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A prospective cohort of men with localized prostate cancer on active surveillance protocol in hong kong,china:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,hong kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

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Research 2024年第1期2023卷 763-778页

作者： Qing liu Qiaoyun Long Jiayu Zhao Wenjie Wu Zexin lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu Alice P.S.kong Jingying Zhou Alfred S.Cheng Hannah Xiaoyan Hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina china-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand department of medicine and Therapeutics The Chinese University of Hong KongHong KongChina hong kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina li ka shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several ***,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown *** findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to *** adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is ***,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)*** adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to *** data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

Apoptosis Induction Potential by Deleted In liver Cancer-1 (DLC-1) gene

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Apoptosis Induction Potential by Deleted In Liver Cancer-1 (...

2008年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Xiangning Zhang~(1*) Peichun Huang~1 Chun-Ming Wong~2 Wenlin Huang~3 1 department of Pathophysiology,Guangdong Medical College,Zhanjiang Guangdong,china 2.department of pathology,li ka shing faculty of medicine,the university of hong kong,pokfulam,hong kong,china 3 State Key Laboratory of Oncology in South china,Sun Yat Sen university Cancer Center,Guangzhou,china.

DLC-1 is a bona fide tumor suppressor gene (TSG) mapped to chromosome 8p22-p21,a region frequently deleted in human *** and epigenetic inactivation of DLC1 is frequently found in cancers,including hepatocellular carci...

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The influence of superficial layer neuron in auditory cortex

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The influence of superficial layer neuron in auditory cortex

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： kai YU~1,Ning-Qian WANG~1,Zhuo ZHANG~1,Ying-shing CHAN~2,Ju-Fang HE~(1,*) 1 department of Rehabilitation Sciences,The hong kong Polytechnic university,hong kong,china 2.department of Physiology and Research Centre of Heart,Brain,Hormone,and Healthy Aging,LKS faculty of medicine, university of hong kong,hong kong,china

＜正＞Pyramidal neurons in different layers of the cerebral cortex send abundant dendrites into the superficial *** the present study,we investigated the functional implication of superficial layer neurons in the auditory cortex in terms of its influence on other cortical *** responses and spontaneous activities in the primary auditory cortex were recorded through in vivo intracellular recordings and multiple extracellular recordings in anesthetized guinea pigs,while electrical stimuli were applied to active neurons in different *** some cases,the firings of single neuron were manipulated by electrical pulses delivered by intracellular *** results showed that electrical stimuli changed the firing pattern of neurons that located in deep and superficial *** long lasting firing of single superficial layer neuron changed the global state of the auditory *** results indicate that the superficial layer plays a modulatory role in the cortex.

关键词： auditory cortex superficial layer brain state modulation

Fatty Connection to Vascular Reactivity

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Fatty Connection to Vascular Reactivity

2008心血管药理学术研讨会

作者： Yu Huang department of Physiology and Institute of Vascular medicine,Chinese university of hong kong,hong kong SAR,china

Perivascular fat is routinely removed for isometric vessel contraction *** and Cassis showed that perivascular fat significantly attenuates vascular responsiveness of rat isolated aortic ring preparations to *** confi...

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Corticothalamic synchronization leads to c-fos expression in the auditory thalamus

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Corticothalamic synchronization leads to c-fos expression in...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yi-Ping GUO~1,Xia SUN~(1,2),Chuan li~1,Ning-Qing WANG~1,Ying-shing CHAN~2,Ju-Fang HE~1 1 department of Rehabilitation Sciences,The hong kong Polytechnic university,Hung Horn,Kowloon,hong kong 2.department of Physiology and Research Centre of Heart,Brain,Hormone and Healthy Aging,LKS faculty of medicine, the university of hong kong,hong kong,china

＜正＞In the present study,we investigated the relationship between c-fos expression in the auditory thalamus and corticofugal *** contribution of neurotransmitters and related receptors,the involvement of thalamic reticular nucleus（TRN） and the role of neuronal firing patterns in this process were also *** principal nuclei of the medial geniculate body（MGB） showed c-fos expression when the auditory cortex（AC） was activated by direct injection of bicuculline methobromide（BIM）.However,no expression was detectable with acoustic stimuli *** indicated that c-fos expression in the principal nuclei of the MGB was triggered by the corticofugal projection,c-fos expression could be elicited in the MGB by direct injection of *** administration of acetylcholine,alternatively,had no effect. BIM injection in the AC also triggered synchronized oscillatory activities sequentially in the AC and *** induced c-fos expression in the MGB was not mediated by a pathway involving the thalamic reticular nucleus since it remained intact after a TRN lesion with kainic *** present results also conclude that c-fos expression is not simply associated with firing rate,but also neuronal firing *** firings that are synchronized with the cortical oscillations are proposed to lead to c-fos expression in the principal nuclei of the MGB.

关键词： c-fos corticothalamic synchronization auditory thalamus thalamic reticular nucleus

Dual Th1/Treg and Th17/Treg imbalances ofα4+β7+RO+CD4+ T cells in HIV-1 infection after prolonged antiretroviral therapy

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Dual Th1/Treg and Th17/Treg imbalances ofα4+β7+RO+CD4+ T c...

中华医学会第五次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议

作者： Qiaoli Peng~1,Haibo Wang~2,Xuan li~1,Guiying li~1,Xiaofan Lu~2,Boping Zhou~1,Hui Wang~1,Zhiwei Chen~2 1 HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory,Shenzhen Third People's Hospital,Shenzhen 518020,PR china 518020 2 AIDS Institute,li ka shing faculty of medicine,the university of hong kong,21 Sassoon Road,Pokfuiam,hong kong SAR,PR china 518020

Gut-homing a4b7ROT ceils are preferentially infected and depleted during HIV-1 *** antiviral therapy（ART）would reconstitute various gut-homing T cell subsets

关键词： HIV Dual Th1/Treg and Th17/Treg imbalances of RO+CD4 T cells in HIV-1 infection after prolonged antiretroviral therapy

Carbon materials for enhanced photothermal conversion:Preparation and applications on steam generation

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Materials Reports(Energy) 2024年第2期4卷 34-44页

作者： Jiayi Zhu liu Huang Feng Bao Guanli Chen kangjin Song Zheling Wang hong Xia Jinping Gao Yibing Song Caizhen Zhu Fushen Lu Tingting Zheng Muwei Ji College of Chemistry and Chemical Engineering Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou515063China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan528458China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen518060China department of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China

Photothermal conversion attracted lots of attention in the past years and sorts of materials were explored to enhance photothermal *** the past years,solar-driven desalination by photothermal conversion was proposed to release the shortage of fresh water and then it was considered much more important to prepare photothermal materials on large scales with high performance and low *** this review,we summarized the works on carbon-based photothermal materials in the past years,including the preparation as well as their application in steam *** these works,we give an outlook on the difficulties and chances of how to design and prepare carbon-based photothermal materials.

关键词： Photothermal conversion Carbon Composites Solar energy Steam generation

Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells

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Angiotensin AT1 receptor activation mediates high glucose-in...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： li ZHOU~1,hong XUE~1,Ping YUAN~1,Jun NI~1,Yu HUANG~2,li-Min LU~1 1 department of Physiology and Pathophysiology,Shanghai Medical College,Fudan university,Shanghai 200032,china 2 Institute of Vascular medicine,li ka shing Institute of Health Sciences and School of Biomedical Sciences,Chinese university of hong kong, hong kong,china

＜正＞Renal tubular epithelial cells undergo epithelial to mesenchymal transition（EMT） under hyperglycaemic conditions,which is associated with renal interstitial *** of the rennin-angiotensin system（RAS） is involved in diabetic *** present study investigated the positive role of angiotensin AT1 receptor activation in high glucose-induced EMT in cultured tubular epithelial cells.A rat kidney proximal tubular epithelial cell line（NRK-52E） was used in the present *** of E-cadherin and vimentin,were estimated using fluorescence immunocytochemistry,mRNA levels of angiotensinogen（AGT）,angiotensin-converting enzyme（ACE） and AT1 receptors were determined by real-time PCR,protein levels of E-cadherin,vimentin,fibronectin,matrix metallopeptidase（MMP）-9 and phosphorylated extracellular signal-regulated kinase（ERK） 1/2 were analyzed by western blotting and the concentrations of angiotensin（Ang） II and transforming growth factor（TGF）-β1 in the culture medium were determined by enzyme immunoassay and *** glucose induced EMT and increased the synthesis of fibronectin and ***,high glucose increased AGT,ACE and AT1 receptor mRNA levels,as well as AngⅡand TGF-β1 concentrations in the culture medium and ERK1/2 *** of cells with the AT1 receptor antagonist losartan attenuated high glucose-induced increases in TGF-β1 and ERK1/2 phosphorylation and reduced EMT,as well as the consequent synthesis of fibronectin *** results suggest that the activated local RAS mediates high glucose-induced *** activating AT1 receptors and stimulating TGF-β1 synthesis,the elevated local RAS participates in high glucose-induced EMT and increased extracellular matrix secretion.

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