检索结果-南通市图书馆

Design,synthesis,antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2.one derivatives

引用

Acta Pharmacologica Sinica 2007年第1期28卷 140-152页

作者： Hai-hong LI~2 Xiu-hua ZHANG~3 Jin-zhi TAN~2 Li-li CHEN~2 Hong LIU~(2,5) Xiao-min LUO~(2,5) Xu SHEN~(2,4) Li-ping LIN~(3,5) Kai-xian CHEN~2 Jian DING~3 Hua-liang JIANG~(2,4)2 Center for Drug Discovery and Design,State Key Laboratory of Drug Research,shanghai Institute of Materia Medica,shanghai Institutes for Biological sciences,and Graduate school,Chinese Academy of sciences,shanghai 201203,china 3 Division of Anti-tumor Pharmacology,shanghai Institute of Materia Medica,shanghai Institutes for Biological sciences,Chinese Academy of sciences,shanghai 201203,china 4 school of Pharmacy,east china university of science and technology,shanghai 2.02.7,china CenterforDrugDiscoveryandDesign StateKeyLaboratoryofDrugResearchShanghaiInstituteofMateriaMedicaShanghaiInstitutesforBiologicalSciencesandGraduateSchoolChineseAcademyofSciencesShanghai201203China

Aim:To design and synthesize a novel class of antitumor agents,featuring the 3,5-substituted indolin-2.one ***:Based on enzyme binding fea-tures of（Z）-SU5402.introducing a β-pyrrole group at the 3-position of the indolin-2.one core,a series of novel 3,5-substituted indolin-2.ones were designed *** human carcinoma cell lines of A-43l,A-549,MDA-MB-468,and Autosomal Dominant Polycystic Kidney disease were chosen for the cellproliferation ***:Twenty new compounds（1a-t）with E configurationhave been designed,synthesized and *** structural features weredetermined by nuclear magnetic resonance（NMR）spectra,low-and high-resolu-tion mass spectra,and confirmed by X-ray *** the enzymeassay showed a weak inhibition effect against the epidermal growth factor receptor,vascular endothelial growth factor receptor,fibroblast growth factor receptor andplatelet-derived growth factor receptor tyrosine kinases,the cell-based antitumoractivity was *** 1 g and lh showed higher inhibitory activitytoward the A-549 and MDA-MB-468 cell lines with IC50of 0.065-9.4 μmol/***:This study provides a new template for further development ofpotent antitumor drugs.

关键词： protein-tyrosine kinase indolin-2.one antitumor drug screening assays drug design molecular models

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

HIGHLY SELECTIVE CATALYTIC DIMERIZATION OF PHENYLACETYLENE BY CYCLOPENTADIENYL RUTHENIUM COMPLEXES

引用

Chinese Journal of Catalysis 1999年第4期20卷 4-5页

作者： Jin Junting, Huang Jiling, Tao Xiaochun, Qian Yanlong (Laboratory of Organometallic chemistry, east{2. university of science and technology, shanghai 2.02.7) 华东理工大学金属有机化学国家重点实验室上海 200237

ＴｒａｎｓｉｔｉｏｎｍｅｔａｌｖｉｎｙｌｉｄｅｎｅｃｏｍｐｌｅｘｅｓＣ（ＭＣＨＲ）ｈａｖｅａｔｒａｃｔｅｄａｇｒｅａｔｄｅａｌｏｆａｔｅｎｔｉｏｎｉｎｒｅｃｅｎｔｙｅａｒｓａｓａｎｅｗｔｙｐｅｏｆｏｒｇａｎｏｍｅｔａ... 详细信息

ＴｒａｎｓｉｔｉｏｎｍｅｔａｌｖｉｎｙｌｉｄｅｎｅｃｏｍｐｌｅｘｅｓＣ（ＭＣＨＲ）ｈａｖｅａｔｒａｃｔｅｄａｇｒｅａｔｄｅａｌｏｆａｔｅｎｔｉｏｎｉｎｒｅｃｅｎｔｙｅａｒｓａｓａｎｅｗｔｙｐｅｏｆｏｒｇａｎｏｍｅｔａｌｉｃｉｎｔｅｒｍｅｄｉａｔｅｓｔ...

