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SIMULATION OF FLUID-SOLID INTERACTION ON WATER DITCHING OF AN AIRPLANE BY ALE METHOD

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Journal of Hydrodynamics 2011年第5期23卷 637-642页

作者： HUA Cheng FANG Chao CHENG Jin Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China School of Mathematical sciences Fudan University Shanghai 200433 China

Ditching is considered as one of the important aspects of safety performances of airplanes. It is related primarily with the fluid-solid interaction, whose studies mainly depend on experiments at the present time. Numerical and analytical methods for fluid-solid interaction by using 3-D full scale airplane＇s model will reduce the dependence on the expensive model tests. Numerical studies can be used to estimate the safety of ditching and provide a reference for the crashworthiness design. This article proposes a 3-D dynamical structural model after the real shape of an airplane and an Arbitrary Lagrange-Euler （ALE） fluid-field model, to simulate the fluid-solid interactions caused by low speed ditching. The simulation is based on interaction computational methods, within LS-DYNA nonlinear finite-element code. The results of pressure distributions and accelerating time histories of the airplane＇s subfloor are discussed in the context of the safety of ditching, and the simulation results and the analytical methods are verified.

关键词： ditching fluid structure interaction Arbitrary Lagrange-Euler (ALE) finite element method

Ultrafast excitation relaxation in light-harvesting complex LH2.from *** 601

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Science china Chemistry 2004年第3期47卷 192-199页

作者： GUO Lijun1,2. LIU Yuan3, LIU Weimin2. GUO Junhua1, XU Chunhe3 & QIAN Shixiong2.1. School of Physics and Information Optoelectronics, Henan university, Kaifeng 475001, china 2. Physics Department,{2., shanghai 200433, china 3. shanghai institute of Plant Physiology, Chinese Academy of sciences, shanghai 2.0032. china School of Physics and Information Optoelectronics Henan University Kaifeng China Physics Department Fudan University Shanghai China shanghai institute of Plant Physiology Chinese Academy of Sciences Shanghai China

The energy relaxation and kinetic evolution of transient spectra of bacteriochloro- phylls (BChls) in light-harvesting complex LH2.from Rb. sphaeroides 601 were investigated using femtosecond pump-probe technique. Upon 783 nm excitation, the energy at B800 BChls ex-periences an intramolecular redistribution with 0.35 ps time constant before transferring to B850 BChls. With tuning the excitation wavelength, the dynamical evolution of excited BChls was clearly observed, which indicates an obvious competition between the ground state bleaching and excited state absorption (ESA) of BChls involved and an isosbestic point near 818 nm, and also demonstrates that from the lower electronic excited state of B800 BChls to the higher exci-tonic state of B850 BChls is an efficient routine for energy transfer. The excitation energy in higher excitonic states of B850 BChls relaxes rapidly to the next lowest excitonic state by inter-conversion, delocalization to adjacent molecular, populating the lowest excitonic state and the change of molecular conformation.

关键词： photosynthesis, light-harvesting complex, energy transfer, ultrafast, dynamics, purple bacteria.

Efficient delivery of human clotting factor IX after injection of lentiviral vectors in utero

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Acta Pharmacologica Sinica 2004年第6期25卷 87-91页

作者： Xiao-guang CHEN1, Huan-zhang ZHU1, Ju-li GONG, Feng LI, Jing-lun XUE2.State Key laboratory of Genetic Engineering, institute of Genetics, Schoolof Life {2., fudan university, shanghai 200433,china institute of Genetics School of Life Sciences Fudan University State Key Laboratory of Genetic Engineering 上海 200433

AIM: To explore gene transfer feasibility for human clotting factor IX (hFIX) mediated by recombinant lentivirus in utero. METHODS: ICR mice fetus at 17-19 d gestation were received lentiviral vectors carrying hFIX cDNA under the control of liver specific promoter by intrahepatic injection. The expression and distribution of hFIX cDNA and possible immune responses against the hFIX were assessed by ELISA, PCR, RT-PCR, and immunohistochemistry, respectively. RESULTS: The serum hFIX protein were detected at different time points in all newborn mice, the highest level of hFIX was 50 μg/L and lasted for more than 30 d. Anti-hFIX antibody was not detected. hFIX cDNA was detected in liver, spleen, and heart. The expression of hFIX cDNA was only detected in liver. Besides, no germ line transmission was found at DNA and RNA levels, and no side effect associated with gene transfer was detected. CONCLUSION: The efficient delivery of hFIX can be achieved by prenatal gene transfer. It thus shows the feasibility of gene therapy for hemophilia in utero.

关键词： lentiviral vector factor IX gene transfer techniques in utero

Identification and Characterization of a Rat Novel Gene RSEP4 Expressed Specifically in Central Nervous System

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 501-507页

作者： Xi-Dao WANG1,2. Ling-Wei KONG1, Zhi-Qin XIE1, Yu-Qiu ZHANG3, Zhi-Xin LIN2. Zhi-Qi ZHAO3,Lei YU4, and Nai-He JING1* 1 laboratory of Molecular Cell Biology, laboratory of Stem Cell Biology, {2. of Biochemistry and Cell Biology, shanghai {2.s for Biological sciences, Chinese Academy of sciences, Graduate School of the Chinese Academy of sciences, shanghai 2.0031, china School of Life Science and Biotechnology, 2. shanghai Jiaotong university, shanghai 2.0030, china {2. of Neurobiology, fudan university, shanghai 200433, china 3 4 Department of Cell Biology, Neurobiology and Anatomy, College of Medicine, university of Cincinnati, Cincinnati, Ohio, USA laboratory of Molecular Cell Biology Laboratory of Stem Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China School of Life Science and Biotechnology Shanghai Jiaotong UniversityShanghai 200030 China institute of Neurobiology Fudan UniversityShanghai 200433 China Department of Cell Biology Neurobiology and Anatomy College of Medicine University of CincinnatiCincinnati Ohio USA

The low-abundantly expressed genes composed the majorities of the mRNAs expressed in the central nervous system (CNS), and were thought to be important for the normal brain functions. Through differential screening a low-abundance cDNA sublibrary with mRNA from neuropathic pain of chronic constriction injury (CCI) model, we have identified a novel rat gene, rat spinal-cord expression protein 4 gene (RSEP4). The total length of RSEP4 cDNA is 2.06 bp, with a 501 nucleotide open reading frame (ORF) that encodes a 167 amino acid polypeptide. Northern blot revealed that RSEP4 was expressed specifically in the CNS. In situ hybridization showed that the mRNA of RSEP4 was strongly expressed in the CA1, CA2. CA3 and DG regions of hippocampus, the Purkinje cells of cerebellum, and the small sensory neurons of dorsal horn and large motor neurons of ventral horn of spinal cord. Over-expression of RSEP4-EGFP fusion protein in the human embryonic kidney 2.3T cells showed that RSEP4 protein was mainly localized in the cell cytoplasm. These results suggest that RSEP4 may play some roles in the CNS.

关键词： central nervous system (CNS) rat Northern blot in situ hybridization

INFINITE DIMENSIONAL TRACKING OPTIMAL CONTROL VIA DYNAMIC OUTPUT FEEDBACK~*

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Chinese Annals of mathematics 1987年第4期8卷 440-448页

作者：尤云程 institute of mathematics{2. shanghai china.

This paper explores implemantation problems of infinite dimensional linear-quadratictracking optimal *** on the closed-loop result,a new formula of optimal controlexpressed by past-time state feedback is *** this,on the conditions of observa-bility,expressions of optimal control via dynamic output feedback are *** mainfeedback operator functions are given by solution of linear integral equations.

关键词： Th INFINITE DIMENSIONAL TRACKING OPTIMAL CONTROL VIA DYNAMIC OUTPUT FEEDBACK VIA

A HYPERBOLIC SYSTEM OF CONSERVATION LAWS FOR FLUID FLOWS THROUGH COMPLIANT AXISYMMETRIC VESSELS

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Acta Mathematica Scientia 2010年第2期30卷 391-427页

作者： Gui-Qiang G.Chen School of Mathematical sciences,fudan {2.,shanghai 200433,china Mathematical institute,{2. of Oxford,2.-2. St Giles,Oxford,OX1 3LB,UK Department of mathematics,Northwestern {2.,Evanston,IL 602.8-2.30,USA Weihua Ruan Department of mathematics,Computer Science and Statistics,Purdue {2. Calumet,Hammond,IN 4632.-2.94,USA School of Mathematical sciences Fudan University Shanghai 200433 China Mathematical institute University of Oxford 24-29 St Giles Oxford OX1 3LB UK Department of mathematics Northwestern University Evanston IL 60208-2730 USA Department of mathematics Computer Science and Statistics Purdue University Calumet Hammond IN 46323-2094 USA

We are concerned with the derivation and analysis of one-dimensional hyperbolic systems of conservation laws modelling fluid flows such as the blood flow through compliant axisyminetric vessels. Early models derived are nonconservative and/or nonho- mogeneous with measure source terms, which are endowed with infinitely many Riemann solutions for some Riemann data. In this paper, we derive a one-dimensional hyperbolic system that is conservative and homogeneous. Moreover, there exists a unique global Riemann solution for the Riemann problem for two vessels with arbitrarily large Riemann data, under a natural stability entropy criterion. The Riemann solutions may consist of four waves for some cases. The system can also be written as a 3 × 3 system for which strict hyperbolicity fails and the standing waves can be regarded as the contact discontinuities corresponding to the second family with zero eigenvalue.

关键词： conservation laws hyperbolic system fluid flow blood flow vessel hyper-bolicity Riemann problem Riemann solution wave curve shock wave rarefaction wave standing wave stability

A measure of semantic similarity between gene ontology terms based on semantic pathway covering

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Progress in Natural Science:Materials International 2006年第7期16卷 721-726页

作者： LI Rong, CAO Shunliang, LI Yuanyuan, TAN Hao, ZHU Yangyong, ZHONG Yang and LI Yixue ( Department of Computing and Information Technology, fudan university, shanghai 200433,{2. shanghai Center for Bioin-formation Technology, shanghai 2.02.5,{2. School of Life sciences, fudan university, shanghai 200433,{2. Bioinfor-rnation Center of shanghai institute for Biological sciences, Chinese Academy of sciences, shanghai 2.0031,{2.) shanghai Ctr Bioinformat Technol Shanghai 200235 Peoples R China fudan Univ Dept Comp & Informat Technol Shanghai 200433 Peoples R China fudan Univ Sch Life Sci Shanghai 200433 Peoples R China Chinese Acad Sci Shanghai Inst Biol Sci Bioinformat Ctr Shanghai 200031 Peoples R China

Semantic similarity between Gene Ontology (GO) terms is critical in resolving semantic heterogeneousness when integrating heterogeneous biological databases. Traditionally, distance based and information content based measures are two major methods. In this paper, a new method based on semantic pathway covering is proposed and an algorithm, COMBINE algorithm, is presented, which considers information contents of two given nodes and those of all nodes included in the two nodes' pathways. Experiments show that COMBINE algorithm obtains the highest correlation index compared with those distance based and information content based algorithms.

关键词： Gene Ontology semantic similarity measure information content.

The non-destructive analysis of ancient jade artifacts unearthed from the Liangzhu sites at Yuhang,Zhejiang

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Science china(Technological sciences) 2010年第12期53卷 3404-3419页

作者： GAN FuXi1,3, CAO JingYan2. CHENG HuanSheng3, Gu DongHong1, RUI GuoYao2. FANG XiangMing2. DONG JunQing1 & ZHAO HongXia1 1Scientific Archeology Center, shanghai institute of Optics and Fine Mechanics, Chinese Academy of {2., shanghai 2.1800, china 2.Research institute of Cultural Relics and Archeology of Zhejiang, Hangzhou 310014, china 3 fudan university, shanghai 200433, china Scientific Archeology Center Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai China fudan university Shanghai China Research institute of Cultural Relics and Archeology of Zhejiang Hangzhou China

Samples of the jade artifacts unearthed from the Liangzhu sites at Yuhang (Fanshan,Yaoshan, Huiguanshan and Tangshan) of Zhejiang province were described. The chemical composition, phase and jade structure of a hundred and more intact samples were analyzed by the non-destructive techniques of PIXE, XRD and laser Raman spectroscopy. Results showed that the minerals of the jade artifacts mostly belonged to tremolite and tremolite-actinolite. Relationship of the civilization development in the Neolithic age and the application of tremolite type mineral in jade artifacts was discussed. The contents of rare and trace elements in tremolite jade artfacts and in mineral samples were measured for the first time. The possible mineral sources of these tremolite type jade artifacts were discussed.

关键词： Liangzhu culture non-destructive analysis ancient jade artifacts essence and source

Ozone decomposition under the irradiation of 2.3.7 nm in the presence of methyl bromide

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Journal of Environmental sciences 2000年第3期12卷 266-269页

作者： LI Chao\|min, HOU Jian, YU Yong, HOU Hui\|qi (institute of Environmental Science, fudan university,{2., china) institute of Environmental Science Fudan University Shanghai 200433 China

In this paper the mechanism and kinetic of ozone decomposition under the irradiation of 2.3.7 nm UV\|light were studied. The quantum yield of the ozone depletion in the presence of methyl bromide is further determine... 详细信息

关键词： methyl bromide ozone UV