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Mechanism of the Spring Persistent Rains over southeastern china

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Science china Earth Sciences 2007年第1期50卷 130-144页

作者： WAN RiJin1,2,3 & WU GuoXiong1 1 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Mechanicals (LASG), Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, china 2.guangdong climate and Agrometeorology center, guangzhou 510080, china 3 Shanghai Typhoon Institute of china Meterological Administration, Shanghai 200030, china State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Mechanicals (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China guangdong climate and Agrometeorology center Guangzhou 510080 China Shanghai Typhoon Institute of china Meterological Administration Shanghai 200030 China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Mechanicals (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

The Spring Persistent Rains (SPR) in the areas to the south of middle and lower reaches of the Yangtze River or over southeastern china (SEC) is a unique synoptic and climatic phenomenon in East Asia. This study reveals a possible mechanism responsible for the climatic cause of SPR formation through climatic mean data analysis and sensitive numerical model experiments. SEC is located at the down-stream of the southwesterly velocity center (SWVC) which lies on the southeastern flank of the Tibetan Plateau (TP). As a result, there are strong southwesterly wind velocity convergence and moisture con-vergence over SEC. This is the immediate climatic cause of SPR formation. In spring, the seasonal evolution of the southwesterly velocity consists with the surface sensible heating over southeastern TP, indicating that the formation of SPR is related to not only the southwesterly wind of mechanical de-flected flow of TP, but also the southwesterly wind of thermal-forced cyclonic low circulation. Sensitive numerical experiments demonstrate that, without TP, both SWVC and the SPR rain belt will disappear. The southwesterly wind velocity increases almost linearly with the amount of the total diabatic heating with TP rising. Therefore, SWVC is the result of the mechanical forcing and thermal forcing of TP. All these strongly suggest that the presence of TP plays a primary role in the climatic formation of SPR.

关键词： SPR climatic cause of formation southwesterly Tibetan Plateau sensitive experiments.

CT-guided needle biopsy through mandibular area for the diagnosis of nasopharyngeal carcinoma in the parapharyngeal space

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Chinese Journal of Cancer 2010年第8期29卷 768-773页

作者： Yong Su1,2, Chong Zhao1,2, Wen-Jie Li1,2, Xue-Ying Deng1,3, Rui-Fang Zeng1,2, Nian-Ji Cui1,2, Tai-Xiang Lu1,2 1 State Key Laboratory of Oncology in South china, guangzhou, guangdong 510060, P. R. china 2 Department of Radiation Oncology, Sun Yat-sen University Cancer center, guangzhou, guangdong 510060, P. R. china 3 Department of Radiotherapy, Dongguan People’s Hospital, Dongguan, guangdong 523000, P. R. china Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060 Department of Radiotherapy Dongguan People's Hospital State Key Laboratory of Oncology in South China Guangdong Guangzhou 510060

Background and Objective: The primary submucous type of nasopharyngeal carcinoma (NPC) or the recurrent NPC in the parapharyngeal space is difficult to be diagnosed histologically by conventional biopsy because of the obstruction of the surrounding structures. This study was performed to evaluate the needle biopsy approach through the madibular area into the parapharyngeal space under the guidance of computed tomography (CT) for NPC. Methods: Between July 6, 2005 and October 23, 2009, a total of 6 patients were enrolled into the study. Two patients with cervical lymph node metastasis were clinically suspicious of NPC according to their clinical manifestations. However, no cancer cell could be found by repeated nasopharyngeal biopsies followed by histologic examinations. The other 4 patients were diagnosed with recurrent NPCs by magnetic resonance imaging (MRI) or/and positron emission tomography (PET)-CT scan, showing tumors in the parapharyngeal spaces in 3 patients and enlarged retropharyngeal lymph node in 1 patient. The CT-guided puncture was performed through the mandibular skin and the cutting needle biopsy was taken at the parapharyngeal space focus. Results: All the cutting needle biopsies of projected locations have been performed safely. Finally, all the 7 specimens met the requirement of pathologic diagnosis and the cases were all confirmed histologically to be NPCs. The main complication was mild ache at the puncture point. No blood vessel or nerve was injured and no patient needed special treatment. Conclusions: The CT-guided puncture biopsy of the parapharyngeal space through the mandibular area is simple and feasible. It can be an additional option for routine nasopharyngeal biopsy.

关键词： CT扫描病理诊断鼻咽癌活检间隙穿刺引导正电子发射断层扫描

A Comparative Evaluation of Humphrey Perimetry and the Multi-channel Pattern Visual Evoked Potentials

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眼科学报 2000年第3期16卷 168-171页

作者： Caiping Hu, Lezheng Wu, De-Zheng Wu, Shixian LongThe Department of Ophthalmology, guangdong Provincial People’s Hospital, guangzhou 510080, china Zhongshan Ophthalmic center, Sun Yat-sen University of Medical Sciences, guangzhou 510060, china Department of Ophthalmology Guangdong Provincial People's Hospital Guangzhou 510080 China

Purposes: To compare the multi-channel pattern visual evoked potentials to Humphrey perimetry in the assessment of central visual function in primary open angle glaucoma. Methods: The multi-channel checkerboard reversal PVEPs waves to full-field and half-field stimulus of 25 normal persons and 74 patients with primary open angle glaucoma were recorded and analyzed, All patients were examined using Humphrey Field Analyzer. The area of visual field corresponding to the area of retina stimulated during multi-channel PVEPs testing were analysed, straight-line correlation and regression analyses of the various multi-channel PVEPs parameters and the total dB losses were ***: The multi-channel PVEPs demonstrated a low detection rate compared with Humprey perimetry in the early glaucoma, absolute latency and field loss were correlated in the late stage of glaucoma, and absolute amplitude and field loss were not correlated. Conclusions: In relation to signalling early loss the multi-channel PVEPs

关键词：青光眼多道PVEP 视野检查法

Climatic fluctuation and disasters during recent 100 years in china’s tropics

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Journal of Geographical Sciences 2004年第S1期 14-22页

作者： HUANG Zhenguo1, ZHANG Weiqiang2(1. guangzhou Institute of Geography, guangzhou 510070, china 2. guangdong Business College, guangzhou 510320, china)

The temperature appeared rising trend during the 20th century in china's tropics. Two cooling stages and two warming stages in the process of climatic fluctuation can be recognized. After the 1980s the climate is the warmest which corresponds to the global change, but the warmest period is the 1940s in Kunming. The climate pattern mostly appears contemporaneity of warming and humidity, which is different from the situation of whole china. The natural disasters tend to be aggravated. The number of typhoons increased. Flood damages occurred frequently in the years of more typhoons. The number of droughts and cold damages increased. It was snowed in guangzhou. There was frost in Haikou and Yaxian. Four years of heavy snow have been recorded in Kunming.

关键词： natural disaster climatic fluctuation china’s tropics

EXPERIMENTAL STUDY OF HFC-134a GAS HYDRATE FORMATION PROCESS

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化工学报 2003年第Z1期54卷 98-101页

作者： LI Jinping~(1,2), LIANG Deqing~2, GUO Kaihua~2, FAN Shuanshi~2 and WANG Ruzhu~1(~1 Institute of Refrigeration and Cryogenics, Shanghai Jiaotong University, Shanghai 200030, china ~2 center for Gas Hydrate Research, guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, guangzhou 510070, guangdong, china) Institute of Refrigeration and Cryogenics Shanghai Jiaotong University Shanghai 200030 China center for Gas Hydrate Research Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510070 Guangdong China center for Gas Hydrate Research Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510070 Guangdong China Institute of Refrigeration and Cryogenics Shanghai Jiaotong University Shanghai 200030 China

Refrigerant gas hydrates have brilliant prospects as cool storage material of air-conditioning system. In this paper, when the ratio of the weight of HFC-134a to that of water is 2. 17%, systematic experiments have been carried out on the formation process of the HFC-134a gas hydrate including of the phase equilibrium, the influence of supercooling degree, and the influence of agitation. The results indicate that the critical decomposition temperature and the critical decomposition pressure of R134a hydrate is 283.4K and 414K respectively, the formation of gas hydrate was promoted with increasing the supercooling degree and the agitation. However, it is desired that the supercooling degree is ***, it is important problem that the study of optimum of supercooling degree for cool storage system.

关键词： refrigerant gas hydrate, formation process, phase equilibrium, agitation, supercooling degree

INFLUENCE OF CHEMICAL ADDITIVES ON GAS HYDRATE FORMATION

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化工学报 2003年第Z1期54卷 37-40页

作者： TANG Cuiping and FAN Shuanshi (center for Gas Hydrate Research, guangzhou Institute of Energy Conversion, Chinese Academy of Science, guangzhou 510070, guangdong, china) center for Gas Hydrate Research Guangzhou Institute of Energy Conversion Chinese Academy of Science Guangzhou 510070 Guangdong China

One surfactant as sodium dodecyl sulfate (SDS) and one synthesized sample as gas hydrate inhibitor are introduced in this paper. Through experiments we prove sodium dodecyl sulfate can accelerate the formation rate of... 详细信息

关键词： natural gas hydrate, chemical additive, kinetic inhibitor

A case report of primary small cell carcinoma of the breast and review of the literature

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Chinese Journal of Cancer 2012年第7期31卷 354-358页

作者： Qi-Dong Ge1,2, Ning Lv1,2, Yun Cao1,3, Xi Wang1,2, Jun Tang1,2, Ze-Ming Xie1,2, Xiang-Sheng Xiao1,2, Peng Liu1,2, Xiao-Ming Xie1,2 and Wei-Dong Wei1,2 Authors’ Affiliations: 1State Key Laboratory of Oncology in South china, guangzhou, guangdong 510060, P. R. china 2Department of Breast Oncology, 3Department of Pathology, Sun Yat-sen University Cancer center, guangzhou, guangdong 510060, P. R. china. Department of Breast Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong People's Republic of China. weiweid@***

Primary small cell carcinoma (SCC) of the breast, an exceedingly rare and aggressive tumor, is often characterized by rapid progression and poor prognosis. We report a case of primary SCC of the breast that was diagnosed through pathologic and immunohistochemical examinations. Computed tomography (CT) scans failed to reveal a non-mammary primary site. Due to the scant number of relevant case summaries, this type of tumor is proved to be a diagnostic and therapeutic challenge. Therefore, we also reviewed relevant literature to share expertise in diagnosis, clinicopathologic characteristics, treatment, and prognosis of this type of tumor. Future studies with more cases are required to define more appropriate treatment indications for this disease.

关键词：乳腺癌细胞文献计算机断层扫描原发性复习病理特征免疫组化

Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer

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World Journal of Gastroenterology 2010年第19期16卷 2428-2434页

作者： Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South china, Biotherapy center, Cancer center, Sun Yat-Sen University, 651 Dongfeng R E, guangzhou 510060, guangdong Province, china Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South china, Department of Gastric and Pancreatic Oncology, Cancer center, Sun Yat-Sen University, 651 Dongfeng R E, guangzhou 510060, guangdong Province, china Rong Zhang, State Key Laboratory of Oncology in South china, Department of Endoscopy, Cancer center, Sun Yat-Sen University, 651 Dongfeng R E, guangzhou 510060, guangdong Province, china Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South china, Department of Experimental Research, Cancer center, Sun Yat-Sen University, 651 Dongfeng R E, guangzhou 510060, guangdong Province, china State Key Laboratory of Oncology in South china Biotherapy Center Sun Yat-sen University 651 Dongfeng R E Guangzhou 510060 Guangdong Province China.

AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer center of Sun Yat-Sen University, guangzhou, china. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer.

关键词： Calreticulin Tumor-infiltrating lymphocyte Colon cancer Immune escape

FG020326-loaded nanoparticle with PEG and PDLLA improved pharmacodynamics of reversing multidrug resistance in vitro and in vivo

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Acta Pharmacologica Sinica 2007年第6期28卷 913-920页

作者： Wen-jing DENG~2,Xiao-qiang YANG~2,Yong-ju LIANG~2,Li-ming CHEN~2,Yan-yan YAN~2,Xin-tao SHUAI~3,Li-wu FU~(2,4)~2 State Key Laboratory of Oncology in Southern china Cancer center,Sun Yat-Sen University,guangzhou 510060,china ~3 School ofChemistry and Chemical Engineering of Sun Yat-Sen University,guangzhou 510275,china State Key Laboratory of Oncology in Southern china Cancer center Sun Yat-Sen University Guangzhou China School of Chemistry and Chemical Engineering of Sun Yat-Sen University Guangzhou China

Aim:FG020326,a novel imidazole derivative,is a potent multidrug-resistance(MDR) modulator in vitro and in ***,FG020326 is ***-FG020326 is a FG020326-1oaded nanoparticle formed with diblock copolymers ofpoly (ethylene glycol)-block-poly (D,L-lactic acid) (PEG:PDLLA,PEDLLA) thatcan solubilize *** work was intended to evaluate the pharmacody-namics of PEDLLA-FG020326 on reversing MDR in vitro and in ***:Cytotoxicity was determined by tetrazolium *** intracellular accumulationand efflux of doxorubicin (Dox) were detected by fluorescence *** function of P-glycoprotein was examined by Rhodamine 123 (Rh123) accumu-lation detected by flow *** KBv200 cell xenograft model was estab-lished to investigate the effect of PEDLLA-FG020326 on reversing MDR in ***:PEDLLA-FG020326 and FG020326 exhibited 56.4-and 35.9-fold activityin reversing KBv200 cells to vincristine (VCR) resistance,respectively and 14.98-and 7.64-fold to Dox resistance,***-FG020326 was much stron-ger than FG020326,resulting in the increase of Dox and Rh 123 accumulation andthe decrease of intracellular Dox extrusion in KBv200 ***,PEDLLA-FG020326 exhibited more powerful activity than FG020326 in enhancing the effectof VCR against KBv200 cell xenografts in nude mice,but did not appear more ***:The pharmacodynamics of FG020326 was improved by incorporatingit into a micellar nanoparticle formed with PEG-block-PDLLA copolymers.

关键词： FG020326 micellar nanoparticle multidrug resistance xenografts