检索结果-南通市图书馆

Down-r.gulation of micr.r.A-2.a p.omotes p.ncr.atic ductal adenocar.inoma initiation and p.ogr.ssion by up.r.gulation of FOXM1 exp.ession

在线全文

cnki会议

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 456-469页

作者： Lixin Liang Tian Cai Xiaojia Li Jianhong An sen Yu Yang Zhang Fengjie Guo Fang Wei Jie He Kep.ng Xie Tingting Jiang center for.p.ncr.atic cancer r.sear.h South China University of Technology School of MedicineGuangzhouGuangdong 510006China department of Labor.tor. Medicine The Sixth Affiliated Hospital and Nanhai People’s HospitalSouth China University of Technology School of MedicineFoshanGuangdong 528200China The Second Affiliated Hosp.tal and guangzhou Fir.t p.op.e’s Hosp.tal South China University of Technology School of MedicineGuangzhouGuangdong 510006China

Tr.nscr.p.ional factor.For.head box M1(FOXM1)p.ays an imp.r.ant r.le in p.ncr.atic ductal adenocar.inoma(p.AC)develop.ent and *** molecular.mechanisms under.ying its dysr.gulation r.main *** identified and functionally validated the micr.r.As(mir.As)that cr.tically r.gulate FOXM1 exp.ession in *** exp.ession levels of mir.A-2.a(mir.2.a-3p.and-5p.wer. alter.d in p.AC cell lines and their.effects on FOXM1 signaling and cell p.olifer.tion and migr.tion and tumor.genesis wer. examined in vitr. and in vivo using mouse p.AC *** with non-tumor.p.ncr.atic tissues,p.AC tissues and cell lines exhibited significantly r.duced levels of mir.2.a *** mir.2.a exp.ession and concomitant incr.ase in FOXM1 exp.ession wer. also obser.ed in acinar.toductal metap.asia and p.ncr.atic intr.ep.thelial neop.asia,the major.p.emalignant lesions of *** exp.ession of mir.2.a r.duced the exp.ession of FOXM1 and sup.r.ssed cell p.olifer.tion and migr.tion in p.AC cells,wher.as the inhibitor. of mir.2.a did the *** or.r.duced levels of mir.2.a incr.ased the levels of FOXM1 exp.ession,while incr.ased exp.ession of FOXM1 down-r.gulated mir.2.a exp.ession,suggesting that mir.2.a and FOXM1 wer. mutual negative r.gulator. of their.exp.ession in p.AC ***,the mir.2.a/FOXM1 signaling axis is imp.r.ant in p.AC initiation and p.ogr.ssion and could ser.e as an inter.entional or.ther.p.utic tar.et for.p.tients with ear.y or.late stages of p.AC.

关键词： FOXM1 Gene exp.ession Gene r.gulation Micr.r.A p.ncr.atic cancer Tar.eted ther.p.

Molecular.mechanisms of adenosine-induced ap.p.osis in human Hep.2.cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta p.ar.acologica Sinica 2006年第4期27卷 477-484页

作者： Ling-fei WU~(2.4) Guo-p.ng LI~2.Jia-lin FENG~3 Ze-jin p.~2.~2.0} of Gastr.enter.logy:~3department of Infor.ation,Second Affiliated Hosp.tal,Shantou {2. medical College,Shantou 515041.china departmentofGastr.enter.logy SecondAffiliatedHospitalShantouUniversityMedicalCollegeShantou515041China

Aim:To investigate effects of adenosine on cell p.olifer.tion and ap.p.osis inhuman Hep.2.***:Hep.2.cells wer. incubated in the p.esence ofadenosine(0.1-5 mmol/L)for.12.48 h,and the effect of adenosine on cell p.olifer.-tion was evaluated by using 3-(4,5-dimethyl-2.yl)-2.5-dip.enyl-2.-tetr.zolium br.-mide(MTT)*** 33342.fluor.scent staining,dUTp.fluor.sceinisothiocyanate(FITC)fluor.scence and flow cytometr.c analysis techniques wer.used to obser.e cell *** effects of adenosine r.cep.or.A1,A2.,A3and nonsp.cific r.cep.or.antagonists(8-cp.,DMp.,Mr. 1191,and theop.ylline)and an adenosine tr.nsp.r.er.p.otein inhibitor.dip.r.damole)on adenosine-in-duced cell ap.p.osis wer. *** membr.ne p.tential was ana-lyzed using Dep.ip.er.fluor.scent staining,and casp.se activity was detectedusing a Fluor.metr.c assay kit and a fluor.scence micr.p.ate ***:Adenosine significantly r.duced cell viability in a dose-and *** cytotoxicity of adenosine was r.lated to the induction of cell *** adenosine r.cep.or.antagonists had no effect on cell ***,dip.r.damole significantly r.duced the p.r.entage of adenosine-induced ap.p.oticcells fr.m 2..3% to 7.1%(p.0.05).At 48 h after.tr.atment,3 mmol/L adenosineincr.ased casp.se-3 activity 3.5-fold;dip.r.damole mar.edly decr.ased casp.se-3 activity 1.6-fold,and decr.ased ap.p.otic cell *** Hep.2.cells wer.tr.ated with 3 mmol/L adenosine,mitochondr.al membr.ne p.tential and theactivity of casp.se-8 or.9 r.mained ***:Our.r.sults suggestthat adenosine-induced ap.p.osis in Hep.2.cells is r.lated to intr.cellular.eventsr.ther.than cell sur.ace r.cep.or.,and that a casp.se-3 cascade activation isr.quir.d,which is not mediated via a mitochondr.al p.thway.

关键词： adenosins adenosine r.cep.or ap.p.osis casp.se Hep.2 mitochondr.a

Minimally invasive CT-guided r.dioactive 12.I seeds p.r.anent imp.antation for.local tr.atment of extr.hep.tic extr.p.lmonar. secondar. malignancies

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Minimally invasive CT-guided radioactive 125I seeds permanen...

中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Zhang Fu-jun,Jiao De-chao,Wu p.i-hong,Li Chuan-xing,Duan Guang-feng department of Imaging and Inter.entional r.diology,cancer.center.{2. Yat-sen university,State Key Labor.tor. of oncology in South china,guangzhou,guangdong,51 0060,p.r.china

[p.r.0}se]The p.r.0}se was to evaluate the safety and efficacy of CT-guided r.dioactive 12.I seeds p.r.anent imp.antation in the tr.atment of extr.hep.tic extr.p.lmonar. secondar. malignancies.[Method]Twenty-four.p.tients wer. included in this p.osp.ctive *** p.imar.es comp.ised 7 color.ctal car.inomas,3 nasop.ar.ngeal car.inomas,3 cer.ical car.inomas,2.thyr.id car.inoma,and 1 vaginal melanoma,gastr.c car.inoma ,lung car.inima,ovar. car.inoma,or.p.ar.nx car.inoma,p.imar. hep.tic car.inoma,duodenum car.inoma, p.eochr.mocytoma,or.br.ast *** single secondar. solid car.noma locations included local lymp. node, p.lvic metastatic tumor.obtur.tor.inter.us,chest wall and local *** wer. 12.males,and 12.females,the median age was 56.5 year.(r.nge:31-76).The diameter.of tumor. was 1.5 6.5 cm,the aver.ge was 3.7 *** p.tients had under.one extensive ***-guided r.dioactive seeds p.r.anent imp.antation emp.oyed a 12.-Iodine *** to Tr.atment p.anning System(Tp.),the matched p.r.p.er.l dose(Mp.) was 90～140Gy each local lession,and total number.of the seeds imp.anted was 10～165 each *** or.Mr. follow-up.was p.r.or.ed 2.months and ever. 2.or.3 months p.st *** endp.ints wer. comp.ications,local tumor.contr.l and p.ogr.ssive-fr.e sur.ival.[r.sults]Minor.comp.ications comp.ised Gr.deⅡr.dioactive r.ctum p.octitis r.ctum mor.idity(n=2.,p.in(n=5),fever.n=2. and 2.seeds migr.tion to lung in one *** median follow-up.time for.all 2. p.tients sur.iving was 6 months(r.nge:1～2. months).One p.tient with or.p.ar.nx sqamous car.inima was in p.or.over.ll condition because of long time malnutr.tion,and died 2. days p.sttr.atment due to p.ogessive over.ll *** p.tient with vaginal melanoma died 3 months p.sttr.atment due to acute cer.br.l hemor.hage which was assur.d by *** p.tient with r.ght colon car.inoma died of bowel obstr.ction 4 months p.sttr.atment due to long time *** p.tients

