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Electric-stimulus rate encoding algorithm of Mandarin tonal information in cochlear implant

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Progress in Natural Science:Materials International 2006年第12期16卷 1315-1321页

作者： GUAN Tian~1, GONG Qin~1 and YE Datian~2.*(1. Department of Biomedical Engineering, tsinghua university, beijing 100084, {2. 2. research center of Biomedical Engineering, Graduate School at Shenzhen, tsinghua university, Shenzhen 518055, {2.) [a]Department of Biomedical Engineering Tsinghua University Beijing China [b]research center of Biomedical Engineering Graduate School at Shenzhen Tsinghua University Shenzhen China

The modern multi-channel cochlear implants usually extract and encode the temporal envelope cues. This kind of algorithms can hardly satisfy the users who speak tonal languages, such as Mandarin. Many studies have tried to enhance the recognition ability of Mandarin through encoding tonal information and made suggestions to frequency-modulate the fixed pulse-rate carrier with the extracted tonal information based on the rate-pitch theory in electric hearing. However, how to encode and deliver the tonal information such as F_0by changing electric-stimulus rate has not got further study in clinical electric-stimulus mode. The present paper focuses on this matter by piecewise calculating the appreciable electric-stimulus rates. Then an electric-stimulus encoding algorithm of Mandarin tone is brought forward and testified through acoustic simulations. Such conclusion can be drawn that this algorithm of electric-stimulus rate could convey tonal information well and help to enhance the Mandarin speech recognition ability.

关键词： cochlear implant tone fundamental frequency electric-stimulus rate.

Theoretical research progress in new-generation Internet architecture

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Science in china(Series F) 2008年第11期51卷 1634-1660页

作者： WU JianPing1,2.3,LIU Ying2.3 & WU Qian2.3 1 Department of Computer Science,tsinghua university,beijing 100084,{2. 2.network research center,tsinghua university,beijing 100084,{2. 3 tsinghua National Laboratory for Information Science and Technology(TNList) ,beijing 100084,{2. 1. Department of Computer Science Tsinghua University Beijing 100084 China 2. network research {2. Tsinghua University Beijing 100084 China 3. tsinghua National Laboratory for Information Science and Technology (TNList) Beijing 100084 China

Internet has become the most important information infrastructure supporting modern socio-economic development, social progress and technological Innovation. Invented 30 years ago, today Internet is facing increasingly severe technical challenges. This paper introduces the progress of the major international newgeneration Internet research plans; analyzes its basic characteristics and the principal contradictions during the development; detsiledly introduces the research carried out by 973 Project ＂research of Future Internet Architecture＂ on the key scientific issues of new-generation Internet architecture and its latest research results; and looks to the future of the research-focus faced with the new situations of the basic research of new-generation Internet architecture as well as the new demands of innovative applications on Internet architecture.

关键词： new-generation Internet network architecture multi-dimension scalability

Explanation of the mechanism of carcinogenesis and syntheses of anticancer agents with high selectivity

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Science china Chemistry 2006年第1期49卷 44-62页

作者： DAI Qianhuan1,2.1. center of Chemistry and Bioengineering of Cancer research, {2. Polytechnic university (Now known as {2. Univer-sity of Technology), {2. 10002., china 2. center of Environmental Sciences, Peking university, {2. 100871, china 1. center of Chemistry and Bioengineering of Cancer research Beijing Polytechnic University Beijing 100022 China 2. center of Environmental Sciences Peking University Beijing 100871 China

In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carcinogen always metabolizes to form a specialbi-functional alky-lating agent. This agent induces cross-linkages between the complementary basepairs in DMA and switches on initial mutageneses in genomes including point and frameshiftmutations. This, in turn, induces further deep mutageneses including the production of variouschimeric chromosomes, deletions and other aberrations found in genomes. In the end this initiatescarcinogenesis of the whole cell through the reverse transcription mechanism after a lengthyincubation period. Recently, this laboratory has verified that physical carcinogenesis, includingthe oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced byendogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing theformation of cross-linkages between the complementary base pairs in DNA. Di-region theory has nowbeen supported by many experimental observations such as mutational spectra of various *** potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together asgenetic toxicity appears to originate almost uniformly from the cross-linking between complementarybases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms ofcross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylationanticancer activity but lack genetic toxicity. The predictable design and synthesis of a highselectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued incancer chemotherapy, have been realized for the first time in this laboratory by inhibitingmalignant and heightening benign cross-linking using the principles of di-region theory. A series ofpatented new anticanc

关键词： mechanism of carcinogenesis, di-region theory, minoplatin, selectivity of anticancer agent, cross-linking between DNA bases, anticancer platinum complexes, predictive design of anticancer agent, second generation anticancer agent.

RRM:An incentive reputation model for promoting good behaviors in distributed systems

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Science in china(Series F) 2008年第11期51卷 1871-1882页

作者： ZHANG Hong1,2.DUAN HaiXin1,3 & LIU Wu1,3 1 tsinghua National Laboratory for Information Science and Technology,tsinghua university,{2. 100084,china 2.Department of Computer Science and Technology,tsinghua university,{2. 100084,china 3 network research center,tsinghua university,{2. 100084,china 1. tsinghua National Laboratory for Information Science and Technology Tsinghua University Beijing 100084 China 2. Department of Computer Science and Technology Tsinghua University Beijing 100084 China 3. network research {2. Tsinghua University Beijing 100084 China

Reputation systems represent soft security mechanisms that complement traditional information security mechanisms. They are now widely used in online e-commerce markets and communities in order to stimulate good behaviors as well as to restrain adverse behaviors. This paper analyzes the limitations of the conversational reputation models and proposes an incentive reputation model called the resilient reputation model （RRM） for the distributed reputation systems. The objective of this reputation model is not only to encourage the users to provide good services and, therefore, to maximize the probability of good transaction outcomes, but also to punish those adverse users who are trying to manipulate the application systems. The simulation results indicate that the proposed reputation model （RRM） could effectively resist against the common adverse behaviors, while protecting the profits of sincere users from being blemished by those adversaries.

关键词： reputation model distributed system trust soft security

The age of synthesis:From cognitive science to converging technologies and hereafter

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Chinese Science Bulletin 2011年第6期56卷 465-475页

作者： CAI ShuShan1,2.1 Department of Psychology, tsinghua university, beijing 10084, {2. 2.center for Psychology and Cognitive Science, tsinghua university, beijing 10084, {2. Department of Psychology Tsinghua University center for Psychology and Cognitive Science Tsinghua University

This paper describes the development of two of the most important scientific disciplines in the last quarter of the 2.th century, cognitive science, which emerged in 1975, and nano-bio-info-cogno (NBIC) converging technologies, which emerged in 2.00. In this century, we will achieve cross-disciplinary integration, innovation in comprehensive knowledge and comprehensive devel opment in human resources. NBIC converging technologies will greatly expand human cognition and communication, improve human health, enhance social outcomes, strengthen national security and unify science and education. Cognitive science and converging technologies will have major effects on the future human development. I argue that the 2.st century represents an age of synthesis, reflected in the continual reintegration between scientific disciplines in recent times. This new age of synthesis will require innovations in thought and methodology that differ from those underlying the age of analysis in the 2.th century. I predict that these developments will allow every individual to realize comprehensive development. Accordingly, the education system will be transformed, and a comprehensive human resources system will be created.

关键词：认知科学融合技术化学合成教育系统人力资源人类健康生物信息综合知识

A preliminary study on vegetation-erosion dynamics and its applications

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Science china Earth Sciences 2005年第5期48卷 689-700页

作者： WANG Zhaoyin 1,2., WANG Guangqian 1 , LI Changzhi 1 & WANG Feixin 1 1. Department of Hydraulic Engineering, tsinghua university, beijing 100084, {2. 2. International research and Training center on Erosion and Sedimentation, beijing 100084, {2. 1. Department of Hydraulic Engineering Tsinghua University 100084 Beijing China 2. International research and Training center on Erosion and Sedimentation 100084 Beijing China

Vegetation-erosion dynamics is a new interdisciplinary science, studying the laws of evolution of watershed vegetation under the action of various ecological stresses. Introducing a qualitative expression of ecological stresses in this paper, the present authors establish the cou- pled differential equations for the vegetation-erosion process and derive a theoretical solution. The model is applied to the Anjiagou watershed on the Loess Pateau and the Xiaojiang water- shed and its sub-watersheds on the Yunnan Plateau. The calculated results agree well with the vegetation development processes. Abstracted from the differential equations the so-called vegetation-erosion chart is worked out, with which we can predict the development trend of vegetation under no human stresses. It is demonstrated that the erosion control is important for vegetation development and reforestation must be a long-term strategy. On the Yunnan Plateau with relatively high precipitation and temperature, vegetation can be greatly improved if erosion is controlled. On the dry and cold Loess Pateau suffering from high rate of soil erosion, however, vegetation can effectively control erosion but erosion reduction exhibits low effectiveness on vegetation development. Vegetation in the area is not stable and management is always needed to maintain the vegetation.

关键词： vegetation-erosion dynamics, human activities, coupled differential equations, erosion control, vigor ofvegetation.

Extremal eigenvalues of measure differential equations with fixed variation

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Science china Mathematics 2010年第10期53卷 2573-2588页

作者： ZHANG MeiRong 1,2.1 Department of Mathematical Sciences,tsinghua university,beijing 100084,{2. 2.Zhou Pei-Yuan center for Applied Mathematics,tsinghua university,beijing 100084,{2. 1. Department of Mathematical Sciences Tsinghua University Beijing 100084 China2. Zhou Pei-Yuan Center for Applied Mathematics Tsinghua University Beijing 100084 China

In this paper we will study eigenvalues of measure differential equations which are motivated by physical problems when physical quantities are not absolutely *** taking Neumann eigenvalues of measure differential equations as an example,we will show how the extremal problems can be completely solved by exploiting the continuity results of eigenvalues in weak* topology of measures and the Lagrange multiplier rule for nonsmooth *** results can give another explanation for extremal eigenvalues of SturmLiouville operators with integrable potentials.

关键词： measure differential equation eigenvalue extremal value weak* topology Frechét derivative sub-differential

A formal method to real-time protocol interoperability testing

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Science in china(Series F) 2008年第11期51卷 1723-1744页

作者： WANG ZhiLiang1,3,YIN Xia2.3 & JING ChuanMing2.3 1 network research {2.,tsinghua university,beijing 100084,china 2.Department of Computer Science and Technology,tsinghua university,beijing 100084,china 3 tsinghua National Laboratory for Information Science and Technology(TNList) ,beijing 100084,china 1. network research {2. Tsinghua University Beijing 100084 China 3. tsinghua National Laboratory for Information Science and Technology (TNList) Beijing 100084 China 2. Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Interoperability testing is an important technique to ensure the quality of implementations of network communication protocol. In the next generation Internet protocol, real-time applications should be supported effectively. However, time constraints were not considered in the related studies of protocol interoperability testing, so existing interoperability testing methods are difficult to be applied in real-time protocol interoperability testing. In this paper, a formal method to real-time protocol interoperability testing is proposed. Firstly, a formal model CMpTIOA （communicating multi-port timed input output automata） is defined to specify the system under test （SUT） in real-time protocol interoperability testing; based on this model, timed interoperability relation is then defined. In order to check this relation, a test generation method is presented to generate a parameterized test behavior tree from SUT model; a mechanism of executability pre-determination is also integrated in the test generation method to alleviate state space explosion problem to some extent. The proposed theory and method are then applied in interoperability testing of IPv6 neighbor discovery protocol to show the feasibility of this method.

关键词： protocol testing interoperability testing real-time testing test generation timed input output automata(TIOA)

Density-functional formula for strongly correlated systems

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Progress in Natural Science:Materials International 2005年第5期15卷 395-401页

作者： WANG Huaiyu1*, HAN Rushan2.and CHEN Nanxian1(1. Department of Physics, tsinghua university, beijing 100084, {2. 2. Department of Physics, Peking university, beijing 100871, {2.) Department of Physics Tsinghua University Beijing 100084 China Department of Physics Peking University Beijing 100871 China

Density functional method is applied for strongly correlated systems. Based on the assumption that the systems are composed of electrons in singly-occupied orbitals and those in doubly-occupied orbitals, a set of self-consistent equations are obtained by standard variation procedure. The equations consist of two parts. One part is to solve the wave functions of the electrons in singly-occupied orbitals and the other is to solve the wave functions of the electrons in doubly-occupied orbitals. The physical meanings of the terms appearing in the equations are discussed.

关键词： density-functional theory strongly correlated systems doubly-occupied orbital two-particle wave function self-consistent equations.