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A new parameterization scheme for sea surface aerodynamic roughness

Progress in Natural Science:Materials International 2008年第11期18卷 1365-1373页

作者： Yuping Pan~(a,b) Wenyu Sha~c Shouxian Zhu~c Sufang Ge~(a,*) a nanjing university of Information Science and Technology,nanjing 2.0044,{2. b Air Force Meteorological center of the nanjing Military Region,nanjing 2.0018,{2. c Meteorology College,The PLA university of Information Science and Technology,nanjing 2.1101,{2. nanjing university of Information Science and Technology Nanjing 210044 China Air Force Meteorological center of the nanjing Military Region Nanjing 210018 China Meteorology College The PLA University of Information Science and Technology Nanjing 211101 China

The dimensionless roughness length derived from dimensional analysis bears a relation to wave age,and the dimensionless form of roughness length can be expressed with the relation with a significant wave *** on six experiments(HEXMAX,RASEX,BIO steady platform,Lake Ontario data analysis FETCH,CBLAST low wind),we verified that the Charnock parameter,Zch,and dimension- less roughness length,z0/Hs,are dependent on wave age,u*/***,we constructed a new scheme for roughness length,and explored its sensitivity to friction velocity and wave *** the newly developed parameterization scheme(PS07)with COARE (Coupled Ocean-Atmosphere Response Experiment V.3.0)algorithm,we calculated the data from the North Sea Platform experiment in December,1985,and made an attempt to validate the suitability of the PS07 compared to the other three schemes of *** found that the calculated results based on the PS07 are close to the *** also conducted an experiment in which the PS07 was combined with the nested model of waves coupling in datasets of 3 typhoons that occurred at the Zhanjiang *** comparison results between the calculated and observed waves around the Naozhou Island indicate that the new parameterization scheme(PS07)has a good applicability.

关键词： Sea surface roughness Parameterization scheme Significant wave height Wave age COARE algorithm

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The study of two-color excitation upconversion of Pr(0.5)Yb(3):ZBLAN

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Science china(Physics,Mechanics & Astronomy) 2006年第2期49卷 169-177页

作者： CHEN Xiaobo1 & SONG Zengfu2.1. Applied Optics Beijing Area Major Laboratory, analysis and testing center, Beijing Normal {2., Beijing 100875, china 2. Peking {2., Physics School, Beijing 100871, china Applied Optics Beijing Area Major Laboratory Analysis and testing center Beijing Normal University Beijing China Physics School Peking University Beijing China

The excited state absorption upconversion of Pr(0.5)Yb(3):ZBLAN glass material, under two-color excitation of the 960 nm semiconductor laser and the Xe lamp light simultaneously, is reported in this article. It was found that the upconversion emission spectra of 480.1, 519.0, 601.9 and 631.8 nm coincide with the common emission spectra. Meanwhile, the upconversion-excitation spectrum has three obvious peaks under two-color excitation, and they respectively correspond to the 856.0 nm upconversion ex-citation transition [1G4(Pr3+)→1I6(Pr3+) and 1G4(Pr3+)→3P1(Pr3+)], the 789.0 nm upconver-sion excitation transition 1G4(Pr3+)→3P2.Pr3+), and the 803.7 nm upconversion excitation transition 3H6(Pr3+)→1D2.Pr3+). The upconversion excitation transition 1G4(Pr3+)→1I6(Pr3+) is strong because its oscillator strength f = 2..040×10?6 is large, which results in a large peak appearing in the upconversion excitation spectrum. That is just the new interesting two-color excitation upconversion luminescence phenomenon of Pr(0.5)Yb(3):ZBLAN induced by one laser and one continuous normal light simultaneously.

关键词： upconversion volumetric three-dimensional display two-color excitation.

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Pharmacokinetics of CPU02.3,a novel endothelin receptor antagonist,after intravenous administration in mice

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Acta Pharmacologica Sinica 2006年第3期27卷 367-371页

作者： Li GUAN~2.Yu FENG~2.Min JI~4 De-zai DAI~(2.3) ~2.esearch Division of Pharmacology,and ~4center of New Drug Research and Development.china Pharmaceutical {2.,nanjing 2.0009.china Research Division of Pharmacology China Pharmaceutical University Nanjing China center of New Drug Research and Development China Pharmaceutical University Nanjing China

Aim:To determine the pharmacokinetics associated with acute toxic doses ofCPU02.3,a novel endothelin receptor antagonist in mice after a single intrave-nous ***:Concentrations in serum and the pharmacokineticparameters of CPU02.3 were assayed by high pressure liquid chromatography(HPLC)following a single intravenous bolus of CPU02.3 at concentrations of 2.,50,and 100 mg/kg in *** intravenous acute toxicity of CPU02.3 was alsoassessed in ***:A simple,sensitive and selective HPLC method wasdeveloped for quantitative determination of CPU02.3 in mouse *** con-centration-time data conform to a 2.compartment model after iv administration ofCPU02.3 at concentrations of 2.,50,100 mg/*** corresponding distributionhalf-lives(T1/2.) were 3.6,4.2.1.1 min and the elimination half-lives(T1/2.)were39.4,70.3,61.9 *** was a linear increase in C0proportional to dose,and thesame as AUC0-tand AUC0-∞.AUC0-tand AUC0-∞were 4.511,13.070,2..666 g·min·L-1and 4.596,13.679,2..115 g·min·L-1,*** intravenous LD50was 315.5mg/***:First order rate pharmacokinetics were observed for CPU02.3within the range of doses used,and the acute toxicity of CPU02.3 is mild.

关键词： CPU02.3 high pressure liquid chromatography mice pharmacokinetics acute toxicity

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《中国卒中中心报告2.2.》概要

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中国脑血管病杂志 2024年第8期21卷 565-576页

作者： Report on Stroke center in china Writing Group 《中国卒中中心报告2.2.》编写组

随着社会老龄化、城市化进程加速和民众不健康生活方式的流行，我国卒中疾病负担呈现快速增长态势。在国家卫生健康委员会的领导下，在全国各级卫生健康主管部门的大力支持以及疾病预防管理机构、医疗卫生机构与广大医务人员的积极参与... 详细信息

随着社会老龄化、城市化进程加速和民众不健康生活方式的流行，我国卒中疾病负担呈现快速增长态势。在国家卫生健康委员会的领导下，在全国各级卫生健康主管部门的大力支持以及疾病预防管理机构、医疗卫生机构与广大医务人员的积极参与下，我国卒中防治工作取得了显著成效。自2.2.年至2.2.年，我国卒中中心的建设以行政为主导，在各级卫生健康行政部门的组织落实和推进下，开展了各医疗机构的资源整合、流程优化和学科协作行动，建立了高效的救治绿色通道，提供了规范化的诊疗服务，并打造了“以患者为中心”的卒中专病诊疗模式，初步实现了极具中国特色的“防、治、管、康、健”五位一体的全流程卒中防治体系。《中国卒中中心报告2.2.》对卒中流行病学、卒中中心建设进展、卒中防治关键适宜技术开展与其相关指标的分析等方面进行了系统回顾，梳理了2.2.年卒中中心工作进展并对未来工作进行展望。

关键词：卒中流行病学卒中中心卒中防治关键适宜技术

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Internalization and distribution of three α1-adrenoceptor subtypes in HEK2.3A cells before and after agonist stimulation

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Acta Pharmacologica Sinica 2007年第3期28卷 359-366页

作者： Shu-yi WANG~2.Yao SONG~2.Ming XU~2.Qi-hua HE~3 Qi-de HAN~2.You-yi ZHANG~(2.4)2.Institute of Vascular Medicine,Peking university Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 100083,china {2. of Medical analysis,Peking university,Health Science center,Beijing 100083,china Institute of Vascular Medicine Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing China center of Medical analysis Peking University Health Science Center Beijing China

Aim:To examine the subcellular distribution of the 3 α1-adrenoceptor（α1-AR）subtypes and their internalization and trafficking upon agonist stimulation in hu-man embryonic kidney 2.3A ***:Confocal real-time imaging,enzymelinked immunosorbent assay（ELISA）and whole cell[3H]-prazosin binding assaywere applied to detect the distribution and localization of the 3 α1B-AR ***:α1A-AR was found both on the cell surface and in the cytoplasm;α1B-AR,however,was predominantly detected on the cell surface,while α1D-AR wasdetected mainly in the intracellular *** stimulation withphenylephrine,localization changes were detected by confocal microscopy forα1A-and α1B-AR, but the localization of α1D-AR were *** promoted a more rapid internalization of α1B-AR than α1A-AR.α1D-ARinternalization was detected only by *** cell[3H]-prazosin bindingassay showed that α1A-AR functional receptors were detected both on the cellsurface and in the cytoplasm;α1B-AR,however,were detected predominantly onthe cell surface,while α1D-AR were detected mainly in intracellular *** stimulation promoted internalization of α1A-and α***:Phenylephrine stimulation induced changes in the localization of the3α1-AR.