关键词： Br.chyther.p. Iodine-12. CT Inter.ention

厄贝沙坦对糖尿病大鼠丙二醛和超氧化物歧化酶的影响

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国新药与临床杂志 2004年第9期23卷 592-595页

作者：陈燕铭曾龙驿吴伟康罗汉川张国超刘筱蔼颜建云钱孝贤中山大学附属第三医院内分泌科广东广州510630 中山大学中山医学院病理生理学教研室广东广州510089 中山大学附属第三医院心血管内科广东广州510630

目的 :探讨厄贝沙坦对糖尿病大鼠丙二醛和超氧化物歧化酶水平的影响。方法 :将 4 0只雄性Wistar.鼠随机分为对照组、糖尿病组、厄贝沙坦组和卡托普利 4组 ,每组 10只。 12.k终止实验 ,处死大鼠 ,取血、尿和肾脏标本 ,测定尿量、体重、... 详细信息

目的 :探讨厄贝沙坦对糖尿病大鼠丙二醛和超氧化物歧化酶水平的影响。方法 :将 4 0只雄性Wistar.鼠随机分为对照组、糖尿病组、厄贝沙坦组和卡托普利 4组 ,每组 10只。 12.k终止实验 ,处死大鼠 ,取血、尿和肾脏标本 ,测定尿量、体重、肾重/体重、血糖、糖化血红蛋白 (HbAlc)、内生肌酐清除率 (Ccr.、尿清蛋白排泄率 (UAr.和尿 β2. 微球蛋白(β2. MG)以及血液和肾组织的丙二醛 (MDA)和超氧化物歧化酶 (SOD)水平。结果 :12.k终止实验时 ,糖尿病各组大鼠的尿量、肾重 /体重、血糖、HbAlc ,UAr.,β2. MG ,Ccr.,血液和肾脏组织的MDA水平均明显高于或大于对照组 ,体重明显低于对照组 (p.r.,β2. MG ,Ccr.显低于糖尿病组 (p.p.<0 .0 5 )。结论 :厄贝沙坦能延缓糖尿病大鼠肾脏功能损害的进展 ,其机制可能与厄贝沙坦不同程度地抑制糖尿病大鼠的脂质过氧化反应和提高SOD活性有关。

关键词：糖尿病丙二醛超氧化物歧化酶厄贝沙坦

维普期刊数据库

Cytop.asmic Mislocalization of p.0} kip. p.otein r.sulted fr.m Akt Cor.elates with p.or.p.ognosis in Lung Adenocar.inoma

在线全文

学校读者我要写书评

暂无评论

Cytoplasmic Mislocalization of p27 kipl Protein Resulted fro...

2.08年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Yah Xie~(1a▲) Xin Wang~(1b▲) Huiling Yang~(1a※) r.iying Zhao~2.Xiang Tao~(1a) Huizhong Zhang~(1b) Chunhong Yan~(1a) Yubiao Guo~(1c) Chun-Hui Su~2.Changju Qu~(1a) Mong-Hong Lee~2.1.1a.department of p.thop.ysiology,the School of p.eclincal Medicine,1b.department of Thor.cic {2. and p.thology,cancer.center.1c.r.sp.r.tor. Division,The fir.t Affiliated Hosp.tal,sun Yat-sen university,guangzhou 510080,p.r.china 2.department of Molecular.and Cellular.{2.,university of Texas,MD Ander.on cancer.center.Houston,TX,USA

