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percutaneous radiofrequency ablation approach through the spleen:initial case report for pancreatic tail gastrinoma

Chinese Journal of cancer 2010年第9期29卷 836-841页

作者： pei-Hong Wu1,2. Chang-Chuan pan1,2. Zi-Lin Huang1,2. Wang Li1,2. Ming Zhao1,2. Zhi-Wei Zhou1,3 1 State Key Laboratory of Oncology in South china, guangzhou, Guangdong 510060,{2. 2.department of medical imaging & inter.entional r.diology, sun yat-sen university cancer.center. guangzhou, Guangdong 510060,{2. 3 department of Abdominal Oncology, sun yat-sen university cancer.center. guangzhou, Guangdong 510060,{2. department of medical {2.& inter.entional r.diology Sun Yat-s en University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 department of Abdominal Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Gastrinoma has a low incidence, and the pancreas-originated gastrinoma is *** gastrinoma patients with liver metastases have poor prognosis and short *** treatment to reduce the tumor burden helps to improve symptoms and slows down tumor progression for patients with unresectable *** report a case of pancreatic tail gastrinoma with unresectable liver *** patient received a comprehensive minimally invasive inter.entional treatment, that is, chemoembolization and radiofrequency ablation for liver metastases, and percutaneous transplenic radiofrequency ablation combined with radioactive 12.I seed implantation for pancreatic tail *** patient was followed up for more than 2. months, and showed no clear evidence of tumor *** explored the safety and feasibility of percutaneous transplenic radiofrequency ablation for unresectable pancreatic tail *** transplenic approach allow more indications for minimally invasive therapy and provides a new treatment option not only for patients with unresectable pancreatic tail tumor but also for patients refusing surgery.

关键词：射频消融胃泌素病例报告尾部局部治疗手术切除肿瘤病介入治疗

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Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture

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World Journal of Gastroenterology 2010年第45期16卷 5766-5772页

作者： Yang-Kui Gu, rong-Guang Luo, Jin-Hua Huang, Qi-Jiao Si Tu, Xiao-Xia Li, Fei Gao,State Key Laboratory of Oncology in Southern china,department of {2. imaging and inter.entional r.diology,cancer.center.sun yat-sen university,guangzhou510060,Guangdong province,china department of {2. imaging and inter.entional r.diology, the First Affiliated Hospital of Nan-Chang university, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi province, china State Key Laboratory of Oncology in Southern china Department of Medical Imaging and Interventional Radiology Cancer Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China. hjinh@***

AIM: To determine the safety and effectiveness of transarterial embolization ablation (TEA) of hepatocellular carcinoma (HCC) with a lipiodol-ethanol mixture. METHODS: Between January 1 and December 31, 2.09, 15 patients with HCC (13 men/two women, aged 38-75 years) accepted TEA treatment and were enrolled in this study, including five newly diagnosed patients and 10 with refractory disease. Two months after TEA, angiography and contrast computed tomography (CT) were performed, and responses were assessed using a modified version of response Evaluation Criteria in Solid Tumors (rECIST version 1.1). The follow-up period was to June 30, 2.10. rESULTS: Every new case was treated once. Angiography was performed immediately after TEA, and showed that the tumor-feeding vessels were completely embolized and that lipiodol was densely deposited inside tumors. Two months after treatment, contrast CT showed no enhanced lesions. Alpha fetoprotein levels returned to normal in four patients and markedly decreased in another. mean ± SD survival after treatment was 10.8 ± 4.5 mo. All five patients survived during the follow-up period. Ten patients with refractory disease were treated a total of 14 times. Angiography immediately after TEA showed that blood flow to the tumors was obviously decreased in all cases, and contrast CT showed obvious depositions of lipiodol. Two months after treatment, the tumors had shrunk (6/10) or were stable (3/10). One had progressed after 2.mo and died of tumor rupture 3 mo after TEA. mean ± SD survival after treatment was 8.6 ± 4.3 mo; two patients survived during the follow-up period. Adverse effects included reversible hepatic decompensation, upper abdominal pain, and fever. CONCLUSION: TEA is an effective therapy for patients with HCC and might be more effective than transcather arterial chemoembolization for treating refractory disease.

关键词： Transarterial embolization ablation Lipiodolethanol mixture Hepatocellular carcinoma

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interstitial implantation of 12.I seeds as salvage therapy for recurrent ovarian cancer and cervical cancer

Interstitial implantation of 125I seeds as salvage therapy f...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Jin-hua Huang 1,Chang-lun Li 1,Ji-hong Liu 2,Qi-dan Huang 2,Yang-gui Gu 1,Fei Gao 1 Authors’ Affiliations:1State Key Laboratory of Oncology in Southern china department of {2. imaging & inter.entional r.diology,cancer.center.sun yat-sen university,guangzhou,Guang Dong,510060,pr china.2State Key Laboratory of Oncology in Southern china department of Gynecology,cancer.center.sun yat-sen university,guangzhou, Guang Dong,510060,pr china. Corresponding Author:Jin-hua Huang,department of {2. imaging & inter.entional r.diology,cancer.center.sun yat-sen university,guangzhou,Guangdong 510060,{2.}.Tel:+86-20-87343247 Fax:+86-20- 87343272.Email:hjinh@***.

Objective To investigate the feasibility,short-term efficacy and adverse effects of 12.I seeds implantation in the treatment of recurrent ovarian cancer and cervical *** A total of 12.patients with recurrent ovarian cancer and 17 patients with cervical cancer treated in sun yat-sen university cancer.center.from June 2.09 to December 2.10 enrolled into the *** there were 49 lesions including 2. ovarian cancer lesions and 2. cervical ***-five lesions were treated with 12. I seed *** ovarian cancer lesions in liver and one lesion in spleen were treated with microwave ***-four lesions were treated under the guidance of CT while only one lesion in one patient was treated under the guidance of real-time *** treating plan was calculated using computerized treatment planning system(TpS) and Memorial Sloan-Ketterin nomograph according to the physiologic 18FDG uptake image in the *** prescribed matched peripheral dose(MpD) was 100～160 Gy. The total number of sources implanted were 6～68 with a median number of *** chemotherapy was given to 13 patients after the inter.entional *** status were evaluated with CT and 18F-FDG pET/CT findings. results One patient with recurrent ovarian cancer and 9 patients with recurrent cervical cancer died and the other patients were still alive after a median follow-up of 15 mouths(range from 5 to 19mouths).Thirteen patients showed complete remission,seven patients showed partial remission,nine patients had progressive *** effective rate was 69.0% (2./2.).There were three patient suffered from Sciatic nerve injury *** complication was found in the other *** 12. I seed implantation was feasible,effective and safe as a salvage local treatment for patients with recurrent gynecologic malignancies,it was worth of development and *** efficacy seems better in recurrent ovarian cancer than in cervical cancer patients.

关键词： ovarian cancer cervical cancer recurrent 12. I seed implantation 18F-FDG pET/CT

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Nasopharyngeal Carcinoma:pET-CT Guided 12.I Seed Implantation Therapy after repeated Traditional radiochemotherapy

Nasopharyngeal Carcinoma:PET-CT Guided 125I Seed Implantatio...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Chuanxing Li1,Weidong Zhang 1,peihong Wu1,Chen Dong1,Jianjun Han1,Ligong Lu2.Fujun Zhang 1 1.department of medical {2. & inter.entional r.diology,cancer.center.and State Key Laboratory of Oncology in South china,sun yat-sen university,guangzhou,510060,{12. ADD:651 Dongfeng road,East,guangzhou,{12. 2.department of inter.entional r.diology,the people’s Hospital of Guangdong province, guangzhou,510080,{12.

The purpose of this study is to evaluate the effectiveness and safety of pET-CT guided 12.I seed implantation in the treatment of patients with refractory nasopharyngeal carcinoma after repeated traditional ***-six patients with refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy,18 males and 8 females,aged 51.3(42. 68),totaling 53 lesions 4.3(0.5-7.8) cm in diameter,were treated by pET-CT guided 12.I seeds implantation according to treatment planning *** the patients received pET-CT scan 2.months after the ***-up was conducted for 30.7(2.43) months to observe the local control rate,overall survival rate,and clinical *** follow-up time ranged from 2.to 43 *** local control rates of refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy after 3,6,12.2. and 36 months were 90.6%(48/53),79.3%(42.53),71.7% (38/53),62.3%(33/53) and 56.6%(30/53),*** overaU 1-,2.,and 3-year survival rates were 87.2.,71.3%,and 56.5%respectively with a median survival time of *** all patients,19.2.(5/2.) died of local recurrence,15.4%(4/2.) died of *** patient died of hypertensive Cerebral Hemorrhage,another patient died from cachexia and *** long-term complications included hyperpigmentation at operative sites(n=5),insensible feeling on lateral cheek (n=2.,dryness of oral cavity(n=1),and headache(n=l).pET-CT guided 12.I seed implantation is effective,safe and feasible method in treating refractory nasopharyngeal carcinoma with minimal damage and few complications.

