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四川省急性弛缓性麻痹病例中肠道病毒71型的基因特征分析

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预防医学情报杂志 2018年第3期34卷 251-255页

作者：庞启迪陈娜童文彬袁萍四川大学华西公共卫生学院成都610041 成都中医药大学附属医院成都610075 四川省疾病预防控制中心成都610041

目的了解2.06-2.14年四川省急性弛缓性麻痹(Acute Flaccid Paralysis,AFP)病例中肠道病毒71型(Enterovirus 71,EV71)的基因特征。方法对四川省2.06-2.14年AFP病例中分离到的10株EV71进行全VP1区逆转录-聚合酶链(RT-PCR)反应扩增和核苷酸序列测定,进行序列比对和构建进化树。结果从3 2.6份AFP粪便标本中,分离出10株EV71病毒。经测序鉴定10株EV71均为C4基因亚型中的C4a进化分支。来源病例的临床诊断分别为:肠道病毒感染3例,格林巴利综合征4例,肌炎3例。10株EV71之间核苷酸同源性为93.6%~98.5%,氨基酸同源性为97.9%~100.0%。结论 2.06-2.14年四川地区AFP病例中分离到的EV71为C4基因亚型中的C4a进化分支。

关键词：肠道病毒71型基因特征进化分析

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成都市细颗粒物对医院门诊就诊量的影响研究

预防医学情报杂志 2018年第3期34卷 264-269页

作者：刘睿聪蒋先雁曾婕张遵真张丽四川省疾病预防控制中心成都610041 四川大学华西公共卫生学院成都610041

目的探讨成都市主城区大气PM 2.5浓度对当地医院门诊就诊量的影响,比较该地区大气PM 2.5浓度对人群健康的影响与我国其他地区的异同,为当地雾霾健康影响预警和干预提供科学依据。方法收集2.13年和2.14年成都市主城区范围内气象、大气PM ... 详细信息

目的探讨成都市主城区大气PM 2.5浓度对当地医院门诊就诊量的影响,比较该地区大气PM 2.5浓度对人群健康的影响与我国其他地区的异同,为当地雾霾健康影响预警和干预提供科学依据。方法收集2.13年和2.14年成都市主城区范围内气象、大气PM 2.5浓度监测和医院门诊就诊量数据,采用时间序列分析中的广义可加模型(GAM)建模,在排除长期变化趋势、气象因素和周末效应等混杂因素的影响后,估算成都市主城区大气PM 2.5浓度与医院门诊就诊量的关系。结果成都市主城区大气PM 2.5日均浓度每增加10μg/m3,综合医院成人呼吸系统当日门诊量增加0.379%(95%CI:0.2.5%~0.52.%),儿科当日总门诊量和呼吸系统门诊量分别增加0.368%(95%CI:0.310%~0.42.%)和0.434%(95%CI:0.362.~0.505%)。结论成都市居民健康受大气PM 2.5浓度影响,但与我国其他城市有所不同。

关键词：细颗粒物 PM2.5 广义可加模型健康影响门诊

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微生物共培养降解β-氯氰菊酯的适宜条件

食品与发酵工业 2018年第7期44卷 8-12页

作者：苏宏南陈切希赵甲元迟原龙贾冬英姚开四川大学轻纺与食品学院四川成都610065 旌阳区食品药品监督管理局四川德阳618000 四川师范大学生命科学学院四川成都610101

从长期喷施拟除虫菊酯类农药的菜园土壤中筛选到1株对β-氯氰菊酯具有降解能力的放线菌。生理生化及16S r DNA序列鉴定结果显示,该菌株归属于链霉菌(Streptomyces sp.K-1)。将该菌株与前期筛选的对β-氯氰菊酯具有较强降解能力的地衣芽... 详细信息

从长期喷施拟除虫菊酯类农药的菜园土壤中筛选到1株对β-氯氰菊酯具有降解能力的放线菌。生理生化及16S r DNA序列鉴定结果显示,该菌株归属于链霉菌(Streptomyces sp.K-1)。将该菌株与前期筛选的对β-氯氰菊酯具有较强降解能力的地衣芽孢杆菌B-1(Bacillus licheniformis B-1)共同培养,确定了其降解β-氯氰菊酯的适宜条件。当两种培养基的混合比例为1∶1(GSM∶LB,v/v)、菌株K-1和菌株B-1的接种比例为2.1(v/v)、接种方式为接种菌株K-1培养2. h后再接种菌株B-1、35℃振荡(150 r/min)培养72.h时,对含量为50μg/m Lβ-氯氰菊酯的降解率可达88.3%。