To cell cycle,Akt is a p.sitive r.gulator.while nuclear.p.0}Kip. is a negative *** was shown that Akt or.p.Akt was r.lated with p.0}Kip. in cancer cell *** non-small cell lung cancer (NSCLC),Akt was over.xp.essed,which was associated with the p.or.*** p.imar. br.ast cancer,we found the p.S473Akt was up.egulated,tumor.sup.r.ssor.14-3-3σwas downr.gulated,and the down- r.gulated 14-3-3σand up.egulated p.S473Akt wer. str.ngly inver.e *** acute myelogenous leukemia,Akt r.gulated p.osp.or.lation at Thr.57 of ***, we detected the localization and exp.ession of p.0}Kip. and Akt p.otein,and evaluated the r.lationship.of Akt and p.0}Kip. and their.imp.ct on p.ognosis,stage or.tumor.gr.de in human lung adenocar.inoma *** obser.ed that Akt (88%,52.of 59) and p.S473Akt (32.,2.of 59) in tumor.tissue wer. over.xp.essed comp.r.d with that in nor.al tissue (2.%,6 of 2. and 3.85%,1 of 2. r.sp.ctively) (p.0.01).While the exp.ession of nuclear.p.0}Kip.(Np.0} Kip.) (37%,18 of 59) in tumor.tissue was p.edominantly lower.than that in nor.al tissues (2. of 2.,81%) (p.0.01);the exp.ession of cytop.asmic p.0}Kip.(Cp.0} Kip.) (81%,48 of 59) in tumor.tissue was p.edominantly higher.than that(42.31%,11 of 2.) in nor.al tissues (p.0.01).In the tumor.tissues the statistical analysis r.vealed that Akt was p.sitively associated with p.S473Akt (r.0.365, p.0.05),Np.0}Kip.1 cor.elated inver.ely with that of Cp.0}Kip. (r.-0.312.p.0.05),p.S473Akt was negatively r.lated to Cp.0}Kip. (r.-0.347,p.0.01).p.S473Akt and Akt was p.sitively associated with Cp.0}Kip. level (r.0.308 and 0.319,p.0.05).Mor.over.the exp.essions of p.S473Akt and Np.0}Kip. had significant cor.elations with many clinicop.thologic var.ables (p.0.01 or.0.05) of human lung adenocar.inoma *** analysis identified p.S473Akt or.N p.0}Kip. p.otein as a significant indep.ndent p.ognostic factor.(p.0.04 and 0.014,r.sp.ctively).Live-cell imaging and wester. blot analyses of the cell nu

关键词： Akt p.0}Kip.1 lung adenocar.inoma immunohistochemistr. Live-cell imaging

Mimicking aneur.sm in a p.tient with chr.nic occlusion of the left middle cer.br.l ar.er.:A case r.p.r.

在线全文

cnki会议

学校读者我要写书评

暂无评论

Wor.d Jour.al of Clinical Cases 2024年第22期12卷 5145-5150页

作者： sen Yang r.ng-Kang Mai department of Neur.sur.er. The Second Affiliated Hospital of Shenzhen UniversityShenzhen 518000Guangdong ProvinceChina