关键词： Nasopharyngeal carcinoma radiochemotherapy pET-CT 12.I seed Therapy

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refractory Nasopharyngeal Carcinoma:pET-CT Guided 12.I Seed Implantation Therapy after repeated Traditional radiochemotherapy

Refractory Nasopharyngeal Carcinoma:PET-CT Guided 125I Seed ...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Chuanxing Lil,Weidong Zhang 1,peihong Wu1,Chen Dong1,Jianjun Han1,Ligong Lu2.Fujun Zhang 1 1.department of medical {2. & inter.entional r.diology,cancer.center.and State Key Laboratory of Oncology in South china,sun yat-sen university,guangzhou,510060,{12. 2.department of inter.entional r.diology,the people’s Hospital of Guangdong province,guangzhou,510080,p.r. china

purpose:To evaluate the effectiveness and safety of pET-CT guided 12.I seed implantation in the treatment of patients with refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy. Materials and Methods:Twenty-six patients with refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy,18 males and 8 females,aged 54(42.68),totaling 53 lesions 4.0(0.5-7.8) cm in diameter,were treated by pET-CT guided 12.I seeds implantation according to treatment planning *** the patients received pET-CT scan 2.months after the treatment. Follow-up was conducted for 31(2.43) months to observe the local control rate,overall survival rate,and clinical complications. results:The follow-up time ranged from 2.to 43 *** local control rates of refractory nasopharyngeal carcinoma after repeated traditional radiochemotherapy after 3,6,12.2. and 36 months were 90.6%(48/53),79.3%(42.53),71.7%(38/53),62.3%(33/53) and 56.6%(30/53), *** overall 1-,2.,and 3-year survival rates were 87.2.,71.3%,and 56.5% respectively with a median survival time of *** all patients,19.2.(5/2.) died of local recurrence,15.4%(4/2.) died of *** patient died of hypertensive Cerebral Hemorrhage,another patient died from cachexia and *** long-term complications included hyperpigmentation at operative sites(n=5),insensible feeling on lateral cheek(n=2.,dryness of oral cavity(n=l),and headache(n=l). Conclusion:pET-CT guided 12.I seed implantation is effective,safe and feasible method in treating refractory nasopharyngeal carcinoma with minimal damage and few complications.

关键词： Nasopharyngeal carcinoma radiochemotherapy pET-CT 12.I seed Therapy

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IL-1beta sensitizes rat intervertebral disc cells to Fas ligand mediated apoptosis in vitro

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Acta pharmacologica Sinica 2007年第10期28卷 1671-1676页

作者： Li-yang CUI~2.Shang-li LIU~(2.4),Yue DING~2.Dong-sheng HUANG~2.ruo-fan MA~2.Wei-guo HUANG~2.Bao-shan HU~2.Qiu-hui pAN~3~2.department of Orthopaedic Surgery and ~3 department of Lin Bai-Xin {2. research center,the Second Affiliated Hospital of sun yat-senuniversity guangzhou 51012.,china ment of Orthopaedic Surgery the Second Affiliated Hospital of Sun Yat-Sen University Guangzhou 510120 China. gzxy168@***.

