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Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1547-1563页

作者： Qiang Zou Hao-Wen Wang xi-Liang Di Yuan Li Hui Gao department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China National Clinical research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China College of Animal Science and technology Northeast Agricultural UniversityHarbin 150030Heilongjiang ProvinceChina department of Hematology and Oncology Linyi People’s HospitalLinyi 251500Shandong ProvinceChina department of Comprehensive Oncology Baotou Cancer HospitalBaotou 014030Inner Mongolia Autonomous RegionChina

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is *** targeted microbubble destruction mediated gene transfection is a new method to overexpress *** To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of *** In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,*** addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell ***,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and *** vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation *** We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of ***,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of *** miR-873-5p mimic counteracted the impact of ***,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to *** discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/*** vivo results showed that HAND2-AS1 silencing sig

关键词： Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA HAND2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2

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Fault prediction model based on evidential reasoning approach

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Science china(Information Sciences) 2010年第10期53卷 2032-2046页

作者： SI xiaoSheng 1,2 , HU ChangHua 1 & ZHOU ZhiJie 1,2 1 Unit 302, xi’an institute of Hi-tech, shaanxi, xi’an 71002., china 2.department of automation, Tsinghua University, Beijing 100084, china 1. Unit 302 Xi’an Institute of Hi-Tech Shaanxi Xi’an 710025 China2. Department of Automation Tsinghua University Beijing 100084 China

In order to deal with fault prediction problems that involve both quantitative and qualitative in-formation for nonlinear complex system, a new fault prediction model is established based on the evidential reasoning (ER) approach, and an optimal learning algorithm for training ER-based prediction model is pre-sented based on the mean square error (MSE) criterion. This prediction model inherits the advantages of ER approach, which can deal with precise data, incomplete data and fuzzy data with nonlinear characteristic. In this model, the input signals transformed using rule based information transformation technique, are aggregated by analytical ER approach, and then the outputs of prediction model are constructed according to the types of system outputs. In addition, two fault decision criteria are defined to conduct fault identification. To overcome the difficulty in determining model parameters accurately and subjectively, a nonlinear optimization model is constructed and the optimal parameters are obtained. Two experimental studies are conducted to evaluate the performance of the proposed model. The results show that the established prediction model and the presented parameters optimization methods can deal with fault prediction problem effectively.

关键词： fault prediction evidential reasoning belief distribution nonlinear optimization

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Automatic Generation Control in a Distributed Power Grid Based on Multi-step Reinforcement Learning

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Protection and Control of Modern Power Systems 2024年第4期9卷 39-50页

作者： Wenmeng Zhao Tuo Zeng Zhihong Liu Lihui xie Lei xi Hui Ma the Electric Power research institute Southern Power GridGuangzhou 510663China the Heyuan Power Supply Bureau Guang-dong Power Grid Co.Ltd.Heyuan 517000China the College of Electrical Engineering&New Energy China Three Gorges UniversityYichang 443002China the College of Electrical Engineering&New Energy and Hubei Provincial Key Laboratory for Operation and Control of Cascaded Hydropower Station China Three Gorges UniversityYichang 443002China IEEE

The increasing use of renewable energy in the power system results in strong stochastic disturbances and degrades the control performance of the distributed power *** this paper,a novel multi-agent collaborative reinforcement learning algorithm is proposed with automatic optimization,namely,Dyna-DQL,to quickly achieve an optimal coordination solution for the multi-area distributed power *** proposed Dyna framework is combined with double Q-learning to collect and store the environmental *** can iteratively update the agents through buffer replay and real-time *** the environmental data can be fully used to enhance the learning speed of the *** mitigates the negative impact of heavy stochastic disturbances caused by the integration of renewable energy on the control *** are conducted on two different models to validate the effectiveness of the proposed *** results demonstrate that the proposed Dyna-DQL algorithm exhibits superior stability and robustness compared to other reinforcement learning algorithms.

关键词： Automatic generation control Dyna framework distributed power grid multi-agent mod-el-based reinforcement learning

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Study on an intelligent fault-tolerant technique for multiple satellite configured navigation under highly dynamic conditions

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Science china(Information Sciences) 2011年第3期54卷 529-541页

作者： WANG ShiCheng 1 , ZHAO xin 1 , MIN HaiBo 1 , LIU ZhiGuo 1 & SI xiaoSheng 2 1 high-tech institute of xi’an, xi’an 71002., china 2.department of automation, Tsinghua University, Beijing 100084, china 1. high-tech institute of xi’an Xi’an 710025 China2. Department of Automation Tsinghua University Beijing 100084 China

The probability of pseudo-range information being faulty will increase when there is increased noise in the receiver due to highly dynamic conditions. In this paper, an intelligent fault-tolerant federated Kalman filter (IFFKF) is presented to solve the problem of invalid position information as a result of the uncertainty in the category and quantity of failed satellites in a multiple configured satellite system. At the same time, a corresponding intelligent fault-tolerant system structure based on a cell-level fusion mode of operation was designed. Furthermore, a fault diagnosis strategy is proposed to deal with gradually or suddenly changing faults. By monitoring the residual and the residual rate, an observation quality gene is obtained using a fuzzy logic control system, and the local filter is adaptively adjusted on-line. Consequently, any filtering divergence arising from a gradually changing fault can, to a large extent, be prevented. The results show that the proposed algorithm and structure can achieve reliable positioning by fully utilizing new multiple satellites, monitoring and managing the gradual fault, as well as detecting and isolating any sudden fault in a synchronous manner. As such, the proposed algorithm has the potential to improve the reliability of a multiple satellite configured navigation system.

关键词： multiple satellite configured systems fuzzy logic control intelligent fault-tolerant filtering federated filtering fault detection and isolation

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Socioeconomic Impact and Response Strategies to the Multifaceted Respiratory Illness Outbreak in Northern china:Beyond Influenza A and Mycoplasma Pneumoniae

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china CDC weekly 2024年第36期6卷 934-938页

作者： xi Wang Rongfeng Zhou Ting Li Shuai Du Ayan Mao Wuqi Qiu Hongzhou Lu institute of Medical Information Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhen CityGuangdong ProvinceChina.

This study examines the socioeconomic and public health effects of a recent respiratory illness outbreak in northern china,focusing on Beijing following the lifting of coronavirus disease 2019(COVID-19)*** analyzes the implications of increased influenza A(H3N2)and Mycoplasma pneumoniae cases on urban health systems and economic *** mixed-methods study integrated a review of academic and governmental literature,a quantitative analysis of public health data,and a qualitative assessment of response *** indicate a significant increase in respiratory illnesses in late 2023,prompting a proactive response from health authorities that involved expanded hospital capacity and intensified ***,including resource limitations and public health fatigue,persisted,affecting response *** outbreak management was achieved through immediate health responses,although the event highlighted the need for improved infrastructure,surveillance,and policy *** emphasize the importance of international collaboration and comprehensive preparedness plans to strengthen global health security for future epidemics.

关键词： intensified lifting prompt

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The Response of Carbonate System to Watershed Urbanization Process in a Semi-Arid River

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Journal of Ocean University of china 2024年第4期23卷 991-1002页

作者： LI Yunxiao DANG Jiajia HUANG xiao YANG Hong WANG xiao LI Lina BAI Jie CHEN xi department of Environmental Science College of Resource and EnvironmentShanxi Agricultural UniversityTaigu 030801China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China department of Geography and Environmental Science University of ReadingWhiteknightsReading RG66ABUK Marine Agriculture research Center Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101China 5 Key Laboratory of Marine Environmental Science and Ecology Ministry of EducationCollege of Environmental Science and EngineeringOcean University of ChinaQingdao 266100China

Different from rivers in humid areas,the variability of riverine CO_(2) system in arid areas is heavily impacted by anthropogenic disturbance with the increasing urbanization and water *** this study,the water chemistry and the controls of carbonate system in an urbanized river(the Fenhe River)on the semi-arid Loess Plateau were *** water chemistry of the river water showed that the high dissolved inorganic carbon(DIC)concentration(about 37 mg L^(-1))in the upstream with a karst land type was mainly sourced from carbonate weathering involved by H_(2)CO_(3) and H_(2)SO_(4),resulting in an oversaturated partial pressure of CO_(2)(pCO_(2))(about 800μatm).In comparison,damming resulted in the widespread appearance of non-free flowing river segments,and aquatic photosynthesis dominated the DIC and pCO_(2) spatiality demonstrated by the enriched stable isotope of DIC(δ^(13)CDIC).Especially in the mid-downstream flowing through major cities in warm and low-runoff August,some river segments even acted as an atmospheric CO_(2) *** noteworthy is wastewater input leading to a sudden increase in DIC(>55 mg L^(-1))and pCO_(2)(>4500μatm)in the downstream of Taiyuan City,and in cold November the increased DIC even extended to the outlet of the *** results highlight the effects of aquatic production induced by damming and urban sewage input on riverine CO_(2) system in semi-arid areas,and reducing sewage discharge may mitigate CO_(2) emission from the rivers.

关键词： dissolved inorganic carbon stable carbon isotope carbonate weathering aquatic photosynthesis sewage input the Fenhe River

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Lactonization of dyes promoted by a coordination cage facilitates cavity-induced chromism as ion mobile detector

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Science china Chemistry 2024年第5期67卷 1554-1560页

作者： Liangliang Zhang Yu Liang Zhifeng xiao Yuxuan Meng Jinyi Huang xi Lin Ji Li Hong-Cai Zhou Yu Fang Strait institute of Flexible Electronics(SIFE Future Technologies)Fujian Normal University and Strait Laboratory of Flexible Electronics(SLoFE)Fuzhou 350017China State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China department of Chemistry Texas A&M UniversityCollege StationTexas 77842-3012USA State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Frontiers Science Center for Flexible Electronics(FSCFE) MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi’an 710072China

Dye molecules often change colors(so-called “chromism”) according to the environment variation. However, they are rarely induced by a catalytic amount of cavity. Through encapsulation in the cavity of a porous coordination cage(PCC-2), Rhodamine B(1) is transformed from red quinonoid form(1q) into colorless lactone form(1l) in aprotic polar solutions. The μ4-OH groups in the cavity of PCC-2 are shown to stabilize the uncommon zwitterion intermediate(1z), followed by converting to 1l, thus accelerating the equilibrium. The chromism is catalyzed by 0.25 mol% of PCC-2, and the reaction rate is improved by 80,400times. 1@PCC-2 can be further fabricated to a sol-gel that exhibits ion recognition properties. The resulting encapsulation and stabilization of an unconventional intermediate by a catalytic amount of the coordination cage provides fundamental insights into molecular isomerization and has potential use in chemical sensing.

关键词： porous coordination cage Zwitterion intermediate cavity Rhodamine B chromism

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Microfacies and diagenetic alteration in a semi-deep to deep lacustrine shale: The Yanchang Formation in the Ordos Basin, china

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Petroleum Science 2024年第3期21卷 1524-1538页

作者： Bin Bai Jing-Yue Hao Ling Fu Yu-xi Liu Jian-Peng Wang Lan Wang Kevin GTaylor Lin Ma Petrochina research institute of Petroleum Exploration and Development Beijing100083China department of Earth and Environmental Sciences University of ManchesterM139PLUK College of Earth Sciences Jilin UniversityChangchun130061jilinChina department of Chemical Engineering University of ManchesterM139PLUK

The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic diagram are proposed in this *** detailed petrographic,mineralogical,and elemental analyses,four distinct shale types are identified:argillaceous shale,siliceous shale,calcareous shale,and carbonate,clay,and silt-bearing *** main diagenetic process in argillaceous shale is the transformation of illite to smectite,negatively impacting shale *** shale undergoes carbonate cementation and quartz dissolution,contributing to increased porosity,particularly in *** shale experiences diagenesis characterised by carbonate formation and dissolution,with a prevalence of *** carbonate,clay,and silt-bearing shale,the dissolution of K-feldspar contributes to illitization of *** shale,characterised by more clay minerals and lower mesopore volume,is identified as a potential hydrocarbon *** shale,with the highest pore volume and abundant inter-mineral pores,emerges as a promising shale oil *** findings contribute to a comprehensive understanding of shale properties,aiding in the prediction of shale oil exploration potential in the studied area.

关键词： Ordos Basin Yanchang Formation Chang 7 Member Diagenesis Microfacies

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A low-cost and high-strength basalt/carbon fiber reinforced polymer improved by imitating tree-root micro/nano aramid short fiber

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Chinese Journal of Aeronautics 2024年第10期37卷 526-538页

作者： Guangming YANG Yanan LYU Fei CHENG Jiaxin HE Shihao ZUO Wenyi HUANG Yunsen HU xiaozhi HU xi CHEN Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Southwest University of Science and TechnologyMianyang 621010China Engineering research Center of Biomass Materials Ministry of EducationSouthwest University of Science and TechnologyMianyang 621010China School of Materials and Chemistry Southwest University of Science and TechnologyMianyang 621010China institute of automation Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100101China School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China department of Mechanical Engineering University of Western AustraliaPerth 6009Australia

The high-strength Basalt Carbon Fiber Reinforced Polymer(BCFRP)composites had been manufactured by guiding Imitating Tree-root Micro/Nano Aramid Short Fiber(ITMNASF)into the interlayer of Basalt Fiber(BF)and Carbon Fiber(CF)plies to form thin interleaving,and various mass proportions of IT-MNASF were designed to discuss the reinforcing effect on the BCFRP heterogeneous *** results of three points bending tests showed that flexural strength and energy absorption of 4wt%IT-MNASF reinforced BCFRP heterogeneous composites had been improved by 32.4%and 134.4%respectively compared with that of unreinforced *** 4wt%IT-MNASF reinforced BCFRP specimens showed both a greater strength and a lower cost(reduced by 31%around)than that of plain CFRP composites.X-ray micro-computed tomography scanning results exhibited that the delamination-dominated failure of plain BCFRP composites was changed into multi-layer BF and CF fabrics *** reinforcing mechanism revealed that the introduced IT-MNASF could construct quasi-vertical fiber bridging,and it was used as"mechanical claws"to grasp adjacent fiber layers for creating a stronger mechanical interlocking,and this effectively improved resin-rich region and interfacial transition region at the *** simple and effective IT-MNASF interleaving technique was very successful in low-cost and high-strength development of BCFRP heterogeneous composites.

关键词： Basalt carbon fiber reinforced polymer Micro/nano aramid fiber Fiber bridging Strength improvement Low-cost substitution

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DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

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Science china Chemistry 2024年第6期67卷 2070-2078页

作者： xing Xu xi Zeng xin Lin Shiyan Lin Shanshan Liang Tian Tian Rui Su Jia Song Chaoyong Yang Collaborative Innovation Center of Chemistry for Energy Materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and Materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation Center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

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