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Role of melatonin in Alzheimer-like neurodegeneration

Acta Pharmacologica Sinica 2006年第1期27卷 41-49页

作者： Jian-zhi WANG~(2.4) Ze-fen WANG~(2.3)2.Pathophysiology Department,Key Laboratory of Neurological Diseases of Hubei Province,Tongji Medical School,Huazhong university of Science and Technology,wuhan 430030,{2. 3 Department of Physiology,Medical College,wuhan university wuhan 430071,{2. Pathophysiology Department Key Laboratory of Neurological Diseases of Hubei Province Tongji Medical School Huazhong University of Science and Technology Wuhan China Department of Physiology Medical College Wuhan University Wuhan China

Alzheimer disease (AD),an age-related neurodegenerative disorder with progres-sive loss of memory and deterioration of comprehensive cognition,is character-ized by extracellular senile plaques of aggregated β-amyloid (Aβ),and intracellularneurofibrillary tangles that contain hyperphosphorylated tau *** showed that melatonin,an indoleamine secreted by the pineal gland,mayplay an important role in aging and AD as an antioxidant and *** decreases during aging and patients with AD have a more profoundreduction in this *** from clinical trials indicate that melatonin supple-mentation improves sleep,ameliorates sundowning,and slows down the progres-sion of cognitive impairment in Alzheimer's *** efficiently pro-tects neuronal cells from Aβ-mediated toxicity via antioxidant and anti-amyloidproperties:it not only inhibits Aβ generation,but also arrests the formation ofamyloid fibrils by a structure-dependent interaction with Aβ.Our recent studieshave demonstrated that melatonin efficiently attenuates Alzheimer-like *** the exact mechanism is still not fully understood,a direct regulatory influence of melatonin on the activities of protein kinases andprotein phosphatases is ***,melatonin also plays a role inprotecting cholinergic neurons and in ***,the neuroprotectiveeffects of melatonin and the underlying mechanisms by which it exerts its effectsare *** capacity of melatonin to prevent or ameliorate tau and Aβpathology further enhances its potential in the prevention or treatment of AD.

关键词： Alzheimer disease melatonin tau,beta amyloid

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Prediction of Tumor Outcome Based on Gene Expression Data

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wuhan university Journal of Natural Sciences 2004年第2期9卷 177-182页

作者： Liu Juan 1,2. Hitoshi Iba 3 1. School of Computer, wuhan university, wuhan 4.0072. Hubei, china 2. State Key Laboratory of Software Engineering, wuhan 4.0072. Hubei, china 3. Department of Frontier Informatics, university of Tokyo, Tokyo 113-8656, Japan School of Computer Wuhan University Wuhan Hubei China State Key Laboratory of Software Engineering Wuhan Hubei China Department of Frontier Informatics University of Tokyo Tokyo Japan

Gene expression microarray data can be used to classify tumor types. We proposed a new procedure to classify human tumor samples based on microarray gene expressions by using a hybrid supervised learning method called MOEA+WV (Multi-Objective Evolutionary Algorithm+Weighted Voting). MOEA is used to search for a relatively few subsets of informative genes from the high-dimensional gene space, and WV is used as a classification tool. This new method has been applied to predicate the subtypes of lymphoma and outcomes of medulloblastoma. The results are relatively accurate and meaningful compared to those from other methods. Key words bioinformatics - tumor classification - Pareto optimization - MOEA CLC number Q 786 - TP 181 Foundation item: Supported by the National Natural Science Foundation of china (60301009), the Foundation of Young Scholars of Ministry of Education of china (150118) and Chenguang Project of {2. City (2.112.009).Biography: Liu Juan (1970-), female, Associate Professor, Postdoctoral, research direction: bioinformatics, data mining, machine learning.

关键词： bioinformatics tumor classification Pareto optimization MOEA

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Multi-resolution representation of digital terrain models with terrain features preservation

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Science china(Technological Sciences) 2008年第S1期51卷 145-154页

作者： LI QingQuan1,WANG Zhi1,2.& YANG BiSheng1 1 State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,wuhan university,wuhan 430079,china 2.School of Remote Sensing and Information Engineering,wuhan university,wuhan 430079,china State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan University Wuhan China School of Remote Sensing and Information Engineering Wuhan University Wuhan China

multi-resolution TIN model is an important issue in the contexts of visu-alization,virtual reality (VR),and geographic information systems (GIS). This paper proposes a new method for constructing multi-resolution TIN models with multi-scale topographic features preservation. The proposed method is driven by a half-edge collapse operation in a greedy framework and employs a new quadric error metric to efficiently measure geometric errors. We define topographic features in a multi-scale manner using a center-surround operator on Gaussian-weighted mean curvatures. Experimental results demonstrate that the proposed method performs better than previous methods in terms of topographic features preservation,and is able to achieve multi-resolution TIN models with a higher accuracy.

