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剪切力对人视网膜色素上皮细胞c-fos和c-myc mRNA表达的影响

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眼视光学杂志 2009年第3期11卷 203-206页

作者：王静波惠延年关娟周历解放军总医院第二附属医院眼科北京100091 第四军医大学西京医院眼科陕西西安710032

目的观察剪切力对体外培养的人视网膜色素上皮(retinal pigment epithelial,RPE)细胞c-fos和c-myc基因mRNA表达的影响。方法用2.yne/cm2.剪切力作用于体外培养的人RPE细胞,作用时间分别为0、0.2.h、0.5h、0.75h、1h、1.5h和3h,采用逆... 详细信息

目的观察剪切力对体外培养的人视网膜色素上皮(retinal pigment epithelial,RPE)细胞c-fos和c-myc基因mRNA表达的影响。方法用2.yne/cm2.剪切力作用于体外培养的人RPE细胞,作用时间分别为0、0.2.h、0.5h、0.75h、1h、1.5h和3h,采用逆转录聚合酶链反应(RT-PCR)观察c-fos和c-myc mRNA的表达变化,并采用单因素方差分析比较各时间点之间表达的差异。结果2.yne/cm2.剪切力作用0.75h后,RPE细胞的形态开始发生变化,包括细胞间隙增大、细胞皱缩和脱落。剪切力作用1.5h及以上时间,细胞极性改为与流动方向一致。在未受剪切力作用的RPE细胞中,c-fos mRNA表达水平低。随着剪切力的作用时间的延长,c-fos mRNA的表达逐渐增强,于1.5h时达峰值,随后开始减弱。剪切力作用3h时,RPE细胞c-fos mRNA的水平仍显著高于未受剪切力作用时的水平。在未受剪切力作用的RPE细胞中,c-myc mRNA表达水平较低。剪切力作用1.5h时,c-myc mRNA的表达增强至峰值,随后开始减弱,但在作用3h时,c-myc mRNA的表达仍高于未受剪切力作用时的RPE细胞的c-myc mRNA的水平。结论2.yne/cm2.剪切力可改变RPE细胞的形态,在短时间内可快速增强RPE细胞c-fos和c-myc mRNA的表达。与c-myc相比,c-fos对剪切力的反应更迅捷,增强幅度更大。

关键词：视网膜色素上皮剪切力 c—fos c—myc

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法洛四联症外科治疗34例

中国心血管病研究 2004年第6期2卷 425-427页

作者：梁葳李韬周其文杨东山广东省茂名市人民医院心胸外科 525000

目的总结法洛四联症(TOF)外科治疗经验。方法 34例法洛四联症患者,32.在中低温体外循环、胸部正中切口行TOF根治术,1例在非体外循环下行改良B-T分流术,1例行根治术同时行双向Glenn分流术。结果术后早期死亡1例,死亡原因为低心排血量... 详细信息

目的总结法洛四联症(TOF)外科治疗经验。方法 34例法洛四联症患者,32.在中低温体外循环、胸部正中切口行TOF根治术,1例在非体外循环下行改良B-T分流术,1例行根治术同时行双向Glenn分流术。结果术后早期死亡1例,死亡原因为低心排血量综合征(los),无远期死亡。结论 TOF应争取早日行根治术,肺动脉发育差者应行改良B-T分流术,右心室发育不良者在行根治术同时行双向Glenn分流术,死亡原因以los多见,应采取合适的手术方式及围术期多种方法预防。

关键词：法洛四联症胸外科手术低心排血量综合征

经皮椎弓根螺钉固定联合伤椎可注射人工骨充填治疗胸腰椎骨折2.例

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生物骨科材料与临床研究 2011年第5期8卷 38-40页

作者：徐峰蔡贤华陈庄洪黄勇康辉张志文广州军区武汉总医院骨科湖北武汉430070

目的探讨经皮椎弓根螺钉系统配合伤椎可注射人工骨充填治疗胸腰椎骨折的可行性及有效性。方法选取2.08年1月-2.11年12.收治无神经症状的胸腰椎爆裂性骨折﹙T12.L1﹚2.例,采用经皮椎弓根螺钉系统联合伤椎可注射用人工骨填充治疗,随访... 详细信息

目的探讨经皮椎弓根螺钉系统配合伤椎可注射人工骨充填治疗胸腰椎骨折的可行性及有效性。方法选取2.08年1月-2.11年12.收治无神经症状的胸腰椎爆裂性骨折﹙T12.L1﹚2.例,采用经皮椎弓根螺钉系统联合伤椎可注射用人工骨填充治疗,随访近期效果。结果手术时间70~90分钟,平均80分钟。术中失血量50-100ml,平均72.l。术后住院时间7~10天,平均8天。随访3~5月,平均3.5月。随访过程中没有患者出现内固定物松动断裂,椎体高度塌陷。随访腰椎CT显示椎体内注入的人工骨边缘模糊,融合良好,无骨吸收现象。伤椎椎体高度维持良好。病椎前缘压缩程度和后凸Cobb角度改变,2.例术前伤椎前缘压缩程度为﹙53.41±7.35﹚%,后凸畸形Cobb角为2..72.5.6°。术后伤椎压缩程度为10.78±4.53°,与术前比较差异有统计学意义﹙P〈0.01﹚,术后后凸cobb角为8.6±3.9°。与术前比较差异有统计学意义﹙〈0.01﹚。结论经皮椎弓根螺钉系统配合伤椎可注射人工骨充填治疗胸腰椎骨折可获得良好的近期临床效果,是一种安全有效的微创手术方法。

