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Two New Polyoxygenated Cyclohexenes from Uvaria calamistrata

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Chinese Chemical Letters 1998年第10期9卷 935-938页

作者： Guang Xiong ZHOU Ruo Yun CHEN and De Quan YU(Institute of Materia Medica, Chinese Academy of medical Science sand peking union medical college, beijing 100050) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

Two new polyoxygenated cyclohexenes, named uvacalolA (1),and B (2) were isolated from the rhizomes of Uvaria calamistrata. On the basis of spectral analysis and chemical derivatization, including preparation of Mosher... 详细信息

关键词： annonaceae Uvaria calamistrata cyclohexene uvacalol

A New Bianthraqinonc Glycoside from Eremurus chinensis

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Chinese Chemical Letters 2000年第2期11卷 135-138页

作者： Jian Gong SHI1 Chong LI2 Ying Peng ZHANG2 Cheng Zhong ZHANG2 (1Institute of Materia Medica, Chinese Academy of medical Sciences and peking union medical, college, beijing, 100050 2department of Pharmacy, Lanzhou medical college, Lanzhou 730000) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China department of Pharmacy Lanzhou Medical College Lanzhou 730000 China

A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7'-bi(1,8-dihydroxy-3- methyl-9, 10-anthraquinonyl)1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques in... 详细信息

关键词： Eremurus chinensis Liliaceae bianthraquinone glycoside.

Stem cell research:from molecular physiology to therapeutic applications

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Science china(Life Sciences) 2009年第7期52卷 597-598页

作者： Chengyu Jiang department of Biochemistry and Molecular Biology,peking union medical college,Chinese Academy of medical Sciences,No.5 DongDanSanTiao,beijing,100005,P.R.china department of Biochemistry and Molecular Biology Peking Union Medical College Chinese Academy of Medical Sciences No. 5 DongDanSanTiao Beijing 100005 P. R. China

Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson’s disease to paralysis. Totipotent embryonic stem cells have great potential for gen... 详细信息

关键词： cell Stem cell research

Preliminary Studies on Acylation of 10β-OH and 7α-OH in 7-Epi-10-deacetylpaclitaxel

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Chinese Chemical Letters 1997年第10期8卷 847-848页

作者： Wei Shuo FANG Qi Cheng FANG and Xiao Tian LIANG (Institute of Materia Medica , Chinese Academy of medical Sciences & peking union medical college.beijing 100050) CHINESE ACAD MED SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA beijing union MED COLL BEIJING 100050PEOPLES R CHINA

10β-OH can be acylated cleanly when 7α-OH is also free, and thus a facile access to semisynthesis of 7-epi-paclitaxel was proposed. A 2's, 3's-oxazoline paclitaxel analog was serendipitously synthesized

关键词： OH in 7-Epi-10-deacetylpaclitaxel TES Preliminary Studies on Acylation of 10

Studies on Agarofurans Ⅳ. The Synthesis of 4-Substitutioned Agarofurans

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Chinese Chemical Letters 2000年第5期11卷 399-400页

作者： Wu Yan ZHANG Ji Yu GUO Xiao Tian LIANG (Institute of Materia Medica. Chinese Academy of medical Sciences & peking union medical college, beijing 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

A new synthetic route for α -agarofuran(1b) is described. Several agarofuran derivatives were synthesized in similar way. Derivative 1d was also synthesized in a novel way, in which the substitution at C-4 was perfor... 详细信息

关键词： Agarofuran synthesis.

Avian influenza H5N1:an update on molecular pathogenesis

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Science china(Life Sciences) 2009年第5期52卷 459-463页

作者： WANG HongLiang & JIANG ChengYu National Key Laboratory of medical Molecular Biology, Institute of Basic medical Sciences, Chinese Academy of medical Sciences and peking union medical college, beijing 100005, china National Key Laboratory of medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China

Avian influenza A virus constitutes a large threat to human health. Recent outbreaks of highly pathogenic avian influenza H5N1 virus in poultry and in humans have raised concerns that an influenza pandemic will occur in the near future. Transmission from avian species to humans remains sporadic, but the mortality associated with human infection is very high (about 62%). To date, there are no effective therapeutic drugs or a prophylactic vaccines available, which means that there is still a long way to go before we can eradicate or cure avian influenza. This review focuses on the molecular pathogenesis of avian influenza H5N1 virus infection. An understanding of the viral pathogenesis may facilitate the development of novel treatments or effective eradication of this fatal disease.

关键词： avian flu H5N1 acute lung injury

Diagnosis and treatment of chronic pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2003年第3期2卷 445-448页

作者： Quan Liao Yu-Pei Zhao Wei-Wei Wu Bing-Lu Li Jia-Yi Li the department of General Surgery, peking union medical college hospital, beijing 100730, china department of General Surgery Peking Union Medical College Hospital Beijing 100730 China.

OBJECTIVE: To summarize our experience in treatment of chronic pancreatitis (CP). METHODS: Clinical data on 245 patients with CP treated at our hospital from May 1983 to October 2001 were reviewed. RESULTS: Of the 245 patients, 122 suffered from CP for a year (49.8%) and 191 for 5 years (78.0%). The rate of positive diagnosis of B-ultrasound, CT, ERCP, B_2-Ty-Para-aminobenzoic acid (PABA) for CP was 74.2%, 80.7%, 76.5% and 72.8%, respectively. 169 patients (69.0%) received surgical treatment. After the operation, 98.8% of the 169 patients experienced decreased pain with a complication rate of 1.2%. CONCLUSION: Early diagnosis and appropriate operative time and management are of vital importance in improving patients' quality of life and controlling the natural history of the disease.

关键词： chronic pancreatitis diagnosis treatment

Solid Phase Synthesis of β-Carbolines

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Chinese Chemical Letters 2000年第11期11卷 955-956页

作者： Jing Xin ZHANG, Xiao Chuan TAN, Ping XIE, Xiao Tian LIANG Institute of Material Medica, Chinese Academy of medical Sciences & peking union medical college, beijing 100050 Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking union Med Coll Beijing 100050 Peoples R China

Synthesis of β-carbolines on solid phase using TCCA as the key reagent is developed.

关键词： Solid phase synthesis β-carbolines TCCA.

The Synthesis and Activity in vitro of a Series of 5-Amino-8-methoxyquinolones

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Chinese Chemical Letters 2004年第12期15卷 1397-1399页

作者： Jiu Yu LIU Yan LU Yu Cheng WANG Hui Yuan GUO Institute of Medicinal Biotechnology, Chinese Academy of medical Science and peking union medical college, beijing 100050 Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College

A series of 1-cyclopropyl-5-amino-6-fluoro-8-methoxyquinoline-3-carboxylic acidshave been prepared and evaluated for antibacterial activity in vitro.

关键词： Quinolone synthesis antibacterial activity.