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Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats

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Acta Pharmacologica Sinica 2007年第6期28卷 763-772页

作者： Li-sheng CHU~(2,3),San-hua FANG~2,Yu ZHOU~2,Guo-liang YU~2,Meng-ling WANG~2,Wei-ping ZHANG~2,Er-qing WEI~(2,4)~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310058,China ~3 Department of Physiology ZhejiangChinese Medical University Hangzhou 310053,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou 310058 China

Aim:To determine whether the anti-inflammatory effect of minocycline on postis-chemic brain injury is mediated by the inhibition of 5-lipoxygenase （5-LOX）expression and enzymatic activation in ***:Focal cerebral ischemiawas induced for 30 min with middle cerebral artery occlusion,followed *** ischemic injuries,endogenous IgG exudation,the accumulationof neutrophils and macrophage/microglia,and 5-LOX mRNA expression weredetermined 72 h after reperfusion.5-LOX metabolites （leukotriene B4and cysteinylleukotrienes） were measured 3 h after ***:Minocycline （22.5and 45 mg/kg,ip,for 3 d） attenuated ischemic injuries,IgG exudation,and theaccumulation of neutrophils and macrophage/microglia 72 h after *** inhibited 5-LOX expression 72 h after reperfusion and the production ofleukotrienes 3 h after reperfusion,Conclusion:Minocycline inhibited postis-chemic brain inflammation,which might be partly mediated by the inhibition of5-LOX expression and enzymatic activation.

关键词： minocycline 5-1ipoxygenase leukotriene focal cerebral ischemia inflammation

Experimental Study on Thermal Conventional Spinning of Ti-6Al-4V Alloy Complex Shape Shell

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稀有金属材料与工程 2011年第S3期40卷 78-81页

作者： Xu Hengqiu1,2, Li Mingzhe1, Zhang Rui2, Wang Dali2, Hou Fengyan2, Li Linlin2, Fan Guisen2, Shen Yujing2 1 Jilin University, Changchun 130025, China 2 Changchun Institute of Equipment Technology, Changchun 130012, China Jilin Univ Roll Forging Res Inst Changchun 130025 Peoples R China Changchun Inst Equipment Technol Changchun 130012 Peoples R China

In this paper, the process of thermal conventional spinning of Ti-6Al-4V alloy complex shape shell is studied by experiment. Billet for Ti-6Al-4V alloy board is headed in the spinning process for multi-pass conventional spinning forming. With two spinning mandrel, the first is conventional spinning pre-forming and the second is conventional end forming, vacuum heat treatment after each spinning forming. As results, the mandrel preheating temperature impacts the spinning and the appropriate temperature range plays an important role in the process of spinning. With supplemental heating means and infrared thermometer measurement ensure a stable temperature. Multi-passing thermal spinning Ti-6Al-4V alloy thins the billet thickness, using the feature obtaining the wanting complex shape shell of thick bottom and thin mouth. The spinning track, the number of spinning pass, feed rate affect the billet thinning. During thermal spinning process Ti-6Al-4V alloy rebound severe. The size reduction and feed have impact on the rebound. By modifying the spinning parameters and the mandrel repair to ensure the dimensional accuracy of workpiece. Spinning workpiece has fine grain and high strength.

关键词： Ti-6Al-4V alloy thermal spinning conventional spinning spinning temperature experimental study

End-Permian conodont fauna from Dongpan section:Correlation between the deep-and shallow-water facies

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Science China Earth Sciences 2008年第11期51卷 1611-1622页

作者： GenMing Luo (1) (2) XuLong Lai (1) (2) QingLai Feng (1) (3) HaiShui Jiang (1) (2) Paul Wignall (4) KeXin Zhang (1) (3) YaDong Sun (2) Jun Wu (1) (2) School of Earth and Environment University of Leeds LS2 9JT Leeds UK

This paper systematically investigated the conodonts from the uppermost Permian to the Lower Triassic at the Dongpan Section, Southern Guangxi, South China, and obtained abundant Late Permian conodonts from the syndepositional limestone lenses of beds 3 and 5-2.at this section. One genus and eight species of conodont P1 element including one new species, Neogondolella dongpanensis sp. nov., have been identified. The feature of conodont fauna indicates that conodonts collected from beds 3 and 5 at the Dongpan Section belong to the Neogondolella yini conodont zone, and correspond to bed 24 at the Meishan Section. Based on these conodont data, we suggest that the Neoalbaillella optima radiolarian zone at the Dongpan Section at least extended to the upper part of the N. yini conodont zone.

关键词： Dongpan Section end-Permian conodont fauna biostratigraphic correlation

Recombinant human B7-H4 expressed in Escherichia coli inhibits T lym-phocyte proliferation and IL-2 secretion in vitro

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Acta Pharmacologica Sinica 2006年第6期27卷 741-746页

作者： Yi-xiang MAO~(2,3)Yong-Jing CHEN~2 Yan GE~2 Hong-bing MA~2 Jian-feng YU~2 Hong-ya WU~2 Yu-min HU~2 Qin WANG~2 Qin SHI~2 Xue-guang ZHANG~(2,4)2 Institute of Biotechnology,Soochow University,Suzhou 215007,China 3 Department of Oncology,First Affiliated Hospital to Soochow University,Suzhou 215007,China Institute of Biotechnology Soochow University

Aim:To explore the biofunctions of human B7-H4 generated from ***:The gene of human B7-H4 extracellular region（IgV-like andIgC-like domains）was obtained by PCR from human cDNA FLJ22418 and theninserted into the prokaryotic expression vector pGEX-5X-3 expressing glutathiones-transferase（GST）fusion *** being identified by restriction enzymedigestion and sequencing,the recombinant vector was transferred into host strainE coli BL21-RIL（DE3）.A 47 kDa fusion protein（GST/hB7-H4）was induced byisopropyl-beta-D-thiogalactopyranoside（IPTG）and purified by standard meth-ods reported in the prokaryotic *** inhibitory effect of GST/hBT-H4 onproliferation of T cells was observed in vitro by CD3mAb activated T-cell cultur-ing system and [3H]-thymidine incorporation *** concentrations ofinterleukin-2.and iterferon-g in the supernatants of T cells were determined ***:We successfully constructed the method for high-level expres-sion and purification of the hB7-H4 extracellular domain as GST fusion proteinfrom E *** GST/hB7-H4 fusion protein produced in bacteria had obviousbiological activity to inhibit T-lymphocyte proliferation and IL-2 ***:The prokaryote expression system could be used to generate hB7-H4 protein with natural spatial conformations and biological functions,whichprovided an efficient and economical way for the preparation of this target protein.

关键词： B7-H4 glutathione s-transferase fusion protein inhibition

Research progress in the inner surface modification of metal tubes by plasma processing

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Progress in Natural Science:Materials International 2006年第11期16卷 1119-1126页

作者： ZHANG Guling~ 1,2 **, WU Xingfang~1, GU Weichao~2, CHEN Guangliang~2, FENG Wenran~2, NIU Erwu~2, LI Li~2, L Guohua~2, CHEN Huan~2, FAN Songhua~2, LIU Chizi~2.and YANG Size~2(1. School of Material Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China 2. Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China) School of Material Science and Engineering University of Science and Technology Beijing Beijing 100083 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

The recent progress in inner surface hardening of tubes by plasma processing is summerized. Several techniques of inner surface plasma source ion implantation and deposition are introduced, and their advantages and disadvantages are discussed. The basic principles, technical features and new progress of inner surface plasma source ion implantation methods for metal tubes, which were developed in our laboratory, are described in detail. And perspectives of the future technical development for inner surface ion implantation of tubes are presented.

关键词： PSII metal tubes inner surface surface modification.

Application　of　mechanical　and　statistical　models　to　the　study　of　seismicity　of　syn-thetic　earthquake

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Acta Seismologica Sinica(English Edition) 1998年第4期11卷 421-430页

作者： Yao-Lin Shi (1) Jie Liu (2) David Vere-Jones (3) Jian-Cang Zhuang (2) Li Ma (2) 1. Graduate School University of Science and Technology of China 100039 Beijing China 2. Center for Analysis and Prediction State Seismological Bureau 100036 Beijing China 3. Institute of Statistics and Operation Research Victoria University of Wellington Wellington New Zealand

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关键词： Application and

Model test of the tunnel subjected to high water pressure in Jinping Second Cascade Hydropower Station,China

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Science China(Technological Sciences) 2011年第S1期54卷 192-198页

作者： WANG JianXiu 1,2,FENG Bo 2,HU LiSheng 2,TIAN PuZhuo 2,SUI DongChang 2,TANG YiQun 1,2 &YANG Ping 1,2 1 Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education,Tongji University,Shanghai 200092,China 2 Department of Geotechnical Engineering,Tongji University,Shanghai 200092,China 1. Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji University Shanghai 200092 China2. Department of Geotechnical Engineering Tongji University Shanghai 200092 China

In the area with high groundwater pressure,grout curtain is often adopted to reduce the water pressure on tunnel lining.A series of model tests for the diversion tunnel of the Jinping Second Cascade Hydropower Station,China,is designed to study the effect of grout *** impact of the thickness of grout curtain,permeability of grout curtain,internal water pressure and drainage inflow on the distribution of water pressure are *** results indicates that under un-drained condition,water pressure is equal to hydrostatic one no matter grout curtain is selected or not,water pressure under drained condition is far less than that of un-drained condition,drainage in tunnel can reduce tunnel water pressure *** same inflow,both increasing of thickness and decrease of hydraulic conductivity of grout curtain can reduce water pressure *** the same water pressure,the smaller inflow of grout curtain,the less volume of water to be *** impact of hydraulic conductivity of grout curtain is more obvious than that of *** increasing of internal water pressure,the water pressure of grout curtain increases too,and the water pressure increases nearly *** proposed thickness of grout curtain for the diversion tunnels is 16 m.

关键词： tunnel grout curtain water pressure model test

A simple lattice Boltzmann scheme for low Mach number reactive flows

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Science China(Technological Sciences) 2006年第6期49卷 714-726页

作者： CHEN Sheng1,2, LIU Zhaohui2, ZHANG Chao2, HE Zhu2, TIAN Zhiwei2, SHI Baochang 2 & ZHENG Chuguang2 1. Technology Center of Wuhan Iron and Steel (Group) Company, Wuhan 430080, China 2. State Key Laboratory of Coal Combustion, Hua Zhong University of Science and Technology, Wuhan 430074, China Technology Center of Wuhan Iron Steel [Group] Company Wuhan 430080 China State Key Laboratory of Coal Combustion Hua Zhong University of Science Technology Wuhan 430074 China

For simulating low Mach number reactive flows, a simple and coupled lattice Boltzmann (CLB) scheme is proposed, by which the fluid density can bear significant changes. Different from the existing hybrid lattice Boltzmann (HLB) scheme and non-coupled lattice Boltzmann (NCLB) scheme, this scheme is strictly lattice Boltzmann style and the fluid density couples directly with the temperature. Because it has got rid of the constraint of traditional thought in lattice Boltzmann scheme,on the basis of the equality among the particle speed c, the time step △t and the lattice grid spacing △x held, both c and △t can be adjusted in this scheme according to a "characteristic temperature" instead of the local temperature. The whole algorithm becomes more stable and efficient besides inheriting the intrinsically outstanding strong points of conventional lattice Boltz-mann scheme. In this scheme, we also take into account different molecular weights of species, so it is more suitable for simulating actual low Mach number reactive flows than previous work. In this paper, we simulated a so-called "counter-flow" premixed propane-air flame, and the results got by our scheme are much better than that obtained by NCLB. And the more important thing is that the exploration in this work has offered a kind of brand-new train of thought for building other novel lattice Boltzmann scheme in the future.

关键词： lattice Boltzmann, low Mach number flows, reactive flows, simulation.

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AIGC应用层发展趋势研究

软件和集成电路 2024年第4期 64-75页

作者： 1.国际数据公司(IDC) 2.钉钉(中国)信息技术有限公司国际数据公司(IDC) 钉钉(中国)信息技术有限公司

AIGC作为一条为用户、企业、社会带来切实价值的AI规模化落地路径,将在与企业/个人业务的深度融合过程中起一场应用的“AI革命”,并带来从应用产品形态、开发模式到价值理念的一系列全新变化,而其实现大规模落地的发力点将集中在应用层... 详细信息

AIGC作为一条为用户、企业、社会带来切实价值的AI规模化落地路径,将在与企业/个人业务的深度融合过程中起一场应用的“AI革命”,并带来从应用产品形态、开发模式到价值理念的一系列全新变化,而其实现大规模落地的发力点将集中在应用层的创新层面。

关键词：产品形态深度融合应用层开发模式 AI 发力点发展趋势研究价值理念