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p53.Gene Mutations in Asbestos Associated Cancers

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Biomedical and Environmental sciences 1998年第3期11卷 226-232页

作者： LIU BING-CI FU DE-CHEN MIAO QING WANG HAI-HUA AND YOU BAO-RONG (institute of Occupotional theicine, chinese {2. of Preventive Medicine, {3. 100050, china) institute of Occupational Medicine Chinese Academy of Preventive Medicine Beijing China.

The accumulation of mutant p53.protein in cancer cells was observed by immunohistochemistry analysis. DNA was extracted from paraffin-embedded tissue. Exons 5, 7 and 8 were amplified and studied by PCR-SSCP and sequencing analysis. Ten cases of asbestos associated cancer tissue were studied, of which five cases had adenocarcinoma, and the other five had mesothelioma, squamous carcinoma, small cell lung cancerl adenosquamous carcinoma and malignant lymphoma respectively. Employing monoclonal antibody PAb1801, five cases were found to be mutant p53.protein mpitive. Seven cases were found to have mutations by PCRSSCP. A total of 7 cases (8 mutations) were found to be positive and 4 cases were found to be opitive by both of these analyses. Of the 8 mutations found by SSCP analysis, 4(50%, 4/8)were clustered in exon 8. A high mutation frequency was noticed in adenocarcinoma (80%,4/5). ffequencing analysis on two specimens revealed two hotspot mutations. In codon 2.4,TAC for tyrooin was mutated to AAC fOr aspar8gine by a T to A transversion of the first letter. In codon 2.3. CGT for arginine was mutated to AGT for serine by a C to A transversion of the first letter. ln conclusion, the mutation of p53.gene is common in asbestos associated cancers. However, the mutational spectrum of asbestos associated cancers might be different from that of non-asbestos associated cancers.

关键词： gene Gene SCLC p53.Gene Mutations in Asbestos Associated Cancers

IMPACTS OF FLOOD EVENTS IN COARSE SEDIMENT-PRODUCING AREAS ON CHANNEL SILTATION AND FLUVIAL PROCESS OF THE LOWER YELLOW RIVER

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International Journal of Sediment Research 2007年第2期22卷 142-149页

作者： Ou-yang ZHANG1, Xiufu FENG2.and Jiong-xin XU3. Bureau of Hydrology, Changjiang Water Resources Commission, Hubei, Wuhan 43.010, china2.Chengdu University of technology, Sichuan, Chengdu 610059, china3.2. of Geographic sciences and Natural Resources Research, CAS, beijing 100101, china Changjiang Water Resources Commiss Bureau Hydrol Wuhan 4310010 Peoples R China Chengdu Univ Technol Chengdu 610059 Peoples R China chinese Acad Sci Inst Geog Sci & Nat Resources Res Beijing 100101 Peoples R China

The method of multiple regression is used to analyze the influences of flood events from the coarse sediment producing areas on the channel siltation and fluvial process of the lower Yellow River based on the flood events from 1950 to 1985. The results showed that the flood events from the coarse sediment producing areas carry larger amounts of sediment load and coarser particle sizes than from other source areas, which increases deposition in the lower river channel. And there exist good correlations between channel siltation of the lower reaches of the Yellow River and the coming water and sediment of flood events from the coarse sediment producing areas. Through these correlations, the amounts of sediment deposition in the lower river channel could be roughly estimated based on the runoff and sediment load of flood events from the coarse sediment producing areas. The sediment deposition caused the fluvial process. There exists a complex response of channel form change to the coming water and sediment load of flood events from the coarse sediment producing areas. When the sediment concentration is smaller than 2.0kg/m3. the ratio between wide-depth ratio after flood and wide-depth ratio before flood((B/h)a / (B/h)b) will increase with the increase of the maximum sediment concentration; when the sediment concentration is near 2.0kg/m3. (B/h)a / (B/h)b reaches the maximum value; and when the sediment concentration reaches the limits of hyperconcentrated flow, (B/h)a / (B/h)b will decrease with the increase of the maximum sediment concentration. Generally, flood events from the coarse sediment producing areas made channel form of the lower Yellow River deeper and narrower, but a large amount of sediment deposition simultaneously occurs. So, the impacts of flood events from the coarse sediment producing areas on the channel of the lower Yellow River are lessened.

