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西安地质学院学报 1989年第4期11卷 80-83页

作者：阎嘉祺尹申平汪洪西安矿业学院陕西省考古研究所中国科学院西安黄土与第四纪地质研究室

在陕西省澄城县采集到一对保存相当完好的南方象第三上臼齿化石。我国关于南方象化石的报导不多,在陕西省则是首次发现。这一发现对了解更新世时期南方象在我国的分布提供了新资料。

关键词：现方象化石更新世陕西

Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction

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Journal of Materials Science & Technology 2021年第9期68卷 160-171页

作者： Mingjun Li Christoph Schlaich Jianguang Zhang Ievgen S.Donskyi Karin Schwibbert Frank Schreiber Yi xi Jorg Radnik Tanja Schwerdtle Rainer Haag Center for Health Science and Engineering Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologySchool of Materials Science and EngineeringHebei University of TechnologyTianjin 300130China Institut fur Chemie und Biochemie Freie Universitat BerlinBerlin 14195Germany Division Biodeterioration and Reference Organisms Federal Institute for Materials Research and Testing(BAM)Berlin 12205Germany Division of Surface Analysis and Interfacial Chemistry Federal Institute for Materials Research and Testing(BAM)Berlin 12205Germany institute of Nutritional Science Department of Food ChemistryUniversity of PotsdamNuthetal D-14558Germany

Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles(Cu NPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol(MI-h PG) coating via a simple dip-coating *** hyperbranched polyglycerol with 10 % catechol groups’ modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone(PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated Cu NPs-incorporated PCL membrane [PCL-(MI-h PG)-Cu NPs]was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus(S. aureus), Escherichia coli(E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-h PG)-Cu NPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing Cu NPs.

关键词： Mussel-inspired coating CuNPs Multi-resistant bacteria Antibacterial Antifouling Osteogenesis

基于SAN架构的开放式网络安全数据存储系统设计

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现代电子技术 2020年第15期43卷 82-85页

作者：奚军无锡市教育科学研究院江苏无锡214001

传统网络安全数据存储系统对于数据的存储量小,且对数据资源的泄露风险较大,无法保证数据的有效存储。针对这一问题,基于SAN架构设计了一种开放式网络安全数据存储系统。系统的硬件部分主要分为管理调控、资源池与虚拟化、安全控制及网... 详细信息

传统网络安全数据存储系统对于数据的存储量小,且对数据资源的泄露风险较大,无法保证数据的有效存储。针对这一问题,基于SAN架构设计了一种开放式网络安全数据存储系统。系统的硬件部分主要分为管理调控、资源池与虚拟化、安全控制及网络安全四大模块,依照各核心模块的具体构造及实现过程,共同完成对数据的存储与管理。软件设计中通过采用虚拟磁盘驱动技术对用户进行加密、解密处理,进而保证存储数据的安全可靠。与传统的数据存储系统进行实验对比,结果表明,基于SAN架构的开放式网络安全数据存储系统设计具有更大的数据存储量,能更好地保证存储数据的安全。

关键词：数据存储 SAN架构开放式网络数据管理数据安全系统设计

椭圆形织构摩擦片在核电站安全制动器中作用机理的数值研究

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摩擦学学报 2020年第3期40卷 299-304页

作者：侯硕贺韶邓玺奚琛路广遥陈帅中广核研究院有限公司广东深圳518124

核电站安全制动器基于高精度、高可靠性设计,而摩擦片是安全制动器功能执行的核心零件,其摩擦性能影响核电站设备的安全性和经济性.本文作者将椭圆织构应用于安全制动器的摩擦片中,通过数值方法研究了椭圆织构摩擦片在电磁制动器中的作... 详细信息

核电站安全制动器基于高精度、高可靠性设计,而摩擦片是安全制动器功能执行的核心零件,其摩擦性能影响核电站设备的安全性和经济性.本文作者将椭圆织构应用于安全制动器的摩擦片中,通过数值方法研究了椭圆织构摩擦片在电磁制动器中的作用机理;建立椭圆织构摩擦片分析模型,同时利用有限元法求解摩擦片端面的压力分布情况,并研究了椭圆倾斜角、长细比、织构深度和摩擦面间隙变化对压力分布的影响规律.结果表明:增加椭圆织构的长细比可以有效地降低摩擦面的磨损;椭圆织构倾斜角为45°时,气膜承载力最大,可以有效降低摩擦面的磨损;椭圆织构太深或太浅均会增加摩擦面的磨损,当深度为1μm时,可以起到很好的减磨效果;椭圆织构产生较大的气膜承载力从而增大间隙,但气膜承载力随摩擦片间隙增加而减小,因而使摩擦片间隙固定在一定范围,既减少了磨损又保证了设备的稳定运行.本文中涉及的数值研究为完善电磁制动器中的椭圆织构摩擦片设计提供解决方法,后续在产品样机中应用并通过了寿命试验验证.

关键词：安全制动器摩擦片微椭圆织构气膜核电站

深海自主水下机器人发展及其在资源调查中的应用

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中国有色金属学报 2021年第10期31卷 2746-2756页

作者：封锡盛李一平徐会希李智刚中国科学院沈阳自动化研究所机器人学国家重点实验室沈阳110016 中国科学院机器人与智能制造创新研究院沈阳110169 辽宁省水下机器人重点实验室沈阳110169

自2.世纪90年代以来,深海自主水下机器人技术得到了长足的发展,在深海资源调查、海洋科学研究以及海洋工程等领域得到了广泛的应用。我国的深海自主水下机器人研究与大洋矿产资源调查是同步发展的。本文简要介绍了30年来我国深海自主水... 详细信息

自2.世纪90年代以来,深海自主水下机器人技术得到了长足的发展,在深海资源调查、海洋科学研究以及海洋工程等领域得到了广泛的应用。我国的深海自主水下机器人研究与大洋矿产资源调查是同步发展的。本文简要介绍了30年来我国深海自主水下机器人的发展现状,以具有代表性的"潜龙"系列自主水下机器人研发过程为例给出了面对的技术挑战,以及在大洋矿产资源调查中的应用情况和取得的部分成果。最后,对未来深海调查装备的发展提出了若干设想和建议。

关键词：深海自主水下机器人矿产资源调查多金属结核热液硫化物

A magnetically enabled simulation of microgravity represses the auxin response during early seed germination on a microfluidic platform

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Microsystems & Nanoengineering 2022年第1期8卷 97-109页

作者： Jing Du Lin Zeng Zitong Yu Sihui Chen xi Chen Yi Zhang Hui Yang Laboratory of Biomedical Microsystems and Nano Devices Center for Bionic Sensing and IntelligenceInstitute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Center for Medical AI Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

For plants on Earth,the phytohormone auxin is essential for gravitropism-regulated seedling establishment and plant ***,little is known about auxin responses under microgravity conditions due to the lack of a tool that can provide an alteration of *** this paper,a microfluidic negative magnetophoretic platform is developed to levitate Arabidopsis seeds in an equilibrium plane where the applied magnetic force compensates for gravitational *** the benefit of the microfluidic platform to simulate a microgravity environment on-chip,it is found that the auxin response is significantly repressed in levitated *** microgravity statistically interrupts auxin responses in embryos,even after chemical-mediated auxin alterations,illustrating that auxin is a critical factor that mediates the plant response to gravity ***,pretreatment with an auxin transportation inhibitor(N-1-naphthylphthalamic acid)enables a decrease in the auxin response,which is no longer affected by simulated microgravity,demonstrating that polar auxin transportation plays a vital role in gravity-regulated auxin *** presented microfluidic platform provides simulated microgravity conditions in an easy-to-implement manner,helping to study and elucidate how plants correspond to diverse gravity conditions;in the future,this may be developed into a versatile tool for biological study on a variety of samples.

关键词： magnetic auxin microgravity

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声呐数据合成与环境仿真研究

系统仿真学报 2004年第8期16卷 1634-1637页

作者：白银生赵俊渭扬日杰董阳泽刘平香杜选民西北工业大学航海工程学院西安710072 船舶重工集团72.研究所上海200025

研究了被动声呐数据合成与环境仿真的系统结构和水声合成信号的生成﹑建模与仿真试验。以水中运动目标为例,给出了水声环境下,合成信号、环境噪声、海洋声学的数学模型和合成环境系统仿真实验。该研究可用于水下探测系统和水声对抗系统... 详细信息

研究了被动声呐数据合成与环境仿真的系统结构和水声合成信号的生成﹑建模与仿真试验。以水中运动目标为例,给出了水声环境下,合成信号、环境噪声、海洋声学的数学模型和合成环境系统仿真实验。该研究可用于水下探测系统和水声对抗系统的环境模拟,及水声设备的性能评估。

关键词：水声信号合成环境环境噪声建模与仿真

Comparative study on the weight loss and lipid metabolism by tea polyphenols in diet induced obese C57BL/6J pseudo germ free and conventionalized mice

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Food Science and Human Wellness 2022年第3期11卷 697-710页

