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Association of DRD2.polymorphisms and chlorpromazine-induced extrapyramidal syndrome in chinese schizophrenic patients

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Acta Pharmacologica Sinica 2006年第8期27卷 966-970页

作者： Sheng-nan WU~(2.3,5,6) Rui GAO~(2.3,6) Qing-he XING~(2.3,6) Hua-fang LI~4 Yi-feng SHEN~4 Niu-fan GU~4 Guo-yin FENG~4 Lin HE~(2.3,7)2.Bio-X Life Science Research Center,shanghai Jiaotong University,shanghai 2.0030,{2. 3 institute of Nutritional sciences,SIBS,chinese academy of sciences,shanghai 2.0031,{2. 4 shanghai institute of Mental Health,shanghai 2.0030,{2. 5 shanghai institute of Hypertension,Ruijin Hospital,Medical School of shanghai Jiaotong University,shanghai 2.002.,{2. Bio-X Life Science Research Center Shanghai Jiaotong University Shanghai 200030 China

Aim:Extrapyramidal syndrome (EPS) is most commonly affected by typical antip-sychotic drugs that have a high affinity with the D2.***,manyresearch groups have reported on the positive relationship between the geneticvariations in the DRD2.gene and the therapeutic response in schizophrenia pa-tients as a result of the role of variations in the receptor in modulating *** this study,we evaluate the role DRD2.plays in chlorpromazine-induced EPS in schizophrenic ***:We identified seven SNP(singlenucleotide polymorphism) (-141Cins>del,TaqIB,TaqID,Ser311Cys,rs62.5,rs62.7and TaqIA) in the DRD2.gene in 146 schizophrenic inpatients (59 with EPS and 87without EPS according to the Simpson-Angus Scale) treated with chlorpromazineafter 8 *** alleles of all loci were determined by PCR (polymerase chainreaction).Results:Polymorphisms TaqlD,Ser311Cys and rs62.7 were not poly-morphic in the population recruited in the present *** statistical signifi-cance was found in the allele distribution of-141Cins>del,TaqIB,rs62.5 andTaqIA or in the estimated haplotypes (constituted by TaqIB,rs62.5 and TaqIA) inlinkage disequilibrium between the two ***:Our results did notlend strong support to the view that the genetic variation of the DRD2.gene playsa major role in the individually variable adverse effect induced by chlorpromazine,at least in chinese patients with *** results confirmed a previousstudy on the relationship between DRD2.and EPS in Caucasians.

关键词： dopamine receptors basal ganglia disease polymorphism chlorpromazine schizophrenia

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Microstructure and Mechanical Properties of Dy-α-sialon/Nano-size SiC Composites

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Journal of Materials Science & Technology 1997年第4期13卷 336-338页

作者： Danyu JIANG Chen ZHANG Jianlin SHI Tingrong LAI and Dongsheng YAN(shanghai institute of Ceramics,{2., shanghai 2.0050, china) shanghai institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

The composite of Dy-α-sialon/10 wt pct nano-size SiC particles has been prepared from precursor powders of Si3N4, AIN, Al2.3, Dy2.3 and nano-size β-SiC. The hardness, toughness and bending strength of the composite at ambient temperature are a little higher than those of Dy-α-*** the bending strength is maintained up to 1000℃ and about 2.times more than that of Dy-α-sialon at the same temperature. The fracture surfaces show that the grain size of the composite is smaller than that of Dy-α-sialon, and both Of them have predominately transgranular mode of fracture. It is believed that the decrease of the bending strength of Dy-α-sialon at elevated temperature is caused by the viscous flow of the grain boundary phase, while the addition of nanosize SiC particles effectively increases the viscosity of the grain boundary phase and therefore prevents the strength loss of Dy-α-sialon/nano-size SiC composites at elevated temperature

关键词： Microstructure and Mechanical Properties of Dy sialon/Nano-size SiC Composites SiC Nano

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Optimum segmentation of simple objects in high-resolution remote sensing imagery in coastal areas

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Science china Earth sciences 2006年第11期49卷 1195-1203页

作者： CHEN Jianyu1,2. PAN Delu1 & MAO Zhihua1 1. State Key Laboratory of Satellite Ocean Environment Dynamics, Second institute of Oceanography, State Oceanic Admini- stration, Hangzhou 310012. china 2. {2. institute of Technical Physics, chinese academy of Science, {2. 2.0083, china 1. State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of Oceanography State Oceanic Administration Hangzhou 310012 China 2. shanghai institute of Technical Physics Chinese Academy of Science Shanghai 200083 China

The optimum segmentation of ground objects in a landscape is essential for interpretation of high-resolution remotely sensed imagery and detection of objects; and it is also a technical foundation to efficiently use spatial information in remote sensing imagery. Landscapes are complex system composed of a large number of heterogeneous components. There are many explicit homogeneous image objects that have similar spectral character and yet differ from surrounding objects in high-resolution remote sensing imagery. Thereby, a new concept of Distinctive Feature of fractal is put forward and used in deriving Distinctive Feature curve of fractal evolution in multiscale segmentation. Through distinguishing the extremum condition of Distinctive Feature curve and the inclusion relationship of fractals in multiscale representation the Scalar Order is built. This can help to determinate the optimum scale in image segmentation for simple-objects, and the potential meaningful image-object fitting the intrinsic scale of the dominant landscape object can be obtained. Based on the application in high-resolution remote sensing imagery in coastal areas, a satisfactory result was acquired.

关键词： optimum scale, multiscale segmentation, image interpretation, remote sensing, coastal area.

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Simulation of Isotopic Angular Effects under Ion Bombardment of a^(92.Mo-^(100)Mo Target

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Journal of Materials Science & Technology 1997年第1期13卷 65-68页

作者： Liping ZHENG (shanghai institute of Nuclear Research,{2., shanghai 2.1800, china)Risheng LI and Shuyou LI(Lab. of Atomic Imaging of Solids, institute of Metal Research,{2.,Shenyang 110015, china) shanghai institute of Nuclear Research Chinese Academy of Sciences Shanghai 201800 China Lab. of Atomic Imaging of Solids Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

Under 5 keV Ar ion bombardment of a 92.o-100Mo target, we have investigated isotopic angular effects by means of the static and the dynamic Monte Carlo programs. Our calculated results are in quantitative agreement with the measured and other calculated results. The conclusion consistences among theories. simulations and measurements are also discussed.

关键词： Mo Target Simulation of Isotopic Angular Effects under Ion Bombardment of a Target

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A simple solution route to control synthesis of Fe_3O_4 nanomaterials at low temperature and their magnetic properties

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Science china Chemistry 2009年第7期52卷 916-923页

作者： LIU Yi1,2. CHEN Yun1, ZENG YuPing2.& WANG ShiLong3 1 Department of Chemistry and Chemical Engineering, Zaozhuang University, Zaozhuang 2.7160, china 2.shanghai {2. of Ceramics, chinese academy of sciences, shanghai 2.0050, china 3 School of Life Science and Technology, Tongji University, shanghai 2.0092. china 1. Department of Chemistry and Chemical Engineering Zaozhuang University Zaozhuang 277160 China 2. shanghai institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China 3. School of Life Science and Technology Tongji University Shanghai 200092 China

A series of nanostructured iron compounds including cubic Fe3O4 and orthorhombic FeOOH were synthesized via a facile low temperature (in the range of 60-100℃) solution method. In the whole process, the interaction between FeCl2.4H2. and methenamine (C6H12.4) was carried out through a reflux device under different reaction conditions such as temperature, solvent, and duration. The samples were detected by XRD, TEM, SAED, physical property measurement system, and Mssbauer spectroscopy, separately. The experiments showed that magnetic mixture nanoparticles had flake and rod morphologies, and cubic Fe3O4 took on grain nanostructure. Magnetism measurements indicated that the saturated magnetization of the as-obtained magnetic mixture was lower than that of the cubic magnetite. Mssbauer spectroscopy testified the sample consisting of cubic magnetite rather than γ-Fe2.3. In addition, a possible growth mechanism of cubic magnetic nanoparticles under different conditions was discussed.

关键词： magnetic nanoparticles cubic Fe3O4 oxidation-coprecipitation method reflux magnetic properties at room temperature Mssbauer spectrum

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Insulin-sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative in vitro

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Acta Pharmacologica Sinica 2007年第3期28卷 417-422页

作者： Hao-shu WU~(2.4) Juan-hong YU~(3,4) Ying-yin LI~2.Yu-she YANG~3 Qiao-jun HE~2.Yi-jia LOU~(2.5) Ru-yun JI~3 ~2.epartment of Pharmacology and Toxicology,College of Pharmaceutical sciences,Zhejiang University,Hangzhou 310058,china ~3State Key Laboratory of Drug Research,{2. institute of Materia Medica,{2. institutes for Biological sciences,Graduate School of the chinese academy of sciences,{2. 2.12.3,china Department of Pharmacology and Toxicology College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Department of State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Shanghai 201203 China

Aim:To examine the insulin sensitizing effects of a novel α-methyl-α-phenoxylpropionate derivative YY2. in insulin-sensitive cell ***:Theperoxisome proliferator-activated receptor γ（PPARγ）agonist bioactivities of YY2.were detected by a preadipocyte differentiation ***-PCR and Westernblotting analysis were used to detect the expression of the target gene or *** effects of YY2. on insulin-mediated glucose consumption were determined inthe HepG2.human hepatocellular carcinoma ***:YY2. could enhancethe differentiation of preadipocytes to adipocytes and upregulate the gene ex-pression of PPARγ2.as well as the protein expression of insulin receptor sub-strate-1（IRS-1）,glucose transporter-4（GLUT4）,and adiponectin（ACRP30）.Theeffects on GLUT4 and ACRP30 could be reversed by the PPARγ inhibitor ***,YY2. efficiently reduced glucose consumptions in HepG2.cells after2. h culture,and the effects were related to insulin and YY2. ***:YY2.,a potential insulin-sensitizing agent like rosiglitazone,couldenhance glucose consumption in HepG2.cells in a concentration-and insulin-dependent *** may improve the insulin resistance associated with type 2.iabetes.

关键词： YY2. peroxisome proliferator-activated receptor y insulin sensitivity glucose consumption

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Study on the stannous halides promoted addition of 1,1,1-trichloro-2.2.2.trifluoroethane to aldehydes and the chemical transformation thereof

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chinese Journal of Chemistry 1994年第2期12卷 183-189页

作者： HU, Chang-Ming CHEN, Jianshanghai institute of Organic Chemistry,{2., shanghai 2.0032. china shanghai institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

Promoted by stannous salts, 1,1,1-trichloro-2.2.2.trifluoroethane reacts readily with aliphatic, aromatic, and α, β-unsaturated aldehydes giving the corresponding alcohols bearing a CF3CCl2.moiety in good to excelle... 详细信息

关键词： 1,1,1-Trichloro-2.2.2.trifluoroethane aldehydes stannous halides addition Jones oxidation ketones.

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SYNTHESIS AND CHARACTERIZATION OF A NOVEL FLUORINE-CONTAINING HYDROPHOBICALLY ASSOCIATING POLYMER

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chinese Journal of Polymer Science 1999年第3期17卷 281-288页

作者： Jin Yang Wei-yuan Huang Laboratory of Organofluorine Chemistry, shanghai institute of Organic Chemistry,{2., shanghai 2.0032. china chinese Acad Sci Shanghai Inst Organ Chem Lab Organofluorine Chem Shanghai 200032 Peoples R China

In this article, the synthesis and characterization of a novel fluoromonomer and its copolymer with acrylamide is reported. 2.perfluoroamyl-4-hydroxylquinoline 2.was synthesized from ethyl 2. 2.dihydroperfluoroheptanoate in high yields. The monomer 4 was then synthesized from 2.in two steps readily in high yields. Synthesis and characterization of copolymers of acrylamide (AM) and the fluoromonomer were investigated. The composition and intrinsic viscosity of these copolymers were studied. It was found that the rheological properties of aqueous solutions of polyacrylamide were modified significantly when a small proportion of the fluoromonomer 4 was incorporated on investigating the viscosity-concentration profiles, pseudoplasticity of these solutions and the effect of the presence of surfactant. These results could be explained by the hydrophobic association of the fluorocarbon segments in the aqueous solutions of these copolymers.

关键词： hydrophobically associating polymer fluorine-containing acrylate perfluoroalkylation with RFI/Na2.2.4

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Suppressed Antiferromagnetism and Superconductivity in As-deficient Iron-based Superconductor of SrFe_(1.8)Co_(0.2.As_x

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稀有金属材料与工程 2011年第S3期40卷 358-361页

作者： Liu Zhiyong1, Lu Yuming1, Liu Jinlei1, Qu Chunqing1,2.3, Chen Changzhao1, Cai Chuanbing1, Huang Fuqiang3, Xie Xiaoming2.1 shanghai University, shanghai 2.0444,{2. 2.State Key Laboratory of Functional Materials for Informatics,shanghai institute of Microsystem and Information Technology,chinese academy of sciences,shanghai 2.0050,{2. 3 shanghai institute of Ceramics,{12., shanghai 2.0050,{2. shanghai Univ Res Ctr Superconductors & Appl Technol Shanghai 200444 Peoples R China chinese Acad Sci Shanghai Inst Microsyst & Informat Technol State Key Lab Funct Mat Informat Shanghai 200050 Peoples R China chinese Acad Sci Shanghai Inst Ceram Shanghai 200050 Peoples R China

Iron-based superconductors namely Sr(Fe1.8Co0.2.As1.8 (FeAs1.8) and Sr(Fe1.8Co0.2.As1.85 (FeAs1.85) with As deficiency are prepared by solid-state reaction. X-ray diffraction reveals that the polycrystalline phase forms in the studied samples, identical to typical SrFe2.s2.(12.) matrix. Resistive and magnetic measurements show that the superconducting transition temperatures (Tc) are about 19 K for both FeAs1.8 and FeAs1.85. Compared with the performances of typical iron-based 12. superconductors arising from Co doping, the present samples show the suppressed superconductivity. Moreover, the antiferromagnetic (AFM) phase correlated with spin-density-wave (SDW) is reduced as well. The AFM transition temperature decreases to 12. K for FeAs1.85, while such a phase transition is absent at all for FeAs1.8, one sample with less As, implying that the existence of SDW and antiferromagnetism is more sensitive to As content.

关键词： antiferromagnetism superconductivity iron-based superconductors

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High Throughput SNP Genotyping with Two Mini-sequencing Assays

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Acta Biochimica et Biophysica Sinica 2004年第6期36卷 379-384页

作者： Chunqing LUO1,2., Libin DENG1#, and Changqing ZENG1,2. The institute of Genetic and Developmental Biology, the chinese academy of sciences, Beijing 100101,{2. 2.eijing Genomics institute, the chinese academy of sciences, Beijing 101300,{2. The institute of Genetic and Developmental Biology the Chinese Academy of SciencesBeijing 100101 China Beijing Genomics institute the Chinese Academy of SciencesBeijing 101300 China

Two mini-sequencing methods, FP-TDI (template-directed dye-terminator incorporation with fluorescence-polarization) and MassArray (matrix assisted laser desorption ionization time of flight detection mass spectrometry), were optimized. A numeric standard was introduced to evaluate the SNP scoring quality of FP-TDI assay, thus made the optimization work easier. At the same time, using multi-PCR technology, 8-plex genotyping of MassArray assay was successfully carried out, some softwares were developed and the data process of MassArray was highly automated. Then these two methods were applied to high throughput SNP genotyping, the accuracy, efficiency and robustness were compared. The result shows FP-TDI is more sensitive to the concentration of SNPprimer and PCR product, as well as extension cycles, the SNPprimer length of FP-TDI should be 2.–30 bp long, whereas MassArray assay prefers to be as short as only 16 *** 6440 SNP sites of human chromosome 3 were genotyped in a sample of 90 individuals, 4792.sites by FP-TDI assay and 1648 sites by MassArray assay, the success rates of FP-TDI and MassArray were 67.7% and 93.6% respectively. The throughput of MassArray was higher than FP-TDI, and the cost of MassArray was lower, MassArray was more suitable for high throughput SNP genotyping.

关键词： SNP genotyping FP-TDI MassArray high throughput

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