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国民经济动员仿真演练系统分层架构研究

系统仿真学报 2009年第14期21卷 4504-4506,4512页

作者：王剑王红卫华中科技大学系统工程研究所武汉430074 国家国民经济动员仿真演练研究中心武汉430074 "图像信息处理与智能控制"教育部重点实验室武汉430074

为了解决国民经济动员实战演练高成本、低灵活性、低协同性问题,研制基于HLA的分布式国民经济动员仿真演练系统成为有效途径。为了满足演练对象、流程及功能的高度复用、动态配置与灵活扩展的需求,具有RTI联邦成员、演练角色及演练系统... 详细信息

为了解决国民经济动员实战演练高成本、低灵活性、低协同性问题,研制基于HLA的分布式国民经济动员仿真演练系统成为有效途径。为了满足演练对象、流程及功能的高度复用、动态配置与灵活扩展的需求,具有RTI联邦成员、演练角色及演练系统三级封装特性的分层架构则是系统实现的必要条件。首先应用角色建模与业务用例建模方法抽象了演练对象与流程,其次基于分层设计模式设计了系统软、硬件体系结构,最后针对系统技术路线进行了分析。

关键词：国民经济动员仿真演练 HLA RTI 分层架构

dynamic tracking and mobility analysis of single GLUT4 storage vesicle in live 3.3.L1 cells

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Cell Research 2004年第6期14卷 480-486页

作者： Chen Hong LI, Li BAI, Dong Dong LI, Sheng XIA, Tao XU Institute of Biophysics and Biochemistry, Huazhong University of Science and Technology, wuhan 43.074, China National key {2. of Biomacromoleculars, Institute of Biophysics, {3. Academy of {3., Beijing 100101, China Institute of Biophysics and Biochemistry Huazhong University of Science and Technology Wuhan China National key laboratory of Biomacromoleculars Institute of Biophysics Chinese Academy of Sciences Beijing China

Glucose transporter 4 (GLUT4) is responsible for insulin-stimulated glucose transporting into the insulin-sensitive fat and muscle cells. The dynamics of GLUT4 storage vesicles (GSVs) remains to be explored and it is unclear how GSVs are arranged based on their mobility. We examined this issue in 3.3.L1 cells via investigating the three-dimensional mobility of single GSV labeled with EGFP-fused GLUT4. A thin layer of cytosol right adjacent to the plasma membrane was illuminated and successively imaged at 5 Hz under a total internal reflection fluorescence microscope with a penetration depth of 13. nm. Employing single particle tracking, the three-dimensional subpixel displacement of single GSV was tracked at a spatial precision of 2. nm. Both the mean square displacement and the diffusion coefficient were calculated for each vesicle. Tracking results revealed that vesicles moved as if restricted within a cage that has a mean radius of 160 nm, suggesting the presence of some intracellular tethering matrix

关键词： Insulin GLUT4 GLUT4 storage vesicle (GSV) 3.3.L1 total internal reflection fluorescence microscopy single particle tracking.

Experimental study of dynamic mechanical properties of reactive powder concrete under high-strain-rate impacts

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Science China(Technological sciences) 2010年第9期53卷 2435-2449页

作者： JU Yang1,2.LIU HongBin1,SHENG GuoHua1,3.& WANG HuiJie1 1 State key laboratory of Coal Resources and Safe Mining,Beijing key laboratory of Fracture and Damage Mechanics of Rocks and Concrete,China University of Mining and Technology,Beijing 100083.China 2.Department of Mechanical and Manufacturing Engineering,University of Calgary,2.00 University Drive,AB T2. 1N4,Canada 3.School of Resources and Civil Engineering,Northeastern University,Shenyang 110004,China State key laboratory of Coal Resources and Safe Mining Beijing Key Laboratory of Fracture and Damage Mechanics of Rocks and Concrete China University of Mining and Technology Beijing China Department of Mechanical and Manufacturing Engineering University of Calgary Calgary Canada School of Resources and Civil Engineering Northeastern University Shenyang China

