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Hyperplastic cholecystoses:efforts should be made to recognize and treat them

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 334-336页

作者： Yu-Lan Liu and Jing-Tong Wang department of Gastroenterology, peking {2. people’s hospital, beijing 100044, China department of Gastroenterology Peking University People's Hospital Beijing 100044 China Liu YL and Wang JT

Acalculous gallbladder diseases do not draw too much attention from researchers because of their low incidence of malignancy, no symptoms, and good prognosis, and therefore there is even no unanimous terminology. Emerged

关键词： Hyperplastic cholecystoses Us than

Effects of 5-hydroxytamine and its antagonists on hepatic stellate cells

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Hepatobiliary & Pancreatic Diseases International 2006年第1期5卷 96-100页

作者： Tao Li, shan-Geng Weng, Xi-sheng Leng, Ji-Run Peng, Yu-Hua Wei, Dong-Cheng Mou and Wan-Xiang Wang department of Hepatobiliary surgery, peking {2. people’s hospital, beijing 100044, China department of Hepatobiliary surgery Peking University People's Hospital Beijing 100044 China.

BACKGROUND: Hepatic stellate cell (HsC) plays a key role in hepatic fibrosis. This study was undertaken to investigate the expression of 5-hydroxytamine receptors in HsC and the effect of 5-hydroxytamine on biological characteristics of HsC. METHODs: Liver ex vivo perfusion of collagenase and density gradient centrifugation were used to isolate HsCs. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of 5-hydroxytamine receptor subtypes 1A, 2., 2. and 3. Western blot hybridization was used to elucidate the effect of 5-hydroxytamine and its 2. receptor antagonist ketanserin and 3 receptor antagonist ondanosetron on the expression of transforming growth factor-β_1(TGF-β_1) and smad4 in HsC. REsULTs: HsC expressed 5-hydroxytamine receptor subtypes 1A, 2. and 2.. 5-hydroxytamine significantly increased the expression of TGF-β_1, and smad4 in HsC (Ps action can be antagonized by ketanserin, not by ondanosetron. CONCLUsIONs: HsC expresses 5-hydroxytamine receptors. 5-hydroxytamine could effect the biological characteristics of HsC through its receptor mediation, and may play a role in the pathogenesis of liver cirrhosis and portal hypertension.

关键词： hepatic stellate cell 5-hydroxytmine receptor transforming growth factor

OCULO-CEREBRO-RENAL sYNDROME (LOWE's sYNDROME)

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眼科学报 1991年第1期7卷 40-42,46页

作者： Youzhao Chen Zhongshan Ophthalmic Center sun Yat-sen university of Medical sciences Guangzhou, China Guoxiang Pang department of {2. peking Union Medical College hospital beijing, China Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou China.

Oculo-cerebro-renal syndrome (Lowe's syndrome) is characterized by mental and motor retardation, cataract, glaucoma and renal abnormalities. It is an X-linked recessive metabolic disease. Two brothers suffering from Lowe's syndrome are reported. Their mother with lenticular opacities and peculiar facial appearance is in concordance with the obligate carrier. The ocular changes and heridity are discussed.

关键词： oculo-cerebro-renal syndrome Lowe’s syndrome congenital cataract carrier female X-R heredity metabolic abnomalities.

A Case of Atopic Dermatitis-like Chronic GVHD After Peripheral Blood stem Cell Transplantation From An Unrelated Donor

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A Case of Atopic Dermatitis-like Chronic GVHD After Peripher...

The 10th China-Japan Joint Meeting of Dermatology 2.th Anniversary

作者： shan Tian Zhou Chen Jianzhong Zhang department of Dermatology peking {2. people’s hospital beijing 100044 China

＜正＞A case of GVHD with characteristic of atopic dermatitis was *** patient was a 2.-year-old *** suffered from acute monocytic leukemia（AML-M5）and underwent unrelated peripheral blood stem cell transplantation（P...

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内质网应激与动脉粥样硬化

实用儿科临床杂志 2010年第13期25卷 1013-1016页

作者：丁晶曾超美杜军保北京大学第一医院儿科北京大学人民医院儿科

内质网应激是继核应激、线粒体应激后人们发现的又一种亚细胞器水平上的应激。内皮细胞、巨噬细胞和平滑肌细胞在动脉粥样硬化形成过程中起重要作用。内质网应激通过调控以上3种细胞的炎性反应、脂质代谢和细胞凋亡过程而参与动脉粥样... 详细信息

内质网应激是继核应激、线粒体应激后人们发现的又一种亚细胞器水平上的应激。内皮细胞、巨噬细胞和平滑肌细胞在动脉粥样硬化形成过程中起重要作用。内质网应激通过调控以上3种细胞的炎性反应、脂质代谢和细胞凋亡过程而参与动脉粥样硬化的发生和发展。

关键词：内质网应激未折叠蛋白反应信号通路动脉粥样硬化内皮细胞巨噬细胞平滑肌细胞

The expression of PsP94 in benign prostatic hyperplasia,prostate cancer and normal prostate

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The expression of PSP94 in benign prostatic hyperplasia,pros...

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： XU Kexin,WANG Xiaofeng The department of Urology, peking {2. people’s hospital, beijing, 100044, China.

Objectives: Prostate-specific Protein-94 (PsP94), also know as beta-microseminoprotein (MsP) or beta-inhibin, an abundant human seminal plasma protein, has been purified from human seminal plasma in 1990. In this stud...

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Neferine,a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis in vitro and in vivo

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Neferine,a bisbenzylisoquinline alkaloid attenuates bleomyci...

2.08年中国药学会学术年会暨第八届中国药师周

作者： Libo Zhao1,,Lin Huang1,Jialing Wang2.Yuzhen Li1 2.1.peking university {2.''s hospital,beijing,China 2.department of Pharmacology,Tongji Medical College,Wuhan,China

In this study,we evaluated the potential antifibrotic property of neferine,a bisbenzylisoquinline alkaloid extracted from the seed embryo of Nelumbo mucifera *** bleomycin administration resulted in pulmonary fibrosis 14 and 2. days posttreatment,as evidenced by increased hydroxyproline content in bleomycin group（2.5.77 ± 97.17 μg/lung and 2.9.74 ± 40.92.μg/lung）compared to sham group（170.78 ± 76.46 μg/lung and 191.2. ± 60.45 μg/lung）,and the hydroxyproline was significantly suppressed（193.07 ± 39.55 μg/lung and 2.1.08 ± 71.74 μg/lung）by neferine administration（2. mg/kg,b.i.d）.The attenuated-fibrosis condition was also validated by histological *** measurements revealed that bleomycin caused a significant decrease in lung superoxidae dismutase（sOD）activity,which was accompanied with significant increase in malondialdehyde（MDA）levels and myeloperoxiase（MPO）activity on the 7th and 14th ***,neferine reversed the decrease in sOD activity as well as the increase of MDA and MPO ***-linked immunosorbent assay and radio-immunity assay showed that treatment with neferine alleviated bleomycin induced increase of proinflammatory cytokines such as tumor necrosis factor（TNF）-α,interleukin（IL）-6 and endothelin（ET）1 in plasma or in ***,neferine blocked bleomycin induced increases of NF-κB in nuclear extracts and TGF-β1 in total protein extracts of murine RAW2.4.7 *** conclusion,neferine attenuates bleomycin-induced pulmonary fibrosis in vitro and in *** beneficial effect of neferine might be associated with its activities of anti-inflammation,antioxidation,cytokine and NF-κB inhibition.

关键词： Bleomycin Pulmonary fibrosis Neferine Mouse Macrophage

Macular function assessed by multifocal electroretinogram in elder patients with macular pucker,subretinal CNV and drusen

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Macular function assessed by multifocal electroretinogram in...

The Third Asian Conference on Vision (ACV2.04)

作者： Chen Jinghua Li XiaoxinEye department the people’s hospital of peking university {2. China

＜正＞ Purpose: To compare macular function assessed by multifocal electroretinogram （mfERG） in a subset of elder patients with macular pucker, subretinal CNV and ***: 18 eyes of 17 patients （aged 56 - 75 years , mean = 67.12.5.41years） suffered from macular pucker, with a best corrected visual acuity of 4/40 to 10/40.10 eyes of 9 patients （aged 55 - 69 years , mean = 60.89 ±4.37 years） suffered from subfoveal choroidal

关键词： multifocal ERGs macular pucker subretinal CNV drusen

Diffusion Tensor Imaging of White Matter Alternations and Its Correlation with Hippocampal Formation Volume in Mild Cognitive Impairment

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Diffusion Tensor Imaging of White Matter Alternations and It...

中华医学会第16次全国放射学学术大会

作者： CHEN Hao HONG Nan department of Radiology peking {2. people’s hospital beijing

PURPOsE *** evaluate the damage of white matter integrity and its correlation with clinical data in subjects with mild cognitive impairment(MCI) by using diffusion tensor imaging(DTI). *** explore the hippocampal form...

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