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Design and optimization of a linker for fusion protein construction

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Progress in Natural Science:Materials International 2009年第10期19卷 1197-1200页

作者： Jianhua Zhang a,Jun Yun b,Zhigang Shang a,Xiaohui Zhang c,Borong Pan b a Department of Biomedical engineering,zhengzhou {2.,zhengzhou 450001,china b Department of General Surgery,Xijing Hospital,Fourth Military Medical {2.,Xi’an 710033,china c college of Medicine,{2. of South Florida,FL 33647,USA [a]Department of Biomedical engineering Zhengzhou University Zhengzhou 450001 China [b]Department of General Surgery Xijing Hospital Fourth Military Medical University Xi’an 710033 China [c]college of Medicine University of South Florida FL 33647 USA

Bivalent,bispecific single-chain antibody fusion protein construction appears to be a promising tool for tumor *** of its drawbacks is that the function and activity of the fusion proteins have varied affinity and/or anti-tumor activity compared with the original molecules from which they are derived.A more optimized linker for fusion proteins would confer more favorable biological activities upon bispecific single-chain ***,it is critical to design and optimize an inter-peptide *** different functional domains and optimized linkers,fusion proteins provide a solid base for targeted immune therapy for *** this paper,we review the inter-peptide linker studies and the design of an optimized linker using genetic *** spatial structure of the fusion protein can be predicted by using genetic and bioinformatics *** on current research,the future focus will be on different correlation models to perform simulations of spatial structures and drug molecule design.

关键词： Homology modeling Improved genetic algorithm Single-chain bispecific antibody Design of inter-peptide linker

Publicly Verifiable Distributed Proxy Blind Signature Scheme

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Wuhan university Journal of Natural Sciences 2007年第1期12卷 155-158页

作者： MA Chuangui CHENG Rui ZHANG Rurun college of Information engineering InformationEngineering University Zhengzhou 450002 Henan China

In this present paper, we propose a new proxy blind signature scheme, which is publicly verifiable distributed. The algorithm uses the idea of secret sharing schemes to distribute original signer＇s ability and the power of the proxy signer, and ensure the property of publicly verifiable secret sharing schemes. A new concept ＂verifiable time period＂ is also introduced to reduce the time cost in the period of verifications and increases the efficiency of our scheme.

关键词： proxy signatures proxy blind signature verifiable secret sharing schemes

Condensing Heat Recovery of Centrifugal Chiller

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湖南大学学报（自然科学版） 2009年第S1期36卷 123-126页

作者： GONG Guang-cai,JIAO Jun-jun,WANG Li-ping,ZENG Wei(college of civil {2.,Hunan university,Changsha,Hunan 410082.china) college of civil {2. Hunan University Changsha 410082 China

To a kind of centrifugal water chiller with R2. and about 1 745 kW of cooling capacity,a heat exchanger was added between the outlet of compressor and original condenser to get part of or all the condensing *** heat can be recovered by compound condensing method,which adopts air-cooling model +water-cooling model or water-cooling model +water-cooling model at the condensing side of the *** exergy analysis and experiment research on compound condensing heat recovery of centrifugal chiller,the results are obtained that the capability of the whole system increases,the energy efficiency ratio(EER)becomes 3.2.5.0 from 2.2.3.4,which implies the EER increases about 1.0～1.5,the exergy efficiency increases about 10%,and the chiller runs more stably after reformation.

关键词： centrifugal chiller condensing heat recovery compound condensing method EER

Photocatalytic degradation of formaldehyde by diffuser of solar light pipe coated with nanometer titanium dioxide thin films

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Science china(Technological Sciences) 2010年第1期53卷 150-154页

作者： WU YanPeng1,ZHANG WenMing1,MA ChongFang2.LU YuanWei2.& LIU Li1 1 School of civil and Environmental engineering,{2. of Science and Technology Beijing,Beijing 100083,china 2.college of Environmental and Energy engineering,Beijing {2. of Technology,Beijing 10002.,china 1. School of civil and Environmental engineering University of Science and Technology Beijing Beijing 100083 China2. College of Environmental and Energy Engineering Beijing University of Technology Beijing 100022 China

The even and transparent nanometer TiO2.thin films named DegussaP2. as photocatalysis deposited on the surface of diffusers of solar light pipe were prepared by sol-gel *** rugged side of the diffusers of solar light pipe was coated evenly with DegussaP2. solution for the quality of 1.75 *** experiments had showed that when the coated side was away from the sun the lighting degree may be reduced compared with that facing the *** average reduction was only 3.03%,which would not have a significant impact on *** are important parts of a light pipe which can diffuse light evenly to the place needed to be *** experiments showed that in a sunny summer day under the direct sunlight,the solar light pipe combined with photocatalysis could reduce the formaldehyde volume fraction in a box of 0.1 m3 from 1.0×10-6 to 0.16×*** 1 h of photodegradation the formaldehyde volume changed from 1.0×10-6 down to 0.1×10-6 with faster and more complete degradation of *** rate of degradation under cloudy and partly cloudy conditions was slower than that under sunny *** was slower in winter than in summer under sunny *** experimental results also showed that the performance of photocatalysis combined with diffusers of light pipe had better effect in a small *** performance in large space,such as open space,will be the next work in the future,which will be a great challenge.

关键词： solar light pipes diffusers photocatalysis decomposition formaldehyde titanium dioxide

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钢板加固混凝土梁试验研究

沈阳建筑大学学报(自然科学版) 2011年第3期27卷 485-489页

作者：张 张哲赵卓郑州大学土木工程学院

目的研究粘贴钢板加固方法的加固效果及加固后梁的抗弯承载力变化.方法制作了2.钢筋混凝土梁试件,其中一根按照规范设计方法采用钢板加固,随后采用千斤顶和反力架对试验梁进行抗弯承载力试验.在试验中通过采集应变、挠度和裂缝宽度等数... 详细信息

目的研究粘贴钢板加固方法的加固效果及加固后梁的抗弯承载力变化.方法制作了2.钢筋混凝土梁试件,其中一根按照规范设计方法采用钢板加固,随后采用千斤顶和反力架对试验梁进行抗弯承载力试验.在试验中通过采集应变、挠度和裂缝宽度等数据,综合评价钢板加固方法的效果.并通过比较各种材料应变随荷载的发展曲线,分析钢筋应变与钢板应变变化协同关系,验证平截面假定是否成立.最后通过各规范所提供的设计方法,将计算结果与试验结果进行对比分析.结果粘贴钢板加固方法对提高钢筋混凝土梁的抗弯承载力具有显著效果,加固梁相对于未加固梁承载力提高70%左右;通过试验数据与规范计算结果的对比,可以认为现有设计方法具有一定的安全性.结论可以为公式的使用提供理论依据,也为实际工程钢板加固设计和施工提供参考.

关键词：钢板加固应变承载力

纤维增强塑料筋混凝土梁正截面抗裂性能的研究

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水力发电学报 2003年第4期22卷 54-59页

作者：高丹盈朱海堂李趁趁郑州大学环境与水利学院郑州450002 大连理工大学土木工程学院大连116024

根据纤维增强塑料筋混凝土梁正截面抗裂度的试验结果 ,建立与钢筋混凝土梁正截面抗裂度计算方法相衔接的纤维增强塑料筋混凝土梁正截面抗裂度的计算方法 ,提出的统一计算公式可供修订我国的《钢纤维混凝土设计与施工规程》以及供设计与... 详细信息

根据纤维增强塑料筋混凝土梁正截面抗裂度的试验结果 ,建立与钢筋混凝土梁正截面抗裂度计算方法相衔接的纤维增强塑料筋混凝土梁正截面抗裂度的计算方法 ,提出的统一计算公式可供修订我国的《钢纤维混凝土设计与施工规程》以及供设计与施工参考。

关键词：水工结构开裂弯矩试验研究纤维增强塑料筋混凝土

环氧/丙烯酸树脂复合水性涂料制备中酯化反应规律的研究

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现代化工 2004年第10期24卷 35-37页

作者：孙绍晖孙培勤刘大壮郑州大学化工学院河南郑州450002

通过环氧／丙烯酸树脂间的酯化反应制备了一种新型水性复合乳液,研究了在叔胺作用下,丙烯酸树脂和环氧树脂的反应规律,发现胺的用量、环氧树脂分子质量、体系固含量以及环氧／胺／丙烯酸摩尔比是影响凝胶的重要因素,并利用三角图方法,... 详细信息

通过环氧／丙烯酸树脂间的酯化反应制备了一种新型水性复合乳液,研究了在叔胺作用下,丙烯酸树脂和环氧树脂的反应规律,发现胺的用量、环氧树脂分子质量、体系固含量以及环氧／胺／丙烯酸摩尔比是影响凝胶的重要因素,并利用三角图方法,测定了物理凝胶和非凝胶区域的范围。

关键词：水性涂料环氧/丙烯酸树脂酯化反应凝胶

Protective effects of glycine pretreatment on brain-death donor liver

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 37-40页

作者： Shui-Jun Zhang, Ji-Hua Shi, Zhe Tang, Yang Wu and Shi Chen zhengzhou, china Department of Surgery, First Affiliated Hospital of{2., zhengzhou 450052. china Institute of Organ Transplantation, Tongji Medical college , Huazhong university of Science and Technology, Wuhan 430030 , china Department of Surgery First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China. zhangshuijin@***

BACKGROUND: Morphological and functional changes commonly occur in livers of brain-death donors. Preven- tion of liver injury from brain-death will benefit the results of transplantation. This study was conducted to evaluate the protection effects of glycine on the liver of brain-death donor. METHODS: Fourty-two male Wistar rats were randomly divided into brain-death donor (BDD) group (B), glycine pretreatment group with BDD (G), and strychnine pre- treatment group with BDD(S). For these groups, brain death model was established in donor rats and liver trans- plantation was performed subsequently utilizing microsur- gical techniques. After the establishment of the model and during cold rinsing of liver donors or liver reperfusion of recipients, glycine was given at a dose of 0. 6 mmol, 2. μmol and 2. μmol in the group G, and a same dose of gly- cine and strychnine (1000 :1) was prescribed for the group S, but nothing for the group B. Before cold rinsing at 2.and 6 hours after portal vein(PV) reperfusion, blood sam- ples were taken from infrahepatic vena cava (IHVC) to de- termine the levels of alanine aminotransferase (ALT), as- partate aminotransferase (AST), tumor necrosis factor al- pha (TNF-α) and hyaluronic acid (HA). At 6 hours after PV reperfusion, graft samples were fixed for morphological observation and apoptosis of hepatocytes was detected using the TUNEL method. RESULTS: Before liver cold rinsing and at 2.and 6 hours af- ter PV reperfusion, the serum levels of ALT, AST, TNF-α, HA and apoptosis index (AI) in the groups B and S were significantly higher than those in the group G (P 0.05). Electron microscopy showed that Kupffer cells were activated and hepatic cells injured more obvious- ly in the groups B and S than in the group G. CONCLUSION: Glycine pretreatment can improve the via-bility of the liver of the brain-death donor rat.

关键词： rats liver transplantation brain death glycine Kupffer cells donor

Influence of processing temperature on microstructure and microhardness of copper subjected to high-pressure torsion

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Science china(Technological Sciences) 2010年第6期53卷 1534-1539页

作者： XIE ZiLing1,2.XIE JiJia2.HONG YouShi2.& WU XiaoLei2.1 college of Architecture and civil {2.,university of Wenzhou,Wenzhou 32.035,china 2.State Key Laboratory of Nonlinear Mechanics,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,china 1. college of Architecture and civil {2. University of Wenzhou Wenzhou 325035 China2. State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

Cu samples were subjected to high-pressure torsion (HPT) with up to 6 turns at room temperature (RT) and liquid nitrogen temperature (LNT),*** effects of temperature on grain refinement and microhardness variation were *** the samples after HPT processing at RT,the grain size reduced from 43 μm to 2.5 nm,and the Vickers microhardness increased from HV52.to ***,for the samples after HPT processing at LNT,the value of microhardness reached its maximum of HV150 near the center of the sample and it decreased to HV80 at the periphery *** observations revealed that HPT straining at LNT induced lamellar structures with thickness less than 100 nm appearing near the central region of the sample,but further deformation induced an inhomogeneous distribution of grain sizes,with submicrometer-sized grains embedded inside micrometer-sized *** submicrometer-sized grains with high dislocation density indicated their nonequilibrium *** the contrary,the micrometer-sized grains were nearly free of dislocation,without obvious deformation trace remaining in *** images demonstrated that the appearance of micrometer-sized grains is the result of abnormal grain growth of the deformed fine grains.

关键词： copper high pressure torsion (HPT) microstructure grain size microhardness cryogenic temperature