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Rice science 2010年第4期17卷 257-268页

作者： HUANG Ming XIE Fang-min CHEN Li-yun ZHAO Xiang-qian L. JOJEE D. MADONNA Rice research Institute Hunan Agricultural University Changsha 410128 China Plant Breeding Genetics and Biotechnology Division International Rice Research Institute Metro Manila DAPO Box 7777 Philippines Grain Quality Nutrition and Postharvest Center International Rice Research Institute Metro Manila DAPO Box 7777 Philippines

Genetic diversity of 36 rice entries from the United States Department of Agriculture （USDA） rice collection was assessed using 103 ILP （intron length polymorphism） and 54 SSR （simple sequence repeats） markers. A total of 236 and 332 alleles were detected by the ILP and SSR markers, respectively. On average, the SSR markers produced higher polymorphism information content value and number of alleles than the ILP markers. Whereas the Nei＇s genetic distance measured using the SSR markers was much higher than that measured using the ILP markers. Manters test indicated that there was a statistically significant correlation （r=0.827, P〈0.001 ） between the two marker systems. UPGMA clustering based on the ILP and SSR markers resulted in consensus dendrograms. The cophenetic correlation coefficient （r=0.918, 0.878 and 0.924, P〈0.001 for the ILP, SSR and combined markers, respectively） showed a highly accurate dendrogram represented the genetic distance among these entries. The 36 entries were divided into four groups. Four African Oryza glaberrima accessions were clustered within a distinct group （I）, and the remaining entries were separated into three groups （11, III and IV）. All the entries could be also clustered into two main groups： One was composed of III and IV, considered as indica group, and the other was composed of I （O. glaberrima） and II （japonica-like）. Model-based cluster analysis revealed that the japonica-like group maintained very pure ancestry while the indica group shared mixed ancestry, especially for group III, which had seven admixtures sharing from 19.5% to 30.0% of ancestry with group IV （based on SSR markers）. It is suggested that ILP and SSR markers could be very useful for the genetic study and breeding in rice.

关键词： rice genetic diversity cluster analysis structure simple sequence repeats intron length polymorphism

Association and linkage analysis of COLIA1 and AHSG gene polymorphisms with femoral neck bone geometric parameters in both Caucasian and Chinese nuclear families

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Acta Pharmacologica Sinica 2007年第3期 375-381页

作者： Hui JIANG~(2,3,5) Shu-feng LEI~(2,5) Su-mei XIAO~2 Yuan CHEN~(2,3) Xiao SUN~2 Fang YANG~(2,3) Li-ming LI~2 Shan WU~2 Hong-wen DENG~(2,4,6)2 Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education,College of Life Sciences,Hu-nan Normal university,changsha 410081,china 3 Osteoporosis research center,Creighton university,Omaha 68131,USA 4 Department of Orthopedic Surgery,School of Medicine,university of Missouri-Kansas City,Kansas City 64108,USA

Aim:To simultaneously investigate the contribution of the alpha 1 chain of col-lagen type 1(COLlAl)and alpha2-HS-glycoprotein(AHSG)genes to the varia-tion of bone geometric parameters in both Caucasians and ***:Sixhundred and five Caucasian individuals from 157 nuclear families and 1228 Chi-nese subjects from 400 nuclear families were genotyped at the AHSG-Sacl,COLIA1-PCOL2 and Spl polymorphisms using polymerase chain reaction(PCR)-restric-tion fragment length polymorphism(RFLP).5 FN bone geometric parameters werecalculated based on bone mineral density and bone area of femoral neck(FN)measured by dual energy X-ray *** stratification,totalfamily association,within-family association,and linkage tests were performed bythe quantitative transmission disequilibrium test ***:The t-testshowed the significant differences of all bone geometric phenotypes(except ED)between Caucasians and Chinese in the offspring using both unadjusted andadjusted(by age,height,weight,and gender)*** Caucasians,we foundsignificant within-family association results between the COLlAl-Spl polymor-phism(rs1800012)and cross sectional area(CSA),cortical thickness(CT),endocortical diameter(ED),buckling ratio(BR)(P=0.018,0.002,0.023,and 0.001,respectively);the COLlAl-Spl polymorphism also detected significant linkagewith BR(P=0.039).In the population of china,the within-family associationsbetween the COLlAl-PCOL2 polymorphism(rs1107946)and CT,BR were signifi-cant(P=0.012 and 0.008,respectively).Furthermore,evidence of linkage wereobserved between the AHSG-Sacl polymorphism(rs4918)and CT,BR(P=0.042and 0.014,respectively)in Caucasians,but not in ***:Ourresults suggest that the COLlAl gene may have significantly association withbone geometry in both Caucasians and Chinese,and the AHSG gene may belinked to bone geometry in Caucasians,but not in *** study representsour first efforts on investigating the importance of the COLlAl and A

关键词： COLIA1 AHSG bone geometry transmission disequilibrium test

Mutation screening of the HDC gene in Chinese Han patients with Tourette syndrome

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Mutation screening of the HDC gene in Chinese Han patients w...

micro-Doppler characteristics of sliding-type scattering center on rotationally symmetric target

中国的遗传学研究——遗传学进步推动中国西部经济与社会发展——2011年中国遗传学会大会

作者： Jing Lei~(1,2),Xiong Deng~1,Jie Zhang~3,Linyan Su~4,Hongbo Xu~1,Hui Liang~1,Xian Huang~2,Zhi Song~2,and Hao Deng~(1,2) 1 center for Experimental Medicine,the Third Xiangya Hospital,Central South university,changsha,china 2 Department of Neurology,the Third Xiangya Hospital,Central South university.changsha,china 3 Department of Neurology.hunan Children’s Hospital,changsha,china 4 Dapartment of Psychiatry,the Second Xiangya Hospital,Central South university,changsha,china

Tourette Syndrome(TS) is a complex neuropsychiatric disorder characterized by vocal and motor *** environmental causes have been proposed to play a role,genetic factors are believed to be the main determinants of the disorder and its clinical ***,A heterozygous G>A transition in exon 9 of the histidine decarboxylase gene(HDC) was reported to be associated with TS in a two-generation *** investigate whether the HDC gene play a role in TS in Chinese Han population,we performed genetic analysis of coding region of the HDC gene in 100 Chinese Han patients with *** variants were found including a C>T transition (IVS1+52C>T),a novel C>A transition(c.426C>A) in exon 4 and a novel G>A transition(c. 1743G>A) in exon 12,both predicted with no amino acid *** analysis was conducted in a total of 120 TS patients and 240 sex,age and ethnicity matched healthy controls. No significant differences in genotypic and allele distribution between patients and controls for these three variants(p = 0.274,p =1.000 and p = 0.632 for genotypic distribution,respectively;p = 0.143,p=1.000 and p = 0.734 for allele distribution,respectively) were observed,suggesting variants in the HDC gene may play little or no role in TS susceptibility in Chinese Han population.

关键词： Tourette Syndrome the HDC gene variant susceptibility

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Science china(Information Sciences) 2011年第9期54卷 1957-1967页

作者： MA Liang,LIU Jin,WANG Tao,LI YongZhen & WANG XueSong School of Electronic Science and Engineering,National university of Defense Technology,changsha 410073,china 1. School of Electronic Science and Engineering National University of Defense Technology Changsha 410073 China

The feature of micro-motion is one of the most effective features used for radar recognition in midcourse *** present,the study of feature extraction and recognition is usually based on the assumption that the micro-motion of the scattering center and warhead itself is the same,and the radar echo is sinusoid-FM ***,this assumption ignores the fact that the scattering center would slide on the warhead with the change of the aspect *** this paper,a complete micro-motion model is set for the scattering centers of different positions on the warhead,and the mathematical expression of the micro-Doppler of the sliding-type scattering center is obtained for the first *** approximation of Taylor expansion under the background of missile confrontation is studied *** curve of this micro-Doppler is not the generally assumed *** measurement of a precessional target in microwave anechoic chamber is done to vividly observe the sliding feature of the scattering *** measurement results agree with the theoretic analysis in this *** research on micro-Doppler characteristics of sliding-type scattering center provides a more accurate model for the micro-motion simulation and feature extraction of precessional warheads.

