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Structural and tectonothermal evolution of the ultrahigh-temperature Bakhuis Granulite Belt,Guiana Shield,Surinam:Palaeoproterozoic to recent

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Geoscience Frontiers 2021年第2期12卷 677-692页

作者： Frank F.Beunk Emond W.F.de Roever Keewook Yi Fraukje M.Brouwer faculty of Science Geology and Geochemistry ClusterVrije Universiteit Amsterdam(VUA)De Boelelaan 10851081HVAmsterdamthe Netherlands Division of Earth and Environmental Sciences Korean Basic Science InstituteOchang363-833South Korea

We constrain the multistage tectonic evolution of the Palaeoproterozoic UHT metamorphic(P=0.9–1.0 GPa,T>1000℃,t=2.88–2.31 Ma)Bakhuis Granulite Belt(BGB)in Surinam on the Guiana Shield,using large-to small-scale structures,Al-in-hornblende thermobarometry and published fluid inclusion and zircon geochronological *** BGB forms a narrow,NE–SW striking belt between two formerly connected,~E–W oriented granite-greenstone belts,formed between converging amazonian and West African continental masses prior to collision and Transamazonian *** detrital zircon in BGB metasediments conforms agewise to Birimian zircon of West Africa and suggests derivation from the subsequently subducted African passive ***-temperature metamorphism may have followed slab break-off and asthenospheric heat *** metamorphic structures result from layer-parallel shearing and folding,reflecting initial transtensional exhumation of the subducted African margin after slab break-off.A second HT event involves intrusion,at ca.0.49 GPa,of charnockites and metagabbros at 1993–1984 Ma and a layered anorthosite at 1980 Ma,after the BGB had already cooled toder the greenstone belts,along a new active margin to their south.A pronounced syntaxial bend in the new margin points northward towards the BGB and is likely the result of indentation by an anticlinorial flexural bulge of the subducting *** of the subducting oceanic plate along this bulge explains why the charnockites are restricted to the *** BGB subsequently experienced doming under an extensional detachment exposed in its southwestern border *** was focused in the BGB as a result of the flexural bulge in the subducting plate and localised heating of the overriding plate by charnockite *** present,straight NE–SW long-side boundaries of the BGB are superimposed mylonite zones,overprinted by pseudotachylites,previously dated

关键词： Bakhuis granulite belt Guiana shield Transamazonian orogeny UHT metamorphism Tectonics P-T-t evolution

Platelet RNA enables accurate detection of ovarian cancer:an intercontinental,biomarker identification study

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蛋白质与细胞:英文版 2023年第8期14卷 579-590页

作者： Yue Gao Chun-Jie Liu Hua-Yi Li Xiao-Ming Xiong Gui-Ling Li Sjors G.J.G.In't Veld Guang-Yao Cai Gui-Yan Xie Shao-Qing Zeng Yuan Wu Jian-Hua Chi Jia-Hao Liu Qiong Zhang Xiao-Fei Jiao Lin-Li Shi Wan-Rong Lu Wei-Guo Lv Xing-Sheng Yang Jurgen M.J.Piek Cornelis D de Kroon C.A.R.Lok Anna Supernat Sylwia Łapińska-Szumczyk Anna Łojkowska Anna J Żaczek Jacek Jassem Bakhos A.Tannous Nik Sol Edward Post Myron G.Best Bei-Hua Kong Xing Xie Ding Ma Thomas Wurdinger An-Yuan Guo Qing-Lei Gao department of Gynecological Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Clinical Research Center for Obstetrics and Gynecology Cancer Biology Research Center(Key Laboratory of the Ministry of Education)Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Center for Artificial Intelligence Biology Hubei Bioinformatics&Molecular Imaging Key LaboratoryKey Laboratory of Molecular Biophysics of the Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Neurosurgery Amsterdam UMCVU University Medical CenterCancer Center AmsterdamDe Boelelaan 11171081 HV AmsterdamThe Netherlands Brain Tumor Center amsterdam Amsterdam UMCVU University Medical CenterCancer Center AmsterdamDe Boelelaan 11171081 HV AmsterdamThe Netherlands department of Gynecological Oncology Women's HospitalSchool of MedicineZhejiang UniversityHangzhou 310011China Gynecological Oncology Key Laboratory Qilu HospitalShandong UniversityJinan 250100China department of Obstetrics and Gynecology Catharina HospitalMichelangelolaan 25623EJ EindhovenEindhovenThe Netherlands department of Obstetrics and Gynecology Leiden University Medical CenterAlbinusdreef 22300 RCLeidenThe Netherlands department of Gynecological Oncology Center of Gynecologic Oncology AmsterdamAntoni van LeeuwenhoekPlesmanlaan 1211066 CX AmsterdamThe Netherlands Laboratory of Translational Oncology Intercollegiate Faculty of BiotechnologyUniversity of Gdansk and Medical University of GdanskGdanskPoland department of Gynecology Gynecological Oncology and Gynecological EndocrinologyMedical University of GdanskGdanskPoland department of Oncology and Radiotherapy Medical University of GdanskGdanskPoland department of Neurology Massachuse

Platelets are reprogrammed by cancer via a process called education,which favors cancer *** transcriptional profile of tumor-educated platelets(TEPs)is skewed and therefore practicable for cancer *** intercontinental,hospital-based,diagnostic study included 761 treatment-naive inpatients with histologically confirmed adnexal masses and 167 healthy controls from nine medical centers(China,n=3;Netherlands,n=5;Poland,n=1)between September 2.16 and May *** main outcomes were the performance of TEPs and their combination with CA12. in two Chinese(VC1 and VC2.and the European(VC3)validation cohorts collectively and *** outcome was the value of TEPs in public pan-cancer platelet transcriptome *** AUCs for TEPs in the combined validation cohort,VC1,VC2.and VC3 were 0.918(95%CI 0.889-0.948),0.92.(0.855-0.990),0.918(0.872.0.963),and 0.887(0.813-0.960),*** of TEPs and CA12. demonstrated an AUC of 0.92.(0.889-0.955)in the combined validation cohort;0.955(0.912.0.997)in VC1;0.939(0.901-0.977)in VC2.0.917(0.82.-1.000)in *** subgroup analysis,TEPs exhibited an AUC of o.858,0.859,and 0.92. to detect early-stage,borderline,non-epithelial diseases and 0.899 to discriminate ovarian cancer from *** had robustness,compatibility,and universality for *** diagnosis of ovarian cancer since it withstood validations in populations of different ethnicities,heterogeneous histoiogical subtypes,and early-stage ovarian ***,these observations warrant prospective validations in a larger population beforeclinicalutilities.

关键词： tumor-educated platelets ovarian cancer liquid biopsy preoperative diagnosis

FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden university Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard university CambridgeMassachusetts 02138USA department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg university Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria university of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical university in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges