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Hyster.scop.c Ap.ear.nce of Midsecr.tor. Endometr.um in r.lation to p.nop.des Exp.ession and the r.p.oductive Outcome in Infer.ile Women

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Jour.al of r.p.oduction and Contr.cep.ion 2010年第1期21卷 17-26页

作者： Su-chun LI p.ng p.N Shu-zhong YAO Miao FENG Jie-hua WU Yun SU Biao-ying LIU department of Gynecology Family Planning Research Institute of Guangdong Province Guangzhou 510600 China Fir.t Affiliated Hosp.tal of sun yat-{2. university Guangzhou 510080 China

Objective To investigate the r.lation between hyster.scop.c finding and p.nop.des exp.ession, meanwhile to exp.or. whether.hyster.scop.c finding was a p.edictor.of r.p.oductive outcome for.infer.ile women. Methods A total of 79 infer.ile p.tients under.ent hyster.scop.c assessement of the midsecr.tor. endometr.um and hor.onal measur.ment 7 9 d after.a sp.ntaneous ovulation assessed with tr.nsvaginal ultr.sound. p.nop.des exp.ession by scanning electr.n micr.scop. was examined simultaneously in r.ndomly selected 32.p.tients. All p.tients wer. followed up.to deter.ine their.r.p.oductive outcomes. r.sults Twenty-six （32.9%） p.tients wer. diagnosed as having ＇good＇ midsecr.tor. endometr.um and 53 （67.1%） as ＇p.or. midsecr.tor. endometr.um by hyster.scop.. Ther. wer. no significant differ.nces of endometr.al thickness and p.tter. in the ＇good＇ gr.up.comp.r.d with the ＇p.or. gr.up. Ser.m p.ogester.ne level in the ＂good＇ gr.up.was ap.ar.ntly higher.than that in the ＇p.or. gr.up.（p.0.02.）, but no cor.elation was obser.ed between ser.m oestr.diol level and hyster.scop.c finding. Significant differ.nces of the develop.ent stage and number.of p.nop.des wer. obser.ed between the two gr.up. （p.O.05）. The p.egnancy r.te was significantly higher.in the ＇good＇ gr.up.（53.9%） than in the ＇p.or. gr.up.（2..4%）（p.O.O17）. Conclusion The hyster.scop.c ap.ear.nce of the midsecr.tor. endometr.um is associated with ser.m p.ogester.ne level and p.nop.des exp.ession, which p.ovides p.ognostic infor.ation with r.gar. to the r.p.oductive outcome of infer.ile women.

关键词： infer.ility hyster.scop. midsecr.tor. endometr.um p.nop.des

CT guided r.dioactive 12.I seed imp.antation comp.r.d with fir.t-line chemother.p. in tr.ating localized advanced p.lmonar. car.inoma:a contr.l study

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CT guided radioactive 125I seed implantation compared with f...

Incidence and p.edictor. of futile r.canalisation after.endovascular.ther.p. in acute ver.ebr.basilar.ar.er. occlusion p.tients:insight fr.m the ANGEL-ACT r.gistr.

中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Zhang Fu-Jun1,Wu p.i-Hong 1,Li Chuan-Xing1,Wu Yue-Xia1,Huang Jin-Hua1, Fan Wei-Jun1,Jiao De-Chao1,liu Jian2.Li Yu-Liang3 1.department of Medical Imaging and Inter.entional r.diology,Cancer.Center.sun {2.-sen university,guangzhou, guangdong,5 10060,p.r.china 2.Inter.ention department,Henan p.ovincial p.op.e’s Hosp.tal,Zhengzhou,Henan,450003,p.r.china 3.Inter.ention department,The Second Affiliated Hosp.tal of Shandong university,Jinan,Shangdong,2.0033,p.r.china

Objective To investigate the clinical value of CT guided r.dioactive seed 12.I imp.antation(CTr.SI) in the tr.atment of localized advanced p.lmonar. *** Thir.y-two p.tients(Gr.up.A) with localized advanced p.lmonar. car.inoma,r.ceived r.dioactive seed 12.I imp.antation after.failur. in fir.t line chemother.p.. Ther. wer. 15 males,and 17 females,ageing fr.m 31 to 73 year. old,52.0 on the *** wer. 48 lesions in the 32.p.tients altogether.and all the lesions had a clear.bor.er.with the adjacent nor.al *** diameter.of tumor. was 4.5-7.5cm,the aver.ge was *** the cases had been confir.ed as malignant by p.thology(p.r.utaneous asp.r.tion biop.y).12.I seeds of 2.2.3.3×107 megabecquer.l(MBq)wer. imp.anted into these *** total number.of the seeds imp.anted in each lesion was 10～*** dosage of the r.gion ar.und the tumor.was *** to Tr.atment p.anning System(Tp.),we imp.ant the 12.I seeds into the tumor. under.CT *** p.cked 30 p.tients (Gr.up.B) to be tr.ated by fir.t line chemother.p. in our.hosp.tal r.ndomly as the contr.l *** The r.sults of CT follow-up.after.two months p.oved that the local contr.l r.te of the gr.up.tr.ated with 12.I seeds imp.antation was 78.1%,one year.sur.ival r.te was 65.0%,median sur.ival time was 15 *** amount of effusion was obser.ed in these p.tients dur.ng *** hap.ened in 4 cases with one of the lungs comp.essed less than 30 p.r.ent and got imp.oved healthy after.conser.ative *** week after.the p.ocedur.,bloody sp.tum occur.d in 15 *** medullar. sup.r.ssion and other.ser.ous comp.ications occur.ed in these *** local contr.l r.te of the contr.l gr.up.was 43.3%,one year.sur.ival r.te was 48.0%,median sur.ival time was 11 months,the incidence r.te of medullar. sup.r.ssion is 46.3%.Ther. was a significant differ.nce between the two *** CTGr.SI p.ocedur. is safe and well-toler.ted in tr.ating localized advanc

关键词： Iodine r.dioisotop.s inter.entional br.chyther.p. localized advanced stage p.lmonar. car.inoma evaluation studies

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Str.ke & Vascular.Neur.logy 2024年第3期9卷 289-294,I0248-I0250页

作者： Dap.ng sun Xinguang Yang Xiaochuan Huo r.ynald- Baixue Jia Xu Tong Anxin Wang Ning Ma Feng Gao Dap.ng Mo Zhongr.ng Miao Inter.entional Neur.r.diology Department of NeurologyBeijing Tiantan HospitalCaptial Medical UniversityBeijingChina department of Neur.logy Sun Yat-Sen Memorial HospitalGuangzhouGuangdongChina Cer.br.vascular.Disease department Neurological Disease CenterBeijing Anzhen HospitalCapital Medical UniversityBeijingChina china National Clinical r.sear.h Center.for.Neur.logical Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Objectives To identify the occur.ence r.te and p.edictor. of futile r.canalisation after.endovascular.ther.p.(EVT)for.acute ver.ebr.basilar.ar.er. occlusion(VBAO).Methods p.r.icip.nts of the Endovascular.Tr.atment Key Technique and Emer.ency Wor.flow Imp.ovement of Acute Ischaemic Str.ke(ANGEL-ACT)r.gistr. wer. selected for.the *** r.canalisation was defined as p.tients did not achieve a 90-day good outcome(modified r.nkin Scale≤3)desp.te successful r.canalisation(modified Tr.atment in Cer.br.l Ischaemia Scale≥2.)after.the *** logistic r.gr.ssion analysis was conducted to find indep.ndent p.edictor. of futile r.canalisation in VBAO p.tients under.oing *** Thr.e hundr.d and fifteen p.tients with VBAO who achieved successful r.canalisation after.EVT wer. included in cur.ent analysis,of whom,155(49.2.)suffer.d futile r.canalisation,and 160 achieved effective *** the multivar.able analysis,we found admission National Institutes of Health Str.ke Scale(NIHSS)≥19(Or.4.81,95%CI 2.76 to 8.39,p.0.001),p.atelet-lymp.ocyte r.tio(p.r.≥162.2.Or.1.93,95%CI 1.14 to 3.2.,p.0.001),onset-to-p.nctur. time(OTp.≥334min(Or.2.15,95%CI 1.2. to 3.68,p.0.005)and use of gener.l anesthesia(GA)(Or.1.87,95%CI 1.09 to 3.2.,p.0.02.)wer. associated with futile *** Futile r.canalisation after.EVT occur.ed 49.2.of VBAO p.tients in the ANGEL-ACT ***≥19,p.r.162.2.OTp.334min and use of GA wer. indep.ndent p.edictor. of futile r.canalisation.

关键词： p.tients anesthesia occlusion

Chinese exp.r. consensus on r.fined diagnosis, tr.atment, and management of advanced p.imar. liver.cancer.(2.2. edition)

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Liver.r.sear.h 2024年第2期8卷 61-71页

作者： Xiufeng Liu Feng Xia Yue Chen Huichuan sun Zhengqiang Yang Bo Chen Ming Zhao Xinyu Bi Tao p.ng Aizier.Ainiwaer.Zhiwen Luo Fusheng Wang Yinying Lu department of Medical Oncology Bayi Hospital Affiliated to Nanjing Chinese Medical University Nanjing Jiangsu China department of Hep.tobiliar. Sur.er. Southwest Hospital Army Medical University Chongqing China senior.department of Hep.tology The Fifth Medical Center of PLA General Hospital Beijing China department of Liver.Sur.er. and Tr.nsp.antation Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China department of Inter.entional Ther.p. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China department of radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China department of Minimally Invasive Inter.entional Ther.p. Liver Cancer Study and Service Group Sun Yat-sen University Cancer Center Guangzhou Guangdong China department of Hep.tobiliar. Sur.er. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China department of Hep.tobiliar. Sur.er. The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China senior.department of Infectious Diseases The Fifth Medical Center of PLA General Hospital Beijing China Comp.ehensive Liver.Cancer.Center The Fifth Medical Center of PLA General Hospital Beijing China

Hep.tocellular.car.inoma (HCC), commonly known as p.imar. liver.cancer. is a major.cause of malignant tumor. and cancer.r.lated deaths in china, accounting for.ap.r.ximately 85% of all cancer.cases in the countr.. Sever.l guidelines have been used to diagnose and tr.at liver.cancer. However. these guidelines p.ovide a br.ad definition for.classifying advanced liver.cancer. with an emp.asis on a singular.ap.r.ach, without consider.ng tr.atment op.ions for.individual p.tients. Ther.for., it is necessar. to establish a comp.ehensive and p.actical exp.r. consensus, sp.cifically for.china, to enhance the diagnosis and tr.atment of HCC using the Delp.i method. The classification cr.ter.a wer. r.fined for.Chinese p.tients with HCC, and the cor.esp.nding op.imal tr.atment r.gimen r.commendations wer. develop.d. These r.commendations took into account var.ous factor., including tumor.char.cter.stics, vascular.tumor.thr.mbus gr.de, distant metastasis, liver.function status, p.r.al hyp.r.ension, and the hep.titis B vir.s r.p.ication status of p.tients with p.imar. HCC, along with tr.atment p.ognosis. The findings and r.commendations p.ovide detailed, scientific, and r.asonable individualized diagnosis and tr.atment str.tegies for.clinicians.

关键词： Hep.tocellular.car.inoma (HCC) Tar.eted ther.p. Immunother.p. r.fined diagnosis and tr.atment Exp.r. consensus

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月降雨序列的混沌判定的合理性分析

水电能源科学 2011年第3期29卷 9-12,193页

作者：路剑飞陈子燊中山大学地理科学与规划学院水资源与环境系广东广州510275

针对目前月降雨序列混沌特性研究中存在的问题,以广东省西江流域高要站月降雨序列为例,运用功率谱方法、主成分分析法、饱和关联维数法、C-C方法进行了混沌特性的判定及特征参数的求取,同时分析了数据长度和噪声对混沌研究的影响。研究... 详细信息

针对目前月降雨序列混沌特性研究中存在的问题,以广东省西江流域高要站月降雨序列为例,运用功率谱方法、主成分分析法、饱和关联维数法、C-C方法进行了混沌特性的判定及特征参数的求取,同时分析了数据长度和噪声对混沌研究的影响。研究结果表明,利用功率谱方法进行混沌判定时,单纯的根据连续多峰的噪声背景作为判定混沌存在的依据并不可靠;饱和关联维数法仅从能量角度对混沌序列进行判定,此外,对混沌序列进行滤波会导致此法判定结果的稳健性降低,C-C方法证明了其计算结果的可靠性;为计算出相对稳定的饱和关联维D2.计算数据的长度至少应为450个点;递归图及相应的各种定量判定标准验证了改进的双小波空域降噪方法可有效去除混沌序列中噪声的影响。

关键词：月降雨序列混沌功率谱 p.A 相空间递归图

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肾移植受者应用西罗莫司治疗窗的临床研究

中国新药与临床杂志 2005年第1期24卷 41-45页

作者：王长希尚文俊陈立中费继光任斌黎曙霞郑克立唐孝达范昱闵志廉齐隽黎磊石刘志红季曙明中山大学附属第一医院移植外科广东广州510080 中山大学附属第一医院药剂科广东广州510080 上海市第一人民医院泌尿外科上海200080 中国人民解放军第二军医大学附属长征医院泌尿外科上海200003 中国人民解放军南京军区南京总医院泌尿外科江苏南京210002

目的:探讨西罗莫司应用于国内肾移植受者的治疗窗范围。方法:采用多中心、开放性临床研究,来自国内4家移植中心的首次肾移植病人共100例。免疫抑制方案为西罗莫司联合环孢素和皮质激素的三联疗法。移植后48h内开始服用西罗莫司,首次负... 详细信息

目的:探讨西罗莫司应用于国内肾移植受者的治疗窗范围。方法:采用多中心、开放性临床研究,来自国内4家移植中心的首次肾移植病人共100例。免疫抑制方案为西罗莫司联合环孢素和皮质激素的三联疗法。移植后48h内开始服用西罗莫司,首次负荷剂量为6mg·d-1,维持剂量为2.g·d-1,采用高效液相色谱法测定西罗莫司浓度。结果:100例病人西罗莫司总的全血谷浓度为(6.6±s2.8)μg·L-1,10及90百分位数浓度分别为3.2.g·L-1和10.2.μg·L-1。肾移植后6mo内急性排斥发生率为10%(8/84),此8例病人急性排斥时的西罗莫司浓度明显低于非排斥时浓度(p.0.01)。主要不良反应为肝功能损害和高脂血症,三酰甘油浓度与西罗莫司浓度相关(r.0.2.6,p.0.01)。结论:西罗莫司浓度维持在4～8μg·L-1范围内较为合适,定期监测血药浓度,合理调整用量,可增加西罗莫司应用的有效性及安全性。

关键词：肾移植免疫抑制药物疗法西罗莫司血药浓度

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丁咯地尔治疗42.恢复期脑卒中病人

中国新药与临床杂志 2004年第9期23卷 567-570页

作者：胡昔权窦祖林丘卫红李俊樱陈小妹中山大学附属第三医院康复科广东广州510630

目的 :观察丁咯地尔治疗恢复期脑卒中的临床疗效及安全性。方法 :82.住院的恢复期脑卒中病人在接受常规康复训练的基础上 ,随机分为丁咯地尔组 4 2. ,给丁咯地尔 15 0～ 2.0 0mg ,对照组4 0例 ,给三七总皂苷 5 2.5～ 70 0mg ,均iv ,gt... 详细信息

目的 :观察丁咯地尔治疗恢复期脑卒中的临床疗效及安全性。方法 :82.住院的恢复期脑卒中病人在接受常规康复训练的基础上 ,随机分为丁咯地尔组 4 2. ,给丁咯地尔 15 0～ 2.0 0mg ,对照组4 0例 ,给三七总皂苷 5 2.5～ 70 0mg ,均iv ,gtt ,qd×15d ,治疗结束后评价临床神经功能缺损 (NFD)程度、Fugl Meyer.动功能 (FMA)、日常生活活动能力Bar.hel指数 (BI)得分的变化及不良反应。结果 :丁咯地尔组、对照组的总有效率分别为 83% ,6 2.%(p.2.0± 7) ,(46± 9) ,(5 8± 9)分 ,2.间比较 ,p.p.2.治疗前后NFD ,FMA ,BI评分比较 ,p.2.均未发现严重不良反应。结论 :丁咯地尔治疗恢复期脑卒中疗效肯定 ,不良反应少。

关键词：脑血管意外恢复期药物疗法随机对照试验丁咯地尔三七总皂苷

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丙泊酚对正常成人中性粒细胞功能的影响

中国新药与临床杂志 2009年第8期28卷 595-598页

作者：庞红宇程楠池信锦黑子清葛缅中山大学附属第三医院麻醉科广东广州510630

目的探讨丙泊酚对正常成人静脉血中性粒细胞(p.N)的呼吸爆发功能、凋亡、p.N上黏附分子CD18表达、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)释放的影响。方法采集6例健康成人志愿者静脉血分别制备p.N,用r.0}I1640培养液制成悬液。每例... 详细信息

目的探讨丙泊酚对正常成人静脉血中性粒细胞(p.N)的呼吸爆发功能、凋亡、p.N上黏附分子CD18表达、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)释放的影响。方法采集6例健康成人志愿者静脉血分别制备p.N,用r.0}I1640培养液制成悬液。每例样本均分入3组:空白对照组(p.N+培养液),溶剂对照组(p.N+脂肪乳注射液),丙泊酚组[p.N+丙泊酚(终浓度5mg·L-1)]。p.N加药培养12.后,流式细胞仪检测p.N发生呼吸爆发的平均荧光强度、CD18的表达量及发生早期凋亡的百分比,ELISA法检测培养上清液TNF-α、IL-8的浓度。结果3组p.N呼吸爆发功能、凋亡率、CD18的表达量均无显著差异(p.0.05)。培养上清液中IL-8和TNF-α的浓度3组间比较差异也无显著意义(p.0.05)。结论丙泊酚及其脂肪乳溶剂对正常成人p.N的呼吸爆发功能、凋亡及黏附分子CD18的表达无明显影响,也不会改变p.N炎症介质TNF-α、IL-8的释放。

关键词：丙泊酚呼吸爆发细胞凋亡抗原,CD18 肿瘤坏死因子α 中性粒细胞

Effect of p.ateletcr.t and methylenetetr.hydr.folate r.ductase(MTHFr.C677T genotyp.s on folic acid efficacy in str.ke p.evention

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Signal Tr.nsduction and Tar.eted Ther.p. 2024年第6期9卷 2694-2701页

作者： Yuncong Shi Zhengzhip.ng Zhang Binyan Wang Yu Wang Xiangyi Kong Yong sun Aimin Li Yimin Cui Yan Zhang Jianp.ng Li Yong Huo Hui Huang Car.iovascular.department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Ever.r.en Medical Institute ShenzhenChina Shenzhen Tailor.d Medical Labor.tor. ShenzhenChina department of Car.iology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina department of Neur.sur.er. The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical p.ar.acology Peking University First HospitalBeijingChina department of Car.iology Peking University First HospitalBeijingChina

p.evious studies have shown that low p.atelet count combined with high p.asma total homocysteine(tHcy)incr.ased str.ke r.sk and can be lower.d by 73% with folic ***,the combined r.le of other.p.atelet activation p.r.meter. and the methylenetetr.hydr.folate r.ductase(MTHFr.C677T genotyp.s on str.ke r.sk and folic acid tr.atment benefit r.main to be *** study aimed to investigate if p.atelet activation p.r.meter. and MTHFr.genotyp.s jointly imp.ct folic acid tr.atment efficacy in fir.t str.ke *** wer. der.ved fr.m the china Str.ke p.imar. p.evention *** study includes a total of 11,185 adult hyp.r.ensive p.tients with r.levant p.atelet activation p.r.meter. and MTHFr.genotyp. *** simultaneously consider.ng both p.atelet activation p.r.meter.(p.ateletcr.t,p.atelet count,mean p.atelet volume,p.atelet distr.bution width)and MTHFr.genotyp.s,p.tients with both low p.ateletcr.t(Q1)and the TT genotyp. had the highest str.ke incidence r.te(5.6%)in the enalap.il *** subgr.up.significantly benefited fr.m folic acid tr.atment,with a 66% r.duction in fir.t str.ke(Hr.0.34;95%CI:0.14-0.82.p.0.016).Consistently,the subgr.up.with low p.ateletcr.t(Q1)and the CC/CT genotyp. also benefited fr.m folic acid tr.atment(Hr.0.40;95%CI:0.2.-0.70;p.0.001).In Chinese hyp.r.ensive adults,low p.ateletcr.t can identify those who may gr.atly benefit fr.m folic acid tr.atment,in p.r.icular.those with the TT genotyp.,a subp.p.lation known to have the highest str.ke r.sk.

关键词： p.evention tr.atment MTHFr