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Effect of In-home Fortification of Complementary Feeding on Intellectual Development of Chinese Children

biomedical and Environmental Sciences 2010年第2期23卷 83-91页

作者： CHUN-MING CHEN, YU-YING WANG, AND SU-YING CHANG Chinese center for Disease Control and Prevention, beijing 100050,{2. [a] Chinese center for Disease Control Prevention Beijing 100050 China

Objective To explore the effect of in-home fortification of complementary feeding on intellectual development of Chinese children aged below 2. months. Methods One thousand and four hundred seventy eight children aged 4-12.months were recruited and divided into study groups （formula 1 group and formula 2.group） and control group. In two study groups, in addition to the usual complementary food, children were fed with a sachet of fortified food supplement each day. Protein and micronutrients were provided in formula 1 group. Formula 2.group had the same energy intake as the formula 1 group . In addition to measurement of physical growth and detection of hemoglobin level, Development Quotient （DQ） or Intelligence Quotient （IQ） was assessed. Results The DQ of children aged below 2. months was 97.2. 95.5, and 93.8 in formula 1 group, formula 2.group and control group, respectively, and the differences were statistically significant （P〈0.05）. The DQ of children in formula 1 group, formula 2.group, and control group was 92.7, 90.4, and 88.3 respectively in the first follow up showing statistically significant differences （P〈0.05）. And, DQ of children in formula 1 group, formula 2.group and control group were 96.7, 94.5, and 93.7 respectively in the second follow up, showing statistically significant differences （P〈0.05）. FulI-IQ of children in the formula 1 group was 3.1 and 4.5 points higher than that in formula 2.group and in control group respectively. Verbal IQ of children in the formula 1 group was 2.1 and 5 points higher than that in formula 2.group and control group respectively. Performance IQ was 2.5 and 3.1 points higher than that in formula 2.group and control group respectively. All above mentioned comparisons were statistically significant. Conclusion Fortification of complementary feeding showed persistent effect on intelligence development of young children which could persist to 6 years of age. The critical time for correction of anemia could be under 18 m

关键词： Complementary feeding Supplement Development Anemia Infant

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一种基于基因表达模型识别酵母细胞周期条件特异调控子网的方法(英文)

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生物化学与生物物理进展 2010年第4期37卷 402-415页

作者：刘齐军王正华刘万霖李栋贺福初朱云平国防科学技术大学并行与分布处理国家重点实验室长沙410073 蛋白质组学国家重点实验室北京蛋白质组研究中心军事医学科学院放射与辐射医学研究所北京102206 复旦大学生物医学科学研究所上海200032

由高通量微阵列技术产生的数据集可以用于解释生物系统基因调控的未知机制.生物过程是动态的,所以很有必要关注某些条件下特异的基因调控子网络.细胞周期是一个基本的细胞过程,识别酵母的细胞周期特异调控子网是理解细胞周期过程的基础... 详细信息

由高通量微阵列技术产生的数据集可以用于解释生物系统基因调控的未知机制.生物过程是动态的,所以很有必要关注某些条件下特异的基因调控子网络.细胞周期是一个基本的细胞过程,识别酵母的细胞周期特异调控子网是理解细胞周期过程的基础,并且有助于揭示其他细胞条件的基因调控机理.使用一个基因表达微分方程模型(GEDEM),从静态网络中识别了动态的细胞周期相关调控关系.与已经报道的细胞周期相关调控相互作用相比,该方法识别了更多的真实存在的条件特异调控关系,取得了比当前的方法更好的性能.在大数据集上,GEDEM 识别了具有高敏感性和特异性的调控子网.组合调控的深入分析显示,条件特异调控子网的转录因子之间的相关性呈现出比静态网络中转录因子相关性更强,这说明条件特异网络比静态网络更加接近真实情况.另外,GEDEM 方法还识别更多潜在的共调控转录因子.

关键词：基因调控网络细胞周期基因表达模型条件特异子网微分方程模型

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The Lower Limb Prosthesis Fitting for Non-ideal Stump

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Chinese Journal of biomedical engineering(English Edition) 1998年第4期7卷 174-177页

作者： Xue-Jun Cao(china Rehabilitation Research center, {2. 100077,PR Chine)

Through 8.5 years practice of prosthesis fitting for 356 lower limb amputees with non-ideal stumps, the paper proposes the effective methods of prosthesis titting of non-ideal stump by suspension band, part weight-bea... 详细信息

关键词： amputation stump, prosthesis

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电子束重熔CoCrW涂层组织及抗微动磨损性能

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同济大学学报（自然科学版） 2001年第9期29卷 1105-1108页

作者：徐向阳刘世参周美玲徐滨士北京工业大学材料学院北京100022 全军装备维修表面工程研究中心北京100074

采用电子束对等离子喷涂CoCrW涂层进行了重熔处理 ,对重熔前后CoCrW涂层的组织及其抗微动磨损性能进行了分析 .结果表明 ,电子束重熔消除了原等离子喷涂层的层间氧化物、孔隙和层状结构 ,重熔层与基体形成冶金结合 ,得到以钴基固溶体为... 详细信息

采用电子束对等离子喷涂CoCrW涂层进行了重熔处理 ,对重熔前后CoCrW涂层的组织及其抗微动磨损性能进行了分析 .结果表明 ,电子束重熔消除了原等离子喷涂层的层间氧化物、孔隙和层状结构 ,重熔层与基体形成冶金结合 ,得到以钴基固溶体为基体 ,以复合碳化物为强化相的细晶组织 ,抗微动磨损性能是原等离子喷涂层的 13.3倍 .

关键词：电子束微动磨损重熔 CoCrW涂层工程机械振动组织等离子束喷涂

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Nanotoxicology and Safety Assessment of Nanomaterials

Nanotoxicology and Safety Assessment of Nanomaterials

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中国生物医学工程学会成立30周年纪念大会暨2.10中国生物医学工程学会学术大会

作者： Yuliang Zhao(CAS Key Lab for biomedical Effects of Nanomaterials & Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,beijing 100049 & National {2. for Nanosciences and Technology of china,beijing 100190,china.)

With the rapid development of nanotechnology,manufactured nanoparticles and nanomaterials have been becoming new sources of human/environmental hazards through inhalation and skin uptake in workplace

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Evaluation of Impact of Major Causes of Death on Life Expectancy Changes in china,1990-2.05

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biomedical and Environmental Sciences 2009年第5期22卷 430-441页

作者： YAN-HONG WANG LI-MING LI Department of Epidemiology&Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective To evaluate the impact of major causes of death on changes of life expectancy in china. Methods Life expectancy was calculated by standard life table techniques using mortality data from the national censuses in 1990 and 2.00 and the 1% National Population Sampling Surveys in 1995 and 2.05, Mortality data about the major causes of death from VR-MOH were used as reference values to estimate their death proportions of the specific age groups by sex and regions, as well as all-cause mortality and age-specific mortality rates of major causes of death. Decomposition method was used to quantitatively evaluate the impact. Results Three key findings were identified in our study. First, china's health challenge was shifted from diseases related to living conditions to those related to behavior and lifestyle, with rural areas relatively lagged behind urban areas, Second, the impacts of cardiovascular diseases and neoplasm on the middle aged and elderly population were stressed. Third, compared to the urban population, the rural population tended to have increasing mortality of neoplasm and cardiovascular diseases, especially in adults at the age of 15-39 years. Conclusion Further efforts should be made to reduce the incidence of neoplasm and cardiovascular diseases, especially in rural areas, by promoting healthy behavior and lifestyle and providing appropriate therapies for all patients in need.

关键词： china Life expectancy Cardiovascular disease Neoplasm

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Biomechanical forces in atherosclerosis-susceptible and -resistant regions of human vasculature differentially regulate endothelial vaso-protective phenotypes

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医用生物力学 2010年第S1期25卷 50-51页

作者： Guohao Dai(Department of biomedical engineering,{2. for Biotechnology and Interdisciplinary Studies,Rensselaer polytechnic Institute,Troy,NY 12.80,USA)

Introduction Atherosclerosis is a potentially life-threatening disease of large arteries that is strongly associated with systemic risk factors such as hypercholesterolemia,hypertension,smoking,and diabetes. However,a... 详细信息

关键词： resistant regions of human vasculature differentially regulate endothelial vaso-protective phenotypes Biomechanical forces in atherosclerosis-susceptible and

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A Research on Medium-sized and Small Enterprises Financial Risk Early Warning Information System Design

A Research on Medium-sized and Small Enterprises Financial R...

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2.11 IEEE 2.d International Conference on Software engineering and Service Science(ICSESS 2.11)

作者： Fen Tian Yu Zhang The internship center to business and law beijing Technology and Business {2. beijing china

Financial risk pre-warning plays an important role in financial risk *** aim to build an ideal financial risk warning system of SME according to the analysis of financial risks in small and medium enterprises （SMES）.The present research firstly analyze the financial risks of SMEs,secondly propose the design of financial analysis pre-warning information system for SMEs from the system structure,database,early warning mechanisms and other aspects.

关键词： SMEs financial risk information warning system

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Comparative study on the mechanisms of action of Liuwei Dihuang and Bawei Dihuang Decoction with NMR-Based metabonomic technique

Comparative study on the mechanisms of action of Liuwei Dihu...

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中国药理学会第十次全国学术会议

作者： Ning Jiang~1,Wen-Xia Zhou~(1*),Yong-Xiang Zhang~(1*),Xian-Zhong Yan~2.Qi Zhang~2.(1.beijing Institute of Pharmacology and Toxicology,2.National center of {2. Analysis,beijing,100850)

Aim To investigate the age-related metabolic change in senescenceaccelerated mouse(SAM) and study and compare the effects and the mechanisms of action of Liuwei Dihuang(LW) and Bawei Dihuang Decoction (BW) with nuclear magnetic resonance spectroscopy(NMR)-Based metabonomic *** The serum metabonomic profile of senescence-prone 8(SAMP8),a murine model for studying aging biology and evaluating anti-aging drugs,was compared with that of control,senescence-resistantl(SAMR1),which shows normal aging ***8 were administered with LW and BW orally for consecutive 30 *** samples were collected for *** NMR experiments were carried out on a Varian INOVA 600 spectrometer.1HNMR spectra of serum were analyzed by pattern recognition using Simca-P 10.0 software(Umetrics AB,Umea,Sweden).Results The serum metabolic patterns of SAMP8 and SAMR1 were significantly *** metabolites responsible for the differences between SAMP8 and SAMR1 were lack of inosine,decreased glucose,PUFA,choline,*** increased lactate,SFA,VLDL,*** SAMP8 compared with those in *** administration of LW and BW both improved metabolic profile of *** metabolites that LW and BW acted on were glucose,choline, phos-phocholine,*** levels of glucose and unsaturated lipids in serum of SAMP8 increased significantly after LW treatment and the levels of choline and phos-phocholine increased,while the level of triglyceride decreased significantly after BW *** These results showed the metabolism disequilibrium in SAMP8 and the differential metabolites between SAMP8 and SAMR1 might play important role in aging of *** and BW could improve the metabolic disturbance of SAMP8 by regulating the levels of endogenous *** common and different metabolites LW and BW acted on might relate with the mechanisms of action of them.

关键词： Senescence-accelerated mouse(SAM) Metabonomics Liuwei Dihuang Decoction Bawei Dihuang Decoction

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Construction of Prophylactic Human Papillomavirus Type 16 L1 Capsid Protein Vaccine Delivered by Live Attenuated Shigella flexneri Strain sh42

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Acta Biochimica et Biophysica Sinica 2005年第11期37卷 743-750页

作者： Xiao-Feng YANG Xin-Zhong QU Kai WANG Jin ZHENG L(?)-Sheng SI Xiao-Ping DONG Yi-Li WANG Key Laboratory of biomedical Information engineering of Ministry of Education,Institute for Cancer Research,Xi'an Jiaotong {2.,Xi'an 710061.china National Institute for Viral Disease Control and Prevention,Chinese center for Disease Control and Prevention,beijing 100052.china Department of Obstetrics and Gynecology,First Hospital of Xi'an Jiaotong {2.,Xi'an 710061,china KeyLab.ofbiomedicalInformationengineeringofMinistryofEducation Inst.forCancerResearchXi'anJiaotongUnivers

To express human papillomavirus(HPV)L1 capsid protein in the recombinant strain of Shigellaand study the potential of a live attenuated Shigella-based HPV prophylactic vaccine in preventing HPVinfection,the icsA/virG fragment of Shigella-based prokaryotic expression plasmid pHS3199 was *** type 16 L1(HPV16L1)gene was inserted into plasmid pHS3199 to form the pHS3199-HPV16L1construct,and pHS3199-HPV16L1 was electroporated into a live attenuated Shigella strain *** analysis showed that HPV16L1 could be expressed stably in the recombinant strain *** test results were negative,which showed that the sh42.HPV16L1 lost ***,the at-tenuated recombinant strain partially maintained the invasive property as indicated by the HeLa cell *** IgG,IgA antibody against HPV16L1 virus-like particles(VLPs)were detected in the sera,intestinal lavage and vaginal lavage from animals immunized by *** number of antibody-secreting cells in the spleen and draining lymph nodes were increased significantly compared with the *** from immunized animals inhibited murine hemagglutination induced by HPV16L1 VLPs,whichindicated that the candidate vaccine could stimulate an efficient immune response in guinea pig's *** may be an effective strategy for the development of an HPV prophylactic oral vaccine.

关键词： human papillomavirus type 16 attenuated Shigella flexneri vaccine cervical cancer prophylactic

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