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Modeling the intracellular dynamics for Vif-APO mediated HIV-1 virus infection

chinese science Bulletin 2010年第22期55卷 2329-2340页

作者： WANG Yi1,2.& LAI LuHua1,3.1 center for theoretical Biology, Peking University, {2. 100871, china 2.School of physics, Peking University, {2. 100871, china 3.BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, {2. 100871, china center for theoretical Biology Peking University Beijing China School of physics Peking University Beijing China BNLMS State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry and Molecular Engineering Peking University Beijing China

The viral infectivity factor (Vif) was found to be essential for controlling HIV-1 virus infectivity. It targets cellular antiviral proteins in APOBEC family (APO) to trigger its fast degradation and inhibits APO packaging into nascent virion. In the present study, we propose a mathematical model to quantitatively study the intracellular dynamics of these typical virus-host interactions. Four sets of published experimental data were compared with simulation results to justify the model. Systematic parameter sensitivity and perturbation analysis showed that parameters related to APO are crucial to the infectivity of newly synthesized HIV-1 virus. Interestingly, we discovered that the synthesis rate of the viral structure protein Gag and the required number per nascent virion are optimized to achieve high virion production with minimal level of packaged APO, and large portion of model parameters are beneficial to virus only within a relatively small range. Furthermore, minor variations in several parameters related to viral protein Tat, the activator of viral RNA synthesis, were found to induce switch-like behaviors on both incorporated Vif and APO. These findings may provide new insights for understanding the high mutation rate of HIV-1 virus and its latency, as well as help identify key targets for therapeutic design.

关键词：病毒感染载脂蛋白 HIV 细胞内动力学抗病毒蛋白建模介导

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Some evidence of drying trend over northern china from 1951 to 2.04

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chinese science Bulletin 2006年第23期51卷 2913-2925页

作者： MA Zhuguo1,2.& FU Congbin1,2.1. Key Laboratory of Regional Climate-Environment for Temperate East Asia, chinese Academy of {3.s, {2. 10002., china 2. START Regional center for Temperate East Asia, Institute of Atmos-pheric physics, chinese Academy of {3.s, {2. 10002., china Key Laboratory of Regional Climate-Environment for Temperate East Asia Chinese Academy of Sciences Beijing China START Regional center for Temperate East Asia Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China

The surface wetness index, Palmer drought sererity index and the retrieval of soil moisture over china were calculated using monthly precipitation and monthly mean surface air temperature. Based on the contrast analysis of the variation of the above three indices and precipitation, the dry/wet spatio-temporal pattern of northern china in the last 54 years was revealed, and the evidence of drying trend over northern china was analyzed, especially. The results show the following four facts: (1) The drying trend is the main characteristic of the eastern part of Northwest china and the central part of North china since the 1980s and it was enhanced in the last 15 years mainly due to the precipitation decrease and the temperature increase; (2. During the last 54 years, there was only one dry/wet shift at the interdecadal scale occurring in the eastern part of Northwest china and the central part of North china in the late 1970s, which was related to 1977/1978 global abrupt change, whereas there were three shifts in Northeast china, one was in the mid 1990s and the other two were in 1965 and 1983. respectively; (3. Unlike the variation trend of other subregions of northern china, the western part of Northwest china is currently located in a relatively wetting period, which is weak-ened due to the temperature increase; (4) The extreme drought frequency is obviously increasing in the eastern part of Northwest china, the central part of North china and Northeast china since the 1980s, which is closely related to the precipitation decrease and temperature increase in these subregions.

关键词：中国北方干燥趋向干旱索引气候背景

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Challenges in the theoretical investigations of lipid membrane configurations

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chinese physics B 2013年第2期22卷 36-44页

作者：涂展春 Department of physics Beijing Normal University Kavli Institute for theoretical physics {2. Chinese Academy of Sciences

We report some key results in the theoretical investigations of configurations of lipid membranes and present several challenges in this field,which involve（i）the exact solutions to the shape equation of lipid vesicles,（ii）the exact solutions to the governing equations of open lipid membranes,（iii）the neck condition of two-phase vesicles in the budding state,（iv） the nonlocal theory of membrane elasticity,and（v）the relationship between the symmetry and the magnitude of the free energy.

关键词： configuration lipid membrane

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The onset and advance of the Asian summer monsoon

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science Bulletin 2006年第1期51卷 80-88页

作者： Lü Junmei1,2.4, ZHANG Qingyun1, TAO Shiyan1 & JU Jianhua3.1. State Key Laboratory of Numerical Modeling for Atmospheric Sci- ences and Geophysical Fluid Dynamics, Institute of Atmospheric physics, chinese Academy of {2.s, beijing 10002., china 2. Department of Atmospheric {2.s, Yunnan University, Kunming 650091, china 3. china Meteorological Administration Training Centre, beijing 100081, china 4. Graduate School of chinese Academy of {2.s, beijing 10003., china State Key Laboratory of Numerical Modeling for Atmospheric sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Department of Atmospheric sciences Yunnan University Kunming China Graduate School of chinese Academy of sciences Beijing China china Meteorological Administration Training Centre Beijing China

Based on the daily outgoing longwave radiation (OLR) data from National Oceanic and At- mospheric Administration (NOAA) satellites, the Cli- mate Prediction center’s merged analysis of pre- cipitation (CMAP) data and the National centers for Environmental Prediction/National center for At- mospheric Research (NCEP/NCAR) reanalysis dataset, the mean intraseasonal variability of the Asian summer monsoon (ASM) is investigated by using power spectrum analysis, band-pass filter, and diagnostic analyses. The processes of the onset and advance of monsoon over the southern part of Indo- {3. Peninsula, the east coast of Bay of Bengal, the South {3. Sea and the Indian subcontinent are explored. It is found that there is an abrupt change in OLR, precipitation and zonal wind during the onset and advance of the ASM. It is also indicated that the southern part of Indo{3. Peninsula and the adja- cent Andaman Sea is the region where the earliest onset of the ASM occurs in the 2.d pentad of May.

关键词： Asian summer monsoon intraseasonal variability onset advance.

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Archean relic body at lower crust in Sulu area:Evidence from magnetic data

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chinese science Bulletin 2003年第6期48卷 589-593页

作者： WU Qifan1,2. LU Fengxiang3. LIU Qingsheng3. ZHENG Jianping3. WANG Maoji2.& WU Wenli4 1. Department of Engineering physics, Tsinghua University, {3. 100084, {2. 2. Aero Geophysical Survey & Remote Sensing center, {3. 100083. {2. 3. {2. University of Geosciences, Wuhan 43.074, {2. 4. Institute of Geophysical & Geochemical Exploration, Langfang 065000, {2. Department of Engineering physics Tsinghua University Beijing China Aero Geophysical Survey & Remote Sensing center Beijing China china University of Geosciences Wuhan China Institute of Geophysical & Geochemical Exploration Langfang China

After the new 1︰1000000 aero magnetic data were processed and the three-dimensional inversion work was carried out, a vast high magnetic body northwestward was discovered. The magnetic body is located at the depth of about 2. km on the west side of Tanlu fault and at about 2. km on the east side of Tanlu fault beneath the Sulu area. There is a difference of vertical distance of 3.5 km in depth between both sides. We think that the magnetic body is an Archean metamorphic plate and belongs to the North china block. The discovery of the magnetic body is significant for us to reconstruct the structure model of the Sulu orogenic belt, delineate the suture of collision between the North china block and the Yangtze block, and estimate the depth of slipping surface when the eastside of Tanlu fault moved northward.

