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Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia

Neuroscience Bulletin 2017年第3期33卷 281-291页

作者： Baojuan Li Long-Biao Cui Yi-Bin xi Karl J.Friston Fan Guo Hua-Ning Wang Lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu School of Biomedical Engineering Fourth Military Medical UniversityXi'an 710032China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi'an 710032China Wellcome Trust Center for Nettroimaging Institute ofNeurologyUniversity College LondonLondon WC1N 3BGUK Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China

Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations（AVHs） in schizophrenia（SZ） remains unclear. In this study, we used stochastic dynamic causal modeling（s DCM） to quantify connections among the left dorsolateral prefrontal cortex（inner speech monitoring）, auditory cortex（auditory processing）, hippocampus（memory retrieval）, thalamus（information filtering）, and Broca＇s area（language production） in 17 first-episode drug-na？¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance ***, we performed receiver operating characteristic（ROC） analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca＇s area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence.

关键词： Effective connectivity Stochastic dynamic causal modeling Auditory verbal hallucinations Schizophrenia

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Characteristics and Time-Dependent Instability of Ga-Doped ZnO Thin Film Transistor Fabricated by Radio Frequency Magnetron Sputtering

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Chinese Physics Letters 2011年第12期28卷 297-299页

作者： HUANG Hai-Qin SUN Jian LIU Feng-Juan ZHAO Jian-Wei HU Zuo-Fu LI Zhen-Jun ZHANG xi-Qing WANG Yong-Sheng Key Laboratory of Luminescence and Optical Information(Ministry of Education) Institute of Optoelectronic TechnologyBeijing Jiaotong UniversityBeijing 100044 Beijing BOE Optoelectronics Technology CO. LTDBeijing 100176

We report on the fabrication and electrical characteristics of Ga-doped ZnO thin film transistors(TFTs).Low Ga-doped(0.7wt%)ZnO thin films were deposited on SiO_(2./p−Si substrates by rf magnetron *** GZO TFTs show a mobility of 1.76 cm2.V⋅s,an on/off ratio of 1.0×10^(6),and a threshold voltage of 35 *** time−dependent instability of the TFT is *** VTH shifts *** addition,the device shows a decrease of the on/off ratio,mainly due to the increase of the *** mechanisms of instability are discussed.

关键词： TFTs film instability

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飞行器易损性指标计算的基本理论与方法(Ⅱ)

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现代防御技术 1999年第5期 36-42页

作者：宋笔锋韩庆西北工业大学飞机生存力技术研究所!陕西西安710072

文章是飞行器易损性指标计算基本理论的第二部分。在第一部分给出的单次击中易损性指标计算公式的基础上，研究了多次击中情况下飞行器易损性指标计算的两种方法，并给出了相应的计算公式。最终通过具体的算例说明了方法的有效性

关键词：易损性易损面积多次击中余度重叠

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Generation and metabolomic characterization of functional ductal organoids with biliary tree networks in decellularized liver scaffolds

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Bioactive Materials 2023年第8期26卷 452-464页

作者： Jiaxian Chen Shiwen Ma Hui Yang xi Liang Heng Yao Beibei Guo Deying Chen Jing Jiang Dongyan Shi Jiaojiao xin Keke Ren xingping Zhou Yun Li Lei Geng Jun Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of Medicine79 Qingchun Rd.Hangzhou310003China Precision Medicine Center Taizhou Central Hospital(Taizhou University Hospital)Taizhou318000China institute of Pharmaceutical Biotechnology Zhejiang University School of MedicineHangzhou310013China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of Medicine79 Qingchun Rd.Hangzhou310003China

Developing functional ductal organoids(FDOs)is essential for liver regenerative *** aimed to construct FDOs with biliary tree networks in rat decellularized liver scaffolds(DLSs)with primary cholangiocytes isolated from mouse bile *** developed FDOs were dynamically characterized by functional assays and metabolomics for bioprocess *** were reconstructed in DLSs retaining native structure and bioactive factors with mouse primary cholangiocytes expressing enriched *** assessment showed that biliary tree-like structures gradually formed from day 3 to day *** cholangiocytes in FDOs maintained high viability and expressed 11 specific ***-apical polarity was observed at day 14 with immunostaining for E-cadherin and acetylatedα-*** rhodamine 12. transport assay and active collection of cholyl-lysyl-fluorescein exhibited the specific functions of bile secretion and transportation at day 14 compared to those in monolayer and hydrogel culture *** metabolomics analysis with 1075 peak pairs showed that serotonin,as a key molecule of the tryptophan metabolism pathway linked to biliary tree reconstruction,was specifically expressed in FDOs during the whole period of *** FDOs with biliary tree networks and serotonin expression may be applied for disease modeling and drug screening,which paves the way for future clinical therapeutic applications.

