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Bacterial Phosphoproteomic Analysis Reveals the Correlation Between Protein Phosphorylation and Bacterial Pathogenicity

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Genomics,Proteomics & Bioinformatics 2011年第Z2期 119-127页

作者： Ruiguang Ge and Weiran Shan laboratory of integrative Biosciences, college of life sciences, sun yat-sen university, guangzhou 510275, china

Increasing evidence shows that protein phosphorylation on serine, threonine and tyrosine residues is a major regulatory post-translational modification in the bacteria. This review focuses on the implications of bacterial phosphoproteome in bacterial pathogenicity and highlights recent development of methods in phosphoproteomics and the connectivity of the phosphorylation networks. Recent technical developments in the high accuracy mass spectrometry have dramatically transformed proteomics and made it possible the characterization of a few exhaus- tive site-specific bacterial phosphoproteomes. The high abundance of tyrosine phosphorylations in a few bacterial phosphoproteomes suggests their roles in the pathogenicity, especially in the case of pathogen-host interactions; the high abundance of multi-phosphorylation sites in bacterial phosphoprotein is a compensation of the relatively small phosphorylation size and an indicator of the delicate regulation of protein functions.

关键词： protein phosphorylation bacterium pathogenicity phosphoproteomics

^(40)Ar/^(39)Ar chronology and geochemistry of high-K volcanic rocks in the Mangkang basin, Tibet

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Science china Earth sciences 2005年第1期48卷 1-12页

作者： ZHANG Huihua, HE Huaiyu, WANG Jianghai & XIE Guanghong guangzhou Institute of Geochemistry, Chinese Academy of sciences, guangzhou 510640, china Institute of Geology and Geophysics, Chinese Academy of sciences, Beijing 100029, china college of life sciences, sun yat-sen university, guangzhou 510275, china 1. Chinese Academy of sciences Guangzhou Institute of Geochemistry 510640 Guangzhou China 2. Chinese Academy of sciences Institute of Geology and Geophysics 100029 Beijing China 3. college of life sciences Sun Yat-Sen University 510275 Guangzhou China

Our two newly obtained high-quality 40Ar/39Ar ages suggest that the high-K volcanic rocks of the Lawuxiang Formation in the Mangkang basin, Tibet were formed at 33.5 ( 0.2 Ma. The tracing of elemental and Pb-Sr-Nd isotopic geochemistry indicates that they were derived from an EM2 enriched mantle in continental subduction caused by transpression. Their evidently negative anomalies in HFSEs such as Nb and Ta make clear that there is an input of continental material into the mantle source. The high-K rocks at 33.5 ( 0.2 Ma in the Mangkang basin may temporally, spatially and compositionally compare with the early one of two-pulse high-K rocks in eastern Tibet distinguished by Wang J. H. Et al., implying that they were formed in the same tectonic setting.

关键词： Cenozoic high-K volcanic rocks, 40Ar/39Ar chronology, Mangkang basin, Tibet.

A provable secure fuzzy identity based signature scheme

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Science china(Information sciences) 2012年第9期55卷 2139-2148页

作者： WANG ChangJi 1,2 1 School of Information Science and Technology,sun yat-sen university,guangzhou 510275,china 2 Guangdong Province Information Security Key laboratory,sun yat-sen university,guangzhou 510275,china 1. School of Information Science and Technology Sun Yat-sen University Guangzhou 510275 China2. Guangdong Province Information Security Key Laboratory Sun Yat-sen University Guangzhou 510275 China

To use biometrics identities in an identity based encryption system,Sahai and Waters first introduced the notion of fuzzy identity based encryption(FIBE) in *** et *** it to digital signature and introduced the concept of fuzzy identity based signature(FIBS) in 2008,and constructed an FIBS scheme based on Sahai and Waters's FIBE *** this paper,we further formalize the notion and security model of FIBS scheme and propose a new construction of FIBS scheme based on bilinear *** proposed scheme not only provides shorter public parameters,private key and signature,but also have useful structures which result in more efficient verification than that of Yang et al.'s FIBS *** proposed FIBS scheme is proved to be existentially unforgeable under a chosen message attack and selective fuzzy identity attack in the random oracle model under the discrete logarithm assumption.

关键词： identity based cryptosystem fuzzy identity based encryption fuzzy identity based signature

RNomics:The New Frontier in the post-genomic era

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Science china(life sciences) 2009年第3期52卷 193-194页

作者： Liang-Hu Qu college of life sciences,sun Yan-sen university,guangzhou 510275,china 1. college of life sciences Sun Yan-Sen University Guangzhou 510275 China

It has been shown that whenever there is breakthrough in DNA structure there follows a bloom period of RNA research.

关键词： RNomics RNA

The three-dimensional structure of Infectious flacherie virus capsid determined by cryo-electron microscopy

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Science china(life sciences) 2009年第12期52卷 1186-1191页

作者： XIE Li1,4, ZHANG QinFen2·, LU XingMeng3, DAI XinHong2, LI KunPeng2, HONG Jian1,4· & ZHOU XuePing11 Institute of Biotechnology, Zhejiang university, Hangzhou 310029, china 2 State Key laboratory of Biocontrol, School of life sciences, sun yat-sen university, guangzhou 510275, china 3 college of Animal sciences, Zhejiang university, Hangzhou 310029, china 4 Center of Analysis and Measurement, Zhejiang university, Hangzhou 310029, china Institute of Biotechnology Zhejiang University Hangzhou 310029 China State Key laboratory of Biocontrol School of Life Sciences Sun Yat-Sen University Guangzhou 510275 China college of Animal sciences Zhejiang University Hangzhou 310029 China Center of Analysis and Measurement Zhejiang University Hangzhou 310029 China

Cryo-electron microscopy and image reconstruction were used to determine the three-dimensional structure of Infectious flacherie virus (IFV). 5047 particles were selected for the final reconstruction. The FSC curve showed that the resolution of this capsid structure was 18 ·. The structure is a psuedo T=3 (P=3) icosahedral capsid with a diameter of 302.4 · and a single shell thickness of 15 ·. The density map showed that IFV has a smooth surface without any prominent protrude or depression. Comparison of the IFV structure with those of the insect picorna-like virus-Cricket paralysis virus (CrPV)and human picornavirus-Human rhinovirus 14 (HRV 14) revealed that the IFV structure resembles the CrPV structure. The "Rossmann canyon" is absent in both IFV and CrPV particles. The polypeptide topology of IFV VP2, IFV VP3 was predicted and the subunit location at the capsid surface was further analyzed.

关键词： Infectious flacherie virus cryo-electron microscopy three-dimensional structure polypeptide folding

Rational design of metal selenides nanomaterials for alkali metal ion(Li^(+)/Na^(+)/K^(+))batteries:current status and perspectives

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Rare Metals 2024年第5期43卷 1906-1931页

作者： Rui sun Feng Xu Cai-Hong Wang Sheng-Jun Lu Yu-Fei Zhang Hao-sen Fan college of Materials Science and Metallurgy Engineering Guizhou UniversityGuiyang550025China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou510006China

Recently,metal selenides have obtained widespread attention as electrode materials for alkali(Li^(+)/Na^(+)/K^(+))batteries due to their promising theoretical capacity and ***,metal selenides,similar to metal oxides and sulfides,also suffer from severe volume explosion during repeated charge/discharge processes,which results in the structure collapse and the following pulverization of electrode ***,it leads to poor cycle stability and influencing their further *** order to solve these issues,some special strategies,including elemental doping,coupling with carbon materials,synthesis of the bimetal selenides with heterostructure,etc.,have been gradually applied to design novel electrode materials with outstanding electrochemical ***,the recent research progress on metal selenides as anodes for alkali ion batteries is summarized,including the regulation of crystal structure,synthesis strategies,modification methods,and electrochemical mechanisms and ***,the challenges of metal selenides and the perspective for future electrode material design are *** is hoped to pave a way for the development of metal selenide electrode materials for the potential applications for alkali metal ion(Li^(+)/Na^(+)/K^(+))batteries.

关键词： Rational design Metal selenides Nanostructure Li^(+) batteries Na^(+) batteries K^(+) batteries

A comparative molecular field analysis of cytotoxic beta-carboline analogs

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Acta Pharmacologica Sinica 2004年第7期25卷 113-119页

作者： Xue-rui HOU, Qi CHEN, Ri-hui CAO, Wen-lie PENG, An-long XU1 Department of Biochemistry and Center for Biopharmaceutical Research, college of life sciences, sun yat-sen university, guangzhou 510275, china Department of Biochemistry and Center for Biopharmaceutical Research College of Life Sciences Sun Yat-sen University Guangzhou 510275 China

AIM: To derive a model that could be used in drug design. METHODS: Beta-carbolines are reported to have antitumor activities on cultured cancer cell lines. A comparative molecular field analysis (CoMFA) was undertaken to elucidate the correlation of cytotoxities and structural parameters of 16 beta-carboline analogs (1-16). The compound 12 was finally used as a template for the other compounds in the dataset because of its highest biological activity. RESULTS: The CoMFA applied to the final alignment resulted in a qcv of 0.656 and it showed that the 2 steric fields contributed 43.3 % of the model information while the electrostatic fields represented the other 56.7 %. CONCLUSION: Three designed compounds, which were predicted to have high, moderate and low activities respectively, were synthesized. The IC50 values of these compounds indicated the significance of the analysis in this study. The model derived from the current study could be further used in design for more active compounds.

关键词： beta-carbolines quantitative structure-activity relationship alkaloids

Studies on rickettsia-like organism (RLO) disease of tropical marine pearl oyster-Epidemiological investigation of RLO disease in juvenile populations of maricultured Pinctada maxima

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Acta Oceanologica Sinica 2003年第3期22卷 421-435页

作者： Xinzhong Wu , Dengfeng Li, Jinpei Pan, Jingbo Jiang college of Animal sciences,Zhejiang university,Hangzhou 310029,china. Email: wuxz@zju.edu.cnSouth china Sea Institute of Oceanology, Chinese Academy of sciences,guangzhou 510301,chinaSchool of life sciences,sun yat-sen university,guangzhou 510275,china Zhejiang Univ Coll Anim Sci Hangzhou 310029 Peoples R China Chinese Acad Sci S China Sea Inst Oceanol Guangzhou 510301 Peoples R China sun yat sen Univ Sch Life Sci Guangzhou 510275 Peoples R China

The death which occurred in juvenile population was a severe problem in the course ofPinctada maxima artificial culture. With the methods of field investigation, histological study and statistic analyses, the epidemiological study was carried out on the disease and death in juvenile populations of Pinctada maxima in the Xinying Pearl Oyster Mariculture Farm of Lingao County (for the A, B and C batches of cultured juveniles hanged in the sea) and the Xincun Pearl Oyster Mariculture Farm of Lingshui County (for the D batch of cultured juvenile hanged in the pond), Hainan Province from November 1993 to April *** results show that the deaths which occurred in juvenile populations of Pinctada maxima presented an outbreak pattern. The peak of mortality rates, in general, occurred in 4-to 6-month old pearl oyster juveniles, and the mortality rates gradully declined with the extention of pearl oyster age after cul-turing 8 months. The correlation between the mortality rates of juvenile populations and mean body lengths of juvenile populations show that the mortality rate become higher under 4 cm of mean body lengths of juvenile population and become obvious declined over 5 cm of mean body lengths. The peak of mortality rate occurred in 1-3 cm of mean body lengths. The results of histological observation showed that rickettsia-like organism inclusions were common, histological widespread infective agent among every batches (A, B, C and D) of cultured juvenile populations. The mean severity indices (SI) of rickettsia-like organism (RLO) infection were positively correlated with mortality rates of juvenile populations. After or within every peaks of RLO infection were all accompanied with the peaks of mortality rates of host populations and the mortality rates declined with decreased RLO infection. So the evidences of histological observation and epidemiology in this study indicated that rickettsia-like organism (RLO) may be as an important pathogenic organism of disease

关键词： Pinctada maxima rickettsia-like organism epidemiology juvenile population

High norbornene incorporation in ethylene-norbornene copolymerization with a bis(α-alkyloxoimine) titanium-MAO catalyst

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Science china Chemistry 2010年第8期53卷 1634-1640页

作者： GAO HaiYang1,2,HU Hao1 & WU Qing1,2 1Institute of Polymer Science,School of Chemistry and Chemical Engineering,sun yat-sen (Zhongshan) university,guangzhou 510275,china 2Key laboratory for Polymeric Composite and Functional Materials of Ministry of Education sun yat-sen (Zhongshan) university,guangzhou 510275,china 1. Institute of Polymer Science School of Chemistry and Chemical Engineering Sun Yat-Sen (Zhongshan) University Guangzhou 510275 China2. Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education Sun Yat-Sen (Zhongshan) University Guangzhou 510275 China

A novel bis(α-alkyloxoimine) titanium(IV) complex was synthesized and used as a catalyst precursor to catalyze homo-and copolymerization of ethylene and *** titanium complex activated with methylalumoxane exhibits good activities for the homopolymerizations of ethylene and norbornene under high temperature to produce high-molecular-weight linear polyethylene and vinyl-type polynorbornene,***-norbornene copolymers with high molecular weight can also be produced by this *** incorporation of norbornene from 0 to 76 mol% in the copolymers can be controlled by varying the charged norbornene.13C NMR analyses show that the microstructures of the ethylene-norbornene copolymers with low norbornene incorporation are predominantly alternated and isolated norbornene units,while those with high norbornene incorporation are random polymers containing long norbornene sequences.

关键词： catalyst ethylene norbornene polymerization copolymerization