关键词： dimerization phenylacetylene ruthenium complex substituted cyclopentadiene

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Design,synthesis and antitumor evaluation of a new series of N-substi-tuted-thiourea derivatives

引用

Acta Pharmacologica Sinica 2006年第9期27卷 1259-1271页

作者： Jian LI~2.Jin-zhi TAN~2.Li-li CHEN~2.Jian ZHANG~2.Xu SHEN~(2.3)Chang-lin MEI~(4,6)Li-li FU~4 Li-ping LIN~5 Jian DING~5 Bing XIONG~2.Xi-shan XIONG~4 Hong LIU~(2.6)Xiao-min LUO~(2.6)Hua-liang JIANG~(2.3)2.Drug Discovery and Design Centre,State Key Laboratory of Drug Research,shanghai Institute of Materia Medica,shanghai Institutes for Biological {2.s,Chinese Academy of {2.s,shanghai 2.12.3.china 3 school of Pharmacy.east china university of {2. and technology,shanghai 2.02.7,china 4 Division of Nephrology,Department of Internal Medicine,Changzheng Hospital,Second Military Medical university,shanghai 2.0003,china 5 Division of Antitumor Pharmacology,shanghai Institute of Materia Medica,shanghai 2.12.3.china 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 3school of Pharmacy East China University of Science and Technology Shanghai 200237 China 3school of Pharmacy East China University of Science and Technology Shanghai 200237 China 4Division of Nephrology Department of Internal Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China 5Division of Antitumor Pharmacology Shanghai Institute of Materia Medica Shanghai 201203 China 5Division of Antitumor Pharmacology Shanghai Institute of Materia Medica Shanghai 201203 China 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 4Division of Nephrology Department of Internal Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2.rug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Bi

Aim:To design and synthesize a novel class of protein tyrosine kinase inhibitors,featuring the N-(2.oxo-1,2.dihydroquinolin-3-yl-methyl)-thiourea ***:First,compounds 1 and 2.were identified using the virtual screeningapproach in conjunction with binding assay based on surface plasmon ***,3 regions of compounds 1 and 2.were selected for chemical *** compounds were characterized potent inhibitory activities toward thehuman lung adenocarcinoma cell line SPAC ***:Forty new compounds(1-2.3a-g,4a-w,and 5a-l)were designed,synthesized and *** com-pounds(1,3e,41,4w,5a,and 5b)were found to show promising inhibitory activityagainst the SPAC1 tumor cell *** inhibitory activity of compound 5aincreases approximately 10 times more than that of the original compound ***:This study provides a promising new template with potential antitu-mot activity.

关键词： N-substituted-thiourea derivatives antitumor SPAC1 tyrosine kinase inhibitor virtual screening

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

将幸福变量引入决策——对效用最大化法则下个体经济行为的补充

引用

商业经济与管理 2009年第10期 22-27页

作者：顾明毅尹伯成华东理工大学传媒学院上海200237 复旦大学经济学院上海200433

众多研究发现增加财富并不一定能增加幸福,国外幸福经济学提出改变传统经济学效用最大化法则,以幸福最大化作为人类行为决策的最终目的。文章分析了幸福经济学与其他经济理论不同的效用最大化曲线,应用幸福经济学前沿理论对微观层面的... 详细信息

众多研究发现增加财富并不一定能增加幸福,国外幸福经济学提出改变传统经济学效用最大化法则,以幸福最大化作为人类行为决策的最终目的。文章分析了幸福经济学与其他经济理论不同的效用最大化曲线,应用幸福经济学前沿理论对微观层面的个体行为决策提出措施和建议,从而推动个体提升幸福水平。

关键词：幸福经济学效用最大化非理性决策幸福效用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMR and molecular modeling

引用

science china {2. 2010年第9期53卷 1987-1993页

作者： LIU Yan1,SHI YanHong2.LIU XiaoXia1,LIN MingKun1,LIN DongHai1,2.& ZHAO YuFen1,3 1Key Laboratory for Chemical Biology of Fujian Province,Department of Chemical Biology,Department of chemistry,College of chemistry and Chemical Engineering,Xiamen {2.,Xiamen 361005,china 2.4} Institute of Materia Medica,shanghai Institutes of Biological sciences,Chinese Academy of sciences,shanghai 2.12.3,china 3Key Laboratory for Bioorganic Phosphorus chemistry and Chemical Biology,Ministry of Education,Department of chemistry,{12. of Life sciences and Engineering,Tsinghua {2.,Beijing 100084,china 1. Key Laboratory for Chemical Biology of Fujian Province Department of Chemical Biology Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China2. Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai 201203 China3. Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry School of Life Sciences and Engineering Tsinghua University Beijing 100084 China

Seryl-Histidine dipeptide(Ser-His) has been previously reported to be capable of cleaving DNAs and carboxyl esters,as well as *** protein cleavage mechanism has not been addressed *** an initial step of protein cleavage activity,the non-covalent binding affinity of Ser-His for proteins is a crucial *** this work,we took cyclophilin A(CyPA) as a substrate protein,and evaluated the non-covalent interaction between CyPA and Ser-His using a combination of NMR spectroscopy and molecular modeling *** independent Ser-His binding sites on CyPA were detected using 15N-1H heteronuclear single-quantum coherence(HSQC) *** binding site binds one Ser-His *** constants,Kd1 and Kd2.were estimated to be 2.07 and 6.66 mmol/L,respectively,indicative of the weak non-covalent interaction between Ser-His and *** on molecular modeling results,we suggest that both the α-amino and the side chain hydroxyl group of Ser-His are crucial for the non-covalent interaction between Ser-His and *** work sheds light on the molecular mechanism of Ser-His and its analogues cleaving proteins.

关键词： Ser-His cyclophilin A HSQC non-covalent interaction binding sites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of temperature on oxidation growth of ZnO nanoparticals

Effect of temperature on oxidation growth of ZnO nanopartica...

引用

第七届中国功能材料及其应用学术会议

作者： LIU Yan-Hui~(1,2.,Zhou Xi-ying~1,Zhi Yan~1 (1.school of Materials Engineering,shanghai {2. of Engineering science,shanghai 2.162.,china 2.school of Mechanical and Power Engineering,east china {2. of science and technology,{12.,china)

Zn nanoparticals,produced by renovated hybrid induction and laser heating,dispersed by ultrasonic wave in ethanol and deposited on flat fundus of AlO ceramic,were used to prepared Granular ZnO films at different temperature(500,600,700℃) in air *** emission scanning electron microscopy(FESEM) investigation reveals that the morphology of ZnO nanoparticals in the granular ZnO films was transformed from flake into granular by combined action of melt and oxidation of nanometer Zn.

关键词： ZnO Zn thermal Oxidation nanoparticals crystal growth

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

3D-QSAR study of 2.(S)-camptothecin analogs

引用

Acta Pharmacologica Sinica 2007年第2期28卷 307-314页

作者： Ai-jun LU~(1,2. Zhen-shan ZHANG~2.Ming-yue ZHENG~2.Han-jun ZOU~2.Xiao-min LUO~2.Hua-liang JIANG~(2.3,4)1 Jiangsu Simcere Pharmaceutical Research Company Ltd,Nanjing 2.0042.china 2.Drug Discovery and Design Center,State Key Lab of Drug Research,shanghai Institute of Materia Medica,Chinese Academy of {2.s,shanghai 2.12.3,china 3 school of Pharmacy,east china university of {2. and technology,shanghai {12.,china Jiangsu Simcere Pharmaceutical Research Company Ltd Nanjing 210042ChinaDrug Discovery and Design CenterState Key Lab of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Aim:To build up a quantitative structure-activity relationship（QSAR）model of2.（S）-camptothecin（CPT）analogs for the prediction of the activity of new CPTanalogs for drug ***:A training set of 43 structurally diverse CPTanalogs which were inhibitors of topoisomerase I were used to construct a quan-titative structure-activity relationship model with a comparative molecular fieldanalysis（CoMFA）.The QSAR model was optimized using partial least squares（PLS）analysis.A test set of 10 compounds was evaluated using the ***:The CoMFA model was constructed successfully,and a good cross-validated correlation was obtained in which q2.as ***,the analysis ofthe non-cross-validated PLS model in which r2.as 0.935 was built and permitteddemonstrations of high predictability for the activities of the 10 CPT analogs inthe test set selected in ***:The CoMFA model indicated thatbulky negative-charged group at position 9,10 and 11 of CPT would increaseactivity,but excessively increasing bulky group at position 10 is adverse to inhibi-tory activity;substituents that occupy position 7 with the bulky positive groupwill enhance the inhibitive *** model can be used to design new CPTanalogs and understand the mechanism of action.