The dynamic mechanical properties of reactive powder concrete subjected to compressive impacts with high strain rates ranging from 10 to 1.1×102.s-1 were investigated by means of SHPB (split-Hopkinson-pressure-bar) tests of the cylindrical specimens with five different steel fiber volumetric *** properties of wave stress transmission,failure,strength,and energy consumption of RPC with varied fiber volumes and impact strain rates were *** influences of impact strain rates and fiber volumes on those properties were characterized as *** general forms of the dynamic stress-strain relationships of RPC were modeled based on the experimental *** investigations indicate that for the plain RPC the stress response is greater than the strain response,showing strong brittle *** RPC with a certain volume of fibers sustains higher strain rate impact and exhibits better deformability as compared with the plain *** a constant fiber fraction,the peak compressive strength,corresponding peak strain and the residual strain of the fiber-reinforced RPC rise by varying amounts when the impact strain rate increases,with the residual strain demonstrating the greatest *** the fiber content makes trivial contribution to improving the residual deformability of RPC when the impact strain rate is *** tests also show that the fiber content affects the peak compressive strength and the peak deformability of RPC in a different *** a constant impact strain rate and the fiber fraction less than 1.75%,the peak compressive strength rises with an increasing fiber *** peak compressive strength tends to decrease as the fiber volume exceeds 1.75%.The corresponding peak strain,however,incessantly rises with the increasing fiber *** total energy Edisp that RPC consumed during the period from the beginning of impacts to the time of residual strains elevates with the fiber volume increment as long as the fiber fraction

关键词： impact reactive powder concrete (RPC) high strain rate dynamic strength energy consumption dynamic stress-strain response

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模拟研究卫-卫跟踪中星间隔的选择问题

天文学报 2005年第1期46卷 62-69页

作者：周旭华吴斌许厚泽彭碧波中国科学院测量与地球物理研究所动力大地测量重点实验室

从两个方面讨论了低轨卫星在做卫-卫跟踪(SST)观测时,星间隔的选择问题. 1)用地球重力位系数作为扰动量,比较该扰动引起的不同间隔的SST星间距离和速度变化大小. 2.用随机误差为1μm／s的星间速度变化作为模拟观测量,恢复不同间隔的 ... 详细信息

从两个方面讨论了低轨卫星在做卫-卫跟踪(SST)观测时,星间隔的选择问题. 1)用地球重力位系数作为扰动量,比较该扰动引起的不同间隔的SST星间距离和速度变化大小. 2.用随机误差为1μm／s的星间速度变化作为模拟观测量,恢复不同间隔的地球重力位系数,并做精度评估.两种结果表明,适当增大SST间隔对求解重力场有利, 但无限制增大无实际意义,对于选定高度为42. km卫星,在作SST观测时,星间隔不宜超过690km.此模拟方法及结果对我国确定重力卫星指标有着重要意义.

关键词： SST 重力位地球模拟观测重力卫星重力场低轨卫星间隔扰动系数

Preliminarily Investigating the Polymorphism of Self-organized Actin Filament in Vitro by Atomic Force Microscope

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 637-643页

作者： Jun ZHANG1,2. Yuan-Liang WANG1*, Xin-Yong Chen3. Chuang-Long HE1, Chao CHENG1, and Yang CAO1 1key Lab of Biomechanics & Tissue Engineering, Chongqing University, Chongqing 400044, China Biology Department, Chongqing University of Medicine sciences, Congqing 400016, China 3.2. of Biophysics and Surface Analysis, University of Nottingham, Nottingham NG7 2.D, United Kingdom key Lab of Biomechanics & Tissue Engineering Chongqing UniversityChongqing 400044 China Biology Department Chongqing University of Medicine SciencesCongqing 400016 China laboratory of Biophysics and Surface Analysis University of NottinghamNottingham NG7 2RD United Kingdom

With the atomic force microscope (AFM), we preliminarily investigated the large-scale structure of actin filaments formed in low concentration protein solution (5 μg/ml) via self-organization without the presence of any F-actin dynamic interfering factors (such as phalloidin) in vitro. It was found that the G-actin could be polymerized into ordered filamentous structures with different diameter from the slimmest filament of single F-actin to giant filament in tree-like branched aggregates. The observed polymerized actin filaments, to which our most intense attention was attracted, was discretely distributed and showed obvious polymorphism distinctly different from those in the presence of phalloidin or actin binding proteins (fimbrin, gelsolin, etc.) in previous experiments. Latter structures were mainly composed of single F-actin and/or multifilaments clearly consisting of several single F-actin. The experimental results clearly demonstrated that non-interference with the F-actin intrinsic dynamics in self-organizing could lead to the polymorphism of actin filamentous structures, and further analysis implied that the disturbance of normal F-actin dynamics by many factors could prevent the emergence of structural polymorphism, more often than not, give rise to formation of specific structures instead and different interference would bring about various particular structures under certain conditions.

关键词： actin self-organization filamentous structure polymorphism atomic force microscope

A Novel Structure of LAPS Array for Cell-Based Biosensor

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稀有金属材料与工程 2006年第S3期 51-54页

作者： Ying Xu~(1,2. Hua Cai~1 Qingjun Liu~1 Lifeng Qin~1 Lijiang Wang~1 Ping Wang~(1,2. (1.Biosensor National Special laboratory,{3. laboratory of Biomedical Engineering of Education Ministry,Department of Biomedical Engineering,Zhejiang University,Hangzhou 3.002.,China) (2.State {3. Lab of Transducer Technology,chinese Academy of {3.,Shanghai 2.0050,China)

The light-addressable potentiometric sensor (LAPS) is a semiconductor-based cellular biosensor with an electrolyte-insulator-semiconductor (EIS) *** depositing biocompatible layers on the sensing surface for cell culture, it can be used to detect bioelectrical parameters of *** characteristic curve for photocurrent versus applied bias voltage to the system shows a current-voltage curve (Ⅰ-Ⅴcurve).This technique can be used to detect the action potential changes towards different drugs based on the bias voltage dependence of an optical current,and provides a dynamic system by scanning light beam at the very cell on the sensor *** LAPS overcomes the limitation of recording sites,but high spatial resolution and sensitivity are also *** paper discussed a novel structure of LAPS array for extracellular monitoring to decrease potential noise *** characteristics of active recording array areas and cell culture conditions are measured.

关键词： light-addressable potentiometric sensor array LAPS sensitivity cell-based biosensor

Analysis of Earthquake-Triggered Failure Mechanisms of Slopes and Sliding Surfaces

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Journal of Mountain Science 2010年第3期7卷 282-290页

作者： WANG Jian YAO Lingkan Arshad Hussain School of Civil Engineering Southwest Jiaotong University Chengdu 610031 China MOE key laboratory of High-speed Railway Engineering Southwest Jiaotong University Chengdu 610031 China Road and Railway Engineering Research Institute Sichuan Key Laboratory of Aseismic Engineering and Technology Chengdu 610031 China National University of sciences and Technology (NUST) Islamabad 44000 Pakistan

