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Pretreatment with insulin enhances anticancer functions of 5-fluorou racil in human esophageal and colonic cancer cells

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Acta Pharmacologica Sinica 2007年第5期28卷 721-730页

作者： Ke ZOU~(1,2.,Ji-hang JU~(1,2.,Hong XIE~(1,3)~1 Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological sciences,chinese {2. of sciences,Shanghai 2.0031,china ~2.graduate school of the chinese academy of sciences,beijing,100049,china Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China graduate school of the{2. Beijing China

Aim:To investigate the effects of insulin on enhancing 5-fluorouracil (5-FU) anti-cancer functions and its mechanisms in the human esophageal cancer cell line(Eca 109) and human colonic cancer cell line (Ls-174-t).Methods:The effect ofinsulin/5-FU combination treatment on the growth of Eca 109 and Ls-174-t cellswas evaluated by 3-(4,5-dimethylthiazol-2.yl)-2.5-diphenyl-tetrazolium bromide(MTT) *** insulin treatment or insulin/5-FU treatment,cell cycle distri-bution of both cell lines was analyzed by flow *** blot assay wasused to assess the expression of caspase-3 and thymidylate synthase (TS).Apoptosis was detected by flow cytometry,DNA fragmentation assay,and termi-nal transferase dUTP nick end labeling assay (TUNEL).Moreover,the changes of5-FU uptake after insulin pretreatment were detected by HPLC assay and Westernblot ***:We found that insulin enhanced the inhibitory effect of 5-FU on cell proliferation when Eca 109 cells and Ls-174-t cells were pretreated withinsulin for the appropriate *** increased the cell number of the S phaseand the uptake of ***/5-FU treatment enhanced apoptosis of tumor cellsand upregulated the expression of cleaved caspase-3 compared with 5-FU ***,insulin/5-FU treatment induced the changes of free TS and the TSternary complex level compared with 5-FU treatment in Eca 109 and Ls-174-t ***:These data suggest that insulin enhances anticancer functions of 5-FU when it is treated before 5-FU for the appropriate time in human esophagealand colonic cancer cell lines.

关键词： apoptosis cell cycle 5-fluorouracil insulin

Novel gaseous transient species:generation and characterization

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Science china Chemistry 2007年第2期50卷 145-169页

作者： ZENG XiaoQing1,2.& WANG DianXun11 State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,chinese academy of Sci-ences,{2. 100080,china 2.graduate school of chinese academy of sciences,{2. 100039,china State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing China graduate school of{2. Beijing China

Due to special properties of transient species, such as short-lived, unstable, reactive, and even explosive, the generation and subsequent characterization is a great challenge for experimental chemists. In our laboratory, systematic researches have been carried out to investigate novel transient species: reactive halogen species (RHS), short-lived free radicals, and metastable pseudohalogen compounds, based on the successive technical improvements on the Hel Photoelectron spectroscopy (PES). In this review, the topic mainly focuses on innovative methods of generating novel transient species, and subsequent geometric and electronic structure characterizations of these species combined with quantum chemical calculations.

关键词： reactive halogen species radicals pseudohalogen compounds Hel Photoelectron Spectroscopy (PES) quantum chemical calculations

Non-Gaussianity of Racetrack Inflation Models

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Communications in Theoretical Physics 2007年第7期48卷 189-192页

作者： SUN Cheng-Yit ZHANG De-Hai Department of Physics,The graduate school of The{2.,beijing 100049,china Department of Physics The Graduate School of The Chinese Academy of Sciences Beijing 100049 China

In this paper,we use the result in[*** and ***,arXiv:astro-ph/0510709]to calculate thenon-Gaussianity of the racetrack models in[***-Pillado,et al.,JHEP 0411(2.04)063;arXiv:hep-th/04062.0]and[***-Pillado,et al.,arXiv:hep-th/060312.].The two models give different *** of themare ***,we find that,for multi-field inflationary models with the non-trivial metric of the field space,the condition of the slow-roll cannot guarantee small non-Gaussianities.

关键词： non-Gaussianity non-linear parameter racetrack inflation

CH_4 uptake flux of Leymus chinensis steppe during rapid growth season in Inner Mongolia,china

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Science china Earth sciences 2010年第7期53卷 977-983页

作者： GENG YuanBo1, LUO GuangQiang1,2.& YUAN GuoFu1 1 Institute of Geographic sciences and Natural Resources Research, chinese academy of sciences, {2. 100101, china 2.graduate University of chinese academy of sciences, {2. 100049, china Institute of Geographic sciences and Natural Resources Research Chinese Academy of Sciences Beijing China graduate University of chinese academy of sciences Beijing China

The influence of near ground atmosphere CH4 concentration, soil water content, soil Eh, plants, soil temperature, and pH on CH4 uptake flux of Leymus chinensis steppe during rapid growth season was studied using field in-situ measurement in Xilin River basin of Inner Mongolia, china. The results showed that CH4 uptake flux was positively correlated with near ground atmosphere CH4 concentration and soil Eh but negatively correlated with soil water content. Precipitation may decrease the CH4 flux by increasing the soil water content. The average fluxes of three treatments during the observation period were 1.52.(natural conditions, 1.51 (aboveground plants were excluded), and 2.00 mg m?2.d?1 (all plants were removed), respectively. The difference between the CH4 flux of natural condition treatment and that of removing aboveground plants treatment is small, whereas the flux of removing all plants treatment is larger than the other two treatments. This means that the contribution of aboveground plants to CH4 uptake flux is smaller than that of roots or roots-removing process. CH4 uptake flux is not sensitive to soil temperature and the narrow-ranged soil pH (6.36–7.86). The Leymus chinensis steppe acts as a sink for CH4, and thus more studies should be focused on its affecting factors and related mechanisms.

关键词： CH4 uptake flux Leymus chinensis steppe affecting factors static opaque chamber/gas chromatography method

Effects of the grain size distribution on the temperature-dependent magnetic susceptibility of magnetite nanoparticles

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Science china Earth sciences 2010年第7期53卷 1071-1078页

作者： ZHAO XiangYu1,2.& LIU QingSong1 1 Paleomagnetism and Geochronology Laboratory (SKL-LE), Institute of Geology and Geophysics, chinese academy of sciences, beijing 10002.,{2. 2.graduate University of chinese academy of sciences, beijing 100049,{2. Paleomagnetism and Geochronology Laboratory (SKL-LE) Institute of Geology and Geophysics Chinese Academy of Sciences Beijing China graduate University of chinese academy of sciences Beijing China

Magnetite is an important magnetic remanence carrier in natural samples and therefore is of great interest in paleo-, rock-, and environmental magnetism. The magnetic properties of magnetite depend on many factors, e.g., concentration and grain size distribution (GSD). In this study, we theoretically investigated the temperature-dependent susceptibility (TDS) of magnetite nanoparticles with a lognormal GSD. Results show that the TDS is affected highly by the GSD mainly in three aspects. Firstly, the unblocking process becomes smoother with the increase of distribution width, characterizing as a wider Hopkinson peak on the TDS curve. Secondly, the blocking temperature increases with the increase of the median diameter or/and the distribution width. Thirdly, the maximum susceptibility decreases with the increase of distribution width, and has a logarithmic function relation with the standard deviation of the distribution. As a case study, this model was further applied to the thermal products of the chinese loess/paleosol samples to determine the granulometry of newly-formed magnetite upon heating based on TDS curves. The results demonstrate the fidelity and feasibility of this method to determine the GSD of nano-sized magnetic particles.

关键词： Néel theory temperature dependence of susceptibility grain size distribution

Interannual variability of Antarctic Oscillation and its influence on East Asian climate during boreal winter and spring

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Science china Earth sciences 2006年第5期49卷 554-560页

作者： FAN Ke1,2.3 & WANG Huijun2.1. Nansen-Zhu International Research Center, Institute of Atmospheric Physics, chinese academy of sciences, beijing 10002.,{2. 2. Department of Atmospheric Science, Yunnan University, Kunming 650091,{2. 3. graduate University of the chinese academy of sciences, beijing 100049,{2. Nansen-Zhu International Research Center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China Department of Atmospheric Science Yunnan University Kunming China graduate University of the chinese academy of sciences Beijing China

The interannual variability of Antarctic Oscillation (AAO) and its influence on East Asian climate during both boreal winter and spring are addressed. The results show that the positive AAO anomaly decreases the cold activity over East Asia during both boreal winter and spring. AAO-related barotropic meridional teleconnection from Antarctic to Arctic is found through analysis of mean me- ridional circulations. This meridional teleconnection is remarkable over Eurasia during boreal winter and over the Pacific Ocean during boreal spring. The results also show that zonal mean zonal wind at high latitudes in Southern Hemisphere has well positive correlation with that of Eurasia during boreal winter and has negative correlation with Pacific North American teleconnection (PNA) during boreal spring, which again display the meridional teleconnection. Thus, local meridional teleconnection is a possible linkage for interaction of circulations at mid-high latitudes between both hemispheres.

关键词： Antarctic Oscillation, Eurasian west wind, meridional teleconnection, mean meridional circulation.

An Efficient High-Resolution Shock-Capturing Scheme for Multi-Dimensional Flows I. Hydrodynamics

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chinese Journal of Astronomy and Astrophysics 2006年第6期6卷 680-688页

作者： Cong Yu National Astronomical Observatories / Yunnan Astronomical Observatory, chinese academy of sciences, Kunming 650011 graduate {2. of chinese academy of sciences, beijing 100049 National Astronomical Observatories / Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 graduate school of{2. Beijing 100049

Many problems at the forefront of theoretical astrophysics require a treatment of dynamical fluid behavior. We present an efficient high-resolution shock-capturing hydrodynamic scheme designed to study such phenomena. We have implemented a weighted, essentially non-oscillatory （WENO） scheme to fifth order accuracy in space, lILLE approximate Riemann solver is used for the flux computation at cell interface, which does not require spectral decomposition into characteristic waves and so is computationally friendly. For time integration we apply a third order total variation diminishing （TVD） Runge-Kutta scheme. Extensive testing and comparison with schemes that *** characteristic decomposition are carried out demonstrating the ability of our scheme to address challenging open questions in astrophysics.

关键词： accretion - hydrodynamics- method numerical - shock waves

Thermal analysis of the baffle structure of the Solar Space Telescope

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Science china(Physics,Mechanics & Astronomy) 2010年第9期53卷 1755-1764页

作者： LI Rong1,2.3 & WANG Sen1,3 1 National Astronomical Observatories,chinese academy of {2.,beijing 100012.china 2.graduate University of chinese academy of sciences,beijing 100049,china 3 Key Laboratory of Solar Activity,National Astronomical Observatories of chinese academy of sciences,beijing 100012.china National Astronomical Observatories Chinese Academy of Sciences Beijing China graduate University of chinese academy of sciences Beijing China Key Laboratory of Solar Activity National Astronomical Observatories of Chinese Academy of Sciences Beijing China

The SST(Space Solar Telescope) is an astronomical telescope with a primary mirror of 1 m in *** observes the sun with a small view field to ensure that its high spatial resolution imaging has 0.1″-0.15″ and high SNR(signal to noise ratio).Surrounding the small view field is still the sun,which is an intense source of both heat and stray *** baffles(the main baffle,the aperture,and the outer baffle),which are used to eliminate the stray light,will change the thermal flux in the SST and will weaken the effect of the thermal control *** this study,the compatibility analysis of the thermal effect of baffle structures in SST is *** GCF(Geometry Composing Function) and BRDF(Bidirectional Reflectance Distribution Function),which are two inherent related parameters in the compatibility analysis,are *** objective and method of the compatibility analysis are *** the thermal analysis software,the temperature fields are calculated for different lengths of the main baffle,different radii of apertures,different lengths of the outer baffle with a 3' tilt angle and 16' tilt angle,and different tilt angles of the outer baffle with a 2.0 mm length.A series of configurations and sizes of the baffles are studied with the goals of both thermal control and elimination of stray *** design of the baffle structure of SST is achieved:the main baffle of length 4100 mm,the internal shield of radius 494 mm,the outer baffle of length 2.0 mm,and the outer baffle of tilt angle 3' are successfully *** paper presents the relationship between the thermal control design and stray light elimination plan in the *** aims of the optimal design of the baffle structure of SST are *** thoughts and methods of the optimal analysis are also useful for similar optical telescopes designed for solar observation.

关键词： baffle the main baffle the outer baffle GCF BRDF

The solid lubricating material experiment device for Shenzhou-7 Spaceship

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Science china(Technological sciences) 2010年第9期53卷 2521-2527页

作者： WANG Ke1,2.REN WeiJia1,WANG ShiDa1 & WENG LiJun3 1 academy of Opto-Electronics,chinese academy of sciences,beijing 100190,china 2.graduate University of chinese academy of sciences,beijing 100049,china 3 Lanzhou Institute of Chemical Physics,chinese academy of sciences,Lanzhou 730000,china academy of Opto-Electronics Chinese Academy of Sciences Beijing China graduate University of chinese academy of sciences Beijing China Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou China

A solid lubricating material exposure experiment in space is one of the missions during the seventh manned spaceflight of china,and the key is to develop a device which can be fixed reliably outside of the orbital module and can be fetched conveniently by an astronaut during space *** solid lubricating material experiment device needs to be locked reliably in a vibrating and impacting environment during the launch phase,and should meet the requirement that it can be unlocked and fetched reliably by the astronaut wearing an extravehicular spacesuit via simple operations in orbit in an environment of high and low *** for the device we developed,the environmental characteristic of the mission was analyzed,the mechanical analysis and thermal analysis were carried out,and then a mechanism with functions of mechanical locking,structural self-locking and manual unlocking was *** device was verified by a sequence of experiments and was fetched by the astronaut during the flight of the Shenzhou-7 Spaceship.

关键词： manned spaceflight exposure experiment mechanism unlock