关键词：经皮椎弓根螺钉可注射用人工骨胸腰椎骨折

Dendritic cell deficiencies persist seven months after SARS-CoV-2.infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2.infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2.***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2.3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

新疆哈萨克族中发现的二例HbD los angeles及其结构分析

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新疆医学院学报 1985年第1期 4-7页

作者：马梅荪钱渡庄怡郭卉王越瞿承亮喻永绥刘素云李维城赵勤新疆医学院生物学教研室新疆医学院儿科学教研室

本文报道1980年在新疆进行普查中发现的哈萨克族二例β链异常血红蛋白的研究结果。结构分析证明:该异常血红蛋白系β链N端第12.位的谷氨酸为谷氨酰胺所替代,为HbD los angeles〔β12.（GH4）Glu→Gln〕。

关键词：异常血红蛋白 β链哈萨克族哈萨克民族 HbD los angeles 新疆

像素闪耀算法在提高单源双能CT低单能量图像对肝内小转移瘤显示的价值

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中国临床医学影像杂志 2018年第11期29卷 782-787页

作者：徐明哲刘爱连刘义军刘静红潘聚东大连医科大学附属第一医院放射科辽宁大连116011 加州大学旧金山分校放射和生物影像科美国加州173304

目的:探讨深度学习像素闪烁(Pixel shine,PS)(AlgoMedica,Inc,Sunnyvale,CA)算法提升单源双能CT平扫单能量图像显示肝内小转移瘤图像质量的价值,尤其提高低能量图像对病灶显示的价值。方法:回顾性搜集肝转移瘤的患者14例,共38个病灶。... 详细信息

目的:探讨深度学习像素闪烁(Pixel shine,PS)(AlgoMedica,Inc,Sunnyvale,CA)算法提升单源双能CT平扫单能量图像显示肝内小转移瘤图像质量的价值,尤其提高低能量图像对病灶显示的价值。方法:回顾性搜集肝转移瘤的患者14例,共38个病灶。使用单源双能CT(GE Discovery HD 750,usa.,行GSI扫描,对AW4.6工作站所得的平扫低单能量图像进行PS算法(A7模式)处理,得到PS前后平扫40~70 KeV单能量图像。由1名影像诊断医师在40~70 KeV单能量图像的同一层面(显示病灶的最大层面)、同一位置分别在肝转移瘤、正常肝实质勾画感兴趣区(ROI),测量并记录各ROI的CT值及SD值,计算PS前后各单能量图像肝转移瘤的SNR、肝转移瘤相对于正常肝实质的CNR以及PS后SNR和CNR较PS前增大的比率。采用Shapiro-Wilk正态分布检验检查数据正态性。比较PS前后40~70 KeV四组单能量图像中肝转移瘤和正常肝实质的CT值、肝转移瘤SNR及CNR,并且,将PS后40 KeV、50 KeV、60 KeV图像中的肝转移瘤SNR、CNR与PS前70 KeV图像相比较。其中符合正态分布的数据使用配对样本t检验比较其差异,余不符合正态分布则使用Wilcoxon符号秩和检验。采用非参数Friedman检验分别比较PS后40~70 KeV各单能量图像SNR和CNR增大比率的差异,若存在差异则采用Wilcoxon符号秩和检验进行两两比较。结果:PS前后40~70 KeV四组单能量图像中肝转移瘤、肝实质的CT值无统计学差异(P>0.05),而PS后40~70 KeV四组单能量图像中肝转移瘤的SNR、CNR均显著大于PS前(P均为0.000)。与PS前70 KeV图像中肝转移瘤SNR、CNR相比,PS后40 KeV图像的肝转移瘤SNR小于PS前70 KeV图像,而PS后50 KeV、60 KeV图像的肝转移瘤SNR以及PS后40 KeV、50 KeV、60 KeV图像的肝转移瘤CNR均明显大于PS前70 KeV图像。Friedman检验显示PS后40~70 KeV单能量图像肝转移瘤SNR和CNR较相应PS前图像SNR和CNR增大的比率之间具有统计学差异(P=0.000,P=0.000),其中40 KeV与50 KeV之间的SNR和CNR的增大比率无统计学差异(P=0.2.5,P=0.42.),40 KeV和50 KeV单能量图像PS后SNR、CNR增大比率均显著大于60 KeV、70 KeV图像。结论:PS算法可以明显提高单源双能CT平扫单能量图像对显示肝内小转移瘤灶的图像质量,并且PS算法在低单能量图像中对病灶显示方面具有更好的效果。

