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Overexpression of Slc35d3 causes obesity by reducing the membrane trafficking of D1 receptor in striatonigral neurons

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Overexpression of Slc35d3 causes obesity by reducing the mem...

第三届细胞结构与功能的信号基础研讨会

作者： Chan-Juan Hao~1,Xiao-Nan Li~2.Yan Li~1,Zhe Zhang~1,Xin He~1,Zongbo Wei~1,Xiang Gao~4,Xue-Chu Zhen~3,Wei Li~1 1 Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developental Biology,chinese academy of {2.,beijing 100101,china 2.Nanjing Medical university,Nanjing 2.0082.china 3 Shanghai Institute of Materia Medica,chinese academy of {2.,Shanghai 2.102.,china 4 Model Animal Research Center,Nanjing university,Nanjing 2.0061

The Slc35d3 gene encodes an orphan nucleotide sugar *** ros mutant mouse harbors a substitution of 7 new amino acids for 10 wild-type amino acids at the N-terminus of the Slc35d3 protein,and that it is specifically expressed in the *** we further showed that Slc35d3 was selectively expressed in the striatum,substantia nigra and olfactory bulb of mouse *** ros mice,there was a 1.8 fold increase of the mutant Slc35d3 transcripts in the striatum,and immunohistochemical detection of dopamine receptor 1(D1R)in the striatum exhibited an intracellular accumulation of *** further found a physical interaction between Slc35d3 and ***35d3 was localized to ER where it is likely involved in the trafficking of D1R to the plasma *** of Slc35d3

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数值分类在关中地区土壤分类中的应用

土壤通报 2004年第6期35卷 673-677页

作者：闫湘常庆瑞雷梅中国农业科学院土壤肥料研究所北京100081 西北农林科技大学资源环境学院陕西杨凌712100 中国科学院地理科学与资源研究所北京100101

选取关中地区12.土壤剖面的15个理化指标,应用主成分分析方法和聚类分析方法对土壤进行了数值分类。研究结果表明,前4个主成分的累计贡献率达到86.41%,取阈值T=4.0,供试12.剖面划分为3类,不同类群之间土壤特性差异明显,类群内部土壤... 详细信息

选取关中地区12.土壤剖面的15个理化指标,应用主成分分析方法和聚类分析方法对土壤进行了数值分类。研究结果表明,前4个主成分的累计贡献率达到86.41%,取阈值T=4.0,供试12.剖面划分为3类,不同类群之间土壤特性差异明显,类群内部土壤特性相似。数值分类结果与系统分类结果比较,虽然个别土壤的类别出现较大差异,但分类结果基本一致,说明数值分类应用于关中地区土壤分类是切实可行的。

关键词：主成分分析聚类分析关中地区土壤分类

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Thrombin receptor regulates hematopoiesis and endothelial to hematopoietic transition

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Thrombin receptor regulates hematopoiesis and endothelial to...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Rui Yue~(1,*),Haisen Li~(1,*),Huan Liu~3,Yuanyuan Li~1,Bin Wei~1,Ge Gao~3,Tingxi Liu~5,Liping Wei~3,Jiulin Du~4 & Gang Pei~(1,2. 1.Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological sciences graduate School of the {2. academy of sciences,Shanghai 2.0031,china. 2.School of Life Science and Technology,Tongji university,Shanghai 2.0092.china.

Hematopoietic and vascular developments are closely related physiological processes during vertebrate ***,endothelial to hematopoietic transition(EHT) is demonstrated to be essential for hematopoietic cells induction,but its underlying regulatory mechanisms still remain poorly *** we show that thrombin receptor(F2.),a protease activated G protein-coupled receptor required for vascular development,negatively regulates hematopoietic differentiation of mouse embryonic stem *** studies reveal that RhoA/ROCK pathway mediates F2. signaling and inhibits EHT in ***,F2.-RhoA/ROCK pathway negatively regulates zebrafish definitive hematopoiesis,EHT and hematopoietic stem cells induction in *** together,this study demonstrates a fundamental role of F2.-RhoA/ROCK pathway in vertebrate hematopoiesis and EHT,as well as an important molecular mechanism keeping the balance between hematopoietic and vascular development.

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Effects of human interleukin 10 gene transfer on the expression of Bcl-2.Bax and apoptosis of hepatocyte in rats with acute hemorrhagic necrotizing pancreatitis

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中华医学杂志(英文版) 2005年第19期000卷 76-78页

作者： GU Jun-chao, WANG Yu, ZHANG Zhong-tao, XUE Jian-guo, LI Jian-she and ZHOU Yan-zhongDepartment of General Surgery, beijing Friendship Hospital, Capital university of Medical {2., beijing 100050, china Department of General Surgery Beijing Friendship Hospital Capital University of Medical Sciences Beijing 100050 China

Acute necrotising pancreatitis is characterized by inflammatory and necrotic events, which follow the initial intra-acinar injury involving enzyme activation, and disruption of the acinar cytoskeleton.~1 At present, apoptosis has become a hot topic in many kinds of disease. Bax and Bcl-2.are the important control gene during cell apoptosis.~2.Previous study has shown that interleukin 10 (IL-10) is a kind of important anti-inflammatory cytokine and plays a role of self-defense mechanism, limiting the intensity of inflammatory process. We used rats model of acute necrotizing pancreatitis (ANP) with liver injury to explore the effect of IL-10 on the expression of Bcl-2. Bax and hepatocyte apoptosis and the role of the expression of Bcl-2. Bax in ANP pathophysiology for finding out possible therapy methods.

关键词： acute necrotizing pancreatitis · cell apoptosis · interleukin 10 · gene transfer

Effect of Caffeic acid on the Tumor Cells U937 Evaluated by an Electrochemical Voltammetric Method

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chinese Chemical Letters 1999年第9期10卷 781-782页

作者： Hong Yan JIAN Cheng Cat AN Jun FENG Yun Xiang CI Yi Li Ayako SUGISAWA Maremitsu IZUMITANI Zhang Liang CHEN (1NLPGE.College of Life sciences. Peking university, {2. 1008712.epartmcnt of Chemistry,Peking university,{2. 1008713Laborutory of F NLPGE College of Life Sciences Peking University Beijing 100871 China Department of Chemistry Peking University Beijing 100871 China Laboratory of Food and Nutrition Kyoritsu Women's University Tokyo 101-0003 Japan

Electrochemical voltammetric method can;be used to monitor cell health state during its growth. Here we studied the effect of caffeic acid on leukemia cells U937 by the voltammetric behavior of the cells. The result showed that this drug had a negative influence on cell health. which suggests that caffeic acid may be used in inhibition of tumor cells.

关键词： voltammetric behavior U937 cells caffeic acid

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COAL RESOURCES OF china

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Bulletin of the chinese academy of {2. 1998年第4期12卷 275-282页

作者： Yang Qi(china university of Geo{2., beijing)

Ⅰ. A SHORT SURVEY OF china’S COAL RESOURCES AND PROBLEMS ENCOUNTERED So far as china’s national economic construction is concerned, no development is possible without coal resources over a rather long period of time. It is generally recognized that coal is the bridge to the lasting energy system whose base is renewable sources of energy. In the Second World Coal Con-

关键词：户口

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Nano-size Distribution of Aerosol from Agricultural Residues Burning Matched to Optical Properties:A Laboratory Study

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Nano-size Distribution of Aerosol from Agricultural Residues...

第五届全国环境化学大会

作者： Dawei Hu~1 Xingnan Ye~1 Hefeng Zhang~1 Tiantao Cheng~(1,2.) Jianmin Chen~(1*) Zhiwei Han~2.Renjian Zhang~2.(1.Center of Atmospheric Chemistry Study,Department of Environmental Science & Engineering, Fudan university,Shanghai 2.0433,china 2.Key Laboratory of Regional Climate-Environment Research for Temperate East Asia,Institute of Atmospheric Physics,{2. academy of sciences, beijing 10002.,china)

＜正＞Laboratory measurements were conducted with a chamber to determine the size distribution and scattering coefficient of aerosol emitted from the rice straw and corn stover burning,two major agricultural residues in *** size distributions of those rice-burned and corn-burned aerosols are well characterized by unimodal lognormal functions,with a remarkable feature of accumulation *** fresh smokes’ median diameters of number distribution centered at 0.15±0.03μm,0.2.±

关键词： Biomass burning Nano-size distribution Optical properties Emission factors

Is an unusual large enhancement of ionospheric electron density linked with the 2.08 great Wenchuan earthquake?

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Is an unusual large enhancement of ionospheric electron dens...

中国科学院地质与地球物理研究所2.08学术年会

作者： Biqiang Zhao,Min Wang,Tao Yu,Weixing Wan,Jiuhou Lei,Libo Liu, and Baiqi Ning 1 beijing National Observatory of Space Environment,Institute of Geology and Geophysics,chinese {2. of sciences,beijing,china. 2.Institute of Earthquake Science,china Earthquake Administration, beijing,china. 3 National Center for Space Weather,china Meteorological Administration, beijing,china. 4 Department of Aerospace Engineering sciences,university of Colorado, Boulder,Colorado,USA.

[1]On 12.May 2.08 at 062. UT a major earthquake M = 8.0 struck Wenchuan County (31.0°N,103.4°E) in southwest *** maximum ionospheric electron density at F peak(NF) recorded an unusual large enhancement during the afternoon-sunset sector by the chinese ionosondes over Wuhan(30.5°N,114.4°E) and Xiamen(2..4°N,12..9°E), which are close to the earthquake *** averaged increase at these two stations is about 2.times on a geomagnetic quiet day,9 May(Kp≤2.,3 days prior to the earthquake,relative to the median value of 1 -12.May,whereas the increase was much less significant over Yamagawa(31.2.N,130.6°E) and Okinawa(2..7°N,12..2.E) in *** the data from the network of 58 global positioning system receivers around china and the global ionospheric map,the variations of the total electron content reveal the region where enhancement persisted for a long period to be within longitudes 90°-130°*** results suggest that this abnormal enhancement is most possibly a seismo-ionospheric signature.

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传统美育与当代美学建设

思想战线 2001年第5期27卷 67-71页

作者：袁济喜中国人民大学中文系北京 100872

中国古代有悠久的审美教育传统 ,它从礼乐文化派生而来 ,体现出深厚的人文精神传统。中西方美育传统之一致在于对人的综合素质之培养。如果没有人文关怀 ,当代美学与传统美学之间的精神纽带就会断裂。当今中国美学出现的低迷状况 ,主要... 详细信息

中国古代有悠久的审美教育传统 ,它从礼乐文化派生而来 ,体现出深厚的人文精神传统。中西方美育传统之一致在于对人的综合素质之培养。如果没有人文关怀 ,当代美学与传统美学之间的精神纽带就会断裂。当今中国美学出现的低迷状况 ,主要由人文精神迷失所致 ,美学未能从工具论的价值观中走出来 ,当代美学建设应积极借鉴我国传统美育思想资源。

关键词：传统美育人文精神工具论当代美学建设