Aim:To determine the apoptotic effect of recombinant rat Fas Ligand on rat inter-vertebral disc cells pre-treated with IL-1beta in vitro,and the expression of Fas incultured rat intervertebral disc ***:Cells were isolated from the innerannulus fibrosus and transition zones of lumbar discs from Sprague-Dawley *** cells were grown in monolayer and divided in 5 treatment ***-1 beta (10ng/mL),FasL (5,2. ng/mL) with/without IL-1beta (10 ng/mL) pre-treatment wasrespectively added in Dulbecco’s modified Eagle’s medium and Ham’s F-12.me-dium with 1% fetal bovine *** 32.h,the cells were stained with annexin V-FITC and propidium iodide to evaluate apoptosis using flow cytometry and toanalysis transcription of Fas using ***:Compared with controlgroup,FasL (2. ng/mL),IL-1β(10 ng/mL)+FasL (5 ng/mL),and IL-1β(10 ng/mL)+FasL (2. ng/mL) induced significant apoptosis of the disc cells (ppoptosis was also induced by FasL 5 ng/mL (preas,apoptosis wasnot induced by 1L-1β(10 ng/mL) (p>0.05).IL-1β(10 ng/mL) enhanced the apoptosis-inducing effects of FasL (5 ng/mL) and FasL (2. ng/mL) in disc *** genetranscription in all groups and Fas expression in the 5 treatment groups wereapproximately 1.2.2.1-fold greater than control group (respectively,ppression in FasL with IL-1β pre-treatment groups were signifi-cantly up-regulated than in FasL groups (presults of thisstudy showed disc cells pre-treated with IL-lbeta increased apoptotic rate inresponse to FasL in vitro and provided insights to understand Fas/FasL system-mediated apoptosis in disc cells which would be enhanced due to inflammationfactor in degenerative disc.

关键词： intervertebral disc cell apoptosis Fas ligand flow cytometry interleukin-1 beta

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Large,unresectable malignant fibrous histiocytoma:pET/CT-guided treatment with a multidisciplinary,minimally invasive approach

Large,unresectable malignant fibrous histiocytoma:PET/CT-gui...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Chuanxing Li,Dong Chen,Ketong Wu,Sheng peng,Fujun Zhang department of medical {2. & inter.entional r.diology,cancer.center.and State Key Laboratory of Oncology in South china,sun yat-sen university,guangzhou,510060,{12..

purpose To evaluate the effectiveness and safety of a pET/CT-guided,multidisciplinary,minimally invasive approach to the treatment of patients with large,unresectable,malignant fibrous *** approach includes microwave ablation and absolute alcohol therapy combined with 12.I seed *** and Methods Seven patients(5 males and 2.females,42.48 years-old,mean 49.7 years-old) with large,unresectable malignant fibrous histiocytoma participated in this *** tumors had an average maximum diameter of 14.1 cm(10.0-19.0 cm) and were treated using a pET/CT-guided,multidisciplinary,minimally invasive *** patients received a pET/CT scan 2.months after the ***-up was conducted for an average of 35.7(2.45) months to determine the local control rate,overall survival rate,and clinical *** Follow-up times ranged from 2.to 45 *** was significantly relieved in patients treated with multidisciplinary,minimally invasive *** on pET/CT, complete response was achieved in 5 patients(71.4%),partial response in the other 2.patients(2..6%).The response rate of this multidisciplinary,minimally invasive treatment was 100%.The median survival time was 35.7 *** patients were alive 2.years after the *** patients were still alive after 3 *** patient died from cachexia and infection in the 3rd year,and another died of lung dysfunction from pulmonary metastases in the 2.d *** 3-year survival rate was 71.4%.The long-term complications included hyperpigmentation at the operative sites(n = 5) and insensible feeling at the ablation sites(n=3).Conclusion:pET/CT-guided multidisciplinary,minimally invasive approach is an effective,safe,and feasible means of treating large,unresectable malignant fibrous histiocytoma with minimal damage and few complications,but large-scale randomized clinical trials are necessary to confirm this assessment.

关键词： Malignant fibrous histiocytoma multidisciplinary approach pET-CT microwave ablation absolute alcohol 12.I brachytherapy

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光学相干断层成像术及其在眼科中的应用

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眼科学报 1998年第2期14卷 116-120页

作者：王梅骆荣江刘嫣芬中山医科大学孙逸仙纪念医院眼科广州510120 中山医科大学中山眼科中心广州510060

光学相干断层成像术(OCT)是近几年始用于临床的新型影象诊断技术。与超声成像等技术不同,它利用光波在生物组织的传播特性并检测反射光的时程延迟,构成组织横断面图象,以观察其微细结构并进行定量分析,纵向分辨力可高达10μm,并具有非... 详细信息

光学相干断层成像术(OCT)是近几年始用于临床的新型影象诊断技术。与超声成像等技术不同,它利用光波在生物组织的传播特性并检测反射光的时程延迟,构成组织横断面图象,以观察其微细结构并进行定量分析,纵向分辨力可高达10μm,并具有非接触性、非侵害性等特点。在眼科,它不仅能够对眼前节的结构进行成像,还可以对视网膜各层次结构进行清晰的显像,为多种眼内疾病、特别是青光眼的早期诊断和研究提供了一种新的有效途径。眼科学报1998;14:116—12.。

关键词：眼科应用 OCT 光学相干断层成像术

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Comparative survival analysis in patients with pulmonary metastases from nasopharyngeal carcinoma treated with radiofrequency ablation.

Comparative survival analysis in patients with pulmonary met...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： pan CC,Wu pH,Yu Jr,Li W,Huang ZL,Wang Jp,Zhao M. Source medical Oncology,Sichuan cancer Hospital & Institute,The Second people’s Hospital of Sichuan province,{2. department of medical imaging & inter.entional r.diology,State Key Laboratory of Oncology in South {2.,sun yat-sen {12. cancer.center.651 Dongfeng road East, guangzhou 510060,pr {2..

pUrpOSE: The aim of this retrospective study was to evaluate technical efficacy and the impact of CT-guided pulmonary radiofrequency ablation(rFA) on survival in patients with pulmonary metastases from nasopharyngeal carcinoma(NpC). MATErIALS AND METHODS: Between 2.00 and 2.09,480 patients were pathologically or clinically confirmed pulmonary metastases from NpC. And ten included patients of them had a total of 2. pulmonary metastases treated with percutaneous rFA under the realtime CT ***,local tumor progression,and survival were evaluated in our ***-pair survival was compared using Kaplan-Meier analysis. rESULTS: A total of 2. ablations were performed to 2. pulmonary metastases in 13 rFA *** requiring chest tube placement developed in 3 of 13(2..1%) rFA *** median metastatic overall survival was 36.1 months for all the 480 NpC patients with pulmonary ***,matched-pair analysis demonstrated patients with rFA treatment had a greater metastatic overall survival than patients without rFA treatment(77.1 months vs 32.4 months,log-rank test,p=0.009).There were no statistically significant differences in the survival probability of patients with rFA treatment(n=10) and surgical resection of pulmonary metastases(n=2.)(log-rank test,p=0.75). CONCLUSION: CT-guided pulmonary rFA is safe and offers a treatment alternative for local tumor control,providing promising survival in selected patients with pulmonary metastases from NpC.

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Biodegradable magnesium alloy as a new connecting material for iodine-12. brachytherapy:an initial experimental study in a rabbit VX2.model

Biodegradable magnesium alloy as a new connecting material f...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Dong Chen1,Guang-feng Duan1,Yan-ling Zhang2.Sheng peng1 Jian-jun Han1,Chuan-xing Li 1*,Fu-jun Zhang 1* 1.department of imaging and {2. r.diology,cancer.center.of sun yat-sen university,guangzhou,510060,people’s republic of china 2.School of Biotechnology,Southern medical university,guangzhou 510515,people’s republic of china

Objective To evaluate the in vivo degradation characteristics and tissue compatibility of new I12. seed chains connected with the biodegradable magnesium alloy AZ31 in New Zealand rabbits. Methods Thirty New Zealand rabbits were randomly divided into three *** group A,magnesium alloy radioactive I12. seeds chains were implanted into VX2.tumors;in group B,magnesium alloy non-radioactive I12. seeds chains were implanted into normal muscle;group C served as an untreated control *** mass loss of the AZ31 magnesium alloy connecting material was measured in the two groups at different time points after implantation of the I12. seed *** and histological changes at the implantation site and in organs were monitored using light microscopy,and seed displacement was assessed using regular X-ray and computed tomography(CT) *** and urine samples were collected from all experimental animals to measure changes in magnesium ion concentrations. results The new 112. seed chains made with AZ31 magnesium alloy began to degrade during the first week after *** day 2.,the degradation rate was 81%in muscle tissue and 83%in tumor tissue;these degradation rates are not statistically *** after implantation,a mild local inflammatory response and gas production were induced;the gas disappeared 2. days after *** magnesium ion concentrations after implantation were relatively stable,but urine magnesium concentrations increased and fluctuated over a larger *** inspection of the liver,kidney,heart,and spleen of all animals implanted with 112. seed chains revealed no significant *** 7 days after the implantation of magnesium alloy radioactive 112. seed chains into tumors,the connecting material showed good connecting and fixing *** 2. days after implantation,the seeds had separated from each other,displacement had occurred,and the radioactive seeds had aggregated in concordance with

关键词： I12. radioactive stranded seeds biodegradable magnesium alloy VX2.tumor biocompatibility

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