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A template of rat brain based on fMRI T2. imaging

Progress in Natural Science:Materials International 2005年第6期15卷 502-506页

作者： HU Zhenghui1, WU Yigen2. WANG Xiaochuan3, WANG Jianzhi3, CHEN Feiyan1 and TANG Xiaowei1*(1. Department of physics and Bio-X laboratory, Zhejiang University, Hangzhou 31002.,{2. 2. institute of high energy physics and key laboratory of nuclear analysis techniques, chinese academy of sciences,beijing 100039,{2. 3. Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,{2.) Department of physics and Bio-X laboratory Zhejiang University Hangzhou 310027 China institute of high {2. physics and key laboratory of nuclear analysis techniques Chinese Academy of Sciences Beijing 100039 China Department of Pathophysiology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

The development of functional magnetic resonance imaging (fMRI) technology has made it possible to carry out functional brain imaging experiments in small animals. Usually, group data is required to form the assessment of population, which can not only increase the sensitivity of the overall experiment, but also allow the generalization of the conclusion to the whole population. In order to average the signals of functional brain images from different subjects, it is necessary to put all the mapping images into the same standard space (template image). However, up to now, most animal brain templates remain unavailable and it must be done by ourselves. In this study, a template image based on the brains of eight male Wistar rats is obtained, and it is successfully used in our present Alzheimer disease (AD)-like rat model studies as template for spatially normalizing images to the same stereotaxical space. The fMRI results processed with statistical parametric mapping (SPM99) software are in agreement with the results from immunohistochemical experiment, which proves that this method is universally applicable to the pathologic models of other small animals and to human brain lesion studies.

关键词： fMRI animal model atlas template normalization T*2.

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The establishment of crystal position look-up table for positron emission tomography with block detectors

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Science china(Technological sciences) 2009年第8期52卷 2418-2423页

作者： CHAI Pei1,2.& SHAN BaoCi1 1 key laboratory of {2. Analytical techniques, institute of high energy physics, chinese academy of sciences, beijing 100049, china 2.Graduate University of chinese academy of sciences, beijing 100049, china key laboratory of {2. Analytical techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Graduate University of chinese academy of sciences Beijing 100049 China

A method has been developed to establish the crystal position look-up table for positron emission tomography with block detectors. It is based on the principle that the counts in crystal position histogram obey the Gaussian mixture model (GMM). This method has taken full consideration of the characteristics of the GMM and the detector itself. The experimental results have proved that it is simple, reliable, and universal.

关键词： positron emission tomography position look-up table 2.D position histogram

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Zircon and apatite fission track analyses on mineralization ages and tectonic activities of Tuwu-Yandong porphyry copper deposit in northern Xinjiang, china

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Science china Earth sciences 2007年第12期50卷 1787-1795页

作者： YUAN WanMing1,BAO ZengKuan2.DONG JinQuan2.GUO ZhaoJie3 & DENG Jun1 1 State key laboratory of Geological Processes and Mineral Resources,{2. University of Geosciences,beijing100083,{2. 2.laboratory of nuclear analysis techniques,institute of high {12. physics,chinese academy of sciences,beijing 100039,{2. 3 Department of Geology,Peking University,beijing 100871,{2. 1. State key laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing 100083 China 2. laboratory of nuclear {2. techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100039 China 3. Department of Geology Peking University Beijing 100871 China

The mineralization ages reported in the past in the Tuwu-Yandong copper district not only are different,but also fall into the Hercynian *** study has achieved 9 zircon and 7 apatite fission track analysis *** zircon fission track ages range from 158 Ma to 2.9 Ma and the apatite ages are between 64 Ma and 140 *** mineralization accords with the regional tectonics in the copper *** consider that the zircon fission track age could reveal the mineralization age based on annealing zone temperature of 140―300℃ and retention temperature of ～2.0℃ for zircon fission track,and metallogenetic temperature of 12.―350℃ in this ore *** three mineralization epochs have been identified,i.e.,2.9―2.6 Ma,2.2.2.0 Ma and 165―158 Ma,and indicate occurrence of the min-eralization in the Indosinian and Yanshan *** to apatite fission track ages,the three tectonic-mineralizing epochs are 140―132.Ma,109―97 Ma and 64 Ma,which means age at about 100℃ after the *** three epochs lasted 146 Ma,108 Ma and about 100 Ma from ～2.0℃ to ～100℃ and trend decrease from early to *** is shown by the fission track modeling that this district underwent three stages of geological thermal histories,stable in Cretaceous and cooling both before Cretaceous and after 2. Ma.

关键词： mineralization age, tectonic epoch, fission track, zircon, apatite, Tuwu-Yandong, Xinjiang

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Correlation of Behavior Changes and BOLD Signal in Alzheimer-like Rat Model

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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 803-810页

作者： Zheng-Hui HU#, Xiao-Chuan WANG1#, Li-Yun LI3, Mai-Li LIU3, Rong LIU1, Zhiqun LING1, Qing TIAN1, Xiao-Wei TANG, Yi-Gen WU2., and Jian-Zhi WANG1* Department of physics and Bio-X disciplinary laboratory, Zhejiang University, Hangzhou 31002.,{2. 1 Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, china 2.4} of high energy physics and key laboratory of nuclear analysis {12., chinese academy of sciences, P.O. Box 918, beijing 100039, china 3Wuhan institute of physics and Mathematics, State key laboratory of Magnetic Resonance and Atomic and Molecular physics, chinese academy of sciences, Wuhan 430071, china Department of physics and Bio-X disciplinary laboratory Zhejiang UniversityHangzhou 310027China Department of Pathophysiology Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China Wuhan institute of physics and Mathematics State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Chinese Academy of SciencesWuhan 430071 China institute of high {2. physics and key laboratory of nuclear analysis techniques Chinese Academy of SciencesP.O. Box 918 Beijing 100039 China

To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2. signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2. signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser396/Ser404 and Ser199/Ser2.2.was signifi- cantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2. An AD-like spatial memory retention disturbance was induced at 2. h after isoproterenol injection. (3) A sensitivity threshold of resting T2. signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2. signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation.

关键词： Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis

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A 12.bit multichannel ADC for pixel detectors in particle physics and nuclear imaging

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Science china(Technological sciences) 2010年第5期53卷 1208-1214页

作者： WEI Wei1,2.3,WANG Zheng1,3 & ZHAO JingWei1,3 1 institute of high {2. physics,chinese academy of sciences,beijing 100049,china 2.Graduate University of chinese academy of sciences,beijing 100049,china 3 {12. Lab of nuclear Detection Technology and nuclear Electronics of chinese academy of sciences,beijing 100049,china 1. institute of high {2. physics Chinese Academy of Sciences Beijing 100049 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. Key Lab of Nuclear Detection Technology and Nuclear Electronics of Chinese Academy of Sciences Beijing 100049 China

Modern pixel detectors in nuclear and particle physics experiments and also in nuclear imaging,starve for highly integrated application specified integrated circuit(ASIC),whereas in china the study of ASIC still stays far away from practical *** lack of ASIC strictly limits the research and development of domestic high energy physics field.A 12.bit multichannel ADC designed for high density readout is introduced as a major candidate for solution.A precise model is discussed and the simulation fully agrees with the model,which indicates a key principle of *** is performed according to the given rule,and novel layout techniques are carried *** results in all aspects are also obtained,showing an excellent real performance,which satisfies the practical requirement.

关键词： application specified integrated circuit high density readout Wilkinson ADC multi-channel ADC

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Systematic distortion in cosmic microwave background maps

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Science china(physics,Mechanics & Astronomy) 2009年第5期52卷 804-808页

作者： LIU Hao 1,3 &LI TiPei 1,2.1key laboratory of Particle Astro{2.,institute of high energy {2.,chinese academy of sciences,beijing 100049,china 2.enter for Astro{2.,Tsinghua University,beijing 100084,china 3 Graduate University of chinese academy of sciences,beijing 100049,china key laboratory of Particle Astro{2. Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Center for Astrophysics Tsinghua University Beijing 100084 China Graduate University of chinese academy of sciences Beijing 100049 China

To minimize instrumentally the induced systematic errors,cosmic microwave background(CMB)anisotropy experiments measure temperature differences across the sky using pairs of horn antennas, temperature map is recovered from temperature difference obtained in sky survey through a map-making *** inspect and calibrate residual systematic errors in the recovered temperature maps is important as most previous studies of cosmology are based on these *** analyzing pixel-ring coupling and latitude dependence of CMB temperatures,we find notable systematic devia- tion from CMB Gaussianity in released Wilkinson Microwave Anisotropy Probe(WMAP)*** detected deviation cannot be explained by the best-fit LCDM cosmological model at a confidence level above 99%and cannot be ignored for a precision cosmology study.

关键词： cosmology cosmic microwave background methods data analysis

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Direct numerical simulation of shock/turbulent boundary layer interaction in a supersonic compression ramp

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Science china(physics,Mechanics & Astronomy) 2010年第9期53卷 1651-1658页

作者： LI XinLiang1,FU DeXun2.MA YanWen2.& LIANG Xian1 1 key laboratory of {2. Temperature Gas Dynamics,institute of Mechanics,chinese academy of sciences,beijing 100190,china 2.The State key laboratory of Nonlinear Mechanics,institute of Mechanics,chinese academy of sciences,beijing 100190,china 1. key laboratory of {2. Temperature Gas Dynamics Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China2. The State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China

A direct numerical simulation of the shock/turbulent boundary layer interaction flow in a supersonic 2.-degree compression ramp is conducted with the free stream Mach number *** blow-and-suction disturbance in the upstream wall boundary is used to trigger the *** the mean wall pressure and the velocity profiles agree with those of the experimental data,which validates the *** turbulent kinetic energy budget in the separation region is *** show that the turbulent production term increases fast in the separation region,while the turbulent dissipation term reaches its peak in the near-wall *** turbulent transport term contributes to the balance of the turbulent conduction and turbulent *** on the analysis of instantaneous pressure in the downstream region of the mean shock and that in the separation bubble,the authors suggest that the low frequency oscillation of the shock is not caused by the upstream turbulent disturbance,but rather the instability of separation bubble.

关键词： compression ramp shock/turbulent boundary layer interaction direct numerical simulation shock oscillation

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Deprojection technique for galaxy cluster considering the point spread function

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Science china(physics,Mechanics & Astronomy) 2010年第S1期53卷 183-186页

作者： WANG YuSa,JIA ShuMei & CHEN Yong key laboratory for Particle Astro{2.,institute of high energy {2.,chinese academy of sciences,beijing 100049,china 1. key laboratory for Particle Astro{2. Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

We present a new method for the analysis of Abell 1835 observed by *** method is a combination of the Direct Demodulation technique and *** eliminate the effects of the point spread function(PSF) with the Direct Demodulation *** then use a traditional deprojection technique to study the properties of Abell *** to only using a deprojection method,the central electron density derived from this method increases by 30%,while the temperature profile is similar.

关键词： PSF Direct Demodulation deprojection Abell 1835 galaxy cluster XMM-Newton

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Properties of the 3/2.-[52.] band in the odd-N rare-earth nuclei

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Science china(physics,Mechanics & Astronomy) 2011年第S1期54卷 37-43页

作者： CHEN Liang1,2. ZHOU XiaoHong1,2. ZHANG YuHu1, ZHANG ShuangQuan3 & ZHU LiHua4 1institute of Modern physics,{2., Lanzhou 730000, china 2.raduate University of{2., beijing 100049, china 3State key laboratory of nuclear physics and Technology, School of physics, Peking University, beijing 100871, china 4china institute of Atomic energy, beijing 102.13, china 1. institute of Modern physics Chinese Academy of Sciences Lanzhou 730000 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. State Key Laboratory of Nuclear Physics and Technology School of Physics Peking University Beijing 100871 China4. China Institute of Atomic Energy Beijing 102413 China

high-spin states in 161Er have been studied experimentally via the 150Nd(16O, 5n) reaction at a beam energy of 86 MeV. Three rotational bands built on the 5/2.[642., 3/2.[52.], and 11/2.[505] configurations have been extended up to high-spin states, and particularly, the α = -1/2.branch of the ground state 3/2.[52.] band has been revised significantly. It is found that signature inversion occurs in the 3/2.[52.] band after the band crossing in 161Er. The systematics of the signature inversion associated with the 3/2.[52.] configuration in the rare-earth region is discussed. The band properties are analyzed within the framework of a triaxial particle-rotor model, and a triaxial deformation is proposed to the 3/2.[52.] band.

关键词： high-spin states signature inversion triaxial particle-rotor model

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New evidence for lack of CMB power on large scales

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Science china(physics,Mechanics & Astronomy) 2010年第3期53卷 567-570页

作者： LIU Hao1 & LI TiPei1,2.3 1 key laboratory of Particle Astro{2., institute of high energy {2., chinese academy of sciences, beijing 100049, china 2.Department of {2. & Center for Astro{2., Tsinghua University, beijing 100084, china 3 Department of Engineering {2. & Center for Astro{2., Tsinghua University, beijing 100084, china 1. key laboratory of Particle Astro{2. Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China2. Department of Physics & Center for Astrophysics Tsinghua University Beijing 100084 China3. Department of Engineering Physics & Center for Astrophysics Tsinghua University Beijing 100084 China

A digitalized temperature map is recovered from the first light sky survey image published by the Planck team, from which an angular power spectrum of the cosmic microwave background (CMB) is derived. The amplitudes of the low multipoles (low-l) measured from the preliminary Planck power spectrum are significantly lower than those reported by the WMAP team. Possible systematical effects are far from enough to explain the observed low-l differences.

关键词： cosmology cosmic microwave background data analysis

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