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Efflux of potassium ion is an important reason of HL-60 cells apoptosis induced by tachyplesin

Acta Pharmacologica Sinica 2006年第10期27卷 1367-1374页

作者： Hal-tao ZHANG~(2.4) Jun WU~3 Hai-feng ZHANG~2 Qi-feng ZHU ~2Institute of Biochemistry.and Molecular Biology,Guangdong Medical College,Zhanjiang 524023,China ~3Affiliated Hospital of Guangdong Medical College,Zhanjiang 524023,China Institute of Biochemistry and Molecular Biology Guangdong Medical College Zhanjiang China Affiliated Hospital of Guangdong Medical College Zhanjiang China

Aim:To investigate the role of intercellular potassium in tachyplesin-induced HL-60cells ***:The concentration of intercellular potassium,cell vol-ume and mitochondrial membrane potential were examined by flow ***:The concentration of intercellular potassium reduced in a time-depen-dent manner in tachyplesin-treated HL-60 *** addition,the loss of mitochon-drial membrane potential was tightly coupled with the shrinkage of cell *** caspase inhibitors protected against DNA degradation but did not pre-vent the loss of HL-60 cell viability induced by ***2+,which was akind of blocker of volume-regulatory K+channels,increased the viability oftachyplesin-treated HL-60 cells and maintained mitochondrial membrane potentialand cell ***:Efflux of K+was an important reason for apoptosisin tachyplesin-treated HL-60 *** of K+affected the viability of tachyplesin-treated HL-60 cells independent of the process of caspase activation.

关键词： horseshoe crab tachyplesin intracellular potassium mitochondrial membrane potential HL-60 cell

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塔里木盆地西北缘四石厂地区下二叠统沉积与物源记录及其反映的构造演化

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地球科学 2018年第11期43卷 4149-4168页

作者：郭春涛高剑李忠山西大同大学建筑与测绘工程学院山西大同037003 中国科学院地质与地球物理研究所北京100029 中国石油天然气集团公司大庆油田人才开发院黑龙江大庆163453 北京市地热研究院北京100143

石炭纪-二叠纪南天山洋-塔里木盆地北部陆缘构造演化众说纷纭.选择塔里木盆地内紧靠南天山的四石厂剖面,针对下二叠统康克林组露头,在沉积、碎屑组分、重矿物组合分析基础上,重点通过LA-ICP-MS分析砂岩样品碎屑锆石的原位U-Pb和Lu-Hf同... 详细信息

石炭纪-二叠纪南天山洋-塔里木盆地北部陆缘构造演化众说纷纭.选择塔里木盆地内紧靠南天山的四石厂剖面,针对下二叠统康克林组露头,在沉积、碎屑组分、重矿物组合分析基础上,重点通过LA-ICP-MS分析砂岩样品碎屑锆石的原位U-Pb和Lu-Hf同位素特征,解析其年代学、物源特征及构造演化等信息.研究显示,砂岩样品碎屑组分基本都落入陆块物源区和成熟岩石与稳定构架合并处,重矿物组合以稳定重矿物为主,反映稳定的大地构造背景.砂岩碎屑锆石定年结果显示5组年龄:407～501Ma、755～873Ma、889～1 129Ma、1 792～2 079Ma、2 393～2.496Ma,主要反映了5期构造热事件.对比潜在物源区,塔里木盆地内古隆起可能为主物源,与西昆仑-阿尔金造山带剥蚀物源相关的塔里木盆地内前二叠纪沉积也可能提供部分再旋回物源.物源特征显示,虽然南天山洋已经闭合,但直到早二叠世阿瑟尔期仍然没有大规模隆升,洋盆闭合事件对塔里木盆地西北缘构造格局和物源体系影响较小.对比前人研究成果认为,早二叠世从阿瑟尔期至萨克马尔期,柯坪地区的物源结构发生重大变化,由盆地内古隆起单一物源转变为盆内和造山带双重物源.已经闭合的南天山洋盆在萨克马尔期开始隆升造山,成为塔里木西北缘的一个重要物源区.

关键词：塔里木盆地西北缘物源体系构造演化沉积学

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Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats

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Acta Pharmacologica Sinica 2006年第5期27卷 527-535页

作者： LLian LI~2 Li-ke ZHANG~5 Yong-zheng PANG~(2.4) Chun-shui PAN~(3.4) Yong-fen QI~(3.4) Li CHEN~4 Xian WANG~(3,4) Chao-shu TANG~(3,4) Jing ZHANG~(2.4,6) ~2Institute of Cardiovascular Research,Peking University First Hospital,Beijing 100034,China:~3Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100083,China ~4Key Laboratory of the Ministry of Education on Molecular Cardiology,Beijing 100083,China:~5Department of Pathophysiology,Capital University of Medicine,Beijing 100054,China Institute of Cardiovascular Research Peking University First Hospital Beijing China Department of Pathophysiology Capital University of Medicine Beijing China Key Laboratory of the Ministry of Education on Molecular Cardiology Beijing China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing China

Aim:To determine the cardioprotective action of ghrelin and des-octanoyl ghrelinin rats with isoproterenol-induced myocardial ***:Rats were subcu-taneously injected with isoproterenol （ISO;20,10,and 5 mg/kg） on d 1,2 and 3,respectively,and then 3 mg/kg for the next 7d with or without ghrelin or des-octanoyl-ghrelin （100μg/kg,twice daily）.Plasma ghrelin and growth hormonelevels were assayed using radioimmunoassay *** hormone secreta-gogue receptor （GHSR） and ghrelin mRNA were determined using *** binding capacity and the affinity for [3H]ghrelin were determined by re-ceptor binding ***:Compared with controls,ISO-treated rats showedsevere myocardial injury,cardiomegaly,infarction-like necrosis and massive fi-brosis with increases in irradiated-ghrelin （ir-ghrelin） content in plasma by 67%and myocardia by 66% and in the mRNA level in the myocardia by 93% （P<0.01）.ISO-treated rats had 95% （P<0.01） higher GHSR mRNA levels in the *** maximal binding capacity of [3H]ghrelin for myocardial sarcolemma was higherin ISO-treated rats than in *** administration improved cardiac func-tion and ameliorated cardiomegaly and attenuated myocardial lipid peroxidationinjury and relieved cardiac fibrosis as compared with ISO treatment ***-istration of des-octanoyl ghrelin effectively antagonized ISO-induced myocardialinjury and improved all parameters ***,the therapeutic effect ofdes-octanoyl ghrelin was significantly weaker than that of *** plasmagrowth hormone level increased markedly,by 1.5-fold （P<0.01）,with ghrelinadministration as compared with that in controls,but was unaltered in the des-octanoyl ghrelin ***:Myocardial ghrelin and GHSR were up-regulated during ISO-induced myocardial *** protective effect of ghrelinagainst ISO-induced cardiac function injury and fibrosis was more potent thanthat of des-octanoyl ghrelin,which suggests that ghrelin could be an endog

关键词： ghrelin des-octanoyl ghrelin myocardium fibrosis isoproterenol

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