关键词： β-氯氰菊酯链霉菌K-1 地衣芽孢杆菌B-1 共培养降解条件

Baseline Characteristics and Treatment Patterns of the Patients Recruited to the china Registry of Hepatitis B

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 322-328页

作者： Shan Shan Hong You Junqi Niu Jia Shang Wen Xie Yuexin Zhang Xun Li Hong Ren Hong Tang Huiguo Ding Xihong Wang Yuemin Nan Xiaoguang Dou Tao Han Lingyi Zhang Xiaoqing Liu Cunliang Deng Jilin Cheng Xiaozhong Wang Qing Xie Shumei Lin Yan Huang Youqing Xu Yong Xiong Wu Li Xuebing Yan Hongxin Piao Wenxiang Huang Qinghua Lu Weijin Gong Shiping Li Xiaoxuan Hu Xiaolan Zhang Shourong Liu Yufang Li Dongliang Yang Hai Li Caixia Yang Mingliang Cheng Liaoyun Zhang Huanwei Zheng Xinhua Luo Feng Lin Lei Wang Guanghua Xu Xiaoyuan Xu Lai Wei Jinlin Hou Zhongping Duan Hui Zhuang Xizhong Yang Yuanyuan Kong Jidong Jia the CR-HepB study group,Beijing,china Liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center for Digestive DiseasesBeijingChina Department of Hepatology First Hospital of Jilin UniversityChangchunJilinChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhouHenanChina Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhouGansuChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Center of Infectious Diseases West China Hospital of Sichuan UniversityChengduSichuanChina Department of Gastroenterology and Hepatology Beijing Youan HospitalCapital Medical UniversityBeijingChina Center of Infectious Diseases The Third People's Hospital of TaiyuanTaiyuanShanxiChina Department of Traditional and Western Medical Hepatology The Third Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Infectious Diseases Shengjing Hospital of China Medical UniversityShenyangLiaoningChina Department of Hepatology Tianjin Third Central HospitalTianjin Medical UniversityTianjinChina Department of Hepatology Lanzhou University Second HospitalLanzhouGansuChina Department of Infectious Diseases Peking Union Medical College HospitalBeijingChina Department of Infectious Diseases The Affiliated Hospital of Southwest Medical UniversityLuzhouGansuChina Department of Gastroenterology Shanghai Public Health Clinical CenterShanghaiChina Department of Hepatology Xinjiang Uygur Autonomous Region Traditional Chinese Medicine HospitalUrumqiXinjiangChina Department of Infectious Diseases Shanghai Ruijin HospitalJiao Tong University School of MedicineShanghaiChina Department of Infectious Diseases Th

Background and Aims: Chronic hepatitis B virus(HBV)in-fection remains a major public health problem ***,we describe the baseline characteristics and treatment pro-files of HBV-infected patients recruited to the china Registry of Hepatitis ***: Inclusion criteria were patients with different stages of chronic HBV infection and complete key *** criteria were patients with hepatocellular *** baseline clinical,laboratory and treatment pro-files were ***: Finally,40,431 patients were *** median age was 43 years,with 65.2.being men and 51.3%being positive for hepatitis B e antigen(HBeAg).The most common initial diagnosis was chronic hep-atitis B(81.0%),followed by cirrhosis(9.3%),inactive carrier of hepatitis B surface antigen(HBsAg)(6.7%),and immune tolerant phase of hepatitis B infection(3.0%).Among the 2.,2.8 patients who were on treatment,88.0%,10.0%and 2.0%received nucleos(t)ide analogues(NAs),interferon or combination of NAs and interferon,*** propor-tion of patients who received preferred NAs(entecavir or te-nofovir disoproxil fumarate)had increased from 13.5%in 2.03 to 79.7%in ***: We concluded that middle-aged men accounted for most of the patients with chronic hepatitis B in this cross-sectional *** half of the patients were *** were the most com-monly used therapy,and use of the preferred NAs had steadily increased in the past decade.

关键词： Hepatitis B Treatment Registry

Treatment and surveillance for non-muscle-invasive bladder cancer:a clinical practice guideline(2.2. edition)

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Military Medical Research 2023年第2期10卷 141-161页