关键词： Channel siltation Fluvial process Coarse sediment-producing areas Flood events Yellow River basin

Generalized Projective Synchronization Between Rssler System and New Unified Chaotic System

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Communications in Theoretical Physics 2007年第7期 132-136页

作者： LI Xin CHEN Yong1 Nonlinear Science Center and Department of Mathematics,Ningbo University,Ningbo 3.52.1,china2.{3. of Theoretical Computing,East{2. Normal University,Shanghai 2.0062.china3.Key Laboratory of Mathematics and Mechanization,the chinese academy of sciences,beijing 100080,china

Based on symbolic computation system Maple and Lyapunov stability theory,an active control method isused to projectively synchronize two different chaotic systems—Lorenz-Chen-Lü system(LCL)and Rssler system,which belong to different dynamic *** this paper,we achieve generalized projective synchronization between thetwo different chaotic systems by directing the scaling factor onto the desired value *** illustrate our result,numerical simulations are used to perform the process of the synchronization and successfully put the orbits of drivesystem(LCL)and orbits of the response system(Rssler system)in the same plot for understanding intuitively.

关键词： Rssler system Lorenz-Chen-Lü system generalized projective synchronization scaling factor active control

Studies on the Chemical Constituents of Lysimachia capillipes Hemsl

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chinese Chemical Letters 1998年第12期9卷 0-0页

作者： Chen XIE Li Zhen XU Bao Hua ZHAO and Shi Lin YANG(institute of Medicinal Plant Development, chinese {2. of Medical {3. and PekingUnion Medical College, beijing 100094) Inst. of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094 China

Eight compounds were isolated from the ethanolic extracts of Lysimachia capillipes Hemsl. They were identified as capilliplactone l, capillipnin 2.β-daucosterol 3. succinic acid 4, quercetin 5, 3.,4',5,5',7-pentahydroxyflavone 6, quercetin-3.O-β-D-glucopyranoside 7 and kaempferol 8 on the basis of chemical and spectral methods. Among them, 1 and 2.were new, their structures were established as all-cis-5-deoxy-pentonic acid-y-lactone and 1,2.4,5-tetrahydroxy-3.n-pentylbenzen-2.4-di-O - D-glucopyranoside through their spectral data (1HNMR, 13.NMR, DEPT, 1H-1H COSY, 1H-13. COSY, HMBC etc).

关键词： Lysimachia lysimachia capillipes, capillplactone capillipnin

CONSENSUS CONTROL FOR LEADER-FOLLOWING MULTI-AGENT SYSTEMS WITH MEASUREMENT NOISES

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Journal of Systems Science & Complexity 2010年第1期23卷 35-49页

作者： Cuiqin MA Tao LI Jifeng ZHANG School of Mathematical sciences Qufu Normal University Qufu 273165 China. Key Laboratory of Systems and Control Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China.

This work is concerned with consensus control for a class of leader-following multi-agentsystems (MASs).The information that each agent received is corrupted by measurement *** the impact of noises on consensus,time-varying consensus gains are adopted,based on whichconsensus protocols are *** using the tools of stochastic analysis and algebraic graph theory,asufficient condition is obtained for the protocol to ensure strong mean square consensus under the *** condition is shown to be necessary and sufficient in the noise-free ***,by using a common Lyapunov function,the result is extended to the switching topology case.

关键词： Consensus protocol leader-following multi-agent system stochastic noise.

