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Effects of chitosan/collagen substrates on the behavior of rat neural stem cells

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Science China(Life Sciences) 2010年第2期53卷 215-222页

作者： YANG ZhaoYang1,MO LinHong2.DUAN HongMei2.& Li XiaoGuang1,2.1 School of Biological Science and Medical engineering,Beihang University,Beijing 100191,China 2.Beijing Institute for neuroscience,Capital Medical University,Beijing 100069,China 1. School of Biological Science and Medical engineering Beihang University Beijing 100191 China2. Beijing Institute for Neuroscience Capital Medical University Beijing 100069 China

Spinal cord and brain injuries usually lead to cavity *** transplantation by combining stem cells and tissue engineering scaffolds has the potential to fill the cavities and replace the lost neural *** chitosan and collagen have their unique *** this study,the effects of chitosan and collagen on the behavior of rat neural stem cells (at the neurosphere level) were tested in vitro in terms of cytotoxicity and supporting ability for stem cell survival,proliferation and *** the serum-free condition,both chitosan membranes and collagen gels had low cytotoxicity to *** is,cells migrated from neurospheres,and processes extended out from these neurospheres and the differentiated *** with the above two materials,chitosan-collagen membranes were more suitable for the co-culture with rat neural stem cells,because,except for low cytotoxicity and supporting ability for the cell survival,in this group,a large number of cells were observed to migrate out from neurospheres,and the differentiating percentage from neurospheres into neurons was significantly *** modification of chitosan-collagen membranes may shed light on in vivo nerve regeneration by transplanting neural stem cells.

关键词： chitosan collagen neural stem cells biocompatibility differentiation

Computational neuroscience in China

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Science China(Life Sciences) 2010年第3期53卷 385-397页

作者： WU Si1 & LIANG PeiJi2.1Institute of neuroscience,Shanghai Institutes for Biological Sciences,State Key laboratory of Neurobiology,Chinese Academy of Sciences,Shanghai 2.0031,China 2.2. of Biomedical engineering,Shanghai Jiaotong University,Shanghai 2.02.0,China 1. Institute of neuroscience Shanghai Institutes for Biological Sciences State Key Laboratory of Neurobiology Chinese Academy of Sciences Shanghai 200031 China2. Department of Biomedical Engineering Shanghai Jiaotong University Shanghai 200240 China

The ultimate goal of Computational neuroscience(CNS) is to use and develop mathematical models and approaches to elucidate brain *** is a young and highly multidisciplinary *** heavily interacts with experimental neuroscience and such other research areas as artificial intelligence,robotics,computer vision,information science and machine *** paper reviews the history of CNS in China,its current status and the prospects for its future *** of CNS research in China are also presented.

关键词： computational neuroscience experimental neuroscience artificial intelligence

Effects of the CNTF-collagen gel-controlled delivery system on rat neural stem/progenitor cells behavior

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Science China(Life Sciences) 2010年第4期53卷 504-510页

作者： YANG ZhaoYang1, QIAO Hui2.& LI XiaoGuang1,3 1School of Biological Science and Medical engineering, Beihang University, Beijing 100191, China 2.ublic Heath School, Ningxia Medical University, Yinchuan 750004, China 3Beijing Institute for neuroscience, Capital Medical University, Beijing 100069, China 1. School of Biological Science and Medical engineering Beihang University Beijing 100191 China2. Public Heath School Ningxia Medical University Yinchuan 750004 China3. Beijing Institute for Neuroscience Capital Medical University Beijing 100069 China

The injury of central nervous system (CNS) usually causes the cavity formation. Although transplantation of neural stem/precursor cells (NSPCs) into the lesioned area of CNS has been shown to be implicated in the functional restoration, the therapeutic result is limited by the poor survival of NSPCs as well as their insufficient proliferation and differentiation abilities. Type-1 collagen is considered as a candidate scaffold or drug delivery system to overcome the aforementioned obstacle. This study observed the effects of the CNTF (ciliary neurotrophic factor)-collagen gel-controlled delivery system and daily addition of soluble-form CNTF on the NSPC survival, migration, proliferation and differentiation. The results showed that, within 12.h of the initial co-culture, CNTF was released in a burst pattern, then the CNTF-collagen gel-controlled delivery system stably released CNTF for up to 12.d. The cell viability test, together with immunohistochemistry, RT-PCR and Western blotting, showed that the CNTF-collagen gel-controlled delivery system supported the NSPCs seeded on the surface of collagen gel survival and facilitated their migration and proliferation. The daily addition of soluble-form CNTF to the medium had similar effects to the CNTF-collagen gel-controlled delivery system, but large quantities of soluble-form CNTF were consumed during the entire process. Taken together, the CNTF-collagen gel-controlled delivery system not only provides a physical scaffold for the transplanted NSPCs to adhere and migrate, but also facilitates the NSPC survival, growth and proliferation, simultaneously reducing the consumption of the expensive growth factors. This system may be used to enhance the microenvironment in the lesioned area of CNS.

关键词： spinal cord neural stem/progenitor cells control release type-1 collagen CNTF

Optimal Control Mechanisms in Human Arm Reaching Movements

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Optimal Control Mechanisms in Human Arm Reaching Movements

第三十届中国控制会议

作者： JIANG Yu~1,JIANG Zhong-Ping~1,QIAN Ning~2.1.department of Electrical and Computer engineering,Polytechnic Institute of New York University,Brooklyn,NY 1{2.1,US A 2.department of neuroscience,Columbia University,New York,NY 10032.usa.College of engineering,Beijing University,P.R. China.

＜正＞In this paper,the continuous-time optimal stationary control theory is employed to model the human motor control system in the presence of signal-dependent *** control scheme is based on Phillis’s earlier work[36],and is simulated and compared with human *** control model is compatible with some important observations,such as the asymmetry of the velocity profiles and the overshoot *** infinite-horizon optimal control model advocated here differs from previous methods in not requiring a priori knowledge of a finite stopping time,but focuses on minimization of the variance in steady state. It is hypothesized that selecting appropriate weighting matrices in the cost function plays a key role in planning arm movement trajectories in the central nervous system,while the stopping time is not necessary to be known in planning movements.

关键词： Optimal Control Stochastic Systems Biological Systems Signal-Dependent Noise

Transplantation of neural stem cells and hyaluronic acid based scaffold for treatment of rat ischemic stroke

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Transplantation of neural stem cells and hyaluronic acid bas...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ying WANG~1 Li-Li XIAO~1 Yong-Juan REN~2.Fu-Zhai CUI~2.Qun-Yuan XU~(1 *) 1 Beijing Institute for neuroscience Capital Medical University Beijing 100069 China 2.1} of Materials Science and {2. Tsinghua University Beijing 100084 China

Introduction Stroke causes death and severe disability highly and often results in cavity formation in the brain. The complexity and the limited regeneration of brain tissue make efforts to repair

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Transplantation of neural stem cells and hyaluronic acid based scaffold for treatment of rat ischemic stroke

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Transplantation of neural stem cells and hyaluronic acid bas...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ying WANG~1,Li-Li XIAO~1,Yong-Juan REN~2.Fu-Zhai CUI~2.Qun-Yuan XU~(1,*) 1 Beijing Institute for neuroscience,Capital Medical University,Beijing 100069,China 2.1} of Materials Science and {2.,Tsinghua University,Beijing 100084,China

Introduction Stroke causes death and severe disability highly and often results in cavity formation in the brain. The complexity and the limited regeneration of brain tissue make efforts to repair it very *** engineering in combination with neural stem cell transplantation offers the hope of the treatment,and it has the potential to fill such a cavity caused by injury and replace the lost *** and Results In our study,a hyaluronic acid(HA)-based biodegradable hydrogel was created as 3-D networks scaffold,mimicking the structure and component of the extracellular matrix(ECM) in the *** molecules of poly-L-lysine(PLL) were immobilized on the backbone of the hydrogel for improving cell adherence and tissue compatibility with the *** addition,the antibody of Nogo receptor(Ab-NgR) was covalently attached to the HA hydrogel,delivering the antibody to the injured brain,which can bind to multiple inhibitory myelin proteins and promote neural *** neural stem cells were seeded on the scaffold,it was found that the hydrogel scaffold was a good place for cells to *** neural stem cells(nestin) were well survived,proliferated and differentiated into neural progenitors,even neurons(β-tubulinI,NF,MAP) and glia(GFAP,O4).After being transplanted into the injured area of the brain of rat stroke model produced by occlusion of the middle cerebral artery,the complex of hydrogel and stem cells correctly bridged the tissue defects and became fully integrated into the host tissue. It clearly showed that the hydrogel had good compatibility with the brain tissue and inhibition of the genesis of glial scar. Thus,it formed a permissive interface with the host *** promoted P-tubulinI,A2.5,GFAP cell regeneration and migration from the border of ischemic area into the scaffold.A part of the implanted neural stem cells could be differentiated intoβ-tubulinI,NF,NeuN and GFAP ***,it could induce angiogenesis and improve beh

关键词： ischemic stroke tissue engineering neural stem cell hyaluronic acid scaffold

触觉-触觉单-模式和听觉-触觉交叉模式工作记忆的神经机制的研究

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心理科学 2010年第5期33卷 1062-1066页

作者：王立平库逸轩华东师范大学认知神经科学研究所上海市功能磁共振成像重点实验室上海200062 清华大学生物医学工程系北京100084

目的:探讨听觉-触觉交叉模式工作记忆的大脑神经活动机理。方法:训练12.正常受试者学习触觉-触觉单一模式和听觉-触觉交叉模式工作记忆任务后,利用Neuroscan EEG系统记录脑电活动,对脑电数据分析,着重考察延时过程中事件相关脑电成分(E... 详细信息

目的:探讨听觉-触觉交叉模式工作记忆的大脑神经活动机理。方法:训练12.正常受试者学习触觉-触觉单一模式和听觉-触觉交叉模式工作记忆任务后,利用Neuroscan EEG系统记录脑电活动,对脑电数据分析,着重考察延时过程中事件相关脑电成分(ERP)在触觉单一模式和交叉模式中的异同。我们以往交叉模式的研究表明:在工作记忆延时过程中存在着2.主要的脑电成分LPC(Late Positive Component)和LNC(Late Negative Component)。本研究中加入了新的感觉模式——听觉,并通过比较单一模式和交叉模式,以及交叉模式中匹配和不需匹配任务间脑电成分的差异,进一步证明了交叉模式工作记忆中相继的LPC和LNC所提示的神经认知功能:不同感觉模式间的信息交互,工作记忆的维持和执行。

关键词：工作记忆交叉模式触觉听觉 EEG

Coherence analysis of magnetoencephalography

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Coherence analysis of magnetoencephalography

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yang ZHANG~1 Wen-Sheng HOU~(1 *) Wei-Na LI~2.Xiao-Ying WU~1 Guo-Cai WU~2.Hua FENG~2.Jun ZHENG~3 1 department of Biomedical engineering Chongqing University Chongqing 400044 China 2.department of Neurosurgery Southwest Hospital Third Military Medical University Chongqing 400038 3 department of Computer Science New Mexico Institute of Mining and Technology Socorro NM 87801 usa

＜正＞Objective The present study is to obtain correlation between spatially separated brain regions,as well as the changes in time and frequency domain through analysis of the magnetoencephalography *** By means of the theory of coherence analysis,coherence coefficient of two signals corresponding to different cortical areas is computed, which reflects synchronization of the above two signals,as well as the correlation between spatially separated brain *** frequency analysis is also used to discuss the cortical correlation changes co-vary closely with time over the course of motor task in the three frequency band-α,βand lowγ.Results（1） By computing the coherence coefficient relative to the selected reference channel,it is suggested that channels with the most significant coherence are approximately in the same area,*** contralateral primary motor cortex and premotor ***,with the increase of frequency band both the coherence coefficient and the coupled area decline.（2. Changes of coherence co-varing with time inα,βand lowγband present the following characteristic:①The coherence shows such a trend that it increases firstly and then decreases over the course of motor task.②The most significant coherence,forαband,is observed from 0 to 0.3 second,while forβand lowγit appears at -0.2.*** The changes of coherence inα,βand lowγbands suggest that there are different neuronal modulations in the contralateral primary motor *** this modulation covaries with time,which consequently reflects the changes of correlation between different brain regions in time and frequency domain.

关键词： magnetoencephalography coherence time frequency analysis

Reference values for amplitude-integrated electroencephalogram in infants from preterm to 3.5 months of age

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Reference values for amplitude-integrated electroencephalogr...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Dan-Dan ZHANG~(1,2.*),Yun-Feng LIU~3,Da-Tian YE~2.Yue-Jia LUO~1 1 State Key laboratory of Cognitive neuroscience and Learning,Beijing Normal University,Beijing 100875,China 2.{2. of Biomedical engineering,Tsinghua University,Beijing 100084,China 3 {2. of Pediatrics,Peking University First Hospital,Beijing 100034,China

＜正＞Objective Amplitude-integrated electroencephalogram（aEEG）is a valuable tool for the continuous evaluation of functional brain maturation in *** amplitudes of the upper and lower margins of aEEG are postulated to change with maturation and correlate with postmenstrual age（PMA）.This study aimed to establish reliable reference values of aEEG amplitudes,providing quantitative guidelines for assessing aEEG maturation in neonates and young *** Normal infants（n=2.4）with PMAs that ranged from 30 to 55 weeks were divided into ten groups according to their *** 5-min segments were selected from each aEEG to calculate the upper/lower margin and bandwidths of the tracing *** Interobserver agreement was achieved with an overall correlation of *** upper and lower margins of aEEG in both active and quiet sleep clearly rose in infants beyond the neonatal *** bandwidth defined as the graphic distance decreased almost monotonically throughout the PMA range from 30 to 55 *** lower margin of aEEG was positively correlated with PMA, with a larger rank correlation coefficient during quiet sleep（r=0.89）than during active sleep（r=0.49）.Conclusion Reference values of aEEG amplitudes were obtained in infants with a wide range of PMA and constitute a basis for the quantitative assessment of aEEG maturation in neonates and young *** normative amplitudes of aEEG margins,especially of the lower margin in quiet sleep,are recommended as reference data for the identification of potentially abnormal aEEG.

关键词： amplitude integrated EEG infant reference values upper and lower margins