关键词：苏鲁地区地壳下层太古代残余体地球物理调查区域性磁场三维反演苏鲁造山带郯鲁断裂带大别-苏鲁超高压变质带

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Temporal study of GRS 1915+105 with rms-flux relation:The importance of magnetic activities in the corona

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science china({2.,Mechanics & Astronomy) 2010年第S1期53卷 120-124页

作者： HAN Dong1,ZHANG ShuangNan2.& SONG LiMing2.1 Department of Engineering physics & {3. for Astrophysics,Tsinghua University,beijing 100084,china 2.Key Laboratory of Particle Astrophysics,Institute of High Energy physics,chinese Academy of sciences,beijing 100049,china Department of Engineering physics & center for Astrophysics Tsinghua University Beijing China Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing China

The rms-flux relations for some observations of GRS 1915+105 are *** rms-flux relations of the light curves in only one state,state C or state A,can be described by the simple non-linear model provided Zhang;we thus interpret that such a linear relation reflects the relative importance of magnetic instability for X-ray emission in the corona of the system,compared to the thermal viscous instability for the X-ray emission in the accretion *** rms-flux relations for state B are very scattered,possibly because of the dominance of thermal viscous instability for the X-ray emission in the accretion *** complex rms-flux relations for the observations of transitions between two or three states are caused by the combination of the different rms-flux relations of these *** underlying physical processes are the combination of magnetic topology in the corona and thermal viscous instability in the accretion disk.

关键词： rms-flux relation data analysis GRS 1915+105 magnetic instability

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A phenomenological equation of state for isospin asymmetric nuclear matter

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science china({2.,Mechanics & Astronomy) 2009年第10期52卷 1494-1505页

作者： CHEN LieWen1,2.1 Department of physics,Shanghai Jiao Tong University,Shanghai 2.02.0,china 2.{2. of theoretical Nuclear physics,National Laboratory of Heavy Ion Accelerator,Lanzhou 73.000,china Department of physics Shanghai Jiao Tong University Shanghai China center of theoretical Nuclear {2. National Laboratory of Heavy Ion Accelerator Lanzhou China

A phenomenological momentum-independent(MID) model is constructed to describe the equation of state(EOS) for isospin asymmetric nuclear matter,especially the density dependence of the nuclear symmetry energy Esym(ρ).This model can reasonably describe the general properties of the EOS for symmetric nuclear matter and the symmetry energy predicted by both the sophisticated isospin and momentum dependent MDI model and the Skyrme-Hartree-Fock *** find that there exists a nicely linear correlation between Ksym and L as well as between J0/K0 and K0,where L and Ksym represent,respectively,the slope and curvature parameters of the symmetry energy at the normal nuclear density ρ0,while K0 and J0 are,respectively,the incompressibility and the third-order derivative parameter of symmetric nuclear matter at ρ*** correlations together with the empirical constraints on K0,L and Esym(ρ0) lead to an estimation of -477 MeV Ksat,2.-2.1 MeV for the second-order isospin asymmetry expansion coefficient for the incompressibility of asymmetric nuclear matter at the saturation point.

关键词： equation of state of nuclear matter isospin the symmetry energy

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Bell States and Two-Qubit Logic Gate with Superconducting Charge Qubits Coupling to a Nanomechanical Resonator

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Communications in theoretical physics 2007年第12期48卷 999-1002页

作者： LIAO Jie-Qiao~1 and WANG Xin-Wen~(2.3.~1 Department of physics,Hunan Normal University,Changsha 410081,china~2.Department of physics,beijing Normal University,beijing 100875,china~3.Department of Electronic Engineering and physics,Hunan University of science and Engineering,Yongzhou 42.100,china Department of physics Hunan Normal University Changsha 410081 China Department of physics Beijing Normal University Beijing 100875 China Department of Electronic Engineering and physics Hunan University of Science and Engineering Yongzhou 425100 China

We propose a scheme for generating Bell states involving two SQUID-based charge qubits by coupling themto a nanomechanical *** also show that it is possible to implement a two-qubit logic gate between the twocharge qu... 详细信息