关键词： comparative molecular field analysis(CoMFA) camptothecin(CPT) topoisomerase I(Top I)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

An Adaptive Genetic Algorithm for the Grid Scheduling Problem

An Adaptive Genetic Algorithm for the Grid Scheduling Proble...

引用

第2.届中国控制与决策会议

作者： ZHOU Wei BU Yan-ping 1. school of Business, east{2. university of science and technology, shanghai, 2.02.72. school of technology, shanghai Jiaotong university, shanghai, 2.1101

Grid computing is a service that shares computational power and data storage capacity over the Internet. The goal of grid tasks scheduling is to achieve high system throughput and to match the application need with the available computing resources. Aiming at the evolution characteristics of genetic algorithm （GA）, an adaptive genetic algorithm （AGA） is presented in this paper. The AGA is used to solve the grid scheduling problem. It can keep all the advantages of the standard GA, such as implementation simplicity, low computational burden, and few control parameters, etc. A set of experiments show that the algorithm is stable and presents low variability. The preliminary results obtained in this research are auspicious. We analyze the laboratory results to show that the modified algorithm has better characteristics than standard GA and Max-Min algorithm when it was used in task scheduling.

关键词： grid task scheduling adaptive genetic algorithm makespan

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Catalytically Trimerize Ethylene to 1-Hexene with Pendant Arene Group Substituted Indenyl Titanium Trichlorides

Catalytically Trimerize Ethylene to 1-Hexene with Pendant Ar...

引用

2.11年全国高分子学术论文报告会

作者： Yanlu Zhang,Haiyan Ma,Jiling Huang Laboratory of Organometallic chemistry,east{2. university of science and technology,shanghai 2.02.7

＜正＞A series of half-sandwich indenyl titanium complexes [Ind-（bridge）-Ar] TiCl3 （1～7） have been synthesized and used to investigate the catalytic behavior towards ethylene trimerization to

关键词： titanium complexes indenyl pendant group ethylene trimerization

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Enhanced Hydrogen Evolution process of Water Electrolysis Assisted by Photocatalysis

Enhanced Hydrogen Evolution process of Water Electrolysis As...

引用

2.11 International Conference on Materials for Renewable Energy & Environment(ICMREE 2.11)

作者： Hongbo He Key Laboratory for Ultra ne Materials of Ministry of Education school of Materials science and Engineering {2. china university of science and technology shanghai 2.02.7 chinaLei Ma Key Laboratory for Ultra ne Materials of Ministry of Education school of Materials science and Engineering {2. china university of science and technology shanghai 2.02.7 chinaMing Chang Key Laboratory for Ultra ne Materials of Ministry of Education school of Materials science and Engineering {2. china university of science and technology shanghai 2.02.7 chinaJindong Lu Key Laboratory for Ultra ne Materials of Ministry of Education school of Materials science and Engineering {2. china university of science and technology shanghai 2.02.7 chinaAiping Chen Key Laboratory for Ultra ne Materials of Ministry of Education school of Materials science and Engineering {2. china university of science and technology shanghai 2.02.7 chinaChunzhong Li Key Laboratory for Ultra ne Materials of Ministry of Education school of Materials science and Engineering {2. china university of science and technology shanghai 2.02.7 china

TiO2.nanotubes were synthesized successfully by hydrothermal process using TiO2.powder and NaOH as the *** anode of water electrolysis equipment was modified by prepared TiO2.*** photocatalytic hydrogen evolution coupled with water electrolysis,a new process of hydrogen evolution,called as the hydrogen evolution of water electrolysis assisted by photocatalysis（HEWEAP）,was proposed and experimental *** rate of hydrogen evolution of HEWEAP in the presence of TiO2.nanotubes increased by 2.% comparing to water electrolysis.X-ray diffraction UV-vis diffuse reflectance spectroscopy FE-SEM TEM and measurement of hydrogen evolution rate were used to characterize the catalyst..

关键词： TiO2.nanotubes water electrolysis photo catalysis hydrogen production

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：