关键词： adrenoceptor agonist stimulation confocal image enzyme-linked immunosorbent assay [~3H]-prazosin binding assay internalization subcellular distribution subtype

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Numerical simulations of self-propelled swimming of 3D bionic fish school

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Science china(Technological Sciences) 2009年第3期52卷 658-669页

作者： WU ChuiJie1 & WANG Liang2.1 State Key Laboratory of Structural analysis for Industrial Equipment, Dalian university of Technology, Dalian 11602.,{2. 2.Research center for Fluid Dynamics, People’s Liberation Army university of Science and Technology, nanjing 2.1101,{2. State Key Laboratory of Structural analysis for Industrial Equipment Dalian University of Technology 2.esearch center for Fluid Dynamics People’s Liberation Army University of Science and Technology

Numerical simulations of self-propelled swimming of a three dimensional bionic fish and fish school in a viscous fluid are carried out. This is done with the assistance of a parallel software package produced for 3D moving boundary problems. This computational fluid dynamics package combines the adaptive multi-grid finite volume method, the immersed boundary method and VOF (volume of fluid) method. By using the package results of the self-propelled swimming of a 3D bionic fish and fish school in a vis- cous fluid are obtained. With comparison to the existing experimental measurements of living fishes, the predicted structure of vortical wakes is in good agreement with the measurements.

关键词： adaptive multi-grid immersed boundary method self-propelled swimming fish school 3D bionic fish

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Possible mechanism of the effect of convection over Asian-Australian “land bridge” on the East Asian summer monsoon onset

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Science china Earth Sciences 2006年第11期49卷 1223-1232页

作者： HE Jinhai1, WEN Min2. DING Yihui3 & ZHANG Renhe2.1. Jiangsu Key Laboratory of Meteorological Disaster (KLME), nanjing Institute of Meteorology, nanjing university of Informa- tion Science and Technology, nanjing 2.0044, china 2. State Key Laboratory of Severe Weather (LaSW), Chinese Academy of Meteorological Sciences, Beijing 100081, china 3. National Climate center, Chinese Meteorological Administration, Beijing 100081, china Jiangsu Key Laboratory of Meteorological Disaster (KLME) Nanjing Institute of Meteorology Nanjing University of Information Science and Technology Nanjing China State Key Laboratory of Severe Weather (LaSW) Chinese Academy of Meteorological Sciences Beijing China National Climate center Chinese Meteorological Administration Beijing China

The Asian-Australian “land bridge” is an area with the most vigorous convection in Asian monsoon region in boreal spring, where the onset and march of convection are well associated with the onset of East Asian summer monsoon. The convection occurs over Indo-china Peninsula as early as mid-April, which exerts critical impact on the evolution of monsoon circulation. Before mid-April there are primarily sensible heatings to the atmosphere over Indo-china Peninsula and Indian Peninsula, so the apparent heating ratios over them decrease with height. However, after mid-April it changes into latent heating over Indo-china Peninsula due to the onset of convection, and the apparent heating ratio increases with height in mid- and lower troposphere. The vertical distribution of heating ratio and its differences between Indo-china Peninsula and Indian Peninsula are the key factors leading to the splitting of boreal subtropical high belt over the Bay of Bengal. Such mechanism is strongly supported by the fact that the evolution of the vertical heating ratio gradient above Indo-china Peninsula leads that of 850 hPa vorticity over the Bay of Bengal. Convections over Indo-china Peninsula and its surrounding areas further increase after the splitting. Since then, there is a positive feedback lying among the convective heating, the eastward retreat of the subtropical high and the march of monsoon, which is a possible mechanism of the advance of summer monsoon and convection from Indo-china Peninsula to South china Sea.

关键词： Asian-Australian 'land bridge', tropical convection, Indo-china Peninsula, the splitting of boreal subtropical high belt, East Asian summer monsoon onset.

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Design,analysis and control of hybrid excited doubly salient stator-permanent-magnet motor

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Science china(Technological Sciences) 2010年第1期53卷 188-199页

作者： ZHU XiaoYong1,2.& CHENG Ming1 1 Engineering Research center for Motion Control of MOE,School of Electrical Engineering,Southeast university,{2. 2.0096,china 2.School of Electrical and Information Engineering,Jiangsu university,Zhenjiang 2.2.13,china Engineering Research center for Motion Control of MOE School of Electrical Engineering Southeast University Nanjing China School of Electrical and Information Engineering Jiangsu University Zhenjiang China

In this paper,a new hybrid excited doubly salient stator-permanent-magnet motor is proposed,where both permanent magnets and DC field windings are located in the *** theory,the mathematical model and design method of the motor are *** corresponding output power equation and the relationship between the flux control capability and the extended speed range are deduced in *** using an efficient "one-step" three-dimensional(3D) finite element method,the electromagnetic performances are analyzed,in which the leakage flux outside the stator circumference and end-effect are taken into *** on the operation principle of the motor,the control strategy and scheme are developed and implemented *** experimental results and finite element analysis show that the proposed motor not only maintains the advantages of doubly salient permanent magnet motors,but also offers high energy efficiency over a wide speed range,which makes the motor an interesting candidate for electric vehicles.

关键词： stator permanent magnet motor hybrid excitation doubly salient finite element method flux weakening control

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Mechanical behavior of a shelter system based on cable-strut structures

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2012年第12期13卷 895-903页

作者： Jian-guo CAI1,2.Ya ZHOU1,Jian FENG1,2.Yi-xiang XU3 (1Key Laboratory of C&PC Structures of Ministry of Education,Southeast university,nanjing 2.0096,{2.) (2.ational Prestress Engineering Research center,Southeast university,nanjing 2.0096,{2.) (3Department of Civil Engineering,Strathclyde university,Glasgow,UK) Key Laboratory of C&PC Structures of Ministry of Education Southeast University National Prestress Engineering Research center Southeast University

A shelter system based on cable-strut structures,consisting of compressive struts and high-tensile elements,is described in this *** deployment of the shelter is achieved by tightening inclined *** cables are used to terminate the *** state of self-stress of the cable-strut structures in the fully deployed configuration is given,and the minimum strut length and the maximum load design of the shelter are *** mechanical behavior of the system was studied under symmetrical and asymmetrical load *** results show that the shelter in the deployed configuration satisfies the ultimate limit and the serviceability limit state ***,the stability of the cable-strut system is investigated,considering the effect of imperfections on the buckling of the *** conclude that the influence of imperfections based on the consistent imperfection mode method is not significant.

关键词： Foldable structures Cable-strut structures Mechanical behavior Self-stress Stability

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Dynamic behavior of fragile X full mutations in cultured female fetal fibroblasts

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Acta Pharmacologica Sinica 2004年第7期25卷 127-130页

作者： Yu-jie SUN1,2.Xiao HAN1,3 1Laboratory of Functional Genomics at nanjing Medical university, nanjing 2.002., china 2.ivision of Molecular Medicine in Beckman Research Institute, Leslie and Susan Gonda (Goldschmied) Diabetes 3 and Genetics Research center, City of Hope National Medical center, Duarte, California Laboratory of Functional Genomics at nanjing Medical university Nanjing 210029

AIM: Toassess mitotic stability ofthe fragile X fullmutations andits relationshipwith DNA methylation. METHODS: The length change of the expanded CGG repeats was examined and correlated it with the methylation status in the DNA samplesisolated fromthe fibroblasts derived from a fragile Xfemale fetus anda fragileX maleadult, respectively. RESULTS: A dramatic instability of the expanded CGG repeats in the female fetal fibroblasts was observed. South- ern blot analysis revealed that the 6.9-kb major expanded band detected in passage 2.was completely replaced by a 7.7-kb band after passage 30. Fibroblast clones derived from the passage 3 displayed an unstable expansion of the CGG repeat during clonal proliferation, while methylation status of the CGG repeat region was maintained. In contrast, in fragile X male fibroblasts the expanded CGG repeats were stable during clonal proliferation. CONCLUSION: The mitotic instability of expanded CGG repeat is not always restricted in early development window as proposed previously and other elements rather than DNA methylation could affect the stability of the expanded CGG repeats in fragile X female fetal fibroblast cells.

关键词： DNA female fetus fibroblasts fragile X syndrome heterozygote human mutation X chromo- some

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