作者： Kashif Hussain Yingying Yang Jie Wang Hengjuan Bian xi Lei Junjie Chen Qianying Li Li Wang Qingping Zhong xiang Fang Yutao Wang Hong Wei Yigang Tong Zhenlin Liao College of Food Science South China Agricultural UniversityGuangzhou 510642China Department of Food Science University of GuelphGuelphOntario N1G 2W1Canada College of Life and Geographic Sciences Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous RegionKashi UniversityKashi 844000China institute of Precision Medicine First Affi liated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

The role of gut microbiota in terms of host health is becoming increasingly *** this study,the comparative effects of tea polyphenols(TPs)on weight loss and lipid metabolism on conventionalized mice(CVZ)and pseudo germ-free(PGF)mice(treated with antibiotics)were *** findings revealed that high fat(HF)diet considerably increased the body weight,total fat and upsurge lipid indices in CVZ mice but PGF mice were not sensitive to the effect of HF diet as CVZ *** the dietary administration of TP,body weight,perirenal fat and epididymal fat,liver weight,glucose(GLU)level,total chloestrol(TC level),high density lipoprotein-cholesterol(HDL-C)level significantly lowered in PGF mice as compared to CVZ mice ***,the area of fat cells and triglyceride(TG)level were significantly increased in PGF *** CVZ mice,TP intervention resulted in a considerable drop in the Firmicutes/Bacteroides ratio as compared to PGF *** intestinal flora of PGF mice was severely reduced after antibiotic treatment,while TP administration restored intestinal diversity;the abundance of Akkermansia and Lactobacillus increased,whereas the abundance of Enterobacteriaceae and Prevotella ***,we can assume that PGF obese mice administered with TP have less anti-obesity effects compared to obese CVZ mice.

关键词： High fat diet Pseudo germ-free mice Tea polyphenol Obesity Lipid metabolism

Synthesis and biological evaluation of Matijing-Su derivatives as potential anti-hepatitis B virus agents

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Synthesis and biological evaluation of Matijing-Su derivativ...

Crystal structure of monkeypox H1 phosphatase,an antiviral drug target

中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会

作者： Jing-Ying Qiu~1,Chang-xiao Liu~2.Zheng-Ming Huang~3,Pei-Xue Cao~1,Wei-Dong Pan~1,Bi-Xue Xu~1,xiao-Jiang Hao~1 and Guang-Yi Liang~(1,4,*) 1 The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,2.2.Shachong South Road,Guiyang 550002.china 2.Tianjin institute of Pharmaceutical {2.,308 Anshan xi Dao,Nankai District,Tianjin 300193,china 3 302.Hospital of PLA,100 xisihuan Zhong Road,Fengtai Beijing 100039,china 4 Guiyang College of Traditional Chinese Medicine,50 Shidong Road,Guiyang 550002.china

A series of Matijing-Su(MTS,N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L -phenylalanol)derivatives were synthesized and evaluated for their abilities to inhibit the replication of hepatitis B virus(HBV)DNA in HepG2.2.2.15 *** 5r(IC:1.31 uM,SI:32..31),5f(IC:6.64 uM,SI:61.72.,5a(IC:6.87 uM,SI:42.74),5d(IC:8.2. uM,SI:58.68)and 5h(IC:10.2. uM,SI:47.2.)*** significant inhibitory on the replication of HBV DNA in 2.2.15 cells,which were better than those of the positive control lamivudine(IC:82.42.uM,SI:41.59).

关键词： MTS derivatives synthesis biological evaluation anti-hepatitis B virus activity

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Protein & Cell 2023年第6期14卷 469-472页

作者： Wen Cui Haojun Huang Yinkai Duan Zhi Luo Haofeng Wang Tenan Zhang Henry C Nguyen Wei Shen Dan Su xi Li xiaoyun Ji Haitao Yang Wei Wang institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Shanghai institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610064China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life SciencesNanjing UniversityNanjing 210023China Shanghai Clinical research and Trial Center Shanghai 201210China Tianjin International Joint Academy of Biotechnology and Medicine Tianjin 300450China

Dear Editor,Since its appearance in May 2.2.,monkeypox has spread to>100 countries and afflicted tens of thousands of *** infected with monkeypox present a fever,an extensive characteristic rash,and usually swollen lymph nodes(Chatterjee et al.,2.2.).The number of confirmed cases worldwide continues to grow at a rapid rate,but the treatment to this highly infectious viral disease is still very *** of new targeted-therapies will be crucial to control of this emerging public health threat.

关键词： monkey Crystal