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Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1637-1650页

作者： Yuanliang Yan Shangjun Zhou Xi Chen Qiaoli Yi songshan Feng Zijin Zhao Yuanhong Liu Qiuju Liang Zhijie Xu Zhi Li Lunquan Sun Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008China Xiangya Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China Key laboratory of Molecular Radiation Oncology Hunan Province Changsha 410008China institute of Cancer Research National Clinical Research Center for Geriatric Disorders(Xiangya)Xiangya HospitalCentral South UniversityChangsha 410008China

Temozolomide(TMZ)represents a standard-of-care chemotherapeutic agent in glioblastoma(GBM).However,the development of drug resistance constitutes a significant hurdle in the treatment of malignant *** specific innovative approaches,such as immunotherapy,have shown favorable clinical outcomes,the inherent invasiveness of most gliomas continues to make them challenging to ***,there is an urgent need to identify effective therapeutic targets for gliomas to overcome chemoresistance and facilitate drug *** investigation used mass spectrometry to examine the proteomic profiles of six pairs of GBM patients who underwent standard-of-care treatment and surgery for both primary and recurrent tumors.A total of 648 proteins exhibiting significant differential expression were *** Set Enrichment Analysis(GSEA)unveiled notable alterations in pathways related to METABOLISM_OF_LIPIDS and BIOLOGICAL_OXIDATIONS between the primary and recurrent *** through glioma tissue arrays and the Xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate(IP3)kinase B(ITPKB)in the recurrence group,correlating with poor survival in glioma *** TMZ-resistant cells,the depletion of ITPKB led to an increase in reactive oxygen species(ROS)related to NADPH oxidase(NOX)activity and restored cell sensitivity to ***,the decreased phosphorylation of the E3 ligase Trim25 at the S100 position in recurrent GBM samples accounted for the weakened ITPKB ***,in turn,elevated ITPKB stability and impaired ROS ***,ITPKB depletion or the ITPKB inhibitor GNF362 effectively overcome TMZ chemoresistance in a glioma xenograft mouse *** findings reveal a novel mechanism underlying TMZ resistance and propose ITPKB as a promising therapeutic target forTMZ-resistant GBM.

关键词： TMZ homeostasis impaired

Optimal and robust control of population transfer in asymmetric quantum-dot molecules

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Chinese Physics B 2024年第2期33卷 353-359页

作者：郭裕马松山束传存 Hunan Provincial Key laboratory of Flexible Electronic materials Genome Engineering School of Physics and Electronic ScienceChangsha University of Science and TechnologyChangsha 410114China Hunan Key laboratory of Nanophotonics and Devices School of PhysicsCentral South UniversityChangsha 410083China

We present an optimal and robust quantum control method for efficient population transfer in asymmetric double quantum-dot *** derive a long-duration control scheme that allows for highly efficient population transfer by accurately controlling the amplitude of a narrow-bandwidth *** overcome fluctuations in control field parameters,we employ a frequency-domain quantum optimal control theory method to optimize the spectral phase of a single pulse with broad bandwidth while preserving the spectral *** is shown that this spectral-phase-only optimization approach can successfully identify robust and optimal control fields,leading to efficient population transfer to the target state while concurrently suppressing population transfer to undesired *** method demonstrates resilience to fluctuations in control field parameters,making it a promising approach for reliable and efficient population transfer in practical applications.

关键词： population transfer quantum optimal control theory quantum-dot molecules

面向虚拟地理环境构建的地理分析模型集成应用方法进展

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遥感学报 2024年第5期28卷 1262-1280页

作者：乐松山闾国年温永宁陈旻南京师范大学地理科学学院南京210023 虚拟地理环境教育部重点实验室(南京师范大学) 南京210023 江苏省地理信息资源开发与利用协同创新中心南京210023

地理分析模型作为求解地理问题、模拟地理环境、支撑决策分析的重要资源,在虚拟地理环境(或数字孪生地理环境)的构建中发挥着重要作用。集成多领域具备不同模拟能力的地理分析模型,能够更加全面的表达现实地理环境,支撑构建可视、可用... 详细信息

地理分析模型作为求解地理问题、模拟地理环境、支撑决策分析的重要资源,在虚拟地理环境(或数字孪生地理环境)的构建中发挥着重要作用。集成多领域具备不同模拟能力的地理分析模型,能够更加全面的表达现实地理环境,支撑构建可视、可用、可分析、可交互的虚拟地理环境。针对地理分析模型的集成应用方法,本文系统性梳理了当前的研究进展,从地理分析模型的演进特征、支撑虚拟地理环境构建的途径、多模型的集成方法和地理信息服务的相关支撑技术等方面进行了综述。总结发现,通过多模型集成来解决复杂地理问题已经成为广泛认可的研究途径,自然—人文相结合、融合大数据与深度学习的集成建模也越来越受到关注。然而,现有模型集成方法仍然面临个案化的局限,在处理异构模型的兼容性方面难以形成持续可复用的集成成果,导致模型集成容易陷入到重复的技术改造工作中。借鉴信息服务领域的容器化理念,本文提出了“地理分析模型容器”的思路并进行了方法实现。通过设计柔性装配结构的信息交互通道和事件响应机制的功能计算通道,构建了能够持续积累和提升模型集成复用能力的容器,并基于此种模型容器来进行配置式的模型集成应用。

关键词：遥感地理分析模型虚拟地理环境数字孪生地理环境模型集成地理分析模型容器

The best of both worlds:cicada males change costly signals to achieve mates while females choose a mate based on both calling and courtship songs

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Current Zoology 2022年第6期68卷 716-725页

作者： Zehai HOU songshan WEI Cong WEI Key laboratory of Plant Protection Resources and Pest Management of the Ministry of Education College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China Beijing Key laboratory for Forest Pest Control Beijing Forestry UniversityBeijing 100083China

Cicadas usually sing and mate in the higher parts of *** addressing the effects of different acoustic signals on mate choice in Cicadidae are very *** investigated the effects of both acoustical features and morphological traits on mate choice in an East Asian cicada Platypleura *** produce high-rate calling songs that attract females,then produce low-rate courtship songs to secure mating when a female is *** calling song rate(CR),shorter single-pulse duration,and shorter pulse period of the calling song,together with lower courtship song rate and longer echeme period of the courtship song,are the most desirable traits used by females to choose a *** traits indicate that the more amale can raise the rate of song production,the higher the probability he is sexually selected by the *** correlation was found between morphological traits and mating *** mating,a minority of males started emitting calling songs again,but the CR was significantly lower than before mating and none of them attracted a new mate *** promotes females mating with unmated *** hypothesize that *** may have the best of both worlds due to the unique song modulation and the mechanism of female mate choice:males change energetically,costly acoustic signals to achieve mates,while females choose a mate based on males’acoustic *** results contribute to better understanding the diversity of mating preference and enrich the mechanism of mate choice in acoustic insects.

关键词： acoustic insects Cicadidae courtship mate choice song modulation

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地理信息学科发展的思考

地球信息科学学报 2024年第4期26卷 767-778页

作者：闾国年袁林旺陈旻张雪英周良辰俞肇元罗文乐松山吴明光南京师范大学地理科学学院南京210023 南京师范大学虚拟地理环境教育部重点实验室南京210023 江苏省地理信息资源开发与利用协同创新中心南京210023

地理信息科学(GIS)既有学科自身发展的需求,也是支撑地理学、地球系统科学和未来地球学等前沿探索的技术方法,还是服务于国家战略与社会发展的支撑技术。面对当今地理信息科学发展的内在规律、相关学科发展的外在驱动,以及人工智能等新... 详细信息

地理信息科学(GIS)既有学科自身发展的需求,也是支撑地理学、地球系统科学和未来地球学等前沿探索的技术方法,还是服务于国家战略与社会发展的支撑技术。面对当今地理信息科学发展的内在规律、相关学科发展的外在驱动,以及人工智能等新技术的牵引,本文首先从描述内容、表达维度、表达方式、分析方法与服务模式6个维度,分析了GIS的发展过程,探索了其发展规律;然后,在解读地理学发展的初心与目标的基础上,提出了面向“物理-人文-信息”三元世界的地理学学科体系,讨论了信息地理学研究对象,提出了一个综合信息7要素与地理描述7维度的概念模型;随后,从信息科学视角的地理信息科学、地理学视角的信息地理学、以及语言学视角的地理语言学3个方面分析了地理信息学科的发展趋势。最后,总结了GIS、信息时代的地理学、地理场景、地理大模型等可能的发展方向和要点,以期丰富对地理信息学科的认识,促进地理信息相关科学的发展,提升学科对国家发展需求支撑和社会服务能力。

关键词：地理信息地理信息系统地理信息科学信息地理学地理语言学地理场景三元世界

Females prefer males producing a high-rate song with shorter timbal-stridulatory sound intervals in a cicada species

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Current Zoology 2022年第1期68卷 103-112页

作者： Zehai HOU Yunxiang LIU songshan WEI Cong WEI Key laboratory of Plant Protection Resources and Pest Management of the Ministry of Education College of Plant ProtectionNorthwest A&F UniversityYanglingShaanxi 712100China Beijing Key laboratory for Forest Pest Control College of ForestryBeijing Forestry UniversityBeijing 100083China

Uncovering mate choice and factors that lead to the choice are very important to understanding sexual selection in evolutionary *** are known for their loud sounds produced by males using the ***,males in certain cicada species emit 2 kinds of sounds using respectively timbals and stridulatory organs,and females may produce their own sounds to respond to *** has never been considered is the mate choice in such cicada ***,we investigate the sexual selection and potential impact of predation pressure on mate choice in the cicada Subpsaltria yangi *** possesses stridulatory sound-producing organs in both sexes in addition to the timbals in *** show that males producing calling songs with shorter timbal–stridulatory sound intervals and a higher call rate achieved greater mating *** morphological traits were found to be correlated with mating success in both sexes,suggesting neither males nor females display mate preference for the opposite sex based on morphological *** do not discriminate among responding females during mate searching,which may be due to the high energy costs associated with their unusual mate-seeking activity and the male-biased predation *** generally mate once but a minority of them re-mated after oviposition which,combined with the desirable acoustic traits of males,suggest females may maximize their reproductive success by choosing a high-quality male in the first *** study contributes to our understanding mechanisms of sexual selection in cicadas and other insects suffering selective pressure from predators.

关键词： Cicadidae female choice mating success predation pressure sexual selection.

基于预制孔的SiCf/SiC复合材料微小孔超声振动辅助钻削加工研究

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电加工与模具 2024年第3期 54-60页

作者：肖培乾汪文虎吴晓锋蒋松山熊一峰西北工业大学机电学院航空发动机高性能制造工业和信息化部重点实验室航空发动机先进制造技术教育部工程研究中心陕西西安710072 中国航发动力股份有限公司陕西西安710021

SiCf/SiC复合材料是典型的硬脆性难加工材料。为解决SiCf/SiC复合材料微小孔(<1 mm)加工难题,提高加工精度和改善加工质量,先采用脉冲激光预制SiCf/SiC微小孔,再在不同预制孔尺寸和加工参数下开展直径0.5 mm的SiCf/SiC微小孔超声振动辅... 详细信息

SiCf/SiC复合材料是典型的硬脆性难加工材料。为解决SiCf/SiC复合材料微小孔(2~10mm/min,可获得加工质量较好的SiCf/SiC微小孔。

关键词：陶瓷基复合材料激光预制孔超声辅助钻削微小孔

Performance analysis of global HYCOM flow field using Argo profiles

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International Journal of Digital Earth 2023年第1期16卷 3536-3559页

作者： Yixuan Zhang songshan Yue Kai Xu Zhuo Zhang Liangcheng Zhou Yihan Zhang Guonian Lü School of Geography Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC)Nanjing Normal UniversityNanjingPeople’s Republic of China State Key laboratory Cultivation Base of Geographical Environment Evolution(Jiangsu Province) NanjingPeople’s Republic of China Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application NanjingPeople’s Republic of China

Flow field data generated by ocean models are important for simulating ocean currents and circulation patterns,which are essential components in digital Earth *** evaluate the accuracy of model-simulatedflow felds,Array for Real-timeGeostrophic Oceanography(Argo)float observations can be considered *** this study,a novel method for comparing Argo profiles with 3-dimensional trajectories obtained by simulating Argo floats in Hybrid Coordinate Ocean Model(HYCOM)-provided flow fields was *** and subsurface trajectories were calculated,and their spatial matching characteristics were *** results demonstrated that(1)the HYCOM surface and subsurface flow felds generally conform to the basic characteristics and trends of ocean currents;(2)the HYCOM sea surface current field error pattern exhibits a symmetrical distribution centered on the equator in the Northern and Southern Hemispheres and increases with increasing latitude;and(3)the HYCOM subsurface flow field exhibits regional differences,with the largest differences in the Gulf Stream,North Atlantic Warm Current,and Westerly Wind Drift *** analysis of the disparities between HYCOM and Argo data,the effectiveness of using model simulation data can be enhanced,and the accuracy and dependability of ocean models can be improved.

关键词： HYCoOM Argo floats ocean flow field trajectory matching ocean modeling

A universal spray printing strategy to prepare gradient hybrid architectures

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Carbon Energy 2022年第4期4卷 517-526页

作者： Lingyu Du songshan Bi Yang Hu Rui Wang Jiacai Zhu Minghui Zhang Zhiqiang Niu Key laboratory of Advanced Energy materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjinP.R.China

Functionally gradient materials(FGMs)have attracted tremendous attention due to their unique properties and ***,it is still a great challenge to prepare scalable FGMs by a universal,cost-effective,and highly efficient ***,a strategy of combining in situ concentration regulation and spraying is developed to fabricate continuously gradient composite films(GCFs),where the component gradient variation can be well *** strategy is universal and versatile,which is beneficial to inducing different components into GCFs with gradient distributions and further constructing them with diverse configurations on various *** gradient design endows the composite films with excellent mechanical strength and gradient electron transport pathways,which ensures that GCFs directly serve as the electrodes in electrochemical *** a proof of concept,free-standing GCFs based on V2O5 nanomaterials are used as cathodes of aqueous zinc-ion *** resultant devices deliver superior electrochemical performances in comparison with the counterparts of homogeneous ***,this universal strategy provides a promising route in the scalable production of FGMs and further extends their applications in various fields.

关键词： aqueous zinc-ion batteries functionally gradient materials spraying universality