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A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease

Neural Regeneration research 2024年第2期19卷 324-330页

作者： xi Chen Yuhu Zhang department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina

The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent but partially *** dopaminergic system acts on the anterior brain and is responsible for executive function,working memory,and *** contrast,the cholinergic system acts on the posterior brain and is responsible for semantic fluency and visuospatial *** from dopaminergic/cholinergic imaging or functional neuroimaging has shed significant insight relating to the involvement of the cerebellum in the cognitive process of patients with Parkinson’s *** research has reported evidence that the cerebellum receives both dopaminergic and cholinergic ***,whether these two neurotransmitter systems are associated with cognitive function has yet to be fully ***,the precise role of the cerebellum in patients with Parkinson’s disease and cognitive impairment remains ***,in this review,we summarize the cerebellar dopaminergic and cholinergic projections and their relationships with cognition,as reported by previous studies,and investigated the role of the cerebellum in patients with Parkinson’s disease and cognitive impairment,as determined by functional *** findings will help us to understand the role of the cerebellum in the mechanisms underlying cognitive impairment in Parkinson’s disease.

关键词： anterior brain system cerebellum cholinergic cognitive impairment dopaminergic dual syndrome hypothesis neuroimage neurotransmitter Parkinson’s disease posterior brain system therapeutic targets

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Capture Efficiency Analysis in the Circular Restricted Three-body Problem

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research in Astronomy and Astrophysics 2024年第5期24卷 198-210页

作者： Yu-Xuan Miao xi-Yun Hou department of Astronomy and Space Science Nanjing UniversityNanjing 210023China institute of Space Environment and Astrodynamics Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two ***, a non-uniform distribution of test particles around the secondary's orbit is obtained by fully accounting the secondary's gravitational influence. Second, the capture efficiency is computed based on the non-uniform distribution. Several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency(p) and the mass ratio(μ) is established, which is given by p ≈ 0.27 × μ^(0.53), within the range of 3.0035 ×10^(-6)≤ μ ≤ 3.0034 × 10^(-5). Taking the Sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. Our studies find that the secondary's orbit eccentricity has a negative influence on the capture efficiency.

关键词： methods numerical-celestial mechanics-planets and satellites dynamical evolution and stability

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Prescribed Performance Tracking Control of Time-Delay Nonlinear Systems With Output Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1557-1565页

作者： Jin-xi Zhang Kai-Di Xu Qing-Guo Wang IEEE the State Key Laboratory of Synthetical automation for Process Industries Northeastern UniversityShenyang 110819China institute of Artificial Intelligence and Future Networks Beijing Normal UniversityZhuhai 519087 Guangdong Key Laboratory of Artificial Intelligence and Multi-Modal Data Processing Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087

The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this ***, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. In addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. It turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.

关键词： Nonlinear systems output constraints prescribed performance reference tracking time delays

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Electrochemical reduction of carbon dioxide to produce formic acid coupled with oxidative conversion of biomass

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Journal of Energy Chemistry 2024年第5期92卷 705-729页

作者： xi Liu Yifan Wang Zhiwei Dai Daihong Gao Xuebing Zhao Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China institute of Applied Chemistry Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Electrochemical reduction of CO_(2)(CO_(2)RR)has become a research hot spot in recent years in the context of carbon *** is one of the most promising products obtained by electrochemical reduction of CO_(2) due to its high energy value as estimated by market price per energy unit and wide application in chemical *** is the most abundant renewable resource in the natural *** biomass oxidative conversion with CO_(2)RR driven by renewable electricity would well achieve carbon *** this work,we comprehensively reviewed the current research progress on CO_(2)RR to produce HCOOH and coupled system for conversion of biomass and its derivatives to produce value-added ***-and Bi-based electrocatalysts are discussed for CO_(2)RR with regards to the structure of the catalyst and reaction ***-oxidation reactions of biomass derived sugars,alcohols,furan aldehydes and even polymeric components of lignocellulose were reviewed as alternatives to replace oxygen evolution reaction(OER)in the conventional electrolysis *** was recommended that to further improve the efficiency of the coupled system,future work should be focused on the development of more efficient and stable catalysts,careful design of the electrolytic cells for improving the mass transfer and development of environment-friendly processes for recovering the formed formate and biomass oxidation products.

