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Transport and uptake characteristics of a new derivative of berberine(CPU-86017) by human intestinal epithelial cell line: Caco-2

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Acta Pharmacologica Sinica 2003年第12期24卷 11-17页

作者： YANG Hai-Tao, WANG Guang-Ji center of Pharmacokinetics, china Pharmaceutical {2., nanjing 2.0009, china center of Pharmacokinetics China Pharmaceutical University Nanjing 210009

AIM: The characteristics of transepithelial transport and uptake of CPU-86017 {[7-(4-chlorbenzyl)-7,8,13,13α-tetrahydroberberine chloride, CTHB]}, a new antiarrhythmia agent and a new derivative of berberine, were investigated on epithelial cell line (Caco-2. to further understand the absorption mechanism of berberine and its derivatives. METHODS: Caco-2.cell was used. RESULTS: 1) The permeability coefficient from the apical (AP) to basolateral (BL) of CPU-86017 was approximately 5 times higher than that from BL-to-AP transport. The effects of a P-glycoprotein (P-gp) inhibitor-cyclosporin A, some surfactants, and lower pH on the transepithelial transport of CPU-86017 were also observed. Cyclosporine A at 7.5 mg/L had no effect on the transepithelial electrical resistance (TEER); an about 4-fold enhancement on the transepithlial transport of CPU-86017 was observed. Some surfactants (sodium citrate, sodium deoxycholate, and sodium dodecyl sulfate) at 100 μmol/L and low pH (pH=6.0) induced a reversible d

关键词： CPU-86017 berberine Caco-2.cell cyclosporine A sodium dodecyl sulfate sodium citrate sodium deoxycholate

Back analysis of mechanical parameters of roller compacted concrete dam

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Science china(Technological Sciences) 2010年第3期53卷 848-853页

作者： GU ChongShi 1,2.3,LI Bo 1,XU GuangLei 4 &YU Hong 1,2.3 1 State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering,Hohai university,nanjing 2.0098,{2. 2.ollege of Water Conservancy Hydropower,Hohai university,nanjing 2.0098,{2. 3National Engineering Research center of Water Resources Engineering Safety,Efficient Utilization and nanjing 2.0098,{2. 4 nanjing Hydraulic Research Institute,nanjing 2.002.,{2. State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing China College of Water Conservancy Hydropower Hohai University Nanjing China National Engineering Research center of Water Resources Engineering Safety Efficient Utilization and Nanjing Nanjing China nanjing Hydraulic Research Institute Nanjing China

In view of the diversity and complexity of mechanical parameters of roller compacted concrete dam(RCCD),the uniform design method,partial least-squares regression(PLS)and least squares support vector machine(LSSVM)were applied to the back analysis of RCCD with the use of the complex nonlinear relationship between dam mechanical parameters and dam *** the process of back analysis,the initial samples of parameters were designed with uniform design ***,a transversely isotropic model of RCCD was established by *** *** this model,training samples of LSSVM model could be *** then,the complex nonlinear relationship between relative values of hydraulic components of dam displacements and mechanical parameters was ***,actual relative values of dam hydraulic components are isolated from the measured data of dam displacements by using *** inputting the isolated relative values into LSSVM model,the back analysis values of RCCD mechanical parameters can be *** example analysis showed that mechanical parameters obtained by the above-mentioned back analysis method are reasonable,and the back analysis method is feasible.

关键词： roller compacted concrete dam mechanical parameters back analysis

Game model of safety monitoring for arch dam deformation

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Science china(Technological Sciences) 2008年第S2期51卷 76-81页

作者： SU HuaiZhi1,2.WU ZhongRu1,2.GU YanChang1,2.HU Jiang1 & WEN ZhiPing3 1 College of Water Conservancy and Hydropower Engineering,Hohai university,nanjing 2.0098,{2. 2.National Engineering Research center of Water Resources Efficient Utilization and Engineering Safety,nanjing 2.0098,{2. 3 Department of Computer Engineering,nanjing Institute of Technology,nanjing 2.0013,{2. College of Water Conservancy and Hydropower Engineering Hohai University Nanjing China National Engineering Research center of Water Resources Efficient Utilization and Engineering Safety Nanjing China Department of Computer Engineering Nanjing Institute of Technology Nanjing China

Arch dam deformation is comprehensively affected by water pressure,temperature,dam's structural behavior and material properties as well as other *** them the water pressure and temperature are external factors(source factors) that cause dam deformation,and dam's structural behavior and material properties are the internal factors of deformation(resistance factors).The dam deformation is the result of the mutual game playing between source factors and resistance ***,resistance factors of structure and materials that reflect resistance character of arch dam structure are introduced into the traditional model,where structure factor is embodied by the flexibility coefficient of dam body and the maximum dam height,and material property is embodied by the elastic modulus of *** the basis of analyzing the correlation between dam deformation and resistance factors,the game model of safety monitoring for arch dam deformation is put forward.