关键词： digital terrain models level of detail differential-geometry quadric error metrics topographic feature

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Mathematical Model of the Identical Slope Surface

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wuhan university Journal of Natural Sciences 2002年第1期7卷 54-58页

作者： Hu Jian-guo 1, Chen yue-ping 2.1. School of Urban Studies,wuhan university,wuhan 4.0072. Hubei, china 2.College of Politics and Administration,wuhan university, wuhan 4.0072.Hubei, china School of Urban Studies Wuhan University Wuhan Hubei China College of Politics and Administration Wuhan University Wuhan Hubei China

The formation of the identical slope surface and the method of construction are discussed. On the basement of building the parameter equation of variable-radius circle family envelope, the frequently used parameter equation of the identical slope surface of the top of taper moving along column helix, horizental arc and line is built. The equation can be used to construct the identical slope surface’s contours, gradient lines and three dimensional figures correctly.

关键词： Key words identical slope surface family of circles mathematical model envelope elevation projection contours

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Fractal Analysis of Gas Diffusion Layer in PEM Fuel Cells

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Journal of wuhan university of Technology(Materials Science) 2006年第1期21卷 22-25页

作者：石英肖金生 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070ChinaSchool of Automation Wuhan University of Technology Wuhan 430070 China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070ChinaSchool of Automotive EngineeringWuhan University of Technology Wuhan 430070China

The aim of this study is to show how fractal analysis can be effectively used to characterize the texture of porous solids. The materials under study were carbon papers, the backing material of the gas diffusion layer （GDL） in Proton Exchange Membrane Fuel Cell （PEMFC）. The fractal dimensions were calculated by analyzing data from mercury porosimetry. The polytotrafluoroethylene （PTFE） treated carbon paper shows a significantly high fractal dimension value than pare sample, and the high fractal dimension signifies that the physical complexity of the pore surface is enhanced. The fractal dimension can be used as a valid parameter to monitor the textural evolution of the samples as the treatment progresses, as this behaves in a similar way to other textural parameters. The use of fractal analysis in conjunction with the results of classical characterization methods leads to a better understanding of textural modificatious in the processing of materials.

关键词： PEMFC gas diffusion layer fractal dimension mewury porosimetry

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Accountability Analysis of Electronic Commerce Protocols by Finite Automaton Model

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wuhan university Journal of Natural Sciences 2004年第3期9卷 293-295页

作者： Xie Xiao-yao 1,2., Zhang Huan-guo 1 1. School of Computer, wuhan university, wuhan 4.0072. Hubei, china 2. Institute of Network Technology, Guizhou university of Technology, Guiyang 550003, Guizhou, china School of Computer Wuhan University Wuhan Hubei China Institute of Network Technology Guizhou University of Technology Guiyang Guizhou China

The accountability of electronic commerce protocols is an important aspect to insures security of electronic transaction. This paper proposes to use Finite Automaton (FA) model as a new kind of framework to analyze the transaction protocols in the application of electronic commerce. Key words finite automaton - electronic commerce - nonrepudiation - information security CLC number TP 393. 08 Foundation item: Supported by the National Natural Science Foundation of china (66973034, 90104005, 60373087)Biography: Xie Xiao-yao (1952.), male, Professor, Ph. D candidate, research direction: information security.

