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Surface deformation at the epicenter of the May 12.2.08 Wenchuan M8 earthquake,at Yingxiu Town of sichuan {2.,china

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Science china(Technological Sciences) 2008年第S2期51卷 154-163页

作者： DONG ShaoPeng,HAN ZhuJun & AN YanFen National Center of Seismic Fault Study,Institute of Geology,china earthquake {2.,Beijing 10002.,china 1. National Center of Seismic Fault Study Institute of Geology China Earthquake Administration Beijing 100029 China

Surface deformation,along National Highway 2.3 at the epicenter of Wenchuan M8 earthquake,at Yingxiu Town of sichuan {2.,china,is surveyed and measured in *** results show two distinct *** is that no horizontal displacement displays,or dextral strike-slip component at the observation point can not be found basically,the other is that uplift amount is 2.72.m,and the short-ening amount is 0.38 m,which reflects thrust shortening deformation is not *** crust uplift amount of 2.71 m is distributed in a belt with width of 60 *** model of lower crustal flow proposed by Royden et al.(1997) about the dynamic process in eastern margin of the Tibetan Plateau seems more suitable to explain the seismic surface deformation characteristics at Yingxiu Town,the epicenter of the May 12.2.08 Wenchuan M8 earthquake.

关键词： Wenchuan M8 earthquake Yingxiu Town surface deformation

Analysis on Dam-Breaking Mode of Tangjiashan Barrier Dam in Beichuan County

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Journal of Mountain Science 2011年第2期8卷 354-362页

作者： HU Xiewen LUO Gang LV Xiaoping HUANG Runqiu SHI Yubin Faculty of Geosciences and Environmental Engineering Southwest Jiaotong University Chengdu 610031 China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology Chengdu 610059 China Aseismic Engineering Technology Key Laboratory of sichuan province Southwest Jiaotong UniversityChengdu 610031 China chengdu Hydroelectric Investigation and Design Institute China Hydropower Consulting Group Chengdu 610072 China

Tangjiashan landslide is a typical high-speed consequent landslide of medium-steep dip angle. This landslide triggered by earthquake took place in about semi-minute. The relative sliding displacement is 900 meters, so average sliding speed is about 30 meters per second. The longitudinal length of barrier dam which is formed by high-speed landslide along river is 803.4 meters; and maximum width crossing river is 611.8 meters. And its volume is estimated about 2..37 million steres. Through detailed geological investigation of the barrier dam, together with early geological information before earthquake, geological structures of the barrier dam and its stability of upstream and downstream slopes are studied when water level reaches different elevations in condition of continual after shocks with seismic intensity of 7 or 8 Richter scale. On this basis, dam-breaking mode of barrier dam is discussed deeply. Thereby, analytic results provide significant guidance and advices to front headquarters of Tangjiashan barrier dam, so that some proper engineering measures can be implemented and flood discharge can be carried out well.

关键词： Tangjiashan Barrier Dam High-speed landslide Blocking river Dam-breaking

Two-dimensional water-filling power allocation algorithm for MIMO-OFDM systems

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Science china(Information Sciences) 2010年第6期53卷 1242-1250页

作者： JIANG YongQuan 1 , SHEN MinFen 1 & ZHOU YuanPing 2.1 Department of Electronic Engineering, Shantou University, Shantou 515063, china 2.Department of Electronic Engineering, sichuan University, {2. 610064, china 1. Department of Electronic Engineering Shantou University Shantou 515063 China2. Department of Electronic Engineering Sichuan University Chengdu 610064 China

Departing from the narrowband channel model, more and more researchers have recently considered the application of multiple-input multiple-output(MIMO) systems over frequency-selective fading channels in combination with the orthogonal frequency-division multiplexing(OFDM) *** this paper, we focus on the capacity of MIMO-OFDM systems and how to increase the *** has been proved that the capacity of a MIMO system with space-dimensional water-filling power allocation is greater than that of the system with uniform power *** MIMO-OFDM systems, there is an additional degree of freedom to allocate power with respect to MIMO systems:the OFDM sub-channels in *** the singular value decomposition(SVD) applied to the channel frequency response matrix, the two-dimensional water-filling power allocation algorithm for MIMO-OFDM systems is proposed based on the Lagrange method, and the corresponding capacity analysis formula is *** results show that the capacity of a MIMO-OFDM system with the proposed two-dimensional water-filling power allocation is greater than that of the system with uniform power allocation and also greater than that of the system with the one-dimensional water-filling power allocation.

关键词： MIMO-OFDM two-dimensional water-filling power allocation capacity analysis singular value decomposition(SVD)

Effects of the tyrosine protein kinase inhibitor genistein on the proliferation,activation of cultured rat hepatic stellate cells

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World Journal of Gastroenterology 2002年第4期8卷 739-745页

作者： Xiao-Jing Liu Ming-Hui Huang Laboratory of Department of Internal Medicine,West china Hospital,sichuan University,{2. 61004.,sichuan province,china Li Yang Qiong Wang Yi-Ping Wang Department of Gastroenterology of West china Hospital,sichuan University,{2. 61004.,sichuan province,china Yong-Qiu Mao Center for Cancer Biotherapy of West china Hospital,sichuan University,{2. 61004.,sichuan province,china Hong-Bin Wu Laboratory of Department of Surgery,West china Hospital,sichuan University,{2. 61004.,sichuan province,china Laboratory of Department of Internal Medicine West China Hospital Sichuan University 37 Wainan Guoxueshang Chengdu 610041 Sichuan Province China. xiaojingliu67@***

AIM: Hepatic stellate cell (HSC) plays a pivotal role inliver fibrosis and is considered as the therapeutic targetfor the treatment of hepatic fibrosis. Tyrosine proteinkinase plays an important role in the proliferation,activation of HSC. The purpose of the study is toinvestigate the effects of the tyrosine protein kinaseinhibitor genistein onthe proliferation and activationof cultured rat HscMETHODS: Rat HSC were isolated from Wistar rats by insitu perfusion of collagenase and pronase and single-stepdensity Nycodenz gradient. Culture-activated HSC wereserum-starved and incubated with 10-3 to 10-5 mol/Lconcentration of genistein for 2., 48 or 72.h. In PDGF-induced HSC proliferation, HSC were stimulatel with L0μg@L-1PDGF-BB for 15 min, and then treaeed with genisteinfor the same time. Cell proliferation was measured byMTr assay and based on flow cytometric analysis of cellcycle. The a-smooth muscle actin (α-SMA) expression inHSC was studied with confocal laser microscopy and flowcytometry. c-fos c-jun and cyclin D1 expression in HSCwas also detected by flow ***: Genistein inhibited basal and PDGF-inducedproliferation of HSC at the concentration of 10-8 to 10-5mol/L, and treatment with 10-7 mol/L concentration ofgenistein for 48 h inhibited the HSC proliferationsignificantly (the inhibition rate was 70.3 %, P＜0.05).Immunofluorescence detected by confocal lasermicroscopy and flow cytometry showed that treatmentwith 10-7 mol/L genistein for 48 h suppressed theexpression of α-SMA significantly in HSC (the specificfluorescence intensity were 60.2.2..5 vs 35.3±11.6and 12.8± 10.4 vs9.54±6.39, respectively, both P＜0.05).The intensity of c-fos, c-jun and cydin D1 expression ofHSCs treated with 10-7 mol/L genistein for 48 h wasalso significantly decreased compared with the ***: Genistein influences proliferation of HSC,suppresses the expression of α-SMA in HSC and tinhibits the intensity of c-fos, c-jun and cyclin D1expression of HSCs. Genistein

关键词：酪氨酸激酶抑制剂肝星形细胞肝纤维化细胞活化细胞增殖动物实验

Interaction of bis-aryl functionalized molecules with nucleosides and nucleic acids

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Science china Chemistry 2010年第1期53卷 103-112页

作者： HUANG Yu1,LIU JunLiang1,ZHANG Ji1,LIU Qiang1,HOU JiTing1,ZHANG Yu1,ZHANG DaWei2.LU QiaoSen1,CHEN ShanYong1,LIN HongHui2.& YU XiaoQi1 1 Key Laboratory of Green Chemistry and Technology,Ministry of Education College of Chemistry,sichuan University,chengdu 610064,{2. 2.Key Laboratory of Bio-resources and Eco-environment,Ministry of Education College of Life Sciences,sichuan University,chengdu 610064,{2.. 1. Key Laboratory of Green Chemistry and Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 China2. Key Laboratory of Bio-resources and Eco-environment Ministry of Education College of Life Sciences Sichuan University Chengdu 610064 China

A series of novel molecules with a cyclen(1,4,7,10-tetraazacyclododecane) moiety appended on and bearing different aromatic fragments in the structures were synthesized and *** binding activities of these compounds towards DNA were systematically studied by spectroscopic,viscometric and gel electrophoresis *** results suggest that the stacking interaction plays an important role in improving the DNA binding ability of the *** binding modes of the compounds towards DNA are also affected by the sizes of the aromatic *** binding interaction between binaphthyl compound 1b and several nucleosides was studied by fluorescence *** interaction and hydrophobic interaction play the key role in such non-selective binding process.

关键词： stacking and hydrophobic interactions DNA binding aromatic compounds nucleosides oligonucleotides

Characterization of codon usage bias in the dUTPase gene of duck enteritis virus

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Progress in Natural Science:Materials International 2008年第9期18卷 1069-1076页

作者： Lichan Zhao a, Anchun Cheng a,b,, Mingshu Wang a,b,, Guiping Yuan c, Mingsheng Caia a Avian Disease Research Center, College of Veterinary Medicine of sichuan Agricultural University, Xinkang Road 46, Ya’an, sichuan 62.014,{2. b Key Laboratory of Animal Disease and Human Health of sichuan province, Ya’an 62.014,{2. c Analytical & Testing Center, sichuan University, chengdu 610064,{2. Avian Disease Research Center College of Veterinary Medicine of Sichuan Agricultural University Xinkang Road 46 Ya’an Sichuan 625014 China Key Laboratory of Animal Disease and Human Health of sichuan province Ya’an 625014 China Analytical & Testing Center Sichuan University Chengdu 610064 China

A comparative analysis of the codon usage bias in the newly discovered dUTPase gene (Assigned Accession No.:DQ486149) of the duck enteritis virus (DEV) and the dUTPase gene of 32.reference herpesviruses was *** results indicated that the DEV dUT-Pase gene encodes a protein of 477 amino acids, which includes five conserved motifs with a 3-1-2.4-5 *** codon adap-tation index (CAI), efiective number of codons (ENC), and GC3S values indicated synonymous codon usage bias in the dUTPase gene of herpesviruses, and this synonymous bias was correlated with host *** codon usage patterns of the DEV dUTPase gene were phylogenetically conserved and similar to that of the dUTPase genes of the avian *** codon usage in each micro-organism was difierent, there were no strain-specific difierences among ***-one codons in the predicted polypeptide, with a strong bias towards A and T at the third codon position, were *** of the codon usage in the dUTPase gene of difierent organisms revealed that there were 19 codons showing distinct codon usage difierences between the DEV and Escherichia coli dUTPase genes;16 between the DEV and yeast dUTPase genes;and 15 between the DEV and human dUTPase *** of variance (ANOVA) showed significant difierences between the DEV and yeast dUTPase genes (r = 0.536, P < 0.01).The extent of codon usage bias in the DEV dUTPase gene was highly correlated with the gene expression level, therefore the results may provide useful information for gene classification and functional studies.

关键词： DEV dUTPase Codon usage bias EMBOSS

Synthesis of an enzyme-dependent prodrug and evaluation of its potential for colon targeting

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World Journal of Gastroenterology 2002年第5期8卷 913-917页

作者： Yi-Nuo Pang Yan Zhang West china School of Pharmacy,sichuan University,{2.,61004.,sichuan province,china West china School of Pharmacy Sichuan University Chengdu 610041 Sichuan Province China.

