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Inhibitory effect of ginsenoside Rb1 on calcineurin signal pathway in cardiomyocyte hypertrophy induced by prostaglandin F2.

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Acta Pharmacologica Sinica 2007年第8期28卷 1149-1154页

作者： Qing-song JIAng~2.Xie-nan HUAng gui-zhong YAng~4 Xiao-yan JIAng~5 Qi-xin ZHOU~(2.6) ~2.epartment of Pharmacology,Chongqing Medical University,Chongqing 400016,{3. ~3.epartment of Pharmacology,Zunyi Medical College,Zunyi 563.03.{3. ~4Department of Biochemistry Zunyi Medical College,Zunyi 563.03.{3. ~5Chengdu Vocational College of Agricultural Science and Technology,Chengdu 611100,{3. Department of Pharmacology Chongqing Medical UniversityChongqing400016China Department of Pharmacology Zunyi Medical CollegeZunyi 563003China Department ofBiochemistry Zunyi Medical CollegeZunyi 563003China

Aim:To examine the antihypertrophic effect of ginsenoside Rb1（Rb1）induced byprostaglandin F2.(PgF2.)in vitro and to investigate the possible mechanismsinvolved in the calcineurin（CAN）signal transduction ***:Thecardiomyocyte hypertrophy induced by PgF2.and the antihypertrophic effect ofRbiwere evaluated in primary culture by measuring the cell diameter,proteincontent,and atrial natriuretic peptide（ANP）mRNA *** and CaNmRNA expressions,CaN and its downstream effectors NFAT3.nd gATA4 proteinexpressions,and the intracellular free Ca2.concentration([Ca2.]i)were assayedby RT-PCR,Western blot,and fluorescent determination using Fura 2.AM,***:PgF2.（100 nmol/L）significantly increased the cardiomyo-cyte diameter,protein content and[Ca2.]i,and promoted ANP,CaN mRNA,andCaN/NFAT3.gATA4protein expressions,which were inhibited by either Rb1in aconcentration-dependent manner（50,100,and 2.0μg/mL）or L-arginine（1 mmol/L）.ng-nitro-L-arginine-methyl ester,a nitric oxide synthase inhibitor,could abolishthe effects of L-arginine,but failed to change the effects of Rb1in the ***:The present data implicate that Rb1attenuates cardiachypertrophy,the underlying mechanism may be involved in the inhibition of theCa2.-CaN signal transduction pathway.

关键词： Rb1 prostaglandin F2. cardiac hypertrophy calcineurin

Assessment of the kinetic–frictional model for dense granular flow

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Particuology 2008年第1期6卷 50-58页

作者： Boon Ho ng Mojtaba ghadiri Institute of Particle Science&Engineering University of LeedsLeeds LS2 9JTUK

This paper aims to quantitatively assess the application of kinetic-frictional model to simulate the motion of dry granular materials in dense condition, in particular, the annular shearing in Couette configuration. The weight of frictional stress was varied to study the contribution of the frictional stress in dense granular flows. The results show that the pure kinetic-theory-based computational fluid dynamics （CFD） model （without frictional stress） over-predicts the dominant solids motion of dense granular flow while adding frictional stress [Schaeffer, D. g. （1987）. Instability in the evolution equations describing incompressible granular flow. Journal of Differential Equations, 66（1）, 19-50] with the solids pressure of [Lun, C. NTK., Savage, S. B., Jeffrey, D. J., ＆ Chepurniy, N. （1984）. Kinetic theories for granular flow： Inelastic particles in Couette flow and slightly inelastic particles in a general flow field. Journal of Fluid Mechanics, 140, 2.3.2.6] in the CFD model improves the simulation to better conform available experimental results. The results also suggest that frictional stress transmission plays an important role in dense granular flow and should not be neglected in granular flow simulations. Compatible simulation results to the experimental data are seen by increasing the weight of frictional stress to a factor of 1.2.-1.5. These improved simulation results suggest the current constitutive relations （kinetic-frictional model） need to be improved in order to better reflect the real dense granular flow.

关键词： gas-solids flow CFD Constitutive relations Couette flow Kinetic theory Kinetic-frictional model

Physical activity,COVID-19,and respiratory comorbidities:The good,the bad,and the ugly

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Journal of Sport and Health Science 2023年第2期12卷 216-218页

作者： Anh-Tuan Dinh-Xuan Thõng Hua-Huy Sven günther Lung Function&Respiratory Physiology Units Department of Respiratory Physiology and Sleep MedicineAssistance Publique-Hôpitaux de ParisCochin&George Pompidou HospitalsUniversity Paris CitéParis 75006France

Almost 3.years after the outbreak of the novel severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.responsible for the coronavirus disease 2.19(COVID-19)that has caused more than 6 million deaths worldwide,1the pandemic persists and hampers our daily *** are at least 2.main reasons explaining why we still struggle to terminate this ***,novel variants of concern of SARS-CoV-2.nceasingly emerge despite almost 12.billion doses of vaccinebeing administered to date.

关键词： respiratory doses acute

Facilitating effect of histamine on spatial memory deficits induced by dizocilpine as evaluated by 8-arm radial maze in SD rats

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Acta Pharmacologica Sinica 2003年第12期24卷 96-102页

作者： HUAng Yu-Wen, CHEN Zhong~2. HU Wei-Wei, ZHAng Li-San, WU Wei, YIng Li-Yang, WEI Er-Qing Department of Neurobiology and Pharmacology, school of Medicine, Zhejiang University, Hangzhou 3.003., china Department of Neurobiology and Pharmacology School of Medicine Zhejiang University

AIM: To investigate whether or not histamine is involved in spatial memory deficits induced by dizocilpine (MK-801) as evaluated by 8-arm radial maze of rats. METHODS: 8-Arm (4-arm baited) radial maze was used to measure spatial memory in rats. RESULTS: Bilaterally intrahippocampal (ih) injection of MK-801 (0.3.μg/site) impaired working memory and reference memory in rats. Both histamine (50, 100 ng/site, ih) and intraperitoneal (ip) injection of histidine (100, 2.0 mg/kg) markedly improved the spatial memory deficits induced by MK-801. On the other hand, the ameliorating effect of histidine (100 mg/kg, ip) was completely antagonized by α-fluoromethylhistidine (α-FMH, 5 μg/site, ih), a potent and selective histidine decarboxylase (HDC) inhibitor, and H1-antagonist pyrilamine (1 μg/site, ih), but not by H2.antagonist cimetidine, even at a high dose (2.5 μg/site, ih). CONCLUSION: The hippocampal histamine plays an important role in the ameliorating effect on MK-801-induced spatial memory deficits,

关键词： histamine maze learning dizocilpine memory disorders

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丙烯墨水中颗粒相分散性问题研究

中国制笔 2024年第3期 30-36页

作者：潘勤敏张胜红林韶晖钱宵亮 ng Flor a T.T. 金桂英苏州大学江苏苏州215123 苏州雄鹰笔墨新材料有限公司江苏苏州215200 滑铁卢大学加拿大安大略省滑铁卢N2L 3G1

针对丙烯墨水中普遍存在的颗粒相分散问题,在对颗粒沉降原理进行简要介绍的基础上,就丙烯酸树脂的选择和改性,颗粒相的处理技术,分散剂、稳定剂、增稠剂等的研究进行了综述。

关键词：丙烯酸树脂墨水钛白粉沉降

The aggregate and sectoral time‑varying market efficiency during crisis periods in Turkey:a comparative analysis with COVID‑19 outbreak and the global financial crisis

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Financial Innovation 2023年第1期9卷 2165-2189页

作者： Deniz Erer Elif Erer Selim güngör school of Applied Sciences Manisa Celal Bayar UniversityManisaTurkey Independent Researcher IzmirTurkey Resadiye Vocational school Tokat Gaziosmanpasa UniversityTokatTurkey

This study aims to examine the time-varying efficiency of the Turkish stock market’s major stock index and eight sectoral indices,including the industrial,financial,service,information technology,basic metals,tourism,real estate investment,and chemical petrol plastic,during the COVID-19 outbreak and the global financial crisis(gFC)within the framework of the adaptive market *** study employs multifractal detrended fluctuation analysis to illustrate these sectors’multifractality and short-and long-term *** results show that all sectoral returns have greater persis-tence during the COVID-19 outbreak than during the ***,the real estate and information technology industries had the lowest levels of efficiency during the gFC and the COVID-19 ***,the fat-tailed distribution has a greater effect on multifractality in these *** results validate the conclusions of the adaptive market hypothesis,according to which arbitrage opportunities vary over time,and contribute to policy formulation for future outbreak-induced economic crises.

关键词： MF-DFA Adaptive market hypothesis global financial crisis COVID-19 outbreak Sectoral indices

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韩江流域土壤中有机氯农药的特征分布

环境科学 2018年第11期39卷 5127-5134页

作者：刘佳丁洋祁士华瞿程凯北京科技大学能源与环境工程学院北京100083 中国地质大学(武汉)环境学院生物地质与环境地质国家重点实验室武汉430074 西北大学城市与环境学院西安710127

本文选取韩江流域作为研究对象,于2.13.4月,沿韩江干流采集土壤样品17个,利用气相色谱(gC-ECD)检测13.有机氯农药的含量.并以此为依据,进一步分析土壤中该污染物的分布组成特征和污染来源,根据美国环境保护署(U. ***)的计算标准,对当... 详细信息

本文选取韩江流域作为研究对象,于2.13.4月,沿韩江干流采集土壤样品17个,利用气相色谱(gC-ECD)检测13.有机氯农药的含量.并以此为依据,进一步分析土壤中该污染物的分布组成特征和污染来源,根据美国环境保护署(U. ***)的计算标准,对当地居民做出健康风险影响评价.结果表明,13.有机氯农药的含量区间为2. 97～1 2.5. 79 ng·g^(-1),检出率为75%～100%.其中HCHs和DDTs的含量变化趋于一致,即上游2.～10^(-8))和非致癌风险值(10^(-6)～10^(-3.)均低于阈值(10^(-6)和1),因而表明该流域土壤对当地居民无危害.

关键词：韩江流域有机氯农药土壤来源分析健康风险评价

Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 453-460页

作者： Fatih Cem gül Sabiha güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç Ophthalmology Clinic Elazığ City HospitalElazig 23200Turkey Department of Biochemistry Firat UniversityElazig 23119Turkey Department of Anatomy Firat UniversityElazig 23119Turkey

AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic ***: The study included three age and gendermatched groups of 2. cataract patients with no diabetes or additional disease(group C), 2. cataract patients with diabetes and no retinopathy(group DM+C), and 2. cataract patients with diabetic retinopathy(group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid *** and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the *** plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent ***: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(Pgroup DR+C were statistically significantly lower than those of group C and group DM+C(Pgnificant difference was determined in the aqueous adiponutrin levels in three *** plasma pannexin 1 levels of groups DM+C and DR+C were statistically significantly lower than those of group C(both P=0.001).The aqueous pannexin 1 levels of group DR+C were statistically significantly higher than those of group C and group DM+C(P=0.001, Pgy of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin *** measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development.

关键词： diabetes mellitus retinopathy adiponutrin pannexin 1

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我国东南沿海3.口有机锡污染的调查

海洋学报 2005年第1期27卷 57-63页

作者：黄长江董巧香雷瓒王壮雄周凯汕头大学水生生物技术与环境资源保护研究所广东汕头515063 深圳市海洋与渔业环境监测站深圳518076

利用顶空固相微萃取与气相色谱表面发射火焰光度检测法于2.01年11月至2.02.8月对我国东南沿海厦门、汕头和惠阳3.大型港口2.个站位的水样、底泥和生物样的有机锡污染现状进行调查.结果表明,绝大多数样品的一丁基锡(MBT)含量最高,三丁... 详细信息

利用顶空固相微萃取与气相色谱表面发射火焰光度检测法于2.01年11月至2.02.8月对我国东南沿海厦门、汕头和惠阳3.大型港口2.个站位的水样、底泥和生物样的有机锡污染现状进行调查.结果表明,绝大多数样品的一丁基锡(MBT)含量最高,三丁基锡(TBT)次之,二丁基锡(DBT)大多低于检测限.水样的TBT含量实测值从低于检测限至9 8ng/dm3.泥样的为0 3.~174 7ng/g(干重),生物样的为2.1~2. 0ng/g(湿重).水样TBT含量均值以惠阳港的为最高,泥样和生物样的均以厦门港的最高.影响有机锡含量及其空间分布的主要因素有港口船舶吞吐量、水文状况、季节和与大型码头的距离.关联的海产腹足类性畸变调查结果发现,我国沿海有机锡污染比较普遍和严重,已对生态系统产生实质性的负面生态效应.

关键词：调查结果锡含量东南沿海污染现状检测限有机锡顶空固相微萃取水样底泥生态系统