关键词： Electrochemical reduction of CO_(2) Formic acid Oxidative conversion of biomass Lignocellulose Coupled system

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Liquid metal biomaterials: translational medicines,challenges and perspectives

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National Science Review 2024年第2期11卷 264-284页

作者： Hanchi Xu Jincheng Lu Yikuang xi Xuelin Wang Jing Liu department of Biomedical Engineering School of Medicine Tsinghua University Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Shanghai World Foreign Language Academy Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering MedicineBeihang University Beijing Key Lab of Cryo-Biomedical Engineering and Key Lab of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical and chemical properties, susceptibility to immune rejection, and concerns about long-term biological safety. As an alternative, liquid metal(LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity,and ease of functionalization. However, despite the unique advantages and successful explorations of LM in biomedical fields, widespread clinical translations and applications of LM-based medical products remain limited. This article summarizes the current status and future prospects of LM biomaterials, interprets their applications in healthcare, medical imaging, bone repair, nerve interface, and tumor therapy, *** to translate LM materials into medicine and obstacles encountered in practices are *** that, we outline a blueprint for LM clinics, emphasizing their potential in making new-generation artificial organs. Last, the core challenges of LM biomaterials in clinical translation, including bio-safety,material stability, and ethical concerns are also discussed. Overall, the current progress, translational medicine bottlenecks, and perspectives of LM biomaterials signify their immense potential to drive future medical breakthroughs and thus open up novel avenues for upcoming clinical practices.

关键词： liquid metal biomaterials translational medicine clinical device healthcare therapeutics

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Molecular cloning and functional analysis of two calcium associated cuticular protein genes in Neocaridina denticulata sinensis

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Journal of Oceanology and Limnology 2024年第5期42卷 1659-1672页

作者： xi GAO Mengmeng DUAN Yuying SUN Jiquan ZHANG School of Life Sciences/Hebei Basic Science Center for Biotic Interaction Hebei UniversityBaoding 071002China institute of Life Science and Green Development Hebei UniversityBaoding 071002China

The body surface of crustaceans is covered with a sturdy *** growth and development of crustaceans are realized through *** denticulata sinensis is a suitable candidate for crustacean scientific *** calcium-associated cuticular protein genes,named NdCAP-1 and NdCAP-2,were obtained from *** *** docking simulated the binding effect of both proteins and calcium ***-quantitative reverse transcription PCR results show that NdCAP-1 is expressed in D_(2-4) stage,NdCAP-2 expressed in D_(2-4) and A-B stages,and both were significantly expressed in the cephalothorax cuticle and ***,it was revealed that NdCAP-1 and NdCAP-2 are regulated by NdEcR-mediated 20 E signaling *** of NdCAP-1 and NdCAP-2 was observed to cause surface *** recombinant proteins(rNdCAP-1 and rNdCAP-2),obtained by prokaryotic expression,had calcium-binding and chitin-binding ability,inhibited formation of calcium carbonate *** results show that calcium-associated cuticular proteins play important roles in cuticle formation and calcification.

关键词： Neocaridina denticulata sinensis calcium-associated cuticular protein molting cycle RNAi calcium-binding ability

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Heterogeneous MXene-based films with graded electrical conductivity towards highly efficient EMI shielding and electrothermal heating

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Nano research 2024年第8期17卷 7264-7274页

作者： Yu Zhang Guangcheng Zhang Zhonglei Ma Jianbin Qin xi Shen department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina shaanxi Key Laboratory of Macromolecular Science and technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China research institute for Sports Science and technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

The increasing need for electromagnetic interference(EMI)shielding of electronics in cold environments such as those in aircraft,space exploration,and wearable heaters to avoid hazardous icing conditions or hypothermia requires the development of thin and lightweight EMI shielding materials preferably by absorbing rather than reflecting electromagnetic(EM)waves while also generating heat through energy-efficient electrothermal ***,it is challenging to achieve absorption-dominant EMI shielding and energy-efficient electrothermal heating simultaneously in a thin and lightweight ***,we develop a heterogeneous composite film comprising a porous multi-walled carbon nanotubes(MWCNTs)/bacterial cellulose(BC)film and an aligned MXene/Ag nanowires(NWs)backing via a sequential vacuum filtration *** porous film contains random conductive networks of MWCNTs with moderate conductivity while the aligned MXene sheets atop Ag NWs network affords high conductivity in the backing,giving rise to graded electrical conductivity for absorption-dominant EMI *** increasing Ag NW coverage leads to significantly increased electrical conductivity without increasing the EM wave reflection as well as the density and thickness of the film,yielding excellent specific EMI shielding effectiveness(>8500 dB/(g·cm^(2))),low driving voltage for energy-efficient electrothermal heating(163℃at 2.5 V),and fast response time(60 s)at a low areal density of 0.015 mg/cm^(2).Combining EMI shielding and electrothermal heating,the heterogeneous film developed here are promising contenders for the protection of electronic equipment in low-temperature environment.

关键词： heterogenous composite film MXene electromagnetic interference(EMI)shielding thermal management

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Unlocking the potential of transdermal drug delivery

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International Journal of Smart and Nano Materials 2024年第3期15卷 432-468页

作者： Shuang Li Jianhao Wu xiangjun Peng xi-Qiao Feng institute of Biomechanics and Medical Engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijingChina

Transdermal drug delivery(TDD)has gained clinical approval over several decades,with extensive research dedicated to novel drug and device *** notable research progress,the mar-ket adoption of TDD devices has not met anticipated levels,with oral administration and injection remaining predominant delivery *** maximize the potential of TDD,we identify bottlenecks hinder-ing its widespread clinical application and propose promising research *** begin by analyzing stringent demands necessary to truly benefit patients,addressing significant challenges in biomechanics,nanomedicine,and flexible ***,we delve into skin anatomy,enhancement strategies,nano-carriers,and their under-lining mechanisms,highlighting the importance and framework of quantitative *** on these discussions,we highlight the core strength of TDD,such as automatic precise administration based on feedback and high delivery efficiencies,especially applicable to localized conditions(e.g.,central nervous system diseases,tumors).Finally,we envision the future of intelligent TDD device and its opera-tion scenario,aiming to steer research efforts toward faster translation of laboratory innovations into widely used products for sufferers.

关键词： Transdermal drug delivery biomechanics nanomedicine flexible electronics

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A hierarchical multi-UAV cooperative framework for infrastructure inspection and reconstruction

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Control Theory and technology 2024年第3期22卷 394-405页

作者： Chuanxiang Gao xinyi Wang xi Chen Ben M.Chen department of Mechanical and automation Engineering The Chinese University of Hong KongHong KongShatinNTChina

Unmanned aerial vehicles(UAVs)are emerging as a powerful tool for inspections and repair works in large-scale and unstructured 3D infrastructures,but current approaches take a long time to cover the entire *** using UAVs for inspections and repair works puts forward a requirement of improving time efficiency in large-scale and cluster *** paper presents a hierarchical multi-UAV cooperative framework for infrastructure inspection and reconstruction to balance the workload and reduce the overall task completion *** proposed framework consists of two stages,the exploration stage and the exploitation stage,resolving the task in a sequential *** the exploration stage,the density map is developed to update global and local information for dynamic load-balanced area partition based on reconstructability and relative positions of UAVs,and the Voronoi-based planner is used to enable the UAVs to reach their best *** obtaining the global map,viewpoints are generated and divided while taking into account the battery capacity of each ***,a shortest path planning method is used to minimize the total traveling cost of these viewpoints for obtaining a high-quality *** experiments are conducted in both a simulated and real environment to show the time efficiency,robustness,and effectiveness of the proposed ***,the whole system is implemented in real applications.

关键词： Multi-UAV Coverage path planning Infrastructure inspection and reconstruction

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Multi-source data integration and multi-scale modeling framework for progressive prediction of complex geological interfaces in tunneling

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Underground Space 2024年第2期15卷 1-25页

作者： Jingxiao Wang Peinan Li xiaoying Zhuang xiaojun Li xi Jiang Jun Wu department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China College of Environmental Science and Engineering Donghua UniversityShanghai 201620China institute of Photonics Department of Mathematics and PhysicsLeibniz University HannoverHannover 30167Germany department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 100872China College of Civil Engineering Shanghai Normal UniversityShanghai 200233China

A reliable geological model plays a fundamental role in the efficiency and safety of mountain tunnel ***,regional models based on limited survey data represent macroscopic geological environments but not detailed internal geological characteristics,especially at tunnel portals with complex geological *** paper presents a comprehensive methodological framework for refined modeling of the tunnel surrounding rock and subsequent mechanics analysis,with a particular focus on natural space distortion of hard-soft rock interfaces at tunnel *** progressive prediction of geological structures is developed considering multi-source data derived from the tunnel survey and excavation *** improve the accuracy of the models,a novel modeling method is proposed to integrate multi-source and multi-scale data based on data extraction and potential field ***,a regional-scale model and an engineering-scale model are built,providing a clear insight into geological phenomena and supporting numerical *** addition,the proposed framework is applied to a case study,the Long-tou mountain tunnel project in Guangzhou,china,where the dominant rock type is *** results show that the data integration and modeling methods effectively improve model structure *** improved model’s calculation deviation is reduced by about 10%to 20%in the mechanical *** study contributes to revealing the complex geological environment with singular interfaces and promoting the safety and performance of mountain tunneling.

关键词： Mountain tunnel Geological modeling Multi-source data Progressive prediction Tunnel portals

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