关键词： Bell states superconducting charge qubit two-qubit logic gate nanomechanical resonator

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Enhancement of magnetism of Zn0.95Co0.05O films by p-type Cu+ doping

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Progress in Natural science:Materials International 2011年第1期21卷 31-35页

作者： Wei-chang HAO~(1,5),Jian-jun LI~2.Huai-zhe XU~3.Jia-ou WANG~4,Tian-min WANG~1 1.center of Materials physics and Chemistry,Beihang University,{2. 100083.china 2.Department of Materials science and Engineering, Anhui University of science and Technology,Huainan 2.2.01,china 3.Department of physics,Beihang University,{2. 100083.china 4.{2. Synchrotron Radiation Facility,Institute of High Energy physics, {12. Academy of sciences,100049,china 5.Key Laboratory of Micro-nano Measurement,Manipulation and physics, Ministry of Education,Beihang University,{2. 100191,china center of Materials physics and Chemistry Beihang University Beijing 100083 China Key Laboratory of Micro-nano Measurement Manipulation and Physics Ministry of Education Beihang University Beijing 100191 China Department of Materials science and Engineering Anhui University of Science and Technology Huainan 232001 China Department of physics Beihang University Beijing 100083 China beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of Sciences 100049 China

Zn0.95Co0.05O and Zn0.91Co0.05Cu0.04O thin films were fabricated on Si（111） substrate by the reactive magnetron sputtering method at different O-Ar *** characterizations by X-ray diffractometry（XRD）,X-ray photo-electronic spectrum（XPS）, and electron paramagnetic resonance（EPR） indicate that the doped Cu ions substitute the Zn2.ions in the ZnO *** doped Cu ions are in Cu+and Cu2.mixture valence *** ferromagnetism of the Zn0.91Co0.05Cu0.04O film increases gradually the increasing Cu+ions *** results indicate that the increase of ferromagnetism is not owing to the magnetic contribution of Cu+ions themselves,but owing to the enhancement of magnetic interaction between Co ions,which suggests that p-type doping of Cu+ions plays an important role in mediating the ferromagnetic coupling between Co ions.

关键词： Zn0.95Co0.05O films Zn0.91Co0.05Cu0.04O films magnetic semiconductors magnetic coupling co-doping

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Pressure-induced crystallite breaking in La_(0.7)Sr_(0.3.Mn_(0.9)Fe_(0.1)O_3.nanosolids

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chinese science Bulletin 1998年第6期43卷 458-461页

作者： ZHENG Fanlei 1, 2. SUI Yu 1, 3. XU Dapeng 1 and SU Wenhui 1, 4 1. Department of physics, Jilin University, Changchun 13.02., {3. 2. Changchun Institute of physics, chinese Academy of sciences, Changchun 13.02., {3. 3. Institute of Metal R Department of physics Jilin University Changchun Chinas Changchun Institute of physics Chinese Academy of Sciences Changchun China Institute of Metal Research Chinese Academy of Sciences Shenyang China International center for Materials physics Chinese Academy of Sceinces Shenyang China center for Condensed Matter and Radiation physics CCAST (World Lab.) Beijing China

In the compacting process of the La 0.7Sr 0.3.n 0.9Fe 0.1O 3.nanosolids under the pressure range of 0.0-4.5 GPa, the apparent pressure-induced crystallite breaking phenomenon in these nanosolids was observed. With increasing pressure up to 4.5 GPa, the average grain size decreases by 46% while the magnetization of nanosolids decrease by 40% and their coercive increases by 3.%. This kind of breaking has a close relation to the existence of oxygen deficiency in La 0.7Sr 0.3.n 0.9Fe 0.1O 3.nanoparticles. A simple and convenient method for preparing the bulk nanosolids with a large number of clean interfaces has been suggested.

关键词： nanosolid pressure-induced breaking high pressure.

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