关键词： finite automaton electronic commerce nonrepudiation information security

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Extended multivariate public key cryptosystems with secure encryption function

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Science china(Information Sciences) 2011年第6期54卷 1161-1171页

作者： WANG HouZhen 1,2., ZHANG HuanGuo 1,2., WANG ZhangYi 1,2.& TANG Ming 1,2.1 The Key Laboratory of Aerospace Information Security and Trusted Computing, Ministry of Education, School of Computer, wuhan university, wuhan 430079, china 2.State Key Laboratory of Software Engineering, wuhan university, wuhan 4.0072. china The Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education School of Computer Wuhan University Wuhan China State Key Laboratory of Software Engineering Wuhan University Wuhan China

Advances in quantum computers pose great threats on the currently used public key cryptographic algorithms such as RSA and ECC. As a promising candidate secure against attackers equipped with quantum computational power, multivariate public key cryptosystems (MPKCs) have attracted increasing attention in recently years. Unfortunately, the existing MPKCs can only be used as a multivariate signature scheme, and it remains unknown how to construct an efficient MPKC enabling secure encryption. Furthermore, some multivariate signature schemes have been shown insecure in recent years, and it is also not trivial to build MPKC which can serve as a secure signature scheme. By employing the basic MQ-trapdoors, this paper proposes a novel MPKC and shows how it can be used as a multivariate signature scheme and a multivariate encryption scheme, respectively. The goal is achieved by incorporating our new hash authentication techniques and some modification methods such as the Shamir's minus method. Thorough analysis shows that our schemes are secure and efficient. Our MPKC gives a positive response to the challenges in multivariate public key cryptography.

关键词： cryptography post-quantum cryptography MQ problem hash function

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Synthesis of todorokite by refluxing process and its primary characteristics

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Science china Earth Sciences 2004年第8期47卷 760-768页

作者： FENG Xionghan1, LIU Fan1, TAN Wenfeng1, LIU Xiangwen2.& HU Hongqing1 1. College of Resources and Environment, Huazhong Agricultural university, wuhan 430070, {2. 2. Testing Center, {2. university of Geosciences, wuhan 430074, {2. College of Resources and Environment Huazhong Agricultural University Wuhan China Testing Center China University of Geosciences Wuhan China

Single phase and well-crystallined todorokite were synthesized by heating and refluxing process from birnessite as a precursor. The average chemical composition of the synthesized todorokites by refluxing for 8 h and for 2. h was Mg0.19MnO2.11(H2.)1.15 and in0.17-MnO2.10(H2.)0.88, respectively. The crystallinity of the todorokite increased and no other phase was produced with increasing refluxing period. The synthesized todorokites have the same morphologies and the similar structural characteristics with the natural todorokites and hydro-thermally synthesized samples. The chemical compositions of the synthetic tordorokites by refluxing process are close to those of todorokites synthesized by hydrothermal process, except a higher average oxidation state of Mn for the former.

关键词： todorokite,birnessite,manganese oxide,refluxing,hydrothermal,synthesis.

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Locating the Polar Cap Boundary of Postnoon Sector from Observations of 630.0 nm Auroral Emission at Zhongshan Station

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wuhan university Journal of Natural Sciences 2002年第1期7卷 59-64页

作者： Liu Li-gang 1, Ai Yong 1, Liu Rui-yuan 2. Yang Hui-gen 2.1. School of Electronic Information, wuhan university, wuhan 4.0072. Hubei, china 2. Polar Research Institute of china, Shanghai 2.012., china School of Electronic Information Wuhan University Wuhan Hubei China Polar Research Institute of china Shanghai China

We studied the ground observations of 630.0 nm auroral emission at Zhongshan Station to determine the polar cap boundary with the latitudinal profile of emission intensity. The open-closed field time boundary is assumed to lie at the boundary between polar rain and plasma sheet precipitation. We assume that nonprecipitation-dependent sources of 630.0 nm emission cause a spatially uniform luminosity in the polar cap and that auroral zone luminosity is also spatially uniform. Therefore we determine the location of the polar cap boundary of postnoon sector from the auroral emission data each time by finding the best fit of the observations to a step function in latitude and we produce a time series of the location of the polar cap boundary. The average error of the practice in the paper is less than 0.8 degree.

关键词： polar cap boundary aurora Zhongshan Station

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Atomic decomposition in L^p(R^n) (12.

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Chinese Science Bulletin 1999年第24期44卷 2221-2225页

作者： YANG QixiangDepartment of Mathematics , wuhan university , wuhan 4.0072., china Department of Mathematics Wuhan University Wuhan China

An atomic decomposition in Lp (1 < p < 2. with tent space is given.

An atomic decomposition in Lp (1 2. with tent space is given.

关键词： Lp s( n) tent space Tp5 q (p Tp5 q) atom (p L2. atom atomic decomposition.

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