作者： Ying-Hui Jin Xian-Tao Zeng Tong-Zu Liu Zhi-Ming Bai Zhong-Ling Dou De-Gang Ding Zhi-Lu Fan Ping Han Yi-Ran Huang Xing Huang Ming Li Xiao-Dong Li Yi-Ning Li Xu-Hui Li Chao-Zhao Liang Jiu-Min Liu Hong-Shun Ma Juan Qi Jia-Qi Shi Jian Wang De-Lin Wang Zhi-Ping Wang Yun-Yun Wang Yong-Bo Wang Qiang Wei Hai-Bo Xia Jin-Chun Xing Si-Yu Yan Xue-Pei Zhang Guo-You Zheng Nian-Zeng Xing Da-Lin He Xing-Huan Wang on behalf of the Chinese Urological Doctor Association(CUDA),Urological Association of Chinese Research Hospital Association(CRHA-UA),Uro-Health Promotive Association of china International Exchange,Promotive Association for Medical,Health Care(CPAM-UHPA) Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Urology Haikou People’s HospitalHaikou Afliated Hospital of Central South University Xiangya School of MedicineHaikou 570208China Department of Urology the First Afliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyang 450052HenanChina Department of Urology Henan Provincial People’s Hospi-talZhengzhou University People’s HospitalZhengzhou 450003China Department of Urology the Second Hospital of Dalian Medical UniversityDalian 116023LiaoningChina Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Urology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Urology the People’s Hos-pital of Xinjiang Uygur Autonomous RegionUrumqi 830002China Depart-ment of Urology Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina Institutes of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Urology the Second Afliated Hospital and Second Clinical Medical College of Fujian Medical UniversityQuanzhou 362000FujianChina Department of Urol-ogy the First Afliated Hospital of Anhui Medical UniversityHefei 230022China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Urology Tianjin First Central HospitalTianjin 300190China Department of Urology Xinhua HospitalSchool of MedicineShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Urology Afliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Urology Qinghai University Afliated HospitalXining 810012China Department of Urology the First Afliated Hospital of Chongqing Medical Univ

Non-muscle invasive bladder cancer(NMIBC)is a major type of bladder cancer with a high incidence worldwide,resulting in a great disease *** and surveillance are the most important part of NIMBC *** 2.18,we issued“Treatment and surveillance for non-muscle-invasive bladder cancer in china:an evidencebased clinical practice guideline”.Since then,various studies on the treatment and surveillance of NMIBC have been *** is a need to incorporate these materials and also to take into account the relatively limited medical resources in primary medical institutions in *** a version of guideline which takes these two issues into account to promote the management of NMIBC is therefore *** formed a working group of clinical experts and *** questionnaire investigation of clinicians including primary medical institutions,2. clinically concerned issues,involving transurethral resection of bladder tumor(TURBT),intravesical chemotherapy and intravesical immunotherapy of NMIBC,and follow-up and surveillance of the NMIBC patients,were determined for this *** and recommendations on the management of NMIBC in databases,guideline development professional societies and monographs were referred to,and the European Association of Urology was used to assess the certainty of generated ***,we issued 2. statements,among which 2. were strong recommendations,and 7 were weak *** recommendations cover the topics of TURBT,postoperative chemotherapy after TURBT,Bacillus Calmette–Guérin(BCG)immunotherapy after TURBT,combination treatment of BCG and chemotherapy after TURBT,treatment of carcinoma in situ,radical cystectomy,treatment of NMIBC recurrence,and follow-up and *** hope these recommendations can help promote the treatment and surveillance of NMIBC in china,especially for the primary medical institutions.

关键词： Non-muscle invasive bladder cancer Bladder cancer Transurethral resection of bladder tumor Treatment Surveillance Guideline

基于Newmark滑块位移法的堆积体边坡稳定性分析

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路基工程 2018年第3期 100-103页

作者：吕汉川董少杰罗磊张一帆四川奥思特边坡防护工程有限公司成都610094 郑州铁路局月山工务段郑州450000

针对堆积体边坡稳定问题,基于摩擦滑移结构的抗震机理,在动力时程响应分析时考虑土体抗剪强度在地震过程中的波动效应,在动强度的基础上将拟静力极限平衡分析与地震动力反应相结合,进而利用Newmark滑块位移法得到位移增量和累计滑动位... 详细信息

针对堆积体边坡稳定问题,基于摩擦滑移结构的抗震机理,在动力时程响应分析时考虑土体抗剪强度在地震过程中的波动效应,在动强度的基础上将拟静力极限平衡分析与地震动力反应相结合,进而利用Newmark滑块位移法得到位移增量和累计滑动位移。计算结果表明,塑性滑动在滑动方向上的累计滑移量更符合实际工程。并根据地震Newmark位移与临界加速度两者之间存在较好的相关性,判别地震滑坡的危险度。

关键词：堆积体边坡地震 Newmark法永久位移

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基于数码印花技术的扎染风格纺织品研究

纺织科学与工程学报 2018年第3期35卷 66-70页

作者：任建华郑雄李远惠冯成龙浩成都纺织高等专科学校材料与环保学院四川成都611731 四川省纺织品生态染整高校重点实验室四川成都611731

扎染是一种广泛流传于世界各地并深受人们喜爱的传统手工染色技艺,随着现代印染技术的高速发展,传统手工扎染逐渐淡出日常服饰舞台。数码印花具有色彩丰富、渐变自然、纹理细腻等特点,以数码印花技术开发的扎染风格纺织品能较好的呈现... 详细信息

扎染是一种广泛流传于世界各地并深受人们喜爱的传统手工染色技艺,随着现代印染技术的高速发展,传统手工扎染逐渐淡出日常服饰舞台。数码印花具有色彩丰富、渐变自然、纹理细腻等特点,以数码印花技术开发的扎染风格纺织品能较好的呈现手工扎染技艺的韵味。对通过数码印花技术制作扎染风格纺织品的思路和方法进行了探讨。

关键词：数码印花技术扎染风格纺织品

不同手术方案治疗化脓性包裹性胸腔积液的疗效及安全性

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昆明医科大学学报 2018年第4期39卷 83-87页

作者：彭俊王允骆艳丽李民杰攀枝花市第二人民医院外科四川攀枝花617068 四川大学华西医院外科四川成都610041

目的分析不同手术方案治疗化脓性包裹性胸腔积液临疗效及安全性,为临床化脓性包裹性胸腔积液患者治疗方案选择提供参考.方法选择2.11年2.至2.17年2.攀枝花市第二人民医院收治的化脓性包裹性胸腔积液患者68例作为研究对象,按照就诊顺... 详细信息

目的分析不同手术方案治疗化脓性包裹性胸腔积液临疗效及安全性,为临床化脓性包裹性胸腔积液患者治疗方案选择提供参考.方法选择2.11年2.至2.17年2.攀枝花市第二人民医院收治的化脓性包裹性胸腔积液患者68例作为研究对象,按照就诊顺序编号,采用数字随机表法将其分为A组和B组,每组34例.A组患者采用胸腔镜小切口胸腔廓清及纤维板剥脱术治疗,术中采用抗菌药物冲洗胸腔,B组患者在A组手术基础上,置入带侧孔静脉导管,术后每日加用抗菌药物冲洗胸腔,连续使用3 d.比较2.患者术后1月的临床疗效、并发症发生情况及静脉导管拔除时间情况.比较2.患者术后3 d静脉导管液中白细胞计数(WBC)、谷氨酸(Glu)、乳酸脱氢酶(LDH)水平,比较2.患者术前及拔除静脉到观后的呼吸功能能指标(FVC、FEV1)、胸膜厚度改善情况,术后随访1 a,比较两组患者复发率.分析2.手术方案治疗化脓性包裹性胸腔积液患者的疗效及安全性的优劣.结果术后1月,A组患者临床总有效率明显低于B组患者(P0.05).术后3 d,A组患者WBC、Glu明显高于B组患者,LDH明显低于B组患者(P2.例患者中4例出现复发,复发率14.81%,B组中治愈出院的31例患者中仅2.复发,复发率6.45%,A组复发率明显高于B组(χ2.4.593,P<0.05).结论胸腔镜小切口胸腔廓清及纤维板剥脱术联合术后抗菌药物冲洗胸腔,可提升患者临床疗效,但同时增加了患者经济负担,临床应个性化选择使用.

关键词：化脓性包裹性胸腔积液胸腔镜小切口胸廓清除纤维板剥脱术临床疗效安全性

体表擦拭取样在两栖动物保护遗传学研究中的应用

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四川动物 2018年第4期37卷 373-380页

作者：艾永斌杨旭升彭卫华陈云梅徐凉燕罗剑夏云曾晓茂四川申果庄省级大熊猫自然保护区管理处四川越西616650 中国科学院成都生物研究所成都610041 中国科学院大学北京100049

相比于其他取样方法,非损伤性取样对动物的伤害可以降到最低,因而在动物保护研究中有着重要的价值。在两栖类中通过体表擦拭进行非损伤性取样的方法已有报道,但是相关研究仅局限于零星物种,且均是在实验室环境下完成取样,并不适用于野... 详细信息

相比于其他取样方法,非损伤性取样对动物的伤害可以降到最低,因而在动物保护研究中有着重要的价值。在两栖类中通过体表擦拭进行非损伤性取样的方法已有报道,但是相关研究仅局限于零星物种,且均是在实验室环境下完成取样,并不适用于野外就地取样。本研究对四川申果庄省级大熊猫自然保护区内有尾两栖类及无尾两栖类6科10属11种进行了就地擦拭取样。线粒体基因序列分析表明,体表擦拭取样法获得的DNA能满足常规的分子生物学实验要求,可用于水生、陆栖等各种两栖动物类群,可在两栖类保护遗传学研究中广泛应用。

关键词：体表擦拭取样两栖类保护遗传学