t,and CL between COPD patients and healthy volunteers(P＞0.05).The values of k and Cl were faster and twas shorter in the middle- aged patients than those in old COPD patients(P＜ 0.05).After administration of nifedipine for 5 consecutive days,the mean serum theophylline concentration de- creased by(1.8±2.0)mg/*** Cand AUC were,Iower than those obtained before nifedipine[(12±6) vs(10±5)mg/L,(82±52)vs(62±39)mg·L·h, P＜0.05 ],*** this study,the mean serum concentration of theophylline determined by UV method was significantly lower than that by HPLC [△C=(-0.6 ±1.6)mg/L,n=123,P＜0.05].However,the phar- macokinetic parameters of theophylline determined by the two methods were no difference(P＞0.05).In addition, the results showed that there was no significant change in theophyiline recovery,in pure serum of theophylline and mixture serum of theophylline and CTRX. CONCLUSION:The pathological state of COPD appears not to affect the pharmacokinetic profiles in middle-aged patients with *** is not necessary to change the ther- apeutic combination wi

关键词： chronic obstructive pulmonary diseases theophylline pharmacokinetics interaction HPLC UV

Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism

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Acta Pharmacologica Sinica 2004年第4期25卷 71-75页

作者： Yin-ye WANG, Zhi-yu TANG, Min DONG, Xiao-yan LIU, Shi-qi PENG2.department of pharmacology, department of Medicinal Chemistry, 2 Schoolof Pharmaceutical Sciences, Peking university, Beijing 100083, china department of pharmacology Department of Medicinal Chemistry School of Pharmaceutical Sciences Peking University

AIM: To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound. METHODS: Platelet aggregation was conducted by Born’s method; bleeding time was determined using tail’s bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess’ method; and cAMP, thromboxane B2 (TXB2) and 6-keto-PGF1α were assessed with commercial kits. RESULTS: The inhibition by PDR (15-60 mg/kg ig or 10 mg/kg iv) of platelet aggregation induced by adenosine diphosphate (ADP), collagen or thrombin at 1 h after oral administration or at 20 min after iv injection for rats (P2 or 6-keto-PGF1α in plasma. CONCLUSION: PDR is a novel, oral effective platelet aggregation inhibitor and its action mechanism possibly related to increasing NO generation.

关键词： platelet aggregation bleeding time platelet adhesiveness polyaspartoyl L-arginine nitric oxide cyclic AMP Thromboxane B2 6-ketoprostaglandin F1 alpha

The neuroprotection of Aspirin on Cerebral Ischemia-Reperfusion rats

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The neuroprotection of Aspirin on Cerebral Ischemia-Reperfus...

第十一届全国神经药理学术会议

作者： Qiu Li--ying Yu Juan Chen Chong--hong Zhou Yu department of pharmacology, department of Pathophysiology, Medical university of Fujian Fuzhou 350004, hebei north university, zhangjiakou 075000, china

AIM: Aspirin ( acetylsalicylic acid, ASA as a nonsteroidal anti - inflammatory drug not only has well - established ef-ficacy in anti - thromboxane, but also has direct neuroprotective effect. In this study, we design to investigate its neuropro-tective effect on focal cerebral ischemia - reperfusion injury ( CIRI rats, and its effect on ATP level from occluded brain tis-sues. METHODS: Right middle cerebral artery was occluded by inserting a thread through internal carotid artery for 2 h,and then reperfused for 24 h or 72 h. 6 mg·kg and 60 mg·kgdoses of aspirin were ig administered at reperfusion 0

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Study of Digital Signature in the Application of CSCW

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Study of Digital Signature in the Application of CSCW

2008'中国信息技术与应用学术论坛

作者： SUN Bai-li~1 HE Xin-long~2 (department of Computer Science,hebei north university,zhangjiakou 075000,china)~1 (Graduate Institute,Shenyang Tecnology university,Shenyang 110168,china)~2

＜正＞Computer Supported Cooperative Work （CSCW） is a cooperative work manner for a group of people making use of ***,it is a study hotspot in and out country,but the contents are usually idiographic applica- tions,lacking in security *** CSCW is based upon network environment,and is full of hazardous securi- ty factors,so it is very necessary to enhance security *** Signature is an important part of information secur- ity system,which uppermost application area is identity *** at the above disadvantage,a discussion in detail is put forward in the paper,namely utilizing digital signature technique to make the CSCW system run safely combining with some of applications in CSCW like electronic commerce and military affairs.

关键词： CSCW Information security Digital signature Identity authentication

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二甲砷基谷胱甘肽对肿瘤的治疗作用及机制

中国新药与临床杂志 2011年第2期30卷 99-102页

作者：杨辉郭春燕河北北方学院药学系河北张家口075000

二甲砷基谷胱甘肽是由二甲基砷与谷胱甘肽结合而成的新型有机砷化合物,在体内外对多种血液系统肿瘤及实体瘤敏感。其作用机制包括针对性地破坏癌细胞线粒体的功能,影响癌细胞信号转导,阻止癌细胞的血管再生,从而导致癌细胞的生长周期停... 详细信息

二甲砷基谷胱甘肽是由二甲基砷与谷胱甘肽结合而成的新型有机砷化合物,在体内外对多种血液系统肿瘤及实体瘤敏感。其作用机制包括针对性地破坏癌细胞线粒体的功能,影响癌细胞信号转导,阻止癌细胞的血管再生,从而导致癌细胞的生长周期停滞和细胞凋亡。二甲砷基谷胱甘肽导致癌细胞凋亡的机制不同于三氧化二砷,因此能杀灭对三氧化二砷具有耐药性的癌细胞。本文对其治疗作用机制、药理学、药动学研究及安全性等作一综述。

关键词：谷胱甘肽二甲砷基谷胱甘肽肿瘤有机砷临床试验