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扎伊尔型埃博拉病毒糖蛋白的原核表达及多克隆抗体的制备

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中国兽医学报 2018年第3期38卷 496-501页

作者：吴芳芳曹增国王琪迟航金宏丽冯娜赵永坤高玉伟王化磊杨松涛夏咸柱军事医学科学院军事兽医研究所吉林省人兽共患病预防与控制重点实验室吉林长春130122 吉林大学动物医学学院吉林长春130062 吉林农业大学动物科学技术学院吉林长春130118

针对扎伊尔型埃博拉病毒（Zaire Ebolavirus,ZEBOV）的糖蛋白（GP）基因（158-368aa）设计引物,将PCR扩增产物克隆至原核表达载体pET30a（＋）,在宿主菌BL21（DE3）中IPTG诱导表达。对诱导条件进行优化,纯化后的蛋白通过SDS-PAGE和Weste... 详细信息

针对扎伊尔型埃博拉病毒（Zaire Ebolavirus,ZEBOV）的糖蛋白（GP）基因（158-368aa）设计引物,将PCR扩增产物克隆至原核表达载体pET30a（＋）,在宿主菌BL21（DE3）中IPTG诱导表达。对诱导条件进行优化,纯化后的蛋白通过SDS-PAGE和Western blot鉴定正确后免疫BALB/c小鼠,二免后分离小鼠血清,制备多克隆抗体并进行间接免疫荧光鉴定。结果显示,埃博拉病毒GP在大肠杆菌中以包涵体的形式成功表达,蛋白最佳诱导条件为37℃,0.4mmol/L IPTG诱导6h。经间接免疫荧光鉴定多克隆抗体可以识别重组杆状病毒rBacmid-GP。本研究成功表达并纯化埃博拉病毒GP,制备鼠多克隆抗体,为建立基于ZEBOV GP的检测方法和相关研究奠定了基础。

关键词：埃博拉病毒原核表达糖蛋白(GP) 多克隆抗体

Short-term and oncological outcomes of natural orifice specimen extraction surgery(NOSES)for colorectal cancer in china:a national database study of 5055 patients

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science Bulletin 2022年第13期67卷 1331-1334,M0003页

作者： Xu Guan Xiyue Hu Zheng Jiang Ye Wei Donghui Sun Miao Wu Haitao Zhou Hongliang Yao Junmin Song Guiyu Wang Junhong Hu Mingyang Ren Qing Xu Jianchun Cai Jian Peng Dan Ma Yangchun Zheng Qingsi He Bo Jiang Zejun Wang Taiyuan Li Su Yan Luchuan Chen Tiegang Li Zhiguo Xiong Pan Chi Liang Kang Gang Yu Xiaodong Deng Hong Zhang Ming Xie Jianbao Wei Hongyan Gong Xuejun Sun Weidong Zang Yongmao Song Peng He Zhengqi Wen Chunxu Zhang Yusheng Wang Yinggang Chen Guangwei Xie Mingzhang Li Shaojun Yu Haiying Liu Min Pu Chuangang Fu Xishan Wang on behalf of china NOSES Alliance department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of General Surgery Zhongshan HospitalFudan UniversityShanghai 200032China department of Gastrointestinal and Anal Surgery Jilin University First HospitalChangchun 130021China department of Gastrointestinal Surgery The Second People’s Hospital of YibinYibin 644000China department of Gastrointestinal Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011China department of Anorectal Surgery First Affiliated HospitalZhengzhou UniversityZhengzhou 450052China department of Colorectal Cancer Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China department of Gastrointestinal Surgery Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China department of Gastrointestinal Surgery Renji HospitalShanghai JiaoTong University School of MedicineShanghai 200240China department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004China department of General Surgery Xiangya HospitalCentral South UniversityChangsha 410008China department of General Surgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037China department of Gastrointestinal Surgery Sichuan Cancer HospitalChengdu 610041China department of General Surgery Shandong University Qilu HospitalJinan 250012China department of Colorectal and Anal Surgery Shanxi Cancer HospitalTaiyuan 030013China department of Gastrointestinal Surgery The Affiliated Cancer Hospital of Guizhou Medical UniversityGuiyang 550008China department of General Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006China department of Gastrointestinal Surgery Qinghai University Affiliated HospitalXining 810012China department of Gastrointestinal Surgery Fujian Medical University Cancer HospitalFuzhou 350014China Depar

经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势... 详细信息

经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势,但绝大多数研究均为小样本、单中心回顾性研究.本研究旨在通过分析我国5055例结直肠肿瘤NOSES患者数据,进一步探讨NOSES的短期疗效与预后.研究对象中,经直肠NOSES占整体比例的90.3%,经阴道NOSES占9.7%.NOSES术后短期并发症发生率为14.1%,吻合口瘘发生率为4.9%,腹盆腔感染率为1.9%.患者3年总生存率为93.2%,无病生存率为82.2%,局部复发率为3.6%.研究结果提示NOSES具有较好的安全性与可行性,为其应用于结直肠肿瘤治疗提供了证据.

关键词：结直肠肿瘤肿瘤学并发症发生率无病生存率吻合口瘘回顾性研究总生存率经直肠

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng Ying-Hui Jin Tong-Zu Liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing Huang Zhi Hou Wan-Li Hu Xin-Li Kang Gong-Hui Li Jian-Xing Li Pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu Zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian Feng Wang Feng Wang Yin-Huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-Hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu Qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-Lin He Xing-Huan Wang 无 department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China department of Urology Qinghai University Affiliated HospitalXi’ning810012China department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

Value of Kidney Disease Improving Global Outcomes Urine Output Criteria in Critically III Patients： A Secondary Analysis of a Multicenter Prospective Cohort Study

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Chinese Medical Journal 2016年第17期129卷 2050-2057页

作者： Jun-Ping Qin Xiang-You Yu Chuan-Yun Qian Shu-Sheng Li Tie-He Qin Er-Zhen Chen Jian-Dong Lin Yu-Hang Ai Da-Wei Wu De-Xin Liu Ren-Hua Sun Zhen-Jie Hu Xiang-Yuan Cao Fa-Chun Zhou Zhen-Yang He Li-Hua Zhou You-Zhong An Yan Kang Xiao-Chun Ma Ming-Yan Zhao Li Jiang Yuan Xu Bin Du Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 100730 China department of Critical Care Medicine Beijing Tongren Hospital Capital Medical University Beijing 100730 China department of Critical Care Medicine First Affiliated Hospital Xinjiang Medical University Urumqi Xinjiang 830054 China department of Emergency Medicine and Medical Intensive Care Unit The First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China department o1 Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510080 China department of Emergency Medicine Ruijin Hospital Shanghai Jiao Tong University Shanghai 200025 China department of Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 350005 China department of Critical Care Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China department of Critical Care Medicine Qilu Hospital Shandong University Jinan Shandong 250012 China department of Emergency and Critical Care Medicine The Second Hospital of Jilin University Changchun Jilin 130041 China department of Critical Care Medicine Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China department of Critical Care Medicine Hebei Medical University Fourth Hospital Shijiazhuang Hebei 050011 China department of Critical Care Medicine Affiliated Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China department of Emergency and Intensive Care Medicine The First Affiliated Hospital Chongqing Medical University Chongqing 400016 China department of Critical Care Medicine Hainan Provincial People's Hospital Haikou Hainan 570311 China department of Critical Care Medicine The Affiliated Hospital of Inner Mongolia Medical College Hohhot Inner Mongolia 010050 China department of C

Background： Urine output （UO） is an essential criterion of the Kidney Disease Improving Global Outcomes （KD1GO） definition and classification system tbr acute kidney injury （AKI）, of which the diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria （KDtGOLro） could improve the diagnostic and prognostic accuracy, compared with KDIGO serum creatinine criteria （KDIGOscr）.Methods： We conducted a secondary analysis of the database of a previous study conducted by china Critical Care Clinical Trial Group （CCCCTG）, which was a 2-month prospective cohort study （July 1,2009 to August 31,2009） involving 3063 patients in 22 tertiary Intensive Care Units in Mainland of china. AKI was diagnosed and classified separately based on KDIGOt,o and KDlGOsc,. Hospital mortality of patients with more severe AKI classification based on KDIGOvo was compared with other patients by univariate and multivariate regression analyses. Results： The prevalence of AKl increased from 52.4% based on KDIGOscr to 55.4% based on KD1GOsc~ combined with KDIGOuo. KDIGOv~~ also restllted in an upgrade of AKI classification in 7.3% of patients, representing those with more severe AK1 classification based on KDIGOvo. Compared with non-AKI patients or those with maximum AKI classification by KDIGOscr, those with maximum AKI classification by KDIGOuo had a significantly higher hospital mortality of 58.4% （odds ratio [OR]： 7.580, 95% confidence interval [CI]： 4.141-13.873, P 〈 0.001）. In a multivariate logistic regression analysis, AKI based on KDIGOuo （OR： 2.891, 95% CI： 1.964-4.254, P 〈 0.001）, but not based on KDIGOscr （OR： 1.322, 95% CI： 0.902-1.939, P = 0.152）, was an independent risk factor for hospital mortality. Conclusion： UO was a criterion with additional value beyond creatinine criterion for AKI diagnosis and classification, which can help identify a group of patients with high risk of death.

关键词： Acute Kidney Injury Critically Ill Mortality Serum Creatinine Urine Output

Chinese guidelines for the application of colon cancer staging recognition systems based on artificial intelligence platforms (2021)

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Intelligent Medicine 2021年第1期1卷 37-42页

作者： Yun Lu Shuai Li Yuan Gao Yong Dai Bo Feng Fanghai Han Jiagang Han Jingjing He Xinxiang Li Guole Lin Qian Liu Guiying Wang Quan Wang Zhenning Wang Zheng Wang Aiwen Wu Bin Wu Yingchi Yang Hongwei Yao Wei Zhang Jianping Zhou Aimin Hao Zhongtao Zhang 无 department of General Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Beihang university State Key Laboratory of Virtual Reality Technology and Systems Beijing 100191China department of General Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China Shanghai Minimally Invasive Surgery Center Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China department of Gastrointestinal Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China department of General Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100027China Institute of International Law Chinese Academy of Social SciencesBeijing 102442China department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Third Hospital of Hebei Medical university ShijiazhuangHebei 50051China department of Colon and Rectum Surgery The First Hospital of Jilin UniversityChangchunJilin 130031China department of Surgical Oncology and General Surgery Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal TumorsMinistry of EducationThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Unit II

The incidence and mortality of colon cancer in china are increasing each *** present,treatment selection for colon cancer patients mainly depends on imaging results,which require a large number of radiologists to *** china,there is a shortage and uneven distribution of experienced radiologists,which leads to delays and bias in the evaluation of imaging *** on these considerations,the Colorectal Surgery Group of the Surgery Branch of the Chinese Medical Association in collaboration with experts at Beihang university has independently developed an artificial intelligence(AI)-based recognition system for the preoperative determination of colon cancer stage to partially replace the work of and relieve the pressure on *** guidelines aim to standardize the use of AI-based recognition systems in the preoperative staging of colon cancer and guide their clinical application.

关键词： Artificial intelligence Colon cancer Deep learning Preoperative staging

Diagnosis and Treatment of Acne Inversa/Hidradenitis Suppurativa in china: An Expert Consensus Statement (2021 Version)

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International Journal of Dermatology and Venereology 2021年第2期4卷 100-108页

作者： Hong Fang Xing-Hua Gao Song-Mei Geng Heng Gu Jun Gu Li He Xian Jiang Hong-Zhong Jin Qiang Ju Xiao-Jing Kang Wei Lai Cheng-Xin Li Hang Li Heng-Jin Li Shan-Shan Li Yu-Zhen Li Qing Sun Juan Tao Baoxi Wang Gang Wang Xin-Feng Wu Lei-Hong Xiang Hong-Fu Xie Hao-Xiang Xu Jin-Hua Xu Yan Yan Zhi-Zhong Zheng department of Dermatology The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310003China department of Dermatology No.1 Hospital of China Medical UniversityShenyangLiaoning 110001China department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China department of Dermatology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China department of Dermatology Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China department of Dermatology and Venereology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510630China department of Dermatology First Medical Center of Chinese PLA General HospitalBeijing 100853China department of Dermatology and Venerology Peking University First HospitalBeijing 100034China department of Dermatology Hainan Hospital of PLA General HospitalSanyaHainan 572013China department of Dermatology and Venereology The First Hospital of Jilin UniversityChangchunJilin 130021China department of Dermatology Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China department of Dermatology Affiliated Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China De

Acne inversa/hidradenitis suppurativa is a chronic,recurrent,inflammatory skin disease that affects the pilosebaceous units,causinfollicular *** etiology and pathogenesis of acne inversa/hidradenitis suppurativa involves internal and external factors such as genetic susceptibility,inflammation and immunity,microorganisms,obesity,and *** inversa/hidradenitis suppurativa is difficult to treat,and the current aim of treatment is to control the frequency and duration of disease flares and improve the quality of *** protocols for acne inversa/hidradenitis suppurativa should be selected based on the disease severity *** treatments include antibiotics,retinoids,biologics,immunosuppressive agents,and antiandrogen *** treatments include surgery and laser/light *** consensus aims to further standardize the diagnosis and treatment procedures of acne inversa/hidradenitis suppurativa in china to facilitate its diagnosis and treatment.

关键词： acne inversa consensus diagnosis hidradenitis suppurativa therapy

哮喘治疗依从性与肺功能和控制水平的相关性分析

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中国呼吸与危重监护杂志 2022年第11期21卷 761-767页

作者：王文雅林江涛刘春涛唐华平霍建民顾玉海刘荣玉陈萍袁雅冬杨晓红许建英孙德俊李娜嘉姜淑娟陈一强王长征杨岚刘晓菊杨冬张伟陈卓昌林其昌周建英周新胡成平蒋萍周玮张捷蔡绍曦邱晨黄茂黄奕江刘辉国中国哮喘研究协作组中日友好医院呼吸与危重症医学科国家呼吸疾病临床研究中心北京100029 四川大学华西医院呼吸与危重症医学科四川成都610041 青岛市立医院呼吸与危重症医学科山东青岛266071 哈尔滨医科大学第一附属医院呼吸科黑龙江哈尔滨150001 青海省人民医院呼吸科青海西宁810007 安徽医科大学第一附属医院呼吸与危重症医学科安徽合肥230022 北部战区总医院呼吸科辽宁沈阳110016 河北医科大学第二附属医院呼吸科河北石家庄050004 新疆维吾尔自治区人民医院呼吸与危重症医学科新疆乌鲁木齐830001 山西白求恩医院呼吸与危重症医学科山西太原030032 内蒙古人民医院呼吸与危重症医学科内蒙古呼和浩特010017 大庆油田总医院呼吸科黑龙江大庆163311 山东省人民医院呼吸与危重症医学科山东济南251411 广西医科大学第一附属医院呼吸内科广西南宁530021 陆军医科大学新桥医院呼吸内科重庆410037 西安交通大学附属第一医院呼吸与危重症医学科陕西西安710061 兰州大学第一医院老年呼吸科甘肃兰州730000 复旦大学附属中山医院呼吸内科上海200032 南昌大学第一附属医院呼吸内科江西南昌330006 河南省人民医院呼吸内科河南郑州450003 福建医科大学第一附属医院呼吸内科福建福州350005 浙江大学医学院附属第一医院呼吸内科浙江杭州310003 上海交通大学医学院附属上海市第一人民医院呼吸内科上海200080 中南大学湘雅医院呼吸与危重症医学科湖南长沙410008 天津市第一中心医院呼吸内科天津300192 宁夏医科大学总医院呼吸与危重症医学科宁夏银川750003 吉林大学第二医院呼吸与危重症医学科吉林长春130041 南方科技大学附属南方医院呼吸与危重症医学科广东广州510515 暨南大学第二临床医学院深圳市人民医院呼吸与危重症医学科广东深圳518020 南京医科大学附属第一医院呼吸与危重症医学科江苏南京211103 海南省人民医院呼吸与危重症医学科海南海口570031 华中科技大学同济医学院附属同济医院呼吸内科湖北武汉430030 不详

目的分析未控制的哮喘患者药物治疗依从性与肺功能、气道炎症水平、哮喘控制水平以及患者生活质量之间的关系,为改善患者依从性和提高哮喘控制水平提供依据。方法以我国内地28个省市32家三甲医院未达到哮喘控制且依从性差的哮喘患者... 详细信息

目的分析未控制的哮喘患者药物治疗依从性与肺功能、气道炎症水平、哮喘控制水平以及患者生活质量之间的关系,为改善患者依从性和提高哮喘控制水平提供依据。方法以我国内地28个省市32家三甲医院未达到哮喘控制且依从性差的哮喘患者作为研究对象,通过问卷调查的方式收集患者一般资料,所有患者均行肺功能、气道炎症水平检测,分析我国成人哮喘患者治疗依从性。结果调查共计923例患者,调查问卷回收率100%。哮喘疾病认知相关问题回答完全正确者占243例(26.33%),哮喘疾病认知相关问题不能完全回答正确者占680例(73.67%)。哮喘患者治疗依从性与肺功能指标呈正相关,与呼出气一氧化氮呈明显负相关。治疗依从性高的哮喘患者,其哮喘控制水平和生活质量更高。哮喘患者治疗依从性不佳将会导致肺功能下降和气道炎症水平升高,使哮喘控制水平以及生活质量下降。结论哮喘治疗依从性与肺功能及气道炎症水平、哮喘控制水平和生活质量相关。

关键词：支气管哮喘治疗依从性哮喘控制生活质量肺功能

Search for the weak decayψ(3686)→■+c.c.

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Chinese Physics C 2023年第1期47卷 19-27页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina R.Baldini Ferroli I.Balossino 班勇 V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.E.de Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold M.Himmelreich 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kappert 柯百谦 I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李翠李聪李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J.Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇梁昊梁浩梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏 Z.H.Lu 罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K.H.Rashid C.F.Redmer 任旷洁 A.Rivetti V.Rodin M.Rolo 荣刚 Ch.Rosn Institute of High Energy Physics Beijing 100049China Beihang university Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-university D-44780 BochumGermany Carnegie Mellon university PittsburghPennsylvania 15213USA Central china Normal university Wuhan 430079China Central South university Changsha 410083China china Center of Advanced science and Technology Beijing 100190China COMSATS university Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan university Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal university Guilin 541004China Guangxi university Nanning 530004China Hangzhou Normal university Hangzhou 310036China Hebei university Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal university Xinxiang 453007China Henan university of science and Technology Luoyang 471003China Henan university of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal university Changsha 410081China Hunan university Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana university BloomingtonIndiana 47405USA AINFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di Perugia I-06100PerugiaItaly university of Perugia I-06100PerugiaItaly INFN Sezione di Ferrara I-44122FerraraItaly university of Ferrara I-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia jilin university Changchun 130012China Johannes Gutenberg university of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany Lanzhou U

Using(448.1±2.9)×10^(6)ψ(3686)for the weak baryonic decayψ(3686)→Λc+∑-+c.c..The analysis procedure is optimized using a blinded *** significant signal is observed,and the upper limit on the branching fraction(B... 详细信息

关键词： weak decay upper limit BESIII detector