AIM: To synthesize dexamethasone-succinate-dextran(DSD) conjugate and to evaluate the potentiality of DSD forthe treatment of inflammatory bowel ***: Dexamethasone was attached to dextran(average molecular weight＝70 400 Dalton) using succinateanhydride in an anhydrous environment catalyzed by 4-dimethylaminopyridine and 1, 1′-carbonyldiimidazole. Thechemical structure of DSD was identified by UV, IR and NMR,and the in vivo drug release behavior of this prodrug wasinvestigated after oral administration of DSD ***: The DSD conjugate was obtained in two stepsand the content of dexamethasone in DSD was 11.2. %.The dextran prodrug was stable in rat stomach and smallintestine and negligibly absorbed from these tracts. Four tonine hours after the oral administration, most of the prodrug(＞95 %) had moved to the cecum and colon, and was easilyhydrolyzed by an endodextranase. Recover ofdexamethasone from colon and cecum after administrationof DSD conjugate was 6-12.folds higher than the recoveryafter administration of unmodified dexamethasone(t＝2.74,P＜0.05). The preferential release of free dexamethasone incecum and colon over that in the small intestine wasstatistically significant (t＝2.2., P＜0.05).CONCLUSION: The results of this study indicate thatdextran conjugates may be useful in selectively deliveringglucocorticoids to the colon.

关键词：结肠疾病酶前体药物药物合成靶向治疗

OBSERVATIONS ON EFFECT OF SODIUM SELENITE IN PREVENTION OF KESHAN DISEASE

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中华医学杂志(英文版) 1979年第7期92卷 471-476页

作者： Keshan Disease Research Group of the Chinese Academy of Medical Sciences, Beijing Antiepidemic Station of sichuan province, {2. Antiepidemic Station of Xichang District, sichuan Antiepidemic Station of Mianning County, sichuan Keshan Disease Research Group of the Chinese Academy of Medical Sciences Beijing Antiepidemic Station of sichuan province Chengdu Antiepidemic Station of Xichang District Sichuan Antiepidemic Station of Mianning County Sichuan

To evaluate the efficacy of sodium selenitein Keshan disease,a study was carried outamong children in Mianning county,sichuanprovince,from 1974 to 1977 *** of Keshan disease in Selenium(Se)supplemented children was found to be 2.2.and 1.0‰ in 1974 and 1975 respectively whilethat in the control groups was 13.5‰ and 9.5‰,the difference being highly significant in *** 1976, both groups were given sodiumselenite and the rate was further decreased to0.32..In 1977,no new cases of Keshan diseasewere discovered among the treated *** 36,603 Se supplemented children,2. casesof the disease occurred during the 4 years *** these, only 3 died and 1 be-came a *** 9,642.children in thecontrol group,107 cases occurred, of which 53became fatal and 6 had insufficient heart *** results indicate that sodium sele-nite could not only lower the morbidity ofKcshan disease but also alleviate its clinicalsigns and improve its *** role of selenium in the etiology of Ke-shan disease and the possible mechanism ofsodium selenite in its prevention are discussed.

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Synthesis and Luminescence Properties of Red Phosphor CaO:Eu^(3+)

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Journal of Wuhan University of Technology(Materials Science) 2009年第1期24卷 20-24页

作者：康明 School of Material Science and Engineering Southwest University of Science and Technology College of Materials Science and Engineering Sichuan University

Ca（NO3）2.4H2., Eu（NO3）3 and H2.2.4·2.2. were adopted to synthesize CaO： Eu3＋ with the chemical co-precipitation method, and the effects of the calcination temperature and Eu3＋ doping concentration on the phosphor structure and its luminescent properties were investigated by TG-SDTA, XRD, and PL-PLE. The results confirm that the Eu3＋ ions as luminescent centers substi-tutes Ca2. sites without changing the crystal structure of cubic CaO. The optimum calcination tem-perature and the optimum concentration of Eu3＋ are 1 100 ℃ and 1 mol%, respectively, under which the best crystallinity and highest PL intensity appeared. The maximum emission wavelength is 592.nm （5D0→7F1） which is excited by xenon lamp with the wavelength of 2.0-2.0 nm, indicating that the Eu3＋ ion mainly locates in the symmetric position （Oh） in the crystal lattice of CaO.

关键词： red phosphor CaO Eu^3+ co-precipitation method rare earths