关键词： rotationally symmetric target sliding-type scattering center precession micro-Doppler

A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir

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Cell research 2007年第4期17卷 357-362页

作者： Chuan-Yun Li~(1,*) Quan Yu~(2,*) Zhi-Qiang Ye~(1,*) Ying Sun~1 Quanyuan He~(1,3) Xiao-Mo Li~1 Wuxue Zhang~1 Jingchu Luo~1 Xiaocheng Gu~1 Xiaofeng Zheng~2 Liping Wei~1 ~1center for Bioinformatics,~2Department of Biochemistry and Molecular Biology,National Laboratory of Protein Engineering and Plant Genetic Engineering,College of Life Sciences,Peking university,Beijing 100871,china ~3Laboratory of Biochemistry,College of Life Sciences,hunan Normal university,changsha 410081,china centerforBioinformatics DepartmentofBiochemistryandMolecularBiology NationalLaboratoryofProteinEngineeringandPlantGeneticEngineeringCollegeofLifeSciencesPekingUniversityBeijing100871China

The use of oseltamivir,widely stockpiled as one of the drugs for use in a possible avian influenza pandemic,has beenreported to be associated with neuropsychiatric disorders and severe skin reactions,primarily in *** we identi-fied a nonsynonymous SNP(single nucleotide polymorphism)in dbSNP database,R41 Q,near the enzymatic active siteof human cytosolic sialidase,a homologue of virus neuraminidase that is the target of *** SNP occurredin 9.29% of Asian population and none of European and African American *** structural analyses and Kimeasurements using in vitro sialidase assays indicated that this SNP could increase the unintended binding affinity ofhuman sialidase to oseltamivir carboxylate,the active form of oseltamivir,thus reducing sialidase *** addition,this SNP itself results in an enzyme with an intrinsically lower sialidase activity,as shown by its increased Km anddecreased Vmax *** administration of oseltamivir to people with this SNP might further reduce theirsialidase *** note the similarity between the reported neuropsychiatric side effects of oseltamivir and the knownsymptoms of human sialidase-related *** propose that this Asian-enriched sialidase variation caused by theSNP,likely in homozygous form,may be associated with certain severe adverse reactions to oseltamivir.

关键词： Asia SNP neuraminidase inhibitor oseltamivir sialidase bioinformatics

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职业兴趣调查表的编制

中国临床心理学杂志 1999年第2期7卷 77-80页

作者：刘少文龚耀先湖南医科大学附二院医学心理研究中心

目的：编制一套适用于我国的职业兴趣量表。方法：以Ｈｏｌａｎｄ理论为框架，在职业、工作活动、娱乐活动和自我评价四个方面收集了符合我国文化与职业分类情况的项目２６８条。在长沙地区５所高校１７个系２８个专业的３～４年级大学... 详细信息

目的：编制一套适用于我国的职业兴趣量表。方法：以Ｈｏｌａｎｄ理论为框架，在职业、工作活动、娱乐活动和自我评价四个方面收集了符合我国文化与职业分类情况的项目２６８条。在长沙地区５所高校１７个系２８个专业的３～４年级大学生取样１２７０人。结果：用因素分析的方法在职业、工作活动和自我评价三个方面内容中得到了符合Ｈｏｌａｎｄ理论的ＲＩＡＳＥＣ因素结构。建立了区域性大学生男、女均数常模和Ｔ分常模，量表的信度和效度符合测量学要求。结论：所制定的量表达到了心理测量学要求。

关键词：职业兴趣调查表常模信度效度

Fundamental study of CO_2 control technologies and policies in china

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Science china(Technological Sciences) 2008年第7期51卷 857-870页

作者： JIN HongGuang1, ZHANG XiLiang2, GAO Lin1, YUE Li2, HE JianKun2 & CAI RuiXian1 1 Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100080, china 2 Institute of Nuclear and New Energy Technology, Tsinghua university, Beijing 100084, china 1. Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100080 China 2. Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China

The technical roadmap and policies for CO2 mitigation suitable for china are a common center of attention in the fields of energy, environment, and management science in the country. Emphasizing interaction between technical research and policy research, this work discovers the potential breakthrough in the integrated field. The technical difficulties of recovering CO2 are pointed out, the mechanism of combining CO2 recovery with energy conversion is investigated, and the basic principle for integrating an environmental-friendly energy system is discussed. Moreover, the formulation of a new energy system that can recover CO2 with very low or even zero energy penalty is proposed, while the assessment methodology and model system for the technical roadmap of CO2 emission control are developed. Finally, a new technical roadmap constructing an energy network suitable for china is proposed, which may provide a new way for the development of sustainable energy and environment technologies.

关键词： CO2 capture and storage technical roadmap energy policy

Analysis of the impact of Satellite Payload’s Channel Characteristic on the performance of carrier tracking

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Analysis of the impact of Satellite Payload’s Channel Chara...

湖南苗族人群HLA-A,-B和-DRB1基因多态性的研究(英文)

第三届中国卫星导航学术年会

作者： Li Caihua *, Chen Lei, Wu Xiangyu, Chen FanSatellite Navigation research and Development center, National university of DefenseTechnology, changsha, china

As the effect of analog device on Satellite Payload, such as amplifier, mixer and filter, there will be distortion for the constant envelope signals, which would affect the performance of carrier tracking. To address this issue, this paper established the generic model for analyzing navigation signals channel characteristic and non-linear distortion, and conducted the relation between channel characteristic and PLL tracking error. Then, we analyzed the impact of channel characteristic on performance of Navigation Signals carrier tracking quantificationally. At last, the analysis result is verified in a software receiver for Galileo signals.

关键词： satellite payload channel characteristic non-linear distortion PLL tracking error software receiver

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中南大学学报（医学版） 2010年第4期35卷 277-285页

作者：钱小兵谢毓滨卢光琇中国科学院研究生院北京100049 人类干细胞国家工程研究中心长沙410078 长沙市血液中心长沙410001 中南大学生殖与干细胞工程研究所长沙410078

目的:探讨湖南苗族人群HLA-A,-B和-DRB1位点等位基因及单倍型遗传多态性。方法:应用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSO)反向流式芯片方法对154例湖南苗族健康个体进行HLA-A,-B和-DRB1位点中低分辨基因分型,计算等位基因频率... 详细信息

目的:探讨湖南苗族人群HLA-A,-B和-DRB1位点等位基因及单倍型遗传多态性。方法:应用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSO)反向流式芯片方法对154例湖南苗族健康个体进行HLA-A,-B和-DRB1位点中低分辨基因分型,计算等位基因频率和单倍型频率,并与其他人群进行比较。结果:154例湖南苗族个体的HLA-A,B,DRB1基因座分别检出等位基因10,25,13种,频率较高的等位基因有A*11(38.96%),A*02(27.27%),A*24(18.83%),B*40(60)(17.53%),B*46(13.96%),B*15(75)(11.69%),DRB1*09(15.26%),DRB1*12(15.26%),DRB1*15(15.26%)及DRB1*04(12.66%)等;高频的单倍型有A11-B60(9.60%),A2-B46(9.27%),A11-B75(9.22%),B75-DR12(6.31%),A11-DR12(9.62%),A11-DR4(9.07%),A11-DR15(6.69%),A11-B75-DR12(5.43%),A11-B60-DR4(4.24%),A2-B46-DR9(3.71%)等。与国内其他人群比较显示,湖南苗族与南方人群HLA多态性较为相近。结论:湖南苗族人群HLA等位基因及单倍型具有较高的遗传多态性,其分布具有中国南方人群的特点。

关键词：苗族 HLA-A,-B,-DRB1 等位基因单倍型基因多态性