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An integrated decision method for prediction of tropical cyclone movement by using genetic algorithm

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Science china Earth Sciences 2005年第3期48卷 429-440页

作者： YANG Yuanqin1 & WANG Jizhi2.1. National Meteorological center, beijing 100081,{2. 2. Chinese Academy of Meteorological Sciences, beijing 100081, china National Meteorological center Beijing China Chinese Academy of Meteorological Sciences Beijing China

In this study an integrated decision method for the multi-prediction results of tropical cyclone movements by using genetic algorithm (GA) has been adopted. A genetic learning artifi- cial neural network (GLANN) as a learning mechanism for track prediction was developed through training with the huge samples of typhoon tracks from 1884 to 2.02. The prediction of typhoon motion is to consider how to suit the dynamic change of environment, where typhoon passed through. The neural network structure is described by GA. A fitness function for choice of GA is given to approach the maximum of fitness (the minimum of the errors). Parallel comparing analyses for prediction abilities of unusual typhoon tracks in recent years by GLANN with multi-forecast methods were conducted. More types of cases were employed in the comparing analyses, which consist of the typhoon, Winnie, No.11, in 1997, characterized by a long life over the ocean and in the mainland with severe effect on china, the 10 unusual typhoon tracks in the 1990s, the tracks with landfall and affected action in 1998 and the typhoons born in the Northwestern Pacific and the South china Sea in 2.00, including the 2.—48 h forecast, etc. The results indicated that for prediction ability of typhoon tracks, specially for unusual typhoons, GA decision-making developed in this study is superior to the others.

关键词： genetic algorithm, integrated decision, prediction of tropical cyclone.

Randomization of protein encoding gene during species evolution

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Chinese Science Bulletin 1998年第4期43卷 299-303页

作者： GE Weiwen 1 and HE Fuchu 2.1. Institute of Hygiene and Environment Medicine, Tianjin 300050, china 2. Institute of radiation Medicine, {2. 100850, china Institute of Hygiene and Environment Medicine Tianjin China Institute of radiation Medicine Beijing China

Employing chi_square test, the authors observed the bias of 4 kinds of bases’ locating in 3 codon positions in gene sequence, and proved that there is a positive correlation between higher chi_square value and protein coding structure. By this, the observation that genes undergo progressive reduction in chi_values along evolution direction will reflect the progressive randomization of gene structures and the loss of the characteristics of protein coding sequences. The result proposed that during the evolution of life, genes are unexpectedly degenerating.

关键词： chi_square test gene sequence randomization evolution.

Explanation of the mechanism of carcinogenesis and syntheses of anticancer agents with high selectivity

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Science china Chemistry 2006年第1期49卷 44-62页

作者： DAI Qianhuan1,2.1. center of Chemistry and Bioengineering of Cancer Research, beijing Polytechnic University (Now known as beijing Univer-sity of Technology), beijing 10002., china 2. center of Environmental Sciences, Peking University, beijing 100871, china center of Chemistry and Bioengineering of Cancer Research Beijing Polytechnic University Beijing China center of Environmental Sciences Peking University Beijing China

In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carcinogen always metabolizes to form a specialbi-functional alky-lating agent. This agent induces cross-linkages between the complementary basepairs in DMA and switches on initial mutageneses in genomes including point and frameshiftmutations. This, in turn, induces further deep mutageneses including the production of variouschimeric chromosomes, deletions and other aberrations found in genomes. In the end this initiatescarcinogenesis of the whole cell through the reverse transcription mechanism after a lengthyincubation period. Recently, this laboratory has verified that physical carcinogenesis, includingthe oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced byendogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing theformation of cross-linkages between the complementary base pairs in DNA. Di-region theory has nowbeen supported by many experimental observations such as mutational spectra of various *** potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together asgenetic toxicity appears to originate almost uniformly from the cross-linking between complementarybases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms ofcross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylationanticancer activity but lack genetic toxicity. The predictable design and synthesis of a highselectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued incancer chemotherapy, have been realized for the first time in this laboratory by inhibitingmalignant and heightening benign cross-linking using the principles of di-region theory. A series ofpatented new anticanc

关键词： mechanism of carcinogenesis, di-region theory, minoplatin, selectivity of anticancer agent, cross-linking between DNA bases, anticancer platinum complexes, predictive design of anticancer agent, second generation anticancer agent.

Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer(2.2. edition)

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radiation Medicine and Protection 2024年第2期5卷 59-67页

作者： Professional Committee of radiation Oncology china Anti-Cancer Association Branch of radiation Oncology Chinese Medical Association Branch of radiation Oncology TreatmentPhysician Chinese Medical Doctor Association Qingsong Pang Jun Wang Zhouguang Hui Wencheng Zhang 不详 Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China the Fourth Hospital of Hebei Medical University Shijiazhuang 050011China National Cancer center National Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Medical University Cancer Hospital China

Radiotherapy represents an essential treatment approach for esophageal *** recent years,immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal *** phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently *** evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal *** consensus,formulated based on the latest study results,in-depth research,and thorough discussions,provides a comprehensive set of *** document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer,inoperable locally advanced esophageal cancer,and advanced esophageal ***,common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed,serving as clinical *** expert group comprised members from the Professional Committee of radiation Oncology,{2. Anti-Cancer Association,the Branch of radiation Oncology,Chinese Medical Association,and the Branch of radiation Oncology Treatment Physician,Chinese Medical Doctor Association.

关键词： Esophageal squamous cell carcinoma Esophageal adenocarcinoma Immunotherapy Chemoradiotherapy Radiotherapy Expert consensus

Collision dynamics of He@C_(60)+He@C_(60) at low energies

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Science china(Physics,Mechanics & Astronomy) 2008年第7期51卷 765-772页

作者： ZHAO Qiang1,2. ZHANG FengShou1,2.3 & ZHOU HongYu1,2.1 Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Institute of Low Energy Nuclear Physics, beijing Normal University, beijing 100875,{2. 2.beijing radiation center, beijing 100875,{2. 3 center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000,{2. Key Laboratory of Beam Technology and Material Modification of Ministry of Education Institute of Low Energy Nuclear Physics Beijing Normal University Beijing China beijing radiation {2. Beijing China center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of Lanzhou Lanzhou China

A semi-empirical molecular dynamics model is developed. The central collisions of C60+C60 and He@C60+He@C60 at different incident energies are investigated based on this model. It is found that the dimer structures have been produced at proper incident energies and these fullerene dimers could be formed by a self-assembly of C60 fullerene and He@C60. The He atom has a significant effect at higher incident energy and this embedded He atom can enhance the stability of the dimer structure.

关键词： C60 He@C60 collision molecular dynamics

Design and screening of antisense oligodeoxynucleotides against PAI-1 mRNA in endothelial cells in vitro

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Acta Pharmacologica Sinica 2006年第8期27卷 1018-1023页

作者： Qi-sheng JIANG Sheng-qi WANG~2.beijing Institute of radiation Medicine,{2. 100850,china beijing Institute of radiation Medicine Beijing China

Aim:To design and screen antisense oligodeoxynucleotides(ASODNs),whichinhibit type-1 plasminogen activator inhibitor(PAI-1)expression in human umbili-cal vein endothelial cells(HUVEC)in ***:Twenty seven ASODNsagainst different sites of PAI-1 mRNA were designed and transfected to HUVECby lipofectin in *** effects of ASODNs on PAI-1 antigen,PAI-1 activityand PAI-1 mRNA expression were detected by ELISA,amidolytical assay and RT-PCR,***:Transforming growth factor β1(TGF-β1)-treatedHUVEC increased the expression of PAI-1 compared with the normal *** among twenty seven designed ASODNs were effective in inhibiting the in-crease in PAI-1 antigen and PAI-1 activity in a dose-dependent manner after *** particular,ASODN 14(AO14)exhibited the best inhibitory *** control sequences of AO14,including sense,scramble,and mismatchsequences,did not significantly inhibit PAI-1 *** was revealed that theinhibitory efficacy of AO14 was in a sequence-specific ***-PCR showedthat ASODN 1,7,8,14,and 15 decreased PAI-1 mRNA expression induced byTGF-β1and AO14 showed the best inhibitory ***:ASODN 1,7,8,14,and 15,among twenty seven designed ASODNs against PAI-1 mRNA,signifi-cantly decreased PAI-1 antigen and PAI-1 activity induced by TGF-β1x in a dose-dependent manner in HUVEC in ***14 showed the best inhibitory effect onPAl-1 expression in a sequence-specific *** results of RT-PCR indicatedthat inhibitory effects of ASODNs on PAI-1 biosynthesis occurred at the *** among five effective target sites of ASODNs located at the translationinitiation Site or within the translation area of PAI-1 mRNA,suggesting that thesesites may be promising sites for the design of effective ASODNs.