Host selection of Helicoverpa armigera and *** and its inheritance

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Progress in Natural Science:Materials International 2004年第10期14卷 40-44页

作者： WANG Chenzhu ,DONG Junfeng,TANG Deliang,ZHANG Jihong,LI Wei and QIN Junde (State Key Laboratory of Integrated Management of Pest Insects and Rodents,institute of Zoology,the chinese academy of sciences,{2.100080,{3.) Lab. of Integrated Mgmt. of Pest Inst. of Zoology Chinese Acad. of Sci. Beijing 100080 China

The difference in host selection between the polyphagous Helicoverpa armigera(H bner)and the oligophagous ***-sulta Quen e was examined,with cotton(Gossypium hirsutum),tomato(Lycopersicon esculentum)(hosts of ***),tobacco(Nicotiana tobaccum)(host of both *** and ***),and bush redpepper(Capsicum frutescens)(host of ***)as testing plants.A multiple-choice test was used with caged plant cuttings for adult oviposition and with leaf discs for larval feeding.A no-choice test was run for evaluating larval growth *** results indicated that the relationship between larval performance and adult pref-erence of *** was more conspicuous than that of *** hybridization between *** and *** followed by backcrossing of the hybrids(F 1 )with *** was also carried out for genetic study on host selection of these two insect species.A two-choice test with cotton and bush redpepper leaf discs showed that *** larvae preferred to feed on cotton,and *** larvae to bush redpepper;feeding preferences of the two F 1 lines were intermediate between those of their parents,but close to that of their female parent;preference indexes of backcross lines also showed that both maternal factor and chromosomal inheritance were involved in feeding selection of two Helicoverpa species.

关键词： Helicoverpa armigera H.assulta host selection hybridization inheritance

Taxayuntin I from Thous Yunnanensis

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chinese Chemical Letters 1999年第1期10卷 43-44页

作者： Jin Yun ZHOU Pei Ling ZHANG Wei Ming CHEN and Qi Cheng FANG(institute of Materia Medica, chinese {2. of Medical {3. and Peking UnionMedical College, beijing 100050) institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

Taxayuntin I, a new 11I (15→1)abeotaxane. was isolated from the leaves and stems ofTaxes yunnanensis. Its structure was elucidated on the basis of spectroscopic data.

关键词： TaxusyUnnanensis taxoids abeotaxane taxayuntin I

Constant-Volume Heat Capacity of Mixed Supercritical Fluids and Molecular Interaction in the Systems

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chinese Chemical Letters 1999年第10期10卷 873-874页

作者： Lei SHI Xi Feng ZHANG Xiao Gang ZHANG Bu Xing HAN Guan Ying YANG Hai Ke YAN(institute of Chemistry, chinese academy of sciences, {2. 100080) institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

Constant-volume heat capacities of supercritical (SC) CO2. SC CO2.n-pentane, and SC CO2.n-heptane mixtures were determined at 3.8.15 K in the pressure range from 6 to 12.MPa. It was found that there is a maximum in ea... 详细信息

关键词： constant-volume heat capacity mixed supercritical fluids molecular interaction

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食欲素神经肽在应激过程中的作用

生物化学与生物物理进展 2010年第7期37卷 713-719页

作者：魏楚光李勇辉韩锦王慧颖隋南中国科学院心理研究所心理健康重点实验室北京100101 中国科学院研究生院北京100049

食欲素因其在调节能量代谢、睡眠和唤醒等生理功能中的作用而备受关注.近年来研究逐渐发现,食欲素参与应激和奖赏过程的调节,特别是其在药物成瘾过程中的作用是目前的研究热点.主要介绍食欲素系统与应激相关系统之间的神经联系,阐述了... 详细信息

食欲素因其在调节能量代谢、睡眠和唤醒等生理功能中的作用而备受关注.近年来研究逐渐发现,食欲素参与应激和奖赏过程的调节,特别是其在药物成瘾过程中的作用是目前的研究热点.主要介绍食欲素系统与应激相关系统之间的神经联系,阐述了其在应激相关的生理、神经内分泌与行为反应中的作用.并进一步介绍了食欲素系统在应激诱发药物成瘾复吸过程中的作用.食欲素对应激反应的调控作用具有相对特异性,受应激的种类、其他应激相关神经递质系统及食欲素神经元的投射通路等多种因素影响.

关键词：食欲素应激药物成瘾复吸