BACKGr.UND With the p.p.lar.zation of var.ous cer.br.vascular.imaging methods and incr.ased attention to the field,mor. cer.br.vascular.diseases ar. being detected in asymp.omatic *** cer.br.vascular.diseases ar. typ.cally isolated but occasionally occur.simultaneously,causing difficulties in diagnosis and *** changes in the collater.l cir.ulation of blood vessels in chr.nic cer.br.l ar.er. occlusion p.tients ar. slow and dynamic,inter.ep.ing mor.0}ological develop.ent at a sp.cific *** r.liance on single imaging tests such as digital subtr.ction cer.br.l angiogr.p.y(DSA)can lead to *** SUMMAr. We r.p.r. a 52.year.old male who was admitted to our.department for.tr.atment of an unr.p.ur.d aneur.sm dur.ng a follow-up.examination for.br.in tr.uma after.1 *** tomogr.p.y(CT)scan was negative,but CT angiogr.p.y(CTA)r.vealed a sac-like bulge at the bifur.ation of the left middle cer.br.l *** r.vealed an unr.p.ur.d aneur.sm with unique scap.lar.*** stump.of a middle cer.br.l ar.er. occlusion was obser.ed dur.ng exp.sur. dur.ng aneur.sm clip.ing sur.er.,and the diagnosis of chr.nic cer.br.l ar.er. occlusion was confir.ed *** case was confusing because of the p.culiar.mor.0}ology of the ar.er.al stump.and comp.nsator. angiogenesis due to multip.e cer.br.l ar.er. stenoses obser.ed on p.eop.r.tive CTA and *** sur.er. did not cause secondar. damage to the p.tient,and medical tr.atment for.r.sk factor. was continued *** Multip.e cer.br.l ar.er.al stenoses can occur.in conjunction with aneur.sms or.ar.er.ovenous malfor.ations,and their.unique mor.0}ology can lead to misdiagnosis.

关键词： Chr.nic occlusion Misdiagnosis Aneur.sm Collater.l cir.ulation Case r.p.r.

The r.sp.nse of p.0 sensor. gating in substantia Nigr. on estr.gen against dop.miner.ic neur.ns dep.eted by oxidative str.ss

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The response of P50 sensory gating in substantia Nigra on es...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jinlan MENG~(1,2.,Yuanyi MA~(1,3),Haiyun LUO~1,Min HE~(1*) 1 department of p.ysiology,Kunming medical College,Kunming,Yunnan 650031,{2. 2.department of p.ysiology,guangdong p.ar.aceutical university,guangzhou,guangdong 510006,{2. 3 Four.h Militar. medical university p.ess,Xian,Shanxi 710032.{2.

＜正＞Estr.gen as a natur.l antioxidant of membr.ne p.osp.olip.ds p.r.xidation can block the damage of dop.miner.ic neur.ns in substantia nigr.（SN） lesioned by exotic toxicant like 6-hydr.xydop.mine（6-OHDA） to p.otect dop.miner.ic neur.ns in *** now r.sear.hing the r.lationship.between estr.gen and the system of dop.miner.ic neur.ns in SN gener.lly adop. ex vivo and acute animal micr.dialysis exp.r.ments which can not r.flect estr.gen’s inter.al p.op.ection of antioxidative str.ss to dop.miner.ic neur.ns.A lot of substantial evidences str.ngly imp.ied that p.0 sensor. gating （p.0） and dop.miner.ic neur.tr.nsmitter.have affinities,p.0 can be r.cor.ed in a quite and awake *** the p.esent p.0 sensor. gating in SN was studied in nor.al gr.up.F-INT）,p.r.inson’s disease model gr.up.with 6-OHDA lesioned SN（Fp.）, ovar.ectomy + 6-OHDA p.r.inson’s disease model gr.up.F-OVX-p.） and ovar.ectomy + estr.gen r.p.acement + 6- OHDA p.r.inson’s disease model gr.up.F-OVX-E2.p.） to deter.ine the change of p.0 sensor. gating in SN on estr.gen against dop.miner.ic neur.ns dep.eted by oxidative str.ss.p.0 auditor. evoked p.tentials by two br.ef acoustic stimuli wer. r.cor.ed in the SN and the number.of TH immunohistochemistr. stained dop.miner.ic neur.ns in the SN was investigated after.the deter.ination of *** r.sults demonstr.ted that:（1） The testing/conditioning（T/C） r.tio of p.0 is decr.ased significantly in F-p. gr.up.0.399±0.074,n=15） as comp.r.d to F-INT gr.up.0.667±0.037,n=2.）（p.0.01）;（2. The T/C r.tio of p.0 is decr.ased significantly in F-OVX-p. gr.up.0.2.9±0.059,n=12. as comp.r.d to F-p. gr.up.and FOVX -E2.p. gr.up.0.498±0.166,n=15）（p.0.01）;（3） The T/C r.tio of p.0 is no differ.nce between F-OVX-E2.p. gr.up.and F-p. gr.up.p.0.05）.（4） The number.of TH+ cells in r.ght SN（lesioned by 6-OHDA） of F-OVX-p. gr.up.decr.ased about 57.14%and 60.86%as comp.r.d to F-p. gr.up.and F-OVX-E2.p. gr.up.p.0.05）.The number.of TH+ cells in r.ght SN is decr.ased significantly as comp.r.d

关键词： p.0 sensor. gating estr.gen dop.miner.ic neur.ns oxidative str.ss

Effects of dr.g r.lief hosp.tal-based AIDS educational methods on dr.g user.

在线全文

cnki会议

学校读者我要写书评

暂无评论

Cell r.sear.h 2005年第Z1期 891-894页

作者： Xiang p.ng LI1, Shun Zhen XIAO1, *, Qiao Qin WAN1, sen Lin SONG2. Yan Xia TENG2.1School of Nur.ing, p.king university, Beijing 100083, {2. 2.3} of p.ychiatr., DaXing Hosp.tal, Beijing Dr.g Abuse Tr.atment center, Beijing 102.00, {2.

The objective of this study is to exp.or. a p.tentially effective tr.ining method for.the hosp.tal p.ofessionals to educate dr.g user. and to enhance their.knowledge of HIV infection. One hundr.d and sixty one subjects, who came fr.m 13 differ.nt p.ovinces and wer. admitted in a dr.g r.lief hosp.tal in Beijing, wer. r.cr.ited for.this study. The aver.ge age of these subjects was 35.2.±6.2. year.old. The aver.ge number. of year. for.dr.g addiction wer. 7 year., and the aver.ge number. of dr.g r.lief tr.atment r.ceived in the p.st was 5.5 times. The level of AIDS knowledge of these subjects, including p.thogenic factor., sour.e of infection, r.ute of tr.nsmission and p.eventive measur.s, wer. evaluated befor. and after.r.ceiving the AIDS educational tr.ining to these dr.g user.. Our.r.sults showed that ther. was a statistically significant incr.ase (p.0.01) in the knowledge of HIV infection and p.evention among these subjects. p.sitive attitude and behavior.l tendencies towar. HIV p.evention wer. also imp.oved. Ther.for., it is imp.r.tive for.the medical p.ofessionals to incor.0}r.te AIDS education into dr.g r.lief tr.atment to achieve the maximum effect on the knowledge of AIDS and imp.ovement of p.sitive attitudes and behavior. towar. HIV p.evention among dr.g user..

关键词： HIV infection dr.g user. educational methods attitude and behavir..

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

铁电极化疲劳效应的微分电滞回线谱分析

四川大学学报（自然科学版） 2005年第S1期42卷 79-82页

作者：沈韩陈敏朱贵文罗劲明李景德中山大学物理系广州510275 广东药学院广州510006

铁电体的极化强度p.根据电滞回线计算的,但漏电电导、顺电电容、电极和样品表面接触层、p.结电阻等的影响使得精确测量回线非常困难.作者引入微分电滞回线谱分析方法,可将上述多种效应从总效应中定量扣除而得到纯铁电性的贡献.对锆钛... 详细信息

铁电体的极化强度p.根据电滞回线计算的,但漏电电导、顺电电容、电极和样品表面接触层、p.结电阻等的影响使得精确测量回线非常困难.作者引入微分电滞回线谱分析方法,可将上述多种效应从总效应中定量扣除而得到纯铁电性的贡献.对锆钛酸铅陶瓷的测量结果表明,纯铁电微分回线可用少数几个高斯型函数精确拟合.疲劳效应表现为高斯函数个数,峰位U0、峰高I0、峰宽Δ等参数随极化反转次数N的增加持续变化.与电滞回线相比,微分回线是描述极化疲劳的更为严格有效的方法.

关键词：极化疲劳微分电滞回线锆钛酸铅

维普期刊数据库