关键词： arch dam deformation monitoring model flexibility coefficient game theory

Probing proton halo of the exotic nucleus ^(2.)S by elastic electron scattering

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Science china(Physics,Mechanics & Astronomy) 2004年第1期47卷 42-51页

作者： WANG Zaijun1 & REN Zhongzhou1’2.1. Department of Physics, nanjing university, nanjing 2.0008,{2. 2. center of Theoretical Nuclear Physics, National Laboratory of Heavy-Ion Accelerator at Lanzhou, Lanzhou 730000,{2. Correspondence should be addressed to Ren Zhongzhou (email: zren@*** zren99@***) Received June 16, 2.03 Department of Physics Nanjing University Nanjing 210008 China center of Theoretical Nuclear Physics National Laboratory of Heavy-Ion Accelerator at Lanzhou Lanzhou 730000 China

Elastic electron scattering on the exotic light nucleus 2.S is investigated in the plane wave Born approximation. The variation of the squared form factors of 2.S with momentum transfer is compared with that of 32.. It is found that the behavior of the form factors near the second minimum (with a moderate momentum transfer) is sensitive to the alteration of the charge density distribution of halo protons in 2.S. This indicates that elastic electron scattering can be a good probe of the structure of proton-halo nuclei.

关键词： elastic electron scattering, cross section, form factor, proton-halo nucleus.

A method of constructing a database-free optimal dynamical system and a global optimal dynamical system

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Science china(Physics,Mechanics & Astronomy) 2008年第7期51卷 905-915页

作者： WU ChuiJie1? & WANG Liang2.1 State Key Laboratory of Structural analysis for Industrial Equipment, Dalian university of Technology, Dalian 11602.,{2. 2.Research center for Fluid Dynamics, School of Science, PLA university of Science and Technology, nanjing 2.1101,{2. State Key Laboratory of Structural analysis for Industrial Equipment Dalian University of Technology Dalian China Research center for Fluid Dynamics School of Science PLA University of Science and Technology Nanjing China

In this paper, to overcome the drawbacks of POT which minimize the reminder, not only the optimal functional with minimal residual is put forward, but also the method of global optimization is used. Under the condition of large reminder, the optimal bases can also be obtained through the method of POTres without the approaching of initial conditions. In addition, compared with local optimization, the advantage of global optimization is remarkable. On the one hand, we can expect that the dynamical system based on the global optimal bases will include more information than the ones based on the local optimal bases, since the global optimal bases are much more precise than the local optimal bases. On the other hand, from the point of view of error, the global optimal bases are independent of the choice of the object functional and the initial bases.

关键词： dynamical system residual global optimization

Inner Attitude Integration Algorithm Based on Fault Detection for Strapdown Inertial Attitude and Heading Reference System

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Chinese Journal of Aeronautics 2010年第1期23卷 68-74页

作者： Liu Jianye,Zhu Yanhua,Lai Jizhou,Yu Yongjun Navigation Research center,nanjing {2. of Aeronautics and Astronautics,nanjing 2.0016,china Navigation Research center Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

This article proposes a new inner attitude integration algorithm to improve attitude accuracy of the strapdown inertial attitude and heading reference system （SIAHRS） , which, by means of a Kalman filter, integrates the calculated attitude from the accelerometers in inertial measuring unit （IMU） , called damping attitudes, with those from the conventional IMU. As vehicle＇ s acceleration could produce damping attitude errors, the horizontal outputs from accelerometers are firstly used to judge the vehicle＇ s motion so as to determine whether the damping attitudes could be reasonably applied. This article also analyzes the limitation of this approach. Furthermore, it suggests a residual chi-square test to judge the validity of damping attitude measurement in real time, and accordingly puts forward proper information fusion strategy. Finally,the effectiveness of the proposed algorithm is proved through the experiments on a real system in dynamic and static states.

关键词： navigation strapdown inertial attitude and heading reference system inner attitude integration algorithm internal damping Kalman filter residual chi-square test

Dispersion of ventricular mRNA of RyR2.and SERCA2.associated with arrhythmogenesis in rats

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Acta Pharmacologica Sinica 2004年第6期25卷 36-41页

作者： Hong-lan WANG, De-zai DAI2. Feng GAO3, Yan-pin ZHANG3, Feng LU Research Division of Pharmacology, china Pharmaceutical university, {2. 2.0009, china 3Laboratorial center ofMedicine, Southeast university, {2. 2.0009, china Research Division of Pharmacology China Pharmaceutical University Nanjing 210009 Laboratorial center of Medicine Southeast University Nanjing 210009

AIM: To investigate the effect of CPU86017 on the changes of mRNA abundance of different calcium handling system in infarcted heart. METHODS: Rats were subjected to left coronary ligation to induce myocardial infarc- tion (MI). The treatment with either propranolol (Pro) 5 mg/kg ip or CPU86017 1, 2. and 4 mg/kg ip was initiated on the next day of operation and continued for 2. d. Medication with isoproterenol (Isop) 3 mg/kg sc started on the d 17-2.. Ventricular mRNA abundance of ryanodine receptor 2.(RyR2., sarcoplasmic reticulum Ca2.-ATPase (SERCA2., L-type Ca2. channel, and Na+/Ca2.exchanger (NCX1) were measured. RESULTS: Arrhythmic scores (AS) in the Isop group was raised up to 5.2.±1.75 (P2.2.±2.04 and sham group 1.50±1.73. The AS was depressed by Pro (1.63±1.53, P2.and 4 mg/kg (3.00±1.2., and 1.70±1.85, P2. and SERCA2.was associated with an increase in AS in Isop group, and it was much depressed in the left than the right ventricle. The dispersion and depression of mRNA were restored significantly by Pro and CPU86017, asso- ciated with suppression on AS. In Isop group, the mRNA abundance of L-type Ca2. channel was not changed; and a moderate increase in the mRNA of NCX1 was seen, the changes were regressed by Pro and CPU86017. CONCLUSION: Isop-induced arrhythmogenesis in MI heart was correlated mainly with a dispersion of depressed mRNA abundance in ventricle likely due to the consequence of PKA over-phosphorylation. A suppression of arrhythmia by Pro and CPU86017 resulted from a regression of the dispersion and depression of RyR2.and SERCA2.

关键词： myocardial infarction isoproterenol arrhythmia calcium 4-chlorobenzyltetrahydroberberine

Large-eddy simulations and vortex structures of turbulent jets in crossflow

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Science china(Physics,Mechanics & Astronomy) 2007年第1期50卷 118-132页

作者： GUAN Hui1,2.& WU ChuiJie2.1 School of Mechanical and Power Engineering,East china university of Science and Technology,Shanghai 2.02.7,{2. 2.Research center for Fluid Dynamics,PLA university of Science and Technology,nanjing 2.1101,{2. School of Mechanical and Power Engineering East China University of Science and Technology Shanghai China Research center for Fluid Dynamics PLA University of Science and Technology Nanjing China

Using the method of large-eddy simulation, the 3-dimensional turbulent jets in crossflow with stream-wise and transverse arrangements of nozzle are simulated, emphasizing on the dynamical process of generation and evolution of vortex structures in these flows. The results show that the basic vortex structures in literatures, such as the counter-rotating vortex pair, leading-edge vortices, lee-side vortices, hanging vortices, kidney vortices and anti-kidney vortices, are not independent physical substances, but local structures of the basic vortex structure of turbulent jets in crossflow-the 3-D stretching vortex rings originating from the orifice of the nozzle, which is discovered in this study. Therefore, the most important large-scale structures of turbulent jets in crossflow are unified to the 3-D vortex rings which stretch and twist in stream-wise and swing in transverse directions. We also found that the shedding frequencies of vortex rings are much lower than the one corresponding to the appearance of leading-edge and lee-side vortices in the turbulent jets.

关键词： turbulent jet in crossflow coherent structure large-eddy simulation

Research on the reconstruction method of porous media using multiple-point geostatistics

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Science china(Physics,Mechanics & Astronomy) 2010年第9期53卷 122-134页

作者： ZHANG Ting 1,2.3, LI DaoLun 1,2., LU DeTang 1,2.& YANG JiaQing 1,2.1 Department of Modern Mechanics, university of Science and Technology of china, Hefei 2.002., china 2.Research center of Oil and Natural Gas, university of Science and Technology of china, Hefei 2.002., china 3 The 2.th Research Institute, china Electronics Technology Group Corporation, nanjing, 2.0007, china university of Science and Technology of china Department of Modern Mechanics Hefei China (GRID:grid.59053.3a) (ISNI:***) university of Science and Technology of china Research Center of Oil and Natural Gas Hefei China (GRID:grid.59053.3a) (ISNI:***) china Electronics Technology Group Corporation The 28th Research Institute Nanjing China (GRID:grid.464269.b) (ISNI:***) university of Science and Technology of china Department of Modern Mechanics Hefei China (GRID:grid.59053.3a) (ISNI:***) university of Science and Technology of china Research Center of Oil and Natural Gas Hefei China (GRID:grid.59053.3a) (ISNI:***)

The pore structural characteristics have been the key to the studies on the mechanisms of fluids flow in porous media. With the development of experimental technology, the modern high-resolution equipments are capable of capturing pore structure images with a resolution of microns. But so far only 3D volume data of millimeter-scale rock samples can be obtained losslessly. It is necessary to explore the way of virtually reconstructing larger volume digital samples of porous media with the representative structural characteristics of the pore space. This paper proposes a reconstruction method of porous media using the structural characteristics captured by the data templates of multiple-point geostatistics. In this method, the probability of each structural characteristic of a pore space is acquired first, and then these characteristics are reproduced according to the probabilities to present the real structural characteristics in the reconstructed images. Our experimental results have shown that: (i) the deviation of LBM computed permeability respectively on the virtually reconstructed sandstone and the original sample is less than 1.2.; (ii) the reconstructed sandstone and the original sample have similar structural characteristics demonstrated by the variogram curves.

关键词： porous media reconstruction multiple-point geostatistics pore space training image variogram data template

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