Earthquake-induced landslides along the Dujiangyan-Yingxiu highway after the Ms 8.0 Wenchuan earthquake in 2.08 were investigated. It was found that：（1） slopes were shattered and damaged during the earthquake and open tension cracks formed on the tops of the slopes; （2. the upper parts of slopes collapsed and slid, while the lower parts remained basically intact, indicating that the upper parts of slopes would be damaged more heavily than the lower parts during an earthquake. Large-scale shaking table model tests were conducted to study failure behavior of slopes under the Wenchuan seismic wave, which reproduced the process of deformation and failure of slopes. Tension cracks emerged at the top and upper part of model, while the bottom of the model remained intact, consistent with field investigations. Depth of the tension crack at the top of model is 3.0}cm, i.e., 3.2.m compared to the prototype natural slope with a height of 14 m when the length scale ratio （proto/model） is lo. Acceleration at the top of the slope was almost twice as large as that at the toe when the measured accelerations on shaking table are 4.85 m/s2.and 6.49 m/s2. which means that seismic force at the top of the slope is twice the magnitude of that at the toe. By use of the dynamic-strength-reduction method, numerical simulation was conducted to explore the process and mechanism of formation of the sliding surface, with other quantified information. The earthquake-induced failure surfaces commonly consist of tension cracks and shear zones. Within 5 mfrom the top of the slope, the dynamic sliding surface will be about 1 m shallower than the pseudo-static sliding surface in a horizontal direction when the peak ground acceleration （PGA） is 1 m/s2. the dynamic sliding surface will be about 2.m deeper than the pseudo-static sliding surface in a horizontal direction when the PGA is lo m/sL and the depths of the dynamic sliding surface and the pseudo-static sliding surface will be almost the sam

关键词： Subgrade engineering slope failuremechanism shaking table model test: seismicsliding surface Wenchuan earthquake

Bioinformatics analyses for signal transduction networks

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Science China(Life sciences) 2008年第11期51卷 994-1002页

作者： LIU Wei1,2. LI Dong2. ZHU YunPing2.& HE FuChu1,2.1 College of Mechanical & Electronic Engineering and Automatization, National University of Defense Technology, Changsha 410073. China 2.State key laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102.06, China College of Mechanical & Electronic Engineering and Automatization National University of Defense Technology Changsha China State key laboratory of Proteomics Beijing Proteome Research Center Beijing Institute of Radiation Medicine Beijing China

Research in signaling networks contributes to a deeper understanding of organism living activities. With the development of experimental methods in the signal transduction field, more and more mechanisms of signaling pathways have been discovered. This paper introduces such popular bioin-formatics analysis methods for signaling networks as the common mechanism of signaling pathways and database resource on the Internet, summerizes the methods of analyzing the structural properties of networks, including structural Motif finding and automated pathways generation, and discusses the modeling and simulation of signaling networks in detail, as well as the research situation and tendency in this area. Now the investigation of signal transduction is developing from small-scale experiments to large-scale network analysis, and dynamic simulation of networks is closer to the real system. With the investigation going deeper than ever, the bioinformatics analysis of signal transduction would have immense space for development and application.

关键词： signal transduction structural motif automated pathways regeneration dynamics simulation

The impulse influence function for de-centralized control

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Science China Mathematics 2004年第Z1期47卷 200-221页

作者： ZHONG WanxieState key laboratory of Structure Analysis for Industrial Equipment, Dalian University of Technology, Dalian 11602., China key laboratory of Complex Systems & Intelligence Science, chinese Academy of {3., Beijing 100080, China (email: wxzhong@***) State key laboratory of Structure Analysis for Industrial Equipment Dalian University of Technology Dalian China key laboratory of Complex Systems & Intelligence Science Chinese Academy of Sciences Beijing China

Impulse influence matrix function is introduced based on that the de-centralized control analysis is analogous to the sub-structural analysis in structural mechanics. The static sub-structural analysis is analogous to the usual de-centralized control, whereas the dynamic sub-structural analysis corresponds to the de-centralized control theory. The reciprocal symmetry for the impulse influence matrix function is proved, and is solved by the precise integration method for time invariant system, giving the results up to computer precision. Based on the impulse influence functions of subsystems, the combination of subsystems can lead to a set of integral equations and be solved numerically. Numerical example demonstrates the effectiveness of the method.

关键词： de-centralized control, subsystem, impulse influence function, precise integration.