关键词： Cholangiocyte Decellularized scaffold Ductal organoid Extracellular matrix

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水蒸气辅助煤与生物质回转炉共热解制高热值可燃气特性研究

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节能技术 2024年第3期42卷 227-236页

作者：孟晓晓李景煜王辉胡耘王兴益司徒汇隽甄文熙孙锐哈尔滨工业大学能源科学与工程学院黑龙江哈尔滨150001 国家能源集团科学技术研究院有限公司江苏南京210023

煤与生物质共热解作为实现这两种含碳资源高效清洁利用的重要技术路径,对实现碳中和目标有重要意义。本文旨在探究水蒸气辅助下,不同条件对煤与生物质共热解制备高值可燃气体(H_(2.、CH_(4)、CO)的影响。在大型回转炉中,探究了褐煤与玉... 详细信息

煤与生物质共热解作为实现这两种含碳资源高效清洁利用的重要技术路径,对实现碳中和目标有重要意义。本文旨在探究水蒸气辅助下,不同条件对煤与生物质共热解制备高值可燃气体(H_(2.、CH_(4)、CO)的影响。在大型回转炉中,探究了褐煤与玉米秸秆共热解及水蒸气辅助共热解温度、掺混比对H_(2.、CH_(4)、CO产气量和热值的影响,并通过Aspen Plus搭建热解模型对其进行验证。实验及仿真结果表明:秸秆与褐煤存在明显的协同效应,无水蒸气时最佳产气条件可燃气热值超过3000 J/L(热解温度600℃,秸秆掺混比80%)。水蒸气条件下,促进了共热解可燃气高热值组分H_(2.、CH_(4)、CO的生成,最佳条件下可燃气热值提升88%达到5639 J/L(热解温度800℃,秸秆掺混比80%)。

关键词：煤生物质回转炉共热解/气化 Aspen Plus 可燃气

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Novel DPY19L2.variants in globozoospermic patients and the overcoming this male infertility

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Asian Journal of Andrology 2019年第2期21卷 183-189页

作者： Yong-Liang Shang Fu-xi Zhu Jie Yan Liang Chen Wen-Hao Tang Sai xiao Wei-Ke Mo Zhi-Guo Zhang xiao-Jin He Jie Qiao Yun-xia Cao Wei Li State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Anhui Province Key Laboratory of Reproductive Health and Genetics Anhui Medical UniversityHefei 230022China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Medical Center of Reproductive and Genetics Peking University First HospitalBeijing 100034China Digital china Health Technologies Co. Ltd.Beijing 100080China Anhui Provincial Engineering Technology research Center for Biopreservation and Artificial Organs Hefei 230022China

Globozoospermia has been reported to be a rare but severe causation of male infertility,which results from the failure of acrosome biogenesis and sperm head *** of dpy-19-like 2.DPY19L2.are highly related to globozoospermia,but related investigations have been mainly performed in patients from Western ***,we performed a screening of DPY19L2.variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2.deletions and the other four patients contained novel DPY19L2.point mutations,as revealed by whole-exome *** 3(P3)contained a heterozygous variant(c.2.2.+5G>A),P6 contained a homozygous nonsense mutation(c.172.C>T,***574*),P8 contained compound heterozygous variants(c.H82.1184delATCf ***394_Ser395deIinsPhe;c.368A>T,***2.Arg),and P9 contained a heterozygous variant(c.H82.1184delATCTTI frameshift).We also reported intracytoplasmic sperm injection(ICSI)outcomes in the related patients,finding that ICSI followed by assisted oocyte activation(AOA)with calcium ionophore achieved high rates of live *** summary,the infertility of these patients results from DPY19L2.dysfunction and can be treated by ICSI together with AOA.

关键词： DPY19L2 globozoospermia male infertility point mutation whole-exome sequencing

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陕西人普通话水平测试中的声调问题

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陕西教育学院学报 2002年第3期18卷 47-49页

作者：韩承红陕西教育学院中文系陕西西安710061

普通话水平测试是新时期推广普通话的最新举措 ,是一项国家考试 ,也是一个亟待研究的重要课题。本文探讨了在普通话水平测试实践中陕西方言区在声调方面存在的主要问题、出现的原因及解决的对策 ,以期提高普通话水平测试工作的质量。

关键词：普通话水平测试声调陕西方言调值

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改性大豆蛋白胶膜纸饰面细木工板的浸渍剥离性能研究

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中国胶粘剂 2019年第8期28卷 11-14页

作者：张曦怀化市产商品质量监督检验所湖南怀化418100

采用杉木芯板和桉木单板为原料,以热压温度、热压时间、桉木单板含水率为影响因素设置单因素和正交试验,并通过检测板坯的浸渍剥离长度,对改性大豆蛋白基胶粘剂浸渍膜纸饰面细木工板的热压工艺进行了研究。研究结果表明:各因素对板坯浸... 详细信息

采用杉木芯板和桉木单板为原料,以热压温度、热压时间、桉木单板含水率为影响因素设置单因素和正交试验,并通过检测板坯的浸渍剥离长度,对改性大豆蛋白基胶粘剂浸渍膜纸饰面细木工板的热压工艺进行了研究。研究结果表明:各因素对板坯浸渍剥离性能影响的主次为热压温度>桉木单板含水率>热压时间;当杉木板芯厚度为12.mm、桉木单板厚度为3 mm、单面施胶量为2.0 g/m2.热压压力为0.8 MPa时,较优的热压工艺参数为热压温度12.℃、热压时间52. s、桉木单板含水率为12.。

关键词：大豆蛋白胶细木工板浸渍剥离性能

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TanSat Mission Achievements： from Scientific Driving to Preliminary Observations

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空间科学学报 2018年第5期38卷 627-639页

作者： LIU Yi WANG Jing YAO Lu CHEN xi CAI Zhaonan YANG Dongxu YIN Zengshan GU Songyan TIAN Longfei LU Naimeng L Daren institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 University of Chinese Academy of Sciences Beijing 100190 Shanghai Engineering Center for Microsatellites Shanghai 201203 National Satellite Meteorological Center

The Chinese global carbon dioxide monitoring satellite(TanSat)was successfully launched in December 2.16 and has completed its on-orbit tests and *** aims to measure the atmospheric Carbon Dioxide column-averaged dry air mole fractions(X_(CO_2.)with a precision of 4 ppm at the regional scale,and further to derive the CO_2.global and regional *** toward these objectives is reviewed and the first scientific results from TanSat measurements are *** the design phase,Observation System Simulation Experiments(OSSE)on TanSat measurements performed prior to launch measurements using a nadir and a glint alternative mode when considering the balance of stable measurements and reduces the flux uncertainty(64%).The constellation measurements of two satellites indicate an extra 10%improvement in flux inversion if the satellite measurements have no bias and similar *** TanSat on-orbit test indicates that the instrument is stable and beginning to produce X_(CO_2.*** preliminary TanSat measurements have been validated with Total Carbon Column Observing Network(TCCON)measurements and have inter-compared with OCO-2.measurements in an overlap measurement.

关键词：科学开车二氧化碳监视卫星干燥空气设计阶段地区性 ppm

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Quantitative Trait Loci Associated with Micronutrient Concentrations in Two Recombinant Inbred Wheat Lines

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Journal of Integrative Agriculture 2014年第11期13卷 2322-2329页

作者： PU Zhi-en YU Ma HE Qiu-yi CHEN Guo-yue WANG Ji-rui LIU Ya-xi JIANG Qian-tao LI Wei DAI Shou-fen WEI Yu-ming ZHENG You-liang Triticeae research institute Sichuan Agricultural University College of Agronomy Sichuan Agricultural University School of Life Science and Engineering Southwest University of Science and Technology

Micronutrient malnutrition affects over three billion people worldwide, especially women and children in developing countries. Increasing the bioavailable concentrations of essential elements in the edible portions of crops is an effective resolution to address this issue. To determine the genetic factors controlling micronutrient concentration in wheat, the quantitative trait locus （QTL） analysis for iron, zinc, copper, manganese, and selenium concentrations in two recombinant inbred line populations was performed. In all, 39 QTLs for ifve micronutrient concentrations were identiifed in this study. Of these, 2. alleles from synthetic wheat SHW-L1 and seven alleles from the progeny line of the synthetic wheat Chuanmai 42.showed an increase in micronutrient concentrations. Five QTLs on chromosomes 2., 3D, 4D, and 5B found in both the populations showed signiifcant phenotypic variation for 2.3 micronutrient concentrations. Our results might help understand the genetic control of micronutrient concentration and allow the utilization of genetic resources of synthetic hexaploid wheat for improving micronutrient efifciency of cultivated wheat by using molecular marker-assisted selection.

关键词： micronutrient concentration synthetic hexaploid wheat QTL

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