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基于二次Lagrange插值模型的控制律设计及仿真

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系统仿真学报 2009年第17期21卷 5520-5523页

作者：王倩艾剑良徐军复旦大学力学与工程科学系上海200433 北京理工大学宇航科学技术学院北京100081

采用增益调参方法对飞机自动驾驶仪的纵向通道进行控制律设计。建立了二次Lagrange插值模型,研究了利用v-间隔度量方法选择工作点并设计了评价准则、以及增益调参设计的方法和原则,并采用此方法对某型号飞机进行了控制律设计和仿真,以... 详细信息

采用增益调参方法对飞机自动驾驶仪的纵向通道进行控制律设计。建立了二次Lagrange插值模型,研究了利用v-间隔度量方法选择工作点并设计了评价准则、以及增益调参设计的方法和原则,并采用此方法对某型号飞机进行了控制律设计和仿真,以评价该插值算法对自动驾驶仪性能和稳定性的影响。仿真结果表明,纵向自动驾驶仪的各个功能模式获得了良好的动态响应特性,满足了各项指标的要求。

关键词：自动驾驶仪 Lagrange插值间隔度量增益调参

牙鲆变态早期cDNA文库的构建和parvalbumin基因的克隆

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水产学报 2005年第4期29卷 467-472页

作者：龚小玲鲍宝龙杨桂梅任大明上海水产大学生命科学与技术学院复旦大学遗传学国家重点实验室上海2.0090 上海2.0090复旦大学遗传学国家重点实验室上海2.0433

在前期的研究中,克隆到牙鲆变态早期和变态前差异表达的parvalbumin基因片断cDNA。为了克隆parvalbumin基因的全长cDNA,构建了变态早期(孵化后2.d仔鱼)牙鲆头部的全长cDNA文库,并对文库的滴度和插入片段大小进行了评估。同时采用锚定PC... 详细信息

在前期的研究中,克隆到牙鲆变态早期和变态前差异表达的parvalbumin基因片断cDNA。为了克隆parvalbumin基因的全长cDNA,构建了变态早期(孵化后2.d仔鱼)牙鲆头部的全长cDNA文库,并对文库的滴度和插入片段大小进行了评估。同时采用锚定PCR法从cDNA文库筛选出parvalbumin基因的全长cDNA。结果表明,所构建的牙鲆变态早期头部cDNA文库的滴度为1.2.106PFU·mL-1,插入片段的平均长度为1000bp左右。parvalbumin基因的全长cDNA的长度为603bp,编码109个氨基酸,含有两个EF手型钙离子结合域:DQDGSGFIEEEEL(52.64)和DSDGDGKIGVEEF(91～103),以及一个ATP/GTP结合位点模序:ACGLAGKS(33～40),是一种典型的钙离子结合蛋白。通过parvalbumin基因氨基酸序列的同源比较分析表明,牙鲆parvalbumin基因是比较保守的蛋白,与其它鱼类享有61.5%～68.8%序列同源。系统分析表明,牙鲆的parvalbumin基因与狭鳕(Theragrachalcogramma)最为接近。

关键词：牙鲆变态早期全长cDNA文库锚定PCR parvalbumin基因钙离子结合蛋白

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吊舱对螺旋桨水动力性能的影响

上海交通大学学报 2003年第8期37卷 1229-1233页

作者：杨晨俊钱正芳马骋上海交通大学船舶与海洋工程学院上海200030 海军装备论证研究中心北京100073

基于单桨式吊舱推进器定常水动力性能的理论计算方法及试验 ,探讨了吊舱对螺旋桨水动力性能的影响 .性能理论计算中螺旋桨采用升力面理论涡格法 ,吊舱采用面元法 ,对螺旋桨与吊舱的相互影响进行了时间平均及迭代处理 .通过计算分析了吊... 详细信息

基于单桨式吊舱推进器定常水动力性能的理论计算方法及试验 ,探讨了吊舱对螺旋桨水动力性能的影响 .性能理论计算中螺旋桨采用升力面理论涡格法 ,吊舱采用面元法 ,对螺旋桨与吊舱的相互影响进行了时间平均及迭代处理 .通过计算分析了吊舱对桨叶载荷分布的影响 ,以及吊舱引起的伴流分布特性 .

关键词：电力推进吊舱推进器螺旋桨涡格法尾涡模型

苯乙烯-异戊二烯嵌段共聚物分子运动的脉冲核磁共振研究

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高分子学报 1989年第6期 641-646页

作者：郭鸣明于同隐薛志元复旦大学材料科学系复旦大学分析测试中心

用西德Bruke,MSL-300核磁共振谱仪研究了三个不同系列的苯乙烯-异戊二烯嵌段共聚物的固体回波谱。用PASCAL语言在谱仪提供的计算机上、用线性最小二乘法回归分析把实验曲线分解成快速和慢速两个组分,它们分别对应于嵌段共聚物中刚性相... 详细信息

用西德Bruke,MSL-300核磁共振谱仪研究了三个不同系列的苯乙烯-异戊二烯嵌段共聚物的固体回波谱。用PASCAL语言在谱仪提供的计算机上、用线性最小二乘法回归分析把实验曲线分解成快速和慢速两个组分,它们分别对应于嵌段共聚物中刚性相和流动相,从而给出样品两相结构的定性定量信息。

关键词：苯乙烯异戊二烯脉冲核磁共振分子运动嵌段共聚物高分子物理结构

cDNA Array analysis of the Differential Expression Change in Virulence-related Genes During the Development of Resistance in Candida albicans

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Acta Biochimica et Biophysica Sinica 2005年第7期37卷 463-472页

作者： Zheng XU Yong-Bing CAO~1 Jun-Dong ZHANG~1 Ying-Ying CAO~1 Ping-Hui GAO~1 De-Jun WANG~1 Xu-Ping FU~2.Kang YING~2.Wan-Sheng CHEN~1 Yuan-Ying JIANG~1 1 Department of Pharmacology,School of Pharmacy,Second Military Medical university,shanghai {2.,China 2.State Key Laboratory of Genetic Engineering,Institute of Genetics.School of Life Science,fudan university,shanghai {2.,China DepartmentofPharmacology SchoolofPharmacySecondMilitaryMedicalUniversityShanghai200433China

Candida albicans is the most frequently isolated fungus in immunocompromised patientsassociated with mucosal and deep-tissue *** investigate the correlation between virulence andresistance on a gene expression profile in ***,we examined the changes in virulence-related genesduring the development of resistance in *** from bone marrow transplant patients using a constructedcDNA array representing 3096 *** addition to the genes known to be associated with azole resistance,16 virulence-related genes were identified,whose differential expressions were newly found to be associatedwith the resistant *** expressions for these genes were confirmed by ***,the up-regulation of EFG1,CPH2.TEC1,CDC2.,SAP10,ALS9,SNF1,SPO72.nd BDF1,and the down-regulation of RAD32.IPF3636 and UBI4 resulted in stronger virulence andinvasiveness in the resistant isolates compared with susceptible *** findings provide a link betweenthe expression of virulence genes and development of resistance during *** infection in bone marrowtransplant (BMT) patients,where *** induces hyphal formation and expression change in multiplevirulence factors.

关键词： Candida albicans cDNA array resistance virulence

analysis OF PULSATILE FLOW IN THE PARALLEL-PLATE FLOW CHAMBER WITH SPATIAL SHEAR STRESS GRADIENT

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Journal of Hydrodynamics 2007年第1期19卷 113-120页

作者： QIN Kai-rong HU Xu-qu LIU Zhao-rong Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200240 China Institute of Biomechanics Fudan University Shanghai 200433 China

The Parallel-Plate Flow Chamber （PPFC）, of which the height is far smaller than its own length and width, is one of the main apparatus for the in-vitro study of the mechanical behavior of cultured vascular Endothelical Cells （ECs） exposed to fluid shear stress. The steady flow in different kinds of PPFC has been extensively investigated, whereas, the pulsatile flow in the PPFC has received little attention. In consideration of the characteristics of geometrical size and pulsatile flow in the PPFC, the 3-D pulsatile flow was decomposed into a 2.D pulsatile flow in the vertical plane, and an incompressible plane potential flow in the horizontal plane. A simple method was then proposed to analyze the pulsatile flow in the PPFC with spatial shear stress gradient. On the basis of the method, the pulsatile fluid shear stresses in several reported PPFCs with spatial shear stress gradients were calculated. The results were theoretically meaningful for applying the PPFCs in-vitro, to simulate the pulsatile fluid shear stress environment, to which cultured ECs were exposed.

关键词： Pulsatile flow fluid shear stress spatialshear stress gradient parallel-plate flow chamber culturedendothelial cells cell mechanics

Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats

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Acta Pharmacologica Sinica 2004年第8期 22-25页

作者： Jing-min SHI, Shun-guo LAI, Chang-jiang XU, Geng-li DUAN, Duan LIDepartment of Pharmacology, Department of Pharmaceutical analysis, School of Pharmacy, fudan university, {2. 2.0032. ChinaNow in {2. Institute for Drug Control.

AIM: To study whether etodolac enantiomers have pharmacokinetic difference after oral administration. METHODS: Fourteen rats, divided into two groups randomly, were orally given S-(+)- or R-(-)-etodolac at a single dose of 2. mg/kg, respectively. Blood samples were collected before and at 5, 10, 2., 30 min and 1, 3, 6, 12. 2., 48, 72.h after treatment. The plasma samples were analyzed with a high-performance liquid chromatographic method. RESULTS: The calibration curves were linear in the range of 0.5-50.0 mg/L (r=0.9999) to S-(+)-etodolac and 2.0-2.0.0 mg/L (r=0.9999) to R-(-)-etodolac, respectively. The main pharmacokinetic parameters of S-(+)- and R-(-)-etodolac were as follows: t1/2.λz)18±4 h vs 19.4±2.2.h, tmax 3.3±2.6 h vs 4±4 h; Cmax 2.±6 mg/L vs97±14 mg/L, AUC0-t 706±100 h·mg·L-1 vs 2.40±400 h·mg·L-1, CL(s) 0.030±0.006 L·kg-1·h-1 vs 0.0065±0.0010 L·kg-1·h-1 and V/F 0.2.±0.2. L·kg-1 vs 0.03±0.05 L·kg-1. There was no significant difference in t1/2.λz) and tmax between S-(+)-

关键词： etodolac non-steroidal anti-inflammatory agents pharmacokinetics stereoisomerism

Risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in shanghai patients with arthropathy

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Acta Pharmacologica Sinica 2004年第3期25卷 103-111页

作者： Wen SHI2.Yong-ming WANG,Shao-li LI3,Min YAN3,Duan Li,Bin-yan CHEN,Neng-neng CHENG Department of Pharmacology,School of Pharmacy,fudan university,{2. 2.0032.The Center for Drug Reevaluation and 3 The Center for Adverse Drug Reaction Monitoring,State Food and Drug Administration,Beijing 100061,China Department of Pharmacology School of Pharmacy Fudan University The Center for Drug Reevaluation and The Center for Adverse Drug Reaction Monitoring State Food and Drug Administration Beijing 100061 China

AIM: The study was to screen the possible risk factors of adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs) in shanghai patients with arthropathy. METHODS: The subjects were ran- domly selected from a database of outpatients with arthropathy from 9 main hospitals in shanghai. A door to door retrospective epidemiological survey was used to collect demographic information about the patients, both indi- vidual and familial. This included data on their medical histories, lifestyle and dietary habits, history of smoking and alcohol consumption, history of drug therapy, quality of life (QOL) prior to NSAIDs intake, history of NSAIDs therapy and its ADR events, etc. Descriptive statistical methods and univariate {2. were also used to identify possible risk factors for ADRs induced by NSAIDs. RESULTS: Of the 1002.patients surveyed, the average length of NSAIDs intake was 2.years. ADR incidence from different NSAIDs was high, in a range from 46.7 %-66.2.%. In general, the candidate risk factors for ADRs were different for each NSAID. Each of the candidate risk factors were defined and studied in order to evaluate its role in the determination of ADRs from NSAIDs. “Family history of ADRs caused by NSAIDs” was found to be a significant risk factor for the four commonly used NSAIDs: meloxicam, diclofenac, nimesulide, and nabumetone. CONCLUSION: A retrospective epidemiological survey was useful in detecting the risk factors for ADRs caused by NSAIDs. The study found that different NSAIDs might have different risk factors and that there is no single risk factor universally applicable to all NSAIDs.

关键词： non-steroidal anti-inflammatory drugs adverse drug reaction risk factors retrospective studies quality of life

ENDOR AND ESR STUDIES OF RADICALS FORMED IN FRIEDEL-CRAFTS REACTIONS

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Science China Chemistry 1991年第11期34卷 1296-1303页

作者：桑鸿汪汉卿陈涛刘旭勤Center of analysis and Research East China university of Chemical Technology {2. 2.02.7 PRC Lanzhou Institute of Chemical Physics Academia Sinica Lanzhou 730000 PRC Center of analysis and Research East China University of Chemical Technology

The present study deals with the study of some Friedel-Crafts alkylating system and the accurate measurement of hyperfine coupling constants by ESR and ENDOR techniques. The results indicate that the observed ESR spectra are due to polycyclic aromatic radical cations formed from their parent *** is suggested that benzyl halides produced in the Friedel-Crafts alkylating reaction undergo Scholl condensation reaction to give polycyclic aromatic hydrocarbons, which were converted into the corresponding polycyclic aromatic radical cations in the presence of aluminum chloride.

关键词： radical cations ESR ENDOR Friedel-Crafts reactions.