关键词：肝肿瘤肿瘤转移体层摄影术,螺旋计算机

肌成纤维细胞转化在恶性肿瘤转移过程中的作用

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中医学报 2018年第3期33卷 350-354页

作者：周天迟笑怡刘传波李泉旺 RAO Jianyu 胡凯文北京中医药大学东方医院北京100078 department of Pathology and Lab Med Ronald Reagan Medical CenterUniversity of California at Los AngelesLos Angeles 90095

肿瘤转移过程是一个多因素调控、多步骤协同的交互过程。肿瘤微环境中肌成纤维细胞转化是促进肿瘤及转移发生的重要病理过程,这一过程可以通过以下作用实现:(1)构成适合肿瘤细胞生长的代谢体系;(2.提供立体生长形态支架;(3)促进肿瘤细... 详细信息

肿瘤转移过程是一个多因素调控、多步骤协同的交互过程。肿瘤微环境中肌成纤维细胞转化是促进肿瘤及转移发生的重要病理过程,这一过程可以通过以下作用实现:(1)构成适合肿瘤细胞生长的代谢体系;(2.提供立体生长形态支架;(3)促进肿瘤细胞上皮间质转化;(4)分泌血管内皮生长因子,促进微循环形成;(5)形成鞘状结构保护肿瘤细胞免受药物及免疫细胞伤害;(6)分泌生长因子和细胞炎性因子,促使纤维细胞和成纤维细胞发生肌成纤维细胞转化。而以上作用很可能是化痰类和活血化瘀类中药抗癌、抗转移的核心作用机制。

关键词：肌成纤维细胞肿瘤微环境转移化痰类中药活血化瘀类中药

MMS星座对磁层顶磁通量绳内离子惯性尺度结构的观测

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空间科学学报 2018年第2期38卷 147-168页

作者：刘杨濮祖荫谢伦郭瑞龙王晓钢肖池阶史全岐 DUNLOP M BOGDANOVA Y V MOORE T E RUSSELL C T LINDQVIST P A TORBERT R B POLLOCK C ZHAO Cong 北京大学地球与空间科学学院北京100871 中国科学院地质与地球物理研究所北京100029 哈尔滨工业大学物理系哈尔滨150001 北京大学物理学院北京100871 山东大学空间科学与物理学院威海264209 RAL Space Rutherford Appleton LaboratorySTFCDidcotOX11 0QXUK Goddard Space Flight Center NASAGreenbeltMDUSA university of california Los AngelesCAUSA Royal Institute of Technology StockholmSweden university of New Hampshire DurhamNHUSA

利用MMS观测数据,对磁层顶通量绳内离子惯性尺度(d_i)的结构进行分析研究.结果发现,许多不同尺度(约1d_i至数十d_i)的通量绳内都存在具有d_i尺度的电流j_m,其方向在磁层顶局地坐标系的-M方向,即与磁层顶查普曼-费拉罗电流同向,由电子在+... 详细信息

利用MMS观测数据,对磁层顶通量绳内离子惯性尺度(d_i)的结构进行分析研究.结果发现,许多不同尺度(约1d_i至数十d_i)的通量绳内都存在具有d_i尺度的电流j_m,其方向在磁层顶局地坐标系的-M方向,即与磁层顶查普曼-费拉罗电流同向,由电子在+M方向的运动(v_(em))携带.这些电流结构具有以下特征:磁鞘与磁层成分混合,磁场为开放形态;离子去磁化,电子与磁场冻结;N方向(即垂直于磁层顶电流片方向)的电场E_n显著增大,幅度达到约2. mV·m^(-1),并伴有明显的尖峰状起伏,该增强和尖峰状起伏的电场对应于霍尔电场.分析表明,电流、电子与离子运动的偏离以及霍尔电场之间遵从广义欧姆定律,三者密切关联.进一步对磁层顶磁重联的探测数据进行分析发现,在很多重联区内也存在与通量绳内相似的结构,其尺度约为d_i量级,其中霍尔电场E_N、电流j_M和电子速度v_(eM)均与通量绳内对应物理量的方向相同且幅度相近.基于上述观测事实,采用经典FTE通量绳模型,对通量绳内电流、电子运动和霍尔电场的起源进行了初步探讨,认为其来源于磁层顶无碰撞磁重联区内的相应结构,并且后者在离子尺度通量绳的形成过程中起到重要作用.

关键词：磁通量绳离子尺度电流霍尔电场磁层顶磁重联

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusa. Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang university HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China university of Geosciences Beijing China university of Geosciences WuhanHubei China university of Mining and Technology XuzhouJiangsu China West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise