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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jian-Hong ZHU National Laboratory for Medical Neurobiology,department of Neurosurgery,Fudan university Huashan {2., {3. Medical College-Fudan university,{3. 2.0040,china

＜正＞Characterizing the properties of adult neural stem cells may ultimately contribute to development of effective medicines for brain tissue repair and *** stem cells are present not only in the developing nervous systems,but also in the adult human central nervous *** head injury often causes damage to brain *** neural tissue is out of the brain,it is generally *** investigated whether such tissue could be used as a source for isolation of neural stem cells and the cultured neural stem cells could be implanted autologously into patients for treatment of neurological deficits caused by *** isolated and propagated adult neural stem cells from the exposed brain tissue of the patients with open brain trauma,and then implanted autologous neural stem cells into the traumatic regions with MRI-guided stereotactic device for the *** 2.years follow-ups,the patients were investigated by functional MRI（fMRI）,F-18-fluorodeoxyglucose positron emission tomography（FDG-PET）,somatosensory evoked potential （SEP） for physiological recovery and assessed by DRS for functional *** to control group,implantation of neural stem cells was associated with a significant improvement in patient’s neurological function investigated by DRS during long-term *** improved brain function was accompanied by partial recovery of activity in damaged areas as assessed by fMRI and SEP,and by significant increases in neural viability within injured territories as assessed by *** of damaged brain tissue with neural stem cells（NSCs） is a promising strategy for reversing neurological *** of stem cell therapy have required non-invasive analysis of the fate and migration of implanted ***,we report the feasibility of labeling human NSCs with superparamagnetic iron oxide nanoparticles and tracking them with magnetic resonance imaging（MRI） and demonstrates that stem cell engraftment and migrat

关键词： adult brain stem cells stem cell therapy traking stem cells

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Screening,purification,and identification of annexin B1 mutants with high phosphatidylserinc-binding activity and reduced immunogenicity

Screening,purification,and identification of annexin B1 muta...

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第八次全国医学遗传学学术会议(中华医学会2.09年医学遗传学年会)

作者： WANG Fang~1,LUO Quan-Yong~2.HE Ying~1,SUN Shu-Han~(1*) 1 department of Medical Genetics,Second Millitary Medical university,{2. 2.043.,china 2.department of Nuclear Medicine,{2. Sixth People’s hospital,{2. Jiao Tong university,{2. 2.02.3.china

Annexin B1 has many potential biomedical applications based on its high affinity for negatively charged phospholipid (phosphatidylserine,PS)in the presence of physiological concentrations of *** immunogenicity is prerequisite for the in vivo application of a non-human protein as a novel imaging *** the present study,three sequence-deleted mutants with different numbers of functional domains were designed and expressed according to the predicted three dimensional structure of annexin *** mutants of annexin B1,as well as the wild-type annexin B1,were expressed as GST-fusion *** mutants with their purity above 80%could be obtained after one-step primary purification procedure on basis of the PS-binding *** immunogenicity of the two mutants was evaluated in mice by detecting the titers of elicited antigen-specific IgG.A member of three mutants of annexin B1,M12. which involved N-terminal amino acid sequence and double functional domainⅠandⅡof annexin B1,was finally selected to detect apoptosis due to its lowest immunogenicity among the candidate ***-labeled M12.could bind the outer membranes of apoptotic cells and discriminate apoptotic cells in the early stage from necrotic cells when used with ***-labeled M12.could recognize the apoptotic hepatocytes induced by anti-Fas antibody *** data in vitro and in vivo demonstrated that M12.could be applied as a promising agent for the detection of apoptosis.

关键词： Annexin B1 Immunogenicity Apoptosis imaging 99mTc

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RNA-interference-based functional research on rat epididymis-specific gene 16 and human paternally expressed gene PEG10 and the therapeutic applications of RNA interference in HBV,SARS,liver cancer,liver fibrosis and keloid fibroblast

RNA-interference-based functional research on rat epididymis...

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第四届全国RNA进展研讨会

作者： Shi Y, Xiong J, Zhou XM, Yang DH, Li GM, Gao ZY and Jin YX The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, shanghai Institutes for Biological Sciences, Chinese Academy of Science, shanghai 2.003.,{2.. department of Immunology, Wuhan university School of Medicine, Wuhan, Hubei 43.071,{2.. Institute of Liver Diseases, tongji hospital, tongji Medical College, Huazhong university of Science and Technology, Wuhan 43.03.,{2..College of Life Science, South{2. Normal university, Guangzhou 51063.,{2.. department of Gastroenterology, Xinhua hospital, shanghai Second Medical university, shanghai 2.0092.{2.. department of Plastic Surgery, Changzheng hospital, Second Military Medical university, shanghai 2.0003.{2..

RNA interference or RNAi is a powerful cellular mechanism of eukaryotic gene regulation in which a short sequence of double-stranded RNA (dsRNA) specifically down-regulates expression of the associated gene. In mammalian cells, siRNAs do not activate interferon pathway genes, thereby making these powerful tools for basic and applied researches. Our application of RNAi ranged from the study of gene function to therapy of diseases. We have designed siRNA targeting the rat epididymis-specific gene 16 and the human paternally expressed gene PEG10 to explore their function.

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Enhancement patterns of small hepatocellular carcinoma shown by dynamic MRI and CT

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Hepatobiliary & Pancreatic Diseases International 2002年第3期1卷 420-424页

作者： Fu-Hua Yan Ji-Zhang Shen Ren-Chen Li Meng-Su Zeng Dong Wu Kang-Rong Zhou Jun Yang Jing-Shan Gong Wei-Bin Shi the department of Radiology, Zhongshan hospital, Fudan {2., {3. 2.003.2} china department of Radiology Zhongshan Hospital Fudan University Shanghai 200032 China. yanfuhua@***

Objectives: To study prospectively the enhancement features of small hepatocellular carcinoma (SHCC) with multi-phase scanning of dynamic MRI and spi- ral CT, and discuss the superiority of dynamic MRI to spiral CT. Methods: Multi-phase dynamic contrast scanning of high field MRI and spiral CT were performed in 53.patients with SHCC. The arterial phase, portal ve- nous phase and delayed phase scanning of spiral CT was done after the pre-contrast scanning of the entire liver. MRI was performed with SE sequence and fast multiplanar spoiled gradient-recalled sequence dy- namic multi-phase contrast scanning. Results: Seventy-six lesions were found in all 53.pa- tients. Sixty-nine and 54 of the 76 lesions enhanced obviously in MRI and spiral CT arterial phase scan- ning respectively. The typical enhancement patterns of SHCC in the arterial phase, portal venous phase and delayed phase scanning of MRI and spiral CT were hyper-hypo-hypointense (dense) and hyper-iso- hypointense (dense). Atypical enhancement patterns were hyper-hyper-hyperintense (dense), hyper-iso- isointense (dense) and hypo-hypo-hypointense (dense). Conclusions: Both MRI and spiral CT multi-phase dynamic contrast-enhanced scanning could demon- strate the enhancement features of SHCC, and arte- rial phase scan of MRI was superior to spiral CT in reflecting the hypervascular characterization of SHCC. In addition, MRI was better than spiral CT in characterization of hepatic lesions combined with SE sequence.

关键词： magnetic resonance imaging computed tomography liver neoplasms dynamic enhancement

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维普期刊数据库

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膝关节周围骨恶性肿瘤瘤段切除灭活再植术的康复治疗

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上海医学 2000年第12期23卷 724-727页

作者：俞光荣蔡宣松梅炯郭荻萍袁锋同济大学医学院附属甘泉医院骨科上海200065

目的　探讨膝关节周围骨恶性肿瘤瘤段切除灭活再植术功能恢复相关的康复治疗。方法　本组79例 ,其中胫骨上端 2.1例 ,股骨远端 5 8例。常见肿瘤中骨肉瘤 5 7例 ,巨细胞瘤 6例 ,恶性纤维组织细胞瘤 6例 ,软骨肉瘤 5例。关节内瘤段切除灭... 详细信息

目的　探讨膝关节周围骨恶性肿瘤瘤段切除灭活再植术功能恢复相关的康复治疗。方法　本组79例 ,其中胫骨上端 2.1例 ,股骨远端 5 8例。常见肿瘤中骨肉瘤 5 7例 ,巨细胞瘤 6例 ,恶性纤维组织细胞瘤 6例 ,软骨肉瘤 5例。关节内瘤段切除灭活再植 75例 ,关节外瘤段切除灭活再植 4例。术后分 3.阶段采用不同的康复计划进行功能训练。结果　 79例随访 1～ 7年 (平均 4.2. ) ,5年生存率 42.% (3.例 )。按Enneking法功能评定 ,关节内瘤段切除灭活再植 44例平均 2.0分 (14～ 2.5分 ) ,优良率达到 77% ;关节外瘤段切除灭活再植 4例平均 2.4分 (2.2. 2.8分 ) ,效果全优。结论　瘤段切除灭活再植术是一种治疗膝关节周围骨恶性肿瘤较好的保肢方法 ,有计划的康复治疗有助于肢体功能的恢复。

关键词：外科手术保肢术康复膝关节周围骨肿瘤

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PROGNOSTIC VALUE OF ELECTROENCEPHALO-GRAPHY BACKGROUND ACTIVITIES IN ASPHYXIATED NEONATES

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Medical Bulletin of shanghai Jiaotong university 2011年第1期23卷 38-45页

作者：王治平陈妍张志芳沈理笑 department of Pediatrics Shanghai Children's Medical CenterShanghai Jiaotong University School of Medicine department of Pediatrics Xinhua HospitalShanghai Jiaotong University School of Medicine

Objective To identify the changes in the electroencephalography (EEG) background activities in asphyxiated neonates and to determine the prognostic value of these changes in neurological *** A total of 46 asphyxiated neonates and 3. healthy newborns were studied using standard ***-three neonates from the asphyxiated group were followed up and had neurological examinations and developmental assessments at 3.6,9 and 12.months of *** parameters that had prognostic significance were statistically analyzed,and the correlations of these parameters with neurological outcome were *** ①Significant EEG changes were found in asphyxiated neonates:a longer maximum duration of interburst interval,lower amplitudes during all states,and a higher incidence of brief burst and sleep-wake cycle disturbance.②There were significant correlations between hypoxic-ischemic encephalopathy (HIE) classification,debased amplitude,positive spikes and sharp waves,and abnormal sleep cycles.③Gestational age,birth weight,EEG amplitude,severity of HIE,occurrence of sleep-wake cycle disturbance,and imaging abnormality were found to be important markers for predicting the outcome of neonates with *** The study suggested that changes in the EEG background activities correlated with the prognosis of neonates with *** is an effective tool for predicting the neurologic outcome of asphyxiated newborns.

关键词： electroencephalography background activity prognosis neonatal asphyxia

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Retroperitoneal laparoscopic nephropexy:a report of 2. cases

Retroperitoneal laparoscopic nephropexy:a report of 28 cases

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第十五届全国泌尿外科学术会议

作者： ZHENG Jun-hua1,PENG Bo1,XU Dan-feng2. GO Yi2.(department of Urology, {3. 10th People’s {2., tongji university, {3. 2.0072.

Objective: To discuss the procedures and clinical effect of retroperitoneal laparoscopic nephropexy (RLN). Methods: From August 2.01 to June 2.06, RLN was performed on 2. female patients (aged 2.-45 years old, mean 3....

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Cytokine and Cytokine Receptor Gene Polymorphisms affect development of uremia

Cytokine and Cytokine Receptor Gene Polymorphisms affect dev...

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第十五届全国泌尿外科学术会议

作者： YANG Jiping1 ZHENG Jun-hua2.MIN Zhi-lian1 department of Urology, shanghai 10th People’s {2., tongji university, shanghai 2.0072

Objective:To determine the distribution of cytokine and cytokine receptor genotype in renal transplant recipient and donor and provide some useful genetic information for the study of pathogenic mechanisms of uremia. ...

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肺癌介入治疗的现状

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铁道医学 2001年第5期29卷 348-350页

作者：周永新同济大学附属同济医院胸外科上海200065

肺癌的介入治疗近几年有了较大的发展 ,有经支气管动脉灌注化疗、栓塞或化疗栓塞 ,经皮下药盒埋置系统化疗 ,肺动脉灌注化疗 ,双介入化疗 ,经皮瘤体内注药等多种方法。其中经支气管动脉灌注化疗已普遍应用于临床 ,并取得了较好的疗效 ,... 详细信息

肺癌的介入治疗近几年有了较大的发展 ,有经支气管动脉灌注化疗、栓塞或化疗栓塞 ,经皮下药盒埋置系统化疗 ,肺动脉灌注化疗 ,双介入化疗 ,经皮瘤体内注药等多种方法。其中经支气管动脉灌注化疗已普遍应用于临床 ,并取得了较好的疗效 ,局部注射治疗及埋入式导管药盒系统的应用也逐渐增多 ,但有些方法如血管栓塞目前仍处于初步应用阶段 ,仍有待于进一步积累经验。介入方法多与其他治疗手段结合使用 ,明显提高了疗效。但对于如何更有效地结合应用各种治疗方法 ,仍有待进一步临床应用总结。

关键词：肺癌药物治疗介入疗法

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维普期刊数据库

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Different pathological categories of breast cancer:imaging with real-time gray scale contrast-enhanced ultrasonography-an initial experience

Different pathological categories of breast cancer:imaging w...

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第二届长三角超声医学论坛暨2.09年浙江省超声医学学术年会

作者： department of Ultrasound,Huashan hospital of Fudan {2.,{3. 2.003.2}china Xiao-hong WANG Ping XU Yi WANG

Objective The purpose of the study was to analyze the imaging characteristics of different pathological categories of breast carcinoma at contrast-enhanced ultrasonography(CEUS) and then objectively evaluate the diagn...

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