关键词： plasminogen activator inhibitor 1 antisense oligodeoxynucleotide endothelial cells

The study of two-color excitation upconversion of Pr(0.5)Yb(3):ZBLAN

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Science china(Physics,Mechanics & Astronomy) 2006年第2期49卷 169-177页

作者： CHEN Xiaobo1 & SONG Zengfu2.1. Applied Optics beijing Area Major Laboratory, Analysis and testing center, beijing Normal University, beijing 100875, china 2. Peking University, Physics School, beijing 100871, china Applied Optics beijing Area Major Laboratory Analysis and testing center Beijing Normal University Beijing China Physics School Peking University Beijing China

The excited state absorption upconversion of Pr(0.5)Yb(3):ZBLAN glass material, under two-color excitation of the 960 nm semiconductor laser and the Xe lamp light simultaneously, is reported in this article. It was found that the upconversion emission spectra of 480.1, 519.0, 601.9 and 631.8 nm coincide with the common emission spectra. Meanwhile, the upconversion-excitation spectrum has three obvious peaks under two-color excitation, and they respectively correspond to the 856.0 nm upconversion ex-citation transition [1G4(Pr3+)→1I6(Pr3+) and 1G4(Pr3+)→3P1(Pr3+)], the 789.0 nm upconver-sion excitation transition 1G4(Pr3+)→3P2.Pr3+), and the 803.7 nm upconversion excitation transition 3H6(Pr3+)→1D2.Pr3+). The upconversion excitation transition 1G4(Pr3+)→1I6(Pr3+) is strong because its oscillator strength f = 2..040×10?6 is large, which results in a large peak appearing in the upconversion excitation spectrum. That is just the new interesting two-color excitation upconversion luminescence phenomenon of Pr(0.5)Yb(3):ZBLAN induced by one laser and one continuous normal light simultaneously.

关键词： upconversion volumetric three-dimensional display two-color excitation.

Technical development of proteomics

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Chinese Science Bulletin 1999年第16期44卷 1441-1447页

作者： WAN Jinghong and HE Fuchu1.Chongqing Medical University, Chongqing 400046, china 2. beijing Institute of {2. Medicine, beijing 100850, china Corresponding author Chongqing Medical University Chongqing China beijing Institute of radiation Medicine Beijing China

Proteome research is an important complementarity for the genome research, which uses quantitative protein-level measurements to characterize biological process. Proteome techniques include two aspects. One is two-dimensional electrophoresis, which is the unique technology to separate the components of proteome. The other is identification of the

关键词： proteome two-dimensional electrophoresis image analysis peptide-mass fingerprinting database.

Study of thin cloud removal method for CBERS-02.image

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Science china(Technological Sciences) 2005年第S2期48卷 91-99页

作者： MA Jianwen1, GU Xingfa1, FENG Chun2.& GUO Jianning2.1. Institute of Remote Sensing Application, Chinese Academy of Sciences, beijing 100101, china 2. china center for Resource Satellite Data and Applications, beijing 100073, china Institute of Remote Sensing Application Chinese Academy of Sciences Beijing 100101 China china center for Resource Satellite Data and Applications Beijing 100073 China

The china Brazil Earth Resources Satellite (CBERS) ended the dependence on foreign satellites. Along with the series of CBERS and the enhancement of satellite applications, it is necessary to search correlative data processing methods. Because cloud appears in the atmosphere, an image with clear sky conditions is often hard to obtain. How to remove cloud is an important sector of increasing image quality. An improved homomorphism filtering method is adopted to remove thin cloud qualitatively at first, and all bands are selected to classify pixels. Based on the fact that visible band images contain more aerosol effects than infrared bands, visible bands are used to determine clear or hazy regions and the reflectances of different surface classes in clear regions are calculated. At last the mean reflectance of the same classes in clear and hazy regions is matched to remove cloud. The image visual effect is improved; meanwhile, the ground reflectance is retrieved to meet the needs of remote sensing quantification.

关键词： CBERS-02 cloud removal surface reflectance mean reflectance matching.