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肌成纤维细胞转化在恶性肿瘤转移过程中的作用

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中医学报 2018年第3期33卷 350-354页

作者：周天迟笑怡刘传波李泉旺 RAO Jianyu 胡凯文北京中医药大学东方医院北京100078 department of Pathology and Lab Med Ronald Reagan Medical CenterUniversity of California at Los AngelesLos Angeles 90095

肿瘤转移过程是一个多因素调控、多步骤协同的交互过程。肿瘤微环境中肌成纤维细胞转化是促进肿瘤及转移发生的重要病理过程,这一过程可以通过以下作用实现:(1)构成适合肿瘤细胞生长的代谢体系;(2)提供立体生长形态支架;(3)促进肿瘤细... 详细信息

肿瘤转移过程是一个多因素调控、多步骤协同的交互过程。肿瘤微环境中肌成纤维细胞转化是促进肿瘤及转移发生的重要病理过程,这一过程可以通过以下作用实现:(1)构成适合肿瘤细胞生长的代谢体系;(2)提供立体生长形态支架;(3)促进肿瘤细胞上皮间质转化;(4)分泌血管内皮生长因子,促进微循环形成;(5)形成鞘状结构保护肿瘤细胞免受药物及免疫细胞伤害;(6)分泌生长因子和细胞炎性因子,促使纤维细胞和成纤维细胞发生肌成纤维细胞转化。而以上作用很可能是化痰类和活血化瘀类中药抗癌、抗转移的核心作用机制。

关键词：肌成纤维细胞肿瘤微环境转移化痰类中药活血化瘀类中药

浅论护理管理者在高山运动健康照护中的角色作用（英文）

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中国高原医学与生物学杂志 2018年第2期39卷 75-78页

作者：贺启莲冯书娥金先革支颜霄孙丽樊辉娟玛丽莲.史密斯-斯托纳青海大学医学院美国加州州立大学圣贝纳迪诺分校

护理人员通过与多学科团队的合作,承担着多种情况下的重要健康护理任务,而对高山探险者的健康照护是其中最具挑战性的工作之一。护理管理者在高海拔地区探险的高山运动员及登山者的健康教育、高山病预防和治疗护理中承担着重要的角色。... 详细信息

护理人员通过与多学科团队的合作,承担着多种情况下的重要健康护理任务,而对高山探险者的健康照护是其中最具挑战性的工作之一。护理管理者在高海拔地区探险的高山运动员及登山者的健康教育、高山病预防和治疗护理中承担着重要的角色。本文以高原病、高原医学及高原护理的相关英文文献为基础,通过其量性及质性研究结论,结合临床指南,简述了高山运动者的健康照护需求及护理领导者应对这些需求所承担的角色作用。

关键词：护理管理者高原病高山运动护理

MMS星座对磁层顶磁通量绳内离子惯性尺度结构的观测

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空间科学学报 2018年第2期38卷 147-168页

作者：刘杨濮祖荫谢伦郭瑞龙王晓钢肖池阶史全岐 DUNLOP M BOGDANOVA Y V MOORE T E RUSSELL C T LINDQVIST P A TORBERT R B POLLOCK C ZHAO Cong 北京大学地球与空间科学学院北京100871 中国科学院地质与地球物理研究所北京100029 哈尔滨工业大学物理系哈尔滨150001 北京大学物理学院北京100871 山东大学空间科学与物理学院威海264209 RAL Space Rutherford Appleton LaboratorySTFCDidcotOX11 0QXUK Goddard Space Flight Center NASAGreenbeltMDUSA University of california Los AngelesCAUSA Royal Institute of Technology StockholmSweden University of New Hampshire DurhamNHUSA

利用MMS观测数据,对磁层顶通量绳内离子惯性尺度(d_i)的结构进行分析研究.结果发现,许多不同尺度(约1d_i至数十d_i)的通量绳内都存在具有d_i尺度的电流j_m,其方向在磁层顶局地坐标系的-M方向,即与磁层顶查普曼-费拉罗电流同向,由电子在+... 详细信息

利用MMS观测数据,对磁层顶通量绳内离子惯性尺度(d_i)的结构进行分析研究.结果发现,许多不同尺度(约1d_i至数十d_i)的通量绳内都存在具有d_i尺度的电流j_m,其方向在磁层顶局地坐标系的-M方向,即与磁层顶查普曼-费拉罗电流同向,由电子在+M方向的运动(v_(em))携带.这些电流结构具有以下特征:磁鞘与磁层成分混合,磁场为开放形态;离子去磁化,电子与磁场冻结;N方向(即垂直于磁层顶电流片方向)的电场E_n显著增大,幅度达到约20 mV·m^(-1),并伴有明显的尖峰状起伏,该增强和尖峰状起伏的电场对应于霍尔电场.分析表明,电流、电子与离子运动的偏离以及霍尔电场之间遵从广义欧姆定律,三者密切关联.进一步对磁层顶磁重联的探测数据进行分析发现,在很多重联区内也存在与通量绳内相似的结构,其尺度约为d_i量级,其中霍尔电场E_N、电流j_M和电子速度v_(eM)均与通量绳内对应物理量的方向相同且幅度相近.基于上述观测事实,采用经典FTE通量绳模型,对通量绳内电流、电子运动和霍尔电场的起源进行了初步探讨,认为其来源于磁层顶无碰撞磁重联区内的相应结构,并且后者在离子尺度通量绳的形成过程中起到重要作用.

关键词：磁通量绳离子尺度电流霍尔电场磁层顶磁重联

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé carmen Gasca-capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa carmen Infante-Domínguez Juan carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-cabrera Pedro camacho-Martínez carmen Infante-Domínguez Marta carretero-Ledesma Juan carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel candela caballero-Eraso Macarena cabrera Enrique calderón Jesús carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-castillo Aurora González-Estrada Demetrio González carmen Gómez-González Rocío González-León carmen Grande-cabrerizo Sonia Gutiérrez carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive care Unit Virgen del Rocío University HospitalSevilleSpain department of Medicine University of SevilleSevilleSpain cardiology and cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo cacciapaglia Hua cai Wenyong cai Wujun cai Yijian cai Yizhou cai Yuchen cai Haiying cai Huacheng cai Lorenzo calibbi Junsong cang Guofu cao Jianshe cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise