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Protective Effects of Vitamin E against Oxidative Damage Induced by Aβ(1-40)Cu(Ⅱ)Complexes

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Acta Biochimica et Biophysica Sinica 2007年第2期39卷 123-130页

作者： Xueling DAI~1 Yaxuan SUN~2.and Zhaofeng JIANG~2.~1college of Life Science,Capital Normal university,Bejing 100037,China ~2.0} of applied sciences humanities of beijing union university,beijing 100083,China college of Life Science Capital Normal UniversityBeijing 100037 China college of applied {2. and humanities of beijing union universitybeijing 100083 China

β-amyloid peptide （Aβ） is considered to be responsible for the formation of senile plaques,which is the hallmark of Alzheimer's disease （AD）.Oxidative stress,manifested by protein oxidation andlipid peroxidation,among other alterations,is a characteristic of AD brain.A growing body of evidence hasbeen presented in support of Aβ1-40forming an oligomeric complex that binds copper at a CuZn superoxidedismutase-like binding site. Aβ1-40Cu（Ⅱ） complexes generate neurotoxic hydrogen peroxide （H2.2. from O2.ia Cue+ reduction,though the precise reaction mechanism is *** toxicity of Aβ1-40or the Aβ1-40Cu（Ⅱ）complexes to cultured primary cortical neurons was partially attenuated when （+）-α-tocopherol （vitamin E）as free radical antioxidant was added at a concentration of 100 μ*** data derived from lactate dehydro-genase （LDH） release and the formation of H2.2.onfirmed the results from the MTT *** findingsindicate that copper binding to Aβ1-40can give rise to greater production of H2.2. which leads to a break-down in the integrity of the plasma membrane and subsequent neuronal *** treated with vitaminE exhibited much slighter damage,suggesting that vitamin E plays a key role in protecting neuronal cellsfrom dysfunction or death.

关键词： Aβ1-40Cu(II)complex vitamin E neuronal oxidative damage H2.2.generation lactate dehydrogenase(LDH)release

Empirical likelihood confidence regions of the parameters in a partially linear single-index model

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Science China Mathematics 2005年第10期48卷 1333-1348页

作者： XUE Liugen~1 & ZHU Lixing~2.1. college of applied {2.,beijing university of Technology,beijing 10002.,China 2. Department of Mathematics,Hong Kong Baptist university,Hong Kong,China college of applied {2. Beijing University of Technology Beijing China Department of Mathematics Hong Kong Baptist University Hong Kong China

In this paper, a partially linear single-index model is investigated, and three empirical log-likelihood ratio statistics for the unknown parameters in the model are suggested. It is proved that the proposed statistics are asymptotically standard chi-square under some suitable conditions, and hence can be used to construct the confidence regions of the parameters. Our methods can also deal with the confidence region construction for the index in the pure single-index model. A simulation study indicates that, in terms of coverage probabilities and average areas of the confidence regions, the proposed methods perform better than the least-squares method.

关键词： partially linear single-index model, empirical likelihood, confidence region, chi-square distribution, coverage probability.

Simultaneous variable selection for heteroscedastic regression models

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Science China Mathematics 2011年第3期54卷 515-530页

作者： ZHANG ZhongZhan1 & WANG DaRong2.1college of applied {2., beijing university of Technology, beijing 10012., China 2.he Pilot college, beijing university of Technology, beijing 101101, China college of applied {2. Beijing University of Technology Beijing China The Pilot college Beijing University of Technology Beijing China

In this paper, we propose a new criterion, named PICa, to simultaneously select explanatory variables in the mean model and variance model in heteroscedastic linear models based on the model structure. We show that the new criterion can select the true mean model and a correct variance model with probability tending to 1 under mild conditions. Simulation studies and a real example are presented to evaluate the new criterion, and it turns out that the proposed approach performs well.

关键词： variable selection heteroscedastic regression models adjusted profile log-likelihood AIC BIC

Effects of 3,4-DichIOrOaniline on Testicle Enzymes as Biological Markers in Rats

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Biomedical and Environmental sciences 2009年第1期22卷 40-43页

作者： Bo ZHANG~2.AND SEN LIN Department ofBiology,college ofapplied {2. and humanities,beijing union university, beijing 100083,China

Objective To investigate the effects of 3,4-dichloroaniline （3,4-DCA） on activities of testicle enzymes as biological markers in rats. Methods Fifty male rats were randomly divided into 5 groups （n=10）. One group was left untreated and used as a solvent control （administered orally by corn oil）, while the other 4 groups were treated with 3, 4-DCA. Corn oil was used as a solvent, and 3,4-DCA was diluted into tested concentrations （39, 81, 170, and 357 mg/kg）. All the groups orally administered 3,4-DCA or corn oil, once a day for 4 weeks. The testicle tissue was homogenized in a 0.1 mol/L potassium phosphate buffer （0.1 mol/L, pH 7.2.. The crude homogenate was centrifuged at 6000 rpm for 5 min at 4 ~C. The supernatant obtained was used as an enzyme extract for determination of the enzyme activities. Results Compared with the control, the activities of ALP, ACP, and SDH were increased significantly at a lower level of 3,4-DCA, and decreased at a higher level of 3, 4-DCA, whreas the activities of LDH, LDH-X, and G6PDH were inhibited significantly with the increased 3,4-DCA concentration. Organ coefficient ＂organ weight/total body weight × 100＂ of testis, liver, and spleen increased significantly with the increased 3,4-DCA concentration. These results suggest that 3,4-DCA toxicity to the male reproductive system was associated with the activities of testicular enzymes which are the sensitive biochemical endpoints reflecting 3,4-DCA toxicity to the male reproductive system. Conclusion 3,4-DCA has toxicity to the reproductive system in male rats.

关键词： 3, 4-dichloraniline Rat Marker testicular enzymes

A heuristic path-estimating algorithm for large-scale real-time traffic information calculating

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Science China(Technological sciences) 2008年第S1期51卷 165-174页

作者： L WeiFeng1,ZHU TongYu1,WU DongDong2.DAI Hong3 & HUANG Jian1 1 State Key Laboratory for Software Development Environment,Beihang university,beijing 100083,China 2.{2. Transportation Information Center,{2. 100055,China 3 college of Arts & Science,beijing union university,beijing 100083,China State Key Laboratory for Software Development Environment Beihang University Beijing China beijing Transportation Information Center Beijing China college of Arts & Science Beijing Union University Beijing China

As the original Global Position System (GPS) data in Floating Car Data have the accuracy problem,this paper proposes a heuristic path-estimating algorithm for large-scale real-time traffic information calculating. It uses the heuristic search method,imports the restriction with geometric operation,and makes comparison between the vectors composed of the vehicular GPS points and the special road network model to search the set of vehicular traveling route candidates. Finally,it chooses the most optimal one according to weight. Experimental results indicate that the algorithm has considerable efficiency in accuracy (over 92.7%) and com-putational speed (max 8000 GPS records per second) when handling the GPS tracking data whose sampling rate is larger than 1 min even under complex road network conditions.

关键词： path-estimating floating car data (FCD) road network vector GPS

Existence of solutions for the dynamic equation of ferrimagnets

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Progress in Natural Science:Materials International 2007年第11期17卷 1279-1283页

作者： Zeng Ming1, Guo Boling2.and Cheng Caozong1(1. college of applied {2., beijing university of Technology, beijing 10002., China 2. Center for Nonlinear Studies, Institute of applied Physics and Computational Mathematics, beijing 100088, China) college of applied {2. Beijing University of Technology Beijing 100022 China Center for Nonlinear Studies Institute of Applied Physics and Computational Mathematics Beijing 100088 China

Ferrimagnet is a kind of basic and important multi-sublattice magnet material. It has attracted more and more attention of physicists and mathematicians. Many results of solitons and numerical computations on this topic have appeared. In this article, the dynamic equation for an isotropic ferrimagnet with two non-equivalent sublattices is studied, existence of weak solutions in multi dimension case is proved through the penalized method, the uniqueness and smoothness of the solution in one dimension case are also obtained by the relation between this equation and hyperbolic equation.

关键词： ferrimagnet weak solutions penalized method finite difference method

A new DNA algorithm to solve graph coloring problem

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Progress in Natural Science:Materials International 2007年第6期17卷 733-738页

作者： Jiang Xingpeng1, Li Yin2. Meng Ya3 and Meng Dazhi2.1. National Laboratory of Pattern Recognition,Institute of Automation, Chinese Academy of sciences, beijing 100080, China 2. {2. of applied sciences, beijing university of Technology, beijing 10002., China 3. School of Science, beijing Institute of Technology, beijing 100081, China) National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100080 China college of applied {2. Beijing University of Technology Beijing 100022 China School of Science Beijing Institute of Technology Beijing 100081 China

Using a small quantity of DNA molecules and little experimental time to solve complex problems successfully is a goal of DNA computing. Some NP-hard problems have been solved by DNA computing with lower time complexity than conventional computing. However, this advantage often brings higher space complexity and needs a large number of DNA encoding molecules. One example is graph coloring problem. Current DNA algorithms need exponentially increasing DNA encoding strands with the growing of problem size. Here we propose a new DNA algorithm of graph coloring problem based on the proof of four-color theorem. This algorithm has good properties of needing a relatively small number of operations in polynomial time and needing a small number of DNA encoding molecules (we need only 6R DNA encoding molecules if the number of regions in a graph is R).

关键词： DNA computing NP-hard problem graph coloring problem.

Spatial heterogeneity of the driving forces of cropland change in China

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Science China Earth sciences 2005年第12期48卷 2231-2240页

作者： LIU Xuhua1,2. WANG Jinfeng1, LIU Mingliang4,1 & MENG Bin1,2.3 1. Institute of Geographic sciences and Natural Resources Research, Chinese Academy of sciences, {2. 100101, China 2. Graduate School of the Chinese Academy of sciences, {2. 100039, China 3. college of Arts and sciences of beijing union university, beijing 100083, China 4. School of Forestry and Wildlife sciences, Auburn university, Auburn, Alabama, AL36849, USA Institute of Geographic sciences and Natural Resources Research Chinese Academy of Sciences Beijing China Graduate School of the Chinese Academy of sciences Beijing China School of Forestry and Wildlife sciences Auburn University Auburn Alabama USA college of Arts and sciences of {2. Beijing China

By using digital satellite remote sensing data acquired in 1987―1989 and 1999―2.00 and GIS combined with the natural and socio-economic data, this paper drew an integrated zonation of the cropland change and its driving forces in China. The results indicated that the cropland change in the study period was constrained by geographical factors and driven by cli-mate change as well as socio-economic system. Moreover, the regional differences of the drivers for cropland change were significant. In the midwest of China, natural condition changes and geographical background were the main constraints and drivers, while in Eastern China, social and economic changes and economic policies were the main driving forces. The cropland loss was nationwide. The dominant factors to cause this decrease included buildup of developing area to attract foreign capital and technologies, changes of industry structure due to urban in-fluence, the change of employment notions thanks to living standard improvement, rapid ur-banization due to the expansion of cities and towns, the diminished farming net income partly because of the global warming effects, and the rapid economic growth stimulated by the con-venient transportation system. These factors interact and interdepend with each other to cause the cropland loss in China recently. The reasons for the increase of cropland were primarily the cultivation and deforestation by the farmers who want to increase income. This study on the mechnism of LUCC relied on the cropland change integrated classification considering the natural or human factors both inside and outside the region, which provides a new approach to study the integrated regionalization and LUCC mechanism.

关键词： land use change, driving force, integrated classification, spatial statistics, cropland, China.

Empirical likelihood-based inference in a partially linear model for longitudinal data

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Science China Mathematics 2008年第1期51卷 115-130页

作者： XUE LiuGen~(1+) & ZHU LiXing~2.1 college of applied {2., beijing university of Technology, beijing 10002., China 2.Department of Mathematics, Hong Kong Baptist university, Hong Kong, China college of applied {2. Beijing University of Technology Beijing China Department of Mathematics Hong Kong Baptist University Hong Kong China

A partially linear model with longitudinal data is considered, empirical likelihood to infer- ence for the regression coefficients and the baseline function is investigated, the empirical log-likelihood ratios is proven to be asymptotically chi-squared, and the corresponding confidence regions for the pa- rameters of interest are then constructed. Also by the empirical likelihood ratio functions, we can obtain the maximum empirical likelihood estimates of the regression coefficients and the baseline function, and prove the asymptotic normality. The numerical results are conducted to compare the performance of the empirical likelihood and the normal approximation-based method, and a real example is analysed.

关键词： partially linear model empirical likelihood confidence region longitudinal data 62.05 62.15 62.2.