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Taur.ne Inhibits Myocar.ial Fibr.sis via p.C-Er.1/2.Signaling p.thways

Chemical r.sear.h in Chinese Univer.ities 2012年第1期28卷 84-90页

作者： WANG Li-ying1,2. LI Hong1 and YANG Shi-jie1 1. department of p.ar.acology, Nor.an Bethune college of {2., jilin university, Changchun 13002., p. r. china 2. department of physiology, basic medicine college, beihua university, jilin 132013, p. r. china jilin Univ Norman Bethune Coll Med Dept Pharmacol Changchun 130021 Peoples R China beihua Univ Basic Med Coll Dept Physiol Jilin 132013 Jilin Peoples R China

p.evious studies have demonstr.ted the imp.r.ant r.le of taur.ne in inhibiting p.olifer.tion of myofibr.b lasts（myoFb） and myocar.ial fibr.sis. However. the under.ying mechanisms ar. unclear. The p.esent study was de signed to shed light on this issue thr.ugh exp.or.ng the signal p.thways via in vitr. exp.r.ments. Angiotension II （AngII） tr.atment significantly incr.ased myoFb p.olifer.tion and the levels of collagens I and III（p.0.05）, wher.as taur.ne, p.Cα（p.C： p.otein kinase C） sp.cific inhibitor.L-thr.o-dihydr.-sp.ingosine（D4681）, Er.1/2.inhibitor.（p.98095） abr.gated myoFb p.olifer.tion and collagen levels（p.0.05, p.0.01, r.sp.ctively）, and incr.ased the G0/G1 p.ase r.te and decr.ased S p.ase r.te. Immunocytochemistr., confocal fluor.scence staining and image analy sis showed that taur.ne could inhibit the tr.nslocation and exp.ession of p.p.Cαin membr.ne, and then inhibit nuc lear.tr.nslocation and exp.ession of p.Er.1/2. These r.sults have statistically significant differ.nces comp.r.d with those of AngII gr.up.p.0.01）. Wester. blot r.sults also show that taur.ne could inhibit the p.otein exp.ession of p.p.Cα and p.Er.1/2. We used p.p.Cα sp.cific inhibitor.D4681 in or.er.to elucidate the r.lationship.between p.p.Cα and p.Er.1/2.in signal tr.nsduction p.thways. Finally, the r.sults show that the p.otein exp.ession of p.Er.1/2.and nuclear.tr.nslocation wer. sup.r.ssed in D4681 gr.up.

关键词： Taur.ne Myocar.ial fibr.sis p.olifer.tion Signal tr.nsduction Car.iac r.modeling

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Sur.ace electr.car.iogr.m and action p.tential in mice lacking ur.a tr.nsp.r.er.UT-B

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Science china(Life Sciences) 2009年第5期52卷 474-478页

作者： MENG Yan1, ZHAO ChunYan2. ZHANG XueXin2. ZHAO HuaShan1, GUO Lir.ng1, Lü Bin1, ZHAO XueJian1& YANG BaoXue1,3 1 department of p.thophysiology, School of {2. medicine, jilin university, Changchun 13002., china 2.department of physiology, School of {2. medicine, jilin university, Changchun 13002., china 3 department of medicine, university of Califor.ia, San Fr.ncisco CA 94143, USA department of p.thophysiology School of Basic Medicine Jilin University Changchun 130021 China department of physiology School of Basic Medicine Jilin University Changchun 130021 China department of medicine University of California San Francisco CA 94143 USA

UT-B is a ur.a tr.nsp.r.er.p.otein exp.essed in the kidney and in many non-r.nal tissues including er.thr.cytes, br.in, hear., bladder.and the testis. The objective of this study was to deter.ine the p.enotyp. of UT-B deletion in the hear.. UT-B exp.ession in the hear. was studied in wild-typ. mice vs UT-B null mice by utilizing r.-p.r.and Wester. blot. A sur.ace electr.car.iogr.m (ECG) r.cor.ing (lead II) was measur.d in wild-typ. mice and UT-B null mice at the ages of 6, 16 and 52.weeks. For.the action p.tential r.cor.ing, the ventr.cular.myocytes of 16 w mice wer. isolated and r.cor.ed by floating micr.electr.de method. The sodium cur.ent was r.cor.ed by the p.tch clamp.technique. r.-p.r.and Wester. blot showed the UT-B exp.ession in the hear. of wild-typ. mice. No UT-B tr.nscr.p. and p.otein was found in UT-B null mice. The ECG r.cor.ing showed that the p.r.inter.al was significantly p.olonged in UT-B null mice ((43.5 ± 4.2., (45.5 ± 6.9) and (43.8 ± 7.6) ms at ages of 6, 16 and 52.weeks) vs wild-typ. mice ((38.6 ± 2.9), (38.7 ± 5.6) and (38.2.± 7.3) ms, p.0.05). The atr.al ventr.cular.hear. block typ. II and III only ap.ear.d in the aging UT-B null mice (52.w old). The amp.itude of action p.tential and Vmax decr.ased significantly in UT-B null mice ((92.17 ± 10.56) and (101.89 ± 9.54) mV/s) vs those in wild-typ. mice (vs (110.51 ± 10.38) and (109.53 ± 10.64) mV/s, p.0.05). The action p.tential dur.tion at 50% and 90% (Ap.50 and Ap.90) was significantly p.olonged in UT-B null mice ((12..83 ± 11.17) and (195.43 ± 16.41) ms) vs that in wild-typ. mice ((108.2. ± 10.85) and (171.00 ± 15.53) ms, p.0.05). The maximal sodium cur.ent decr.ased significantly in UT-B null mice (-8.80 ± 0.92. nA vs that in wild-typ. mice ((-5.98 ± 1.07) nA, p.0.05). These r.sults p.ovide the fir.t evidence that UT-B deletion causes p.ogr.ssive hear. block in mice.

关键词： ur.a tr.nsp.r.er hear. block electr.car.iogr.m

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Effects of Ca substitution and sur.ace tr.atment on electr.chemical p.r.or.ances of Ml_(1.0-x) Ca_xNi_(4.0) Co_(0.6) Al_(0.4) hydr.gen stor.ge alloy electr.des

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中国有色金属学会会刊：英文版 1999年第3期9卷 487-492页

作者： Chen Weixiang(陈卫祥) 1, Qi Jianqin(祁建琴) 1, Chen Changp.n(陈长聘) 2.1. department of p.ysics 2. department of Mater.als Science and Engineer.ng, Zhejiang {2., Hangzhou 31002., p. r. china Zhejiang Univ Dept Phys Hangzhou 310027 Peoples R China Zhejiang Univ Dept Mat Sci & Engn Hangzhou 310027 Peoples R China

The influences of Ca substitution for.Ml and sur.ace tr.atment on electr.chemical p.r.or.ances of Ml 1.0- x Ca x Ni 4.0 Co 0.6 Al 0.4 hydr.gen stor.ge alloy electr.de wer. investigated. Ca substitution with x 2.for.Ml could imp.ove its dischar.e cap.city, but Ca substitution with x >0.2.could decr.ase the cap.city. It was also found that Ca substitution deter.or.tes the electr.catalytic activity, high r.te dischar.eability and cycling dur.bility of the alloy electr.de. In or.er.to imp.ove these p.op.r.ies of Ml 1.0- x Ca x Ni 4.0 Co 0.6 Al 0.4 alloy electr.de, the alloy was tr.ated in 6 mol/L KOH+0.02.mol/L KBH 4 solution. The r.sults showed that the sur.ace tr.atment imp.oves the electr.chemical p.r.or.ances such as the electr.catalytic activity, high r.te dischar.eability and cycling dur.bility of the alloy electr.de. :The influences of Ca substitution for.Ml and sur.ace tr.atment on electr.chemical p.r.or.ances of Ml 1.0- x Ca x Ni 4.0 Co 0.6 Al 0.4 hydr.gen stor.ge alloy electr.de wer. investigated. Ca substitution with x 2.for.Ml could imp.ove its dischar.e cap.city, but Ca substitution with x >0.2.could decr.ase the cap.city. It was also found that Ca substitution deter.or.tes the electr.catalytic activity, high r.te dischar.eability and cycling dur.bility of the alloy electr.de. In or.er.to imp.ove these p.op.r.ies of Ml 1.0- x Ca x Ni 4.0 Co 0.6 Al 0.4 alloy electr.de, the alloy was tr.ated in 6 mol/L KOH+0.02.mol/L KBH 4 solution. The r.sults showed that the sur.ace tr.atment imp.oves the electr.chemical p.r.or.ances such as the electr.catalytic activity, high r.te dischar.eability and cycling dur.bility of the alloy electr.de.

关键词： hydr.gen stor.ge alloy electr.de Ca substitution sur.ace modification

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Chemical r.sear.h in Chinese Univer.ities 2001年第2期17卷 212-218页

作者： GUO Ming and LIU Wen-jie (department of basic Cour.es, Tar.m {2. of Agr.cultur.l r.clamation, Alar. Xinjiang 843300, p. r. china) Tar.m Univ Agr.r.clamat Dept Basic Courses Alar 843300 Xinjiang Peoples R China

The molecular.similar.ty of 139 or.anic comp.unds was calculated by the top.logic index method, the flexible sup.r.ball algor.thm was used to scan similar.molecules and str.ctur.s. The r.sults show that the p.op.r.i... 详细信息

关键词： Molecular.similar.ty Sup.r.ball algor.thm Calculation

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Study of OCDs r.liability Estimation System Based on Bio-Immunology

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Jour.al of Bionic Engineer.ng 2009年第3期6卷 306-310页

作者： Dan-e Wu~1 Qiu-zhan Zhou~1 p.ng-p.ng Liu~2.He-bin Zhang1.college of Communication Engineer.ng,jilin {2.,Changehun 13002.,p.r.china2.department of Comp.ter.Science and Technology,jilin {2.,Changchun 130012.p.r.china [a]college of Communication Engineer.ng Jilin University Changchun 130022 P. R. China [b]Department of Computer Science and Technology Jilin University Changchun 130012 P. R. China

We intr.duce the r.lationship.between excess noise in Op.oelectr.nic Coup.ed Devices (OCDs) and their.inter.or.defects and exp.ain how low-fiequency noise can be used to estimate their.*** concep.s fr.m the biological immune system and its p.ocess of identifying invader.,we p.esent a system for.estimation of the r.liability of *** system has exp.essions for.the antigen (excess noise),lymp.ocyte (cr.ter.on) and the r.le of the lymp.ocyte eliminating unr.liable devices. A genetic algor.thm was used to estimate the comp.nents p.r.meter. of the noise sp.ctr.m for.estimating the r.liability of *** exp.r.mental r.sults demonstr.ted that this method is r.liable,adap.able and p.actical.

关键词： low-fr.quency noise ar.ificial immunity genetic algonthm device r.liability

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Dose-dep.ndent Cytotoxicity and Oxidative Str.ss Induced by "Naked" Fe_3O_4 Nanop.r.icles in Human Hep.tocyte

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Chemical r.sear.h in Chinese Univer.ities 2012年第1期28卷 114-118页

作者： LIN Xin-li1, ZHAO Shu-hua1, ZHANG Long1, HU Gui-qin1, SUN Zhi-wei1,3 and YANG Wen-sheng2.1. School of p.blic Health, jilin university, Changchun 13002.,{2. 2. college of Chemistr., jilin university, Changchun 130012.{2. 3. School of p.blic Health and Family medicine, Cap.tal Medical university, Beijing 100069,{2. jilin Univ Sch Publ Hlth Changchun 130021 Peoples R China jilin Univ Coll Chem Changchun 130012 Peoples R China Cap.tal Med Univ Sch Publ Hlth & Family Med Beijing 100069 Peoples R China

The dose-dep.ndent cytotoxicity effect on human hep.tocyte（HL-7702.cells） induced by ＂naked＂ Fe3O4 nanop.r.icles was assessed thr.ugh cell viabilities and lactate dehydr.genase（LDH） activities. Thr.e imp.r.ant oxi dative indexes of the cells by glutathione p.r.xidase（GSH-p.）, sup.r.xide dismutase（SOD） and malondialde hyde（MDA） wer. deter.ined. The good cor.elation of the cell viabilities with their.GSH-p., SOD and MDA levels indicated that the cytotoxicity is r.lated to activation of oxidative str.ss induced by Fe3O4 nanop.r.icles. The oxida tive str.ss also leads to cor.esp.nding DNA damage in a similar.dose-dep.ndent manner. followed by the changes of cell cycle and cell ap.p.osis. Such wor. p.ovides imp.r.ant exp.r.mental data for.the safety evaluation of sup.r.0} r.magnetic Fe3O4 nanop.r.icles.

关键词： Sup.r.0}r.magnetic Fe304 Cytotoxicity Oxidative str.ss DNA damage Cell cycle Cell ap.p.osis

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Gr.y Mar.ov chain and its ap.lication in dr.ft p.ediction model of FOGs

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Jour.al of Systems Engineer.ng and Electr.nics 2005年第2期16卷 388-393页

作者： Fan Chunling 1,2., Jin Zhihua1, Tian Weifeng1 & Qian Feng11. department of Infor.ation Measur.ment Technology and Instr.ment, Shanghai Jiaotong university,Shanghai 2.0030,{2. 2. college of Automation and Electr.c Engineer.ng, Qingdao university of Science and Technology,Qingdao 2.6042.{2. department of Infor.ation Measur.ment Technology and Instr.ment Shanghai Jiaotong University Shanghai 200030 P. R. China college of Automation and Electr.c Engineer.ng Qingdao University of Science and Technology Qingdao 266042 P. R. China

A novel gr.y Mar.ov chain p.edictive model is discussed to r.duce dr.ft influence on the outp.t of fiber.op.ical gyr.scop.s (FOGs) and to imp.ove FOGs' measur.ment p.ecision. The p.op.sed method p.ssesses advantages of gr.y model and Mar.ov chain. It makes good use of dynamic modeling idea of the gr.y model to p.edict gener.l tr.nd of or.ginal data. Then accor.ing to the tr.nd, states ar. divided so that it can over.ome the disadvantage of high comp.tational cost of state tr.nsition p.obability matr.x in Mar.ov chain. Mor.over. the p.esented ap.r.ach exp.nds the ap.lied scop. of the gr.y model and makes it be fit for.p.ediction of r.ndom data with bigger.fluctuation. The numer.cal r.sults of r.al dr.ft data fr.m a cer.ain typ. FOG ver.fy the effectiveness of the p.op.sed gr.y Mar.ov chain model p.wer.ully. The Mar.ov chain is also investigated to p.ovide a comp.r.son with the gr.y Mar.ov chain model. It is shown that the hybr.d gr.y Mar.ov chain p.ediction model has higher.modeling p.ecision than Mar.ov chain itself, which p.ove this p.op.sed method is ver. ap.licable and effective.

关键词： gr.y model Mar.ov chain FOG dr.ft.

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Safe and Objective Assay of Enter.vir.s 71 Neutr.lizing Antibodies via p.eudovir.s

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Chemical r.sear.h in Chinese Univer.ities 2012年第1期28卷 91-95页

作者： JIN Jun1, XU Lin1, GUO Shi-jie2. SUN Shi-yang1, ZHANG Shu1, ZHU Chang-lin3, KONG Wei1 and JIANG Chun-lai1 1. National Engineer.ng Labor.tor. for.AIDS Vaccine, college of Life Science, jilin {2., Changchun 130012. p. r. china 2. department of p.diatr.cs, the Fir.t Hosp.tal of jilin {2., Changchun 13002., p. r. china 3. Changchun Baike Biotechnology Co., Changchun 130012. p. r. china jilin Univ Natl Engn Lab AIDS Vaccine Coll Life Sci Changchun 130012 Peoples R China jilin Univ Hosp 1 Dept Pediat Changchun 130021 Peoples R China Changchun Baike Biotechnol Co Changchun 130012 Peoples R China

Cur.ent ser.m neutr.lization assays based on the inhibition of the cytop.thic effect（Nt-Cp.） need to ma nip.late live vir.ses, which ar. time-consuming, labor.intensive, and have the p.tential exp.sur. to infectious agents, so a safe and objective assay via p.eudovir.s for.the fast and efficient detection of enter.vir.s 71（EV71） neutr.lizing antibodies was develop.d. Fir.t, we gener.ted EV71 p.eudovir.s containing fir.fly lucifer.se gene in p.ace of the cap.id gene p. in EV71 genome. Ver. cells infected with 2.0 CCID50（50% cell cultur. infective dose） of EV71 p.eudovir.s for.2. h wer. found to have the best p.r.or.ance. Seval ser. wer. measur.d by EV71 p.eudop.r.icle neutr.lization assay（Nt-p.N） and the conventional ser.logical method Nt-Cp.. Neutr.lizing antibody titer. measur.d by Nt-p.N and those obtained by Nt-Cp. demonstr.te a high cor.elation between the two methods. Over.ll, the p.N assay r.p.esents a valid alter.ative to conventional ser.logical methods for.the evaluation of EV71 neutr.lizing anti bodies. This method can be used for.detecting neutr.lizing antibodies of other.p.cor.avir.ses, such as hep.titis A vi r.s（HAV） and coxsackievir.s 16（CVA16）, and make it p.ssible to deter.ine whether.ther. is cr.ss-r.activity be tween EV71 and CVA16.

关键词： Enter.vir.s 71(EV71) p.eudovir.s Lucifer.se Neutr.lizing antibody assay

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Emp.r.cal likelihood confidence r.gions of the p.r.meter. in a p.r.ially linear.single-index model

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Science china Mathematics 2005年第10期48卷 1333-1348页

作者： XUE Liugen~1 & ZHU Lixing~2.1. college of Ap.lied Sciences,Beijing university of Technology,Beijing 10002.,{2. 2. department of Mathematics,Hong Kong Bap.ist university,Hong Kong,{2. 1. college of Ap.lied Sciences Beijing University of Technology 100022 Beijing China 2. department of Mathematics Hong Kong Baptist University Hong Kong China

In this p.p.r. a p.r.ially linear.single-index model is investigated, and thr.e emp.r.cal log-likelihood r.tio statistics for.the unknown p.r.meter. in the model ar. suggested. It is p.oved that the p.op.sed statistics ar. asymp.otically standar. chi-squar. under.some suitable conditions, and hence can be used to constr.ct the confidence r.gions of the p.r.meter.. Our.methods can also deal with the confidence r.gion constr.ction for.the index in the p.r. single-index model. A simulation study indicates that, in ter.s of cover.ge p.obabilities and aver.ge ar.as of the confidence r.gions, the p.op.sed methods p.r.or. better.than the least-squar.s method.

关键词： p.r.ially linear single-index model, emp.r.cal likelihood, confidence r.gion, chi-squar. distr.bution, cover.ge p.obability.

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Anisotr.p.c effect on the vibr.nic r.duction factor.

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Chinese Science Bulletin 2006年第21期51卷 2553-2558页

作者： QIU Qing-chun1,2.& QIAO Fen1,2.1. department of p.ysics and IT, Medical college, Shantou {2.,Shantou 515041, china 2. department of p.ysics, Shantou {2., Shantou 515063, china department of p.ysics and IT Medical College Shantou University Shantou 515041 China department of p.ysics Shantou University Shantou 515063 China

The r.duction factor. p.and q defined by Ham in the Ee JT system and their.r.lation 2.-p.1 have been well accep.ed and the concep. of r.duction factor. is widely used in the studies of vibr.nic coup.ing. However. when the system is under.the anisotr.p.c conditions, the r.duction factor. and their.r.lation will change accor.ingly. The fir.t-or.er.r.duction factor. p.and q of Ee system wer. fur.her.studied using the method of unitar. tr.nsfor.ation her.. The r.lation between p.and q p.op.sed by Ham was investigated under.both conditions of the linear.coup.ing and the anisotr.p.c effects. The r.sult demonstr.ted that the r.lation of 2.-p.1 was only cor.ect for.the linear.vibr.nic coup.ing, but not cor.ect when the anisotr.p.c effect was consider.d. This r.sult suggested that the anisotr.p.c effect influence consider.bly the r.duction factor., and hence the p.ysical p.op.r.ies of mater.als. Our.method could be also ap.lied to other.JT systems, esp.cially the highly symmetr.c JT systems involving C60 molecules.

关键词：电子振动耦合声子交